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Kim, Dong-Ha,Lim, Yun-Young,Kim, Hyeong-Mi,Kim, So-Young,Kim, Beom-Joon,Park, Sung-Gil,Lee, Tae-Hoon,Cho, Soo-Muk Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.1
A novel synthetic hexapeptide (SFKLRY-$NH_2$) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-$NH_2$ on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-$NH_2$ in HaCaT cells and B16F10 cells. SFKLRY-$NH_2$ induced no skin irritation at low concentration ($10{\mu}m$), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-$NH_2$ in clinical use.
The Smad7–Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-β
Kim, Tae-Aug,Kang, Jin Muk,Hyun, Ja-Shil,Lee, Bona,Kim, Staci Jakyong,Yang, Eun-Sung,Hong, Suntaek,Lee, Ho-Jae,Fujii, Makiko,Niederhuber, John E.,Kim, Seong-Jin The Company of Biologists Ltd. 2014 Journal of cell science Vol.127 No.2
<P>In most human cancers the Myc proto-oncogene is highly activated. Dysregulation of Myc oncoprotein contributes to tumorigenesis in numerous tissues and organs. Thus, targeting Myc stability could be a crucial step for cancer therapy. Here we report Smad7 as a key molecule regulating Myc stability and activity by recruiting the F-box protein, Skp2. Ectopic expression of Smad7 downregulated the protein level of Myc without affecting the transcription level, and significantly repressed its transcriptional activity, leading to inhibition of cell proliferation and tumorigenic activity. Furthermore, Smad7 enhanced ubiquitylation of Myc through direct interaction with Myc and recruitment of Skp2. Ablation of Smad7 resulted in less sensitivity to the growth inhibitory effect of TGF-β by inducing stable Myc expression. In conclusion, these findings that Smad7 functions in Myc oncoprotein degradation and enhances the cytostatic effect of TGF-β signaling provide a possible new therapeutic approach for cancer treatment.</P>
Kim, Tae Jung,Park, Jae Chan,Hwang, Soon Yong,Byun, Jun Seok,Park, Han Gyeol,Kang, Yu Ri,Kim, Young Dong,Hwang, Soo Min,Lee, Seung Muk,Joo, Jinho 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
We report the optical properties of amorphous LaAlOx (LAO) films grown by using the sol-gel process. The dielectric functions epsilon of the LAO films are obtained from 0.7 to 8.6 eV as a function of post-annealing temperature using spectroscopic ellipsometry. The LAO precursor sols were prepared at a molar ratio of La:Al = 1:1, were deposited on p-type Si substrates, and were sintered at 400 A degrees C. Post-annealing was performed for 1 min in N-2 by rapid thermal annealing (RTA) at 700, 850, and 1000 A degrees C. The e spectra of the resulting LAO films were obtained from the measured pseudodielectric functions by using multilayer calculations with the Tauc-Lorentz dispersion relation. We found that the values of epsilon for the sol-gel-deposited LAO films depended on the RTA temperature. This dependence provides a fundamental tuning basis for the solution-processed manufacture of LAO devices.
위선암종에서 p53 단백 및 CREB-결합 단백의 면역조직화학적 발현양상
노태호(Tae Ho Noh),지경천(Kyung Choun Chi),임현묵(Hyun Muk Lim),이정효(Jung Hyo Lee),박용검(Yong Gum Park),김범규(Beom Gyu Kim),김미경(Mi Kyung Kim),김진수(Jin Soo Kim) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.6
Purpose: The wild-type p53 protein participates in suppressing cell transformations while its mutant forms has tumorigenic potential. Alterations in the structure of the p53 protein are one of the most common changes associated with human cancers. CREB-binding protein (CBP) and its homologue, p300, are transcriptional co-activators of various sequence-specific DNA-binding transcription factors and are involved in a wide range of cellular activities, such as DNA repair, cell growth, differentiation, and apoptosis. Several studies suggested that an association between p53 and p300 might account for the p53-responsible negative regulation. This study examined the relationship between p53 and CBP expression in terms of the clinicopathological factors and significance. Methods: The level of p53 protein and CBP expression was measured in 150 gastric adenocarcinoma patients, who had undergone a gastrectomy, and the relationship between p53 and CBP was examined. Immunohistochemical stain was performed on formalin-fixed paraffin-embedded sections using monoclonal anti-p53 and anti-CBP antibody. Results: 1. p53 protein was expressed in 46.3% (31/67) of early gastric cancers (EGC), 69.9% (58/83) of advanced gastric cancers (AGC)(P<0.05), 69.1% (65/94) of the intestinal type, 42.9% (24/56) of the diffuse type (P<0.05), 78.5% (55/70) of patients with a lymph node metastasis and 42.5% (34/80) of patients without a lymph node metastasis (P<0.01). 2. CBP expression was observed in 65% (61/94) of intestinal type, 51% (29/56) of the diffuse type (P>0.05), 47.8% (32/67) of EGC, 69.8% (58/83) of AGC (P<0.05), 68.6% (48/70) of patients with a lymph node metastasis and 52.5% (42/80) of patients without a lymph node metastasis (P>0.05). 3. p53 protein and CBP expression was coincidentally observed in 66.7% of gastric adenocarcinomas, and there was a significant correlation between the expression of both (P<0.05). Conclusion: That the expression of the p53 protein and CBP indirectly indicate the malignant potential of a cell, and may play an indirect role in the CBP and p53-mediated tumorigenic potential.