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        Risk factors and trajectories of opioid use following total knee replacement

        ( Ralph Ward ),( David Taber ),( Haley Gonzales ),( Mulugeta Gebregziabher ),( William Basco ),( Jenna Mccauley ),( Patrick Mauldin ),( Sarah Ball ) 대한슬관절학회 2022 대한슬관절학회지 Vol.34 No.-

        Background: Opioids are commonly used to manage orthopedic pain in those undergoing total knee arthroplasty (TKA). There are limited studies assessing patterns of perioperative opioid use and risk factors for chronic use in patients undergoing TKA. Methods: This is a retrospective longitudinal cohort study of Medicaid enrollees undergoing TKA between 2014 and 2017 using de-identified medical and pharmacy claims. The primary outcome was chronic opioid use (opioid prescription filled 90-270 days following TKA). Trajectory group membership was determined by identifying distinct groups of patients with similar patterns of daily morphine milligram equivalent (MME) values during the postsurgery follow-up period. Results: In total, 1666 TKA surgeries performed in 1507 patients were included; 69% of patients were classified as chronic opioid users. Multivariable analyses identified prior opioid use, high opioid doses during the month after TKA, concomitant mood therapies and benzodiazepines, and comorbid conditions as important risk factors. Group-based trajectory analysis identified five distinct post-TKA surgery opioid use phenotypes with several key characteristics predicting group membership. Conclusions: This large-scale analysis demonstrated that chronic opioid use was common after TKA surgery and established several important risk factors for chronic use following TKA. Novel analysis revealed five distinct opioid use trajectories and identified key characteristics to help guide clinicians when determining perioperative opioid use. Results demonstrate that interventional studies attempting to reduce opioids after TKA are needed if reductions in long-term use are to be realized in this high-risk patient population.

      • KCI등재후보

        Evaluationof Phosphorus Rateand Mixing Depthonthe Growthand Establishment of Kentucky bluegrass(Poapratensis L.) in Sand-Based Systems

        이상국,David D. Minner,Nick E, Christians,Henry G. Taber 한국잔디학회 2009 Weed & Turfgrass Science Vol.23 No.2

        Phosphorus (P) is one of the essential elements of the phospholipids that are involved in the formation of plant cell membranes. Phosphorus is highly immobile in soils and is often a limiting nutrient for plant growth. Phosphorus mobility and availability varies with several factors such as application frequency, placement in the soil, and the amount of irrigation or precipitation. This study was conducted to evaluate the effect of P applications at level of 0, 146, and 293 kg․ha-1 at four mixing depths (0, 7.6, 15.2, and 22.9 cm )on the growth and establishment of Kentucky bluegrass (Poapratensis L.) in a sand-based system.Grass clipping samples were collectedevery two weeks, dried, and weighed. Total root dry weight, root organic matter, and tissue content of P were measured at the end of the study. Leachate was collected weekly and analyzed for total P concentration. No difference was found between application of P to the surface and to the 7.6 cm mixing depth. However, surface application with 146 and 293 kg P․ha-1 produced 8-10% and 16-20% more P in tissue than subsurface applications, respectively Phosphorus (P) is one of the essential elements of the phospholipids that are involved in the formation of plant cell membranes. Phosphorus is highly immobile in soils and is often a limiting nutrient for plant growth. Phosphorus mobility and availability varies with several factors such as application frequency, placement in the soil, and the amount of irrigation or precipitation. This study was conducted to evaluate the effect of P applications at level of 0, 146, and 293 kg․ha-1 at four mixing depths (0, 7.6, 15.2, and 22.9 cm )on the growth and establishment of Kentucky bluegrass (Poapratensis L.) in a sand-based system.Grass clipping samples were collectedevery two weeks, dried, and weighed. Total root dry weight, root organic matter, and tissue content of P were measured at the end of the study. Leachate was collected weekly and analyzed for total P concentration. No difference was found between application of P to the surface and to the 7.6 cm mixing depth. However, surface application with 146 and 293 kg P․ha-1 produced 8-10% and 16-20% more P in tissue than subsurface applications, respectively

      • Evaluationof Phosphorus Rateand Mixing Depthonthe Growthand Establishment of Kentucky bluegrass(Poapratensis L.) in Sand-Based Systems

        이상국,데이비드미너,닉크리스챤,헨리테이버,Lee, Sang-Kook,Minner, David D.,Nick E., Christians,Taber, Henry G. Turfgrass Society of Korea 2009 한국잔디학회지 Vol.23 No.2

        인산은 식물세포막의 형성과 관련 있는 인지질의 주요 구성요소이다. 인산은 토양에서 움직일 수 없기 때문에 자주식물 생장에 저해요인으로 작용하기도 한다. 인산의 이동성과 식물의 이용성은 인산의 시용빈도, 토양에서의 위치, 관수량 및 강우와 같은 다양한 요인에 따라 다르게 나타난다. 본 연구에서는 모래시공 골프장에서 인산의 시용량(0, 146, 293 $kg{\cdot}ha^{-1}$)이 인산을 혼합하는 깊이(0, 7.6, 15.2, 22.9 cm)에 따라 캔터키블루그래스의 생장과 정착에 미치는 영향을 평가하였다. 그 결과 인산은 토양표면과 7.6cm의 깊이에 시용하였을 때 통계적인 유의성이 발견되지 않았다. 하지만 헥타아르당 146과 293kg을 시용하였을 때 무처리보다 식물 체조직 내에서 8~10%와 16~20%의 인산이 검출되었다. Phosphorus (P) is one of the essential elements of the phospholipids that are involved in the formation of plant cell membranes. Phosphorus is highly immobile in soils and is often a limiting nutrient for plant growth. Phosphorus mobility and availability varies with several factors such as application frequency, placement in the soil, and the amount of irrigation or precipitation. This study was conducted to evaluate the effect of P applications at level of 0, 146, and 293 $kg{\cdot}ha^{-1}$ at four mixing depths (0, 7.6, 15.2, and 22.9 cm )on the growth and establishment of Kentucky bluegrass (Poapratensis L.) in a sand-based system.Grass clipping samples were collectedevery two weeks, dried, and weighed. Total root dry weight, root organic matter, and tissue content of P were measured at the end of the study. Leachate was collected weekly and analyzed for total P concentration. No difference was found between application of P to the surface and to the 7.6 cm mixing depth. However, surface application with 146 and 293 kg $P{\cdot}ha^{-1}$ produced 8-10% and 16-20% more P in tissue than subsurface applications, respectively.

      • KCI등재

        Evaluationof Phosphorus Rateand Mixing Depthonthe Growthand Establishment of Kentucky bluegrass(Poapratensis L.) in Sand-Based Systems

        Sang-Kook Lee(이상국),David D. Minner(데이비드미너),Nick E Christians(닉크리스챤),Henry G. Taber(헨리테이버) 한국잡초학회·한국잔디학회 2009 Weed & Turfgrass Science Vol.23 No.2

        인산은 식물세포막의 형성과 관련 있는 인지질의 주요 구성요소이다. 인산은 토양에서 움직일 수 없기 때문에 자주식물 생장에 저해요인으로 작용하기도 한다. 인산의 이동성과 식물의 이용성은 인산의 시용빈도, 토양에서의 위치, 관수량 및 강우와 같은 다양한 요인에 따라 다르게 나타난다. 본 연구에서는 모래시공 골프장에서 인산의 시용량(0, 146, 293 ㎏?㏊<SUP>-1</SUP>)이 인산을 혼합하는 깊이(0, 7.6, 15.2, 22.9 ㎝)에 따라 캔터키블루그래스의 생장과 정착에 미치는 영향을 평가하였다. 그 결과 인산은 토양표면과 7.6 ㎝의 깊이에 시용하였을 때 통계적인 유의성이 발견되지 않았다. 하지만 헥타아르당 146과 293 ㎏을 시용하였을 때 무처리보다 식물 체조직내에서 8~10%와 16~20%의 인산이 검출되었다. Phosphorus (P) is one of the essential elements of the phospholipids that are involved in the formation of plant cell membranes. Phosphorus is highly immobile in soils and is often a limiting nutrient for plant growth. Phosphorus mobility and availability varies with several factors such as application frequency, placement in the soil, and the amount of irrigation or precipitation. This study was conducted to evaluate the effect of P applications at level of 0, 146, and 293 ㎏?㏊<SUP>-1</SUP> at four mixing depths (0, 7.6, 15.2, and 22.9 ㎝ )on the growth and establishment of Kentucky bluegrass (Poapratensis L.) in a sand-based system.Grass clipping samples were collectedevery two weeks, dried, and weighed. Total root dry weight, root organic matter, and tissue content of P were measured at the end of the study. Leachate was collected weekly and analyzed for total P concentration. No difference was found between application of P to the surface and to the 7.6 ㎝ mixing depth. However, surface application with 146 and 293 ㎏ P?㏊<SUP>-1</SUP> produced 8-10% and 16-20% more P in tissue than subsurface applications, respectively.

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