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Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin
Park, T.Y.,Kim, S.H.,Shin, Y.C.,Lee, N.H.,Lee, R.K.C.,Shim, J.H.,Glimcher, L.H.,Mook-Jung, I.,Cheong, E.,Kim, W.K.,Honda, F.,Morio, T.,Lim, J.S.,Lee, S.K. Elsevier Science Publishers 2013 Journal of controlled release Vol.166 No.3
Inhibition of the early intracellular event that triggers neurodegenerative cascades and reversal of neuronal cell death are essential for effective treatment of Alzheimer's disease (AD). In this study, a novel therapeutic for AD, a transducible humanin with an extended caspase-3 cleavage sequence (tHN-C3), was developed and showed multiple mechanisms of therapeutic action. These included targeted delivery of anti-apoptotic protein humanin through the blood-brain barrier (BBB) to neuronal cells, specific inhibition of caspase-3 activation to inhibit the early triggering of AD progression, and delivery of humanin into the cytoplasm of neuronal cells undergoing apoptosis where it exerts its anti-apoptotic functions effectively. The tHN-C3 prevented neuronal cell death induced by H<SUB>2</SUB>O<SUB>2</SUB>, or soluble Aβ<SUB>42</SUB>, via Bax binding. In animal models of AD induced by amyloid beta, in Tg2576 mice, and in the rat middle cerebral artery occlusion model of stroke, tHN-C3 effectively prevented neuronal cell death, inflammatory cell infiltration into the brain, and improved cognitive memory. The therapeutic effectiveness of tHN-C3 was comparable to that of Aricept, a clinically approved drug for AD treatment. Therefore, tHN-C3 may be a new remedy with multiple therapeutic functions targeting the early and late stages of neurodegeneration in AD and other brain injuries.
Measurement of Unbound Excited States of ^(24)O
추경호,사토,T. Nakamura,N. Aoi,방형찬,S. CHOI,S. Deguchi,F. Delaunay,J. Gibelin,T. Honda,M. Ishihara,Y. Kawada,Y. Kondo,T. Kobayashi,N. Kobayashi,F. M. Marques,M. Matsushita,Y. Miyashita,T. Motobayashi,Y. Nak 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The unbound excited states of the most neutron-rich oxygen isotope, ^(24)O (Z = 8, N = 16), have been investigated using the ^(24)O(p,p') ^(24)O^* → ^(23)O+n reaction at RIKEN, where a 63 MeV/neuclon secondary beam of ^(24)O was produced in a Be production target by the projectile-like fragmentation of a 95 MeV/u ^(40)Ar primary beam. The first excited 2^* state was observed in the invariant mass spectrum. This experiment will give us a deeper understanding of the new magic number at N=16 in the neutron-rich oxygen isotopes.
Fabrication of 8Cr-2W ferritic steel tile for reduction in toroidal magnetic field ripple on JT-60U
yusuke Kudo,K. Masaki,M. Honda,N. Miya,R. Takahashi,S. Jitsukawa,S. Sakurai,T. Sawai,T. Sasajima,T. Hayashi,Y. Suzuki 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
The objectives are to fabricate the ferritic steel for the reduction in the toroidal magnetic field ripple on JT-60U. The ferritic steel (8Cr-2W-0.2V) is selected by saturated magnetization and fabrication processes with more than 20 tons melting are reported. Although the magnetic properties of the plates fabricated are clarified, the little variation is observed but the saturated magnetization is lower than expected. Additional material conditions are clarified to improve the saturated magnetization without degradation of mechanical properties but it is decided not to adapt this process on grounds of cost-effectivenessP
Measurement of Unbound Excited States of 24O
Tshoo, K.,Satou, Y.,Nakamura, T.,Aoi, N.,Bhang, H. C.,Choi, S.,Deguchi, S.,Delaunay, F.,Gibelin, J.,Honda, T.,Ishihara, M.,Kawada, Y.,Kondo, Y.,Kobayashi, T.,Kobayashi, N.,Marques, F. M.,Matsushita, M Korean Physical Society 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.2