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Ueta, M.,Sawai, H.,Sotozono, C.,Hitomi, Y.,Kaniwa, N.,Kim, M.K.,Seo, K.Y.,Yoon, K.C.,Joo, C.K.,Kannabiran, C.,Wakamatsu, T.H.,Sangwan, V.,Rathi, V.,Basu, S.,Ozeki, T.,Mushiroda, T.,Sugiyama, E.,Maekaw Mosby 2015 The Journal of allergy and clinical immunology Vol.135 No.6
Background: Stevens-Johnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface, oral cavity, and genitals. These reactions are very rare but are often associated with inciting drugs, infectious agents, or both. Objective: We sought to identify susceptibility loci for cold medicine-related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement (SMI). Methods: A genome-wide association study was performed in 808 Japanese subjects (117 patients with CM-SJS/TEN with SMI and 691 healthy control subjects), and subsequent replication studies were performed in 204 other Japanese subjects (16 cases and 188 control subjects), 117 Korean subjects (27 cases and 90 control subjects), 76 Indian subjects (20 cases and 56 control subjects), and 174 Brazilian subjects (39 cases and 135 control subjects). Results: In addition to the most significant susceptibility region, HLA-A, we identified IKZF1, which encodes Ikaros, as a novel susceptibility gene (meta-analysis, rs4917014 [G vs T]; odds ratio, 0.5; P = 8.5 x 10<SUP>-11</SUP>). Furthermore, quantitative ratios of the IKZF1 alternative splicing isoforms Ik1 and Ik2 were significantly associated with rs4917014 genotypes. Conclusion: We identified IKZF1 as a susceptibility gene for CM-SJS/TEN with SMI not only in Japanese subjects but also in Korean and Indian subjects and showed that the Ik2/Ik1 ratio might be influenced by IKZF1 single nucleotide polymorphisms, which were significantly associated with susceptibility to CM-SJS/TEN with SMI.
Fabrication of 8Cr-2W ferritic steel tile for reduction in toroidal magnetic field ripple on JT-60U
yusuke Kudo,K. Masaki,M. Honda,N. Miya,R. Takahashi,S. Jitsukawa,S. Sakurai,T. Sawai,T. Sasajima,T. Hayashi,Y. Suzuki 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
The objectives are to fabricate the ferritic steel for the reduction in the toroidal magnetic field ripple on JT-60U. The ferritic steel (8Cr-2W-0.2V) is selected by saturated magnetization and fabrication processes with more than 20 tons melting are reported. Although the magnetic properties of the plates fabricated are clarified, the little variation is observed but the saturated magnetization is lower than expected. Additional material conditions are clarified to improve the saturated magnetization without degradation of mechanical properties but it is decided not to adapt this process on grounds of cost-effectivenessP