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Lee, S.E.,Chang, H.J.,Rizvi, A.,Hadamitzky, M.,Kim, Y.J.,Conte, E.,Andreini, D.,Pontone, G.,Volpato, V.,Budoff, M.J.,Gottlieb, I.,Lee, B.K.,Chun, E.J.,Cademartiri, F.,Maffei, E.,Marques, H.,Leipsic, J C. V. Mosby Co 2016 American Heart Journal Vol.182 No.-
<P>Background The natural history of coronary artery disease (CAD) in patients with low-to-intermediate risk is not well characterized. Although earlier invasive serial studies have documented the progression of atherosclerotic burden, most were focused on high-risk patients only. The PARADIGM registry is a large, prospective, multinational dynamic observational registry of patients undergoing serial coronary computed tomographic angiography (CCTA). The primary aim of PARADIGM is to characterize the natural history of CAD in relation to clinical and laboratory data. Design The PARADIGM registry (ClinicalTrials. gov NCT02803411) comprises >= 2,000 consecutive patients across 9 cluster sites in 7 countries. PARADIGM sites were chosen on the basis of adequate CCTA volume, site CCTA proficiency, local demographic characteristics, and medical facilities to ensure a broad-based sample of patients. Patients referred for clinically indicated CCTA will be followed up and enrolled if they had a second CCTA scan. Patients will also be followed up beyond serial CCTA performance to identify adverse CAD events that include cardiac and noncardiac death, myocardial infarction, unstable angina, target vessel revascularization, and CAD-related hospitalization. Summary The results derived from the PARADIGM registry are anticipated to add incremental insight into the changes in CCTA findings in accordance with the progression or regression of CAD that confer prognostic value beyond demographic and clinical characteristics.</P>
Biomechanical study of the Spider Crab as inspiration for the development of a biomimetic robot
Rynkevic, Rita,Silva, Manuel F.,Marques, M. Arcelina Techno-Press 2015 Biomaterials and biomedical engineering Vol.2 No.4
A problem faced by oil companies is the maintenance of the location register of pipelines that cross the surf zone, the regular survey of their location, and also their inspection. A survey of the state of art did not allow identifying operating systems capable of executing such tasks. Commercial technologies available on the market also do not address this problem and/or do not satisfy the presented requirements. A possible solution is to use robotic systems which have the ability to walk on the shore and in the surf zone, subject to existing currents and ripples, and being able to withstand these ambient conditions. In this sense, the authors propose the development of a spider crab biologically inspired robot to achieve those tasks. Based on these ideas, this work presents a biomechanical study of the spider crab, its modeling and simulation using the SimMechanics toolbox of Matlab/Simulink, which is the first phase of this more vast project. Results show a robot model that is moving in an "animal like" manner, the locomotion, the algorithm presented in this paper allows the crab to walk sideways, in the desired direction.
Altmeyer, S,Do, Y,Marques, F,Lopez, J M Published by the American Physical Society through 2012 Physical review. E, Statistical, nonlinear, and so Vol.86 No.4
<P>The nonlinear dynamics of Taylor-Couette flow in a small-aspect-ratio wide-gap annulus in the counterrotating regime is investigated by solving the full three-dimensional Navier-Stokes equations. The system is invariant under arbitrary rotations about the axis, reflection about the annulus midplane, and time translations. A systematic investigation is presented both in terms of the flow physics elucidated from the numerical simulations and from a dynamical system perspective provided by equivariant normal form theory. The dynamics are primarily associated with the behavior of the jet of angular momentum that emerges from the inner cylinder boundary layer at about the midplane. The sequence of bifurcations as the differential rotation is increased consists of an axisymmetric Hopf bifurcation breaking the reflection symmetry of the basic state leading to an axisymmetric limit cycle with a half-period-flip spatiotemporal symmetry. This undergoes a Hopf bifurcation breaking axisymmetry, leading to quasiperiodic solutions evolving on a 2-torus that is setwise symmetric. These undergo a further Hopf bifurcation, introducing a third incommensurate frequency leading to a 3-torus that is also setwise symmetric. On the 3-torus, as the differential rotation is further increased, a saddle-node-invariant-circle bifurcation takes place, destroying the 3-torus and leaving a pair of symmetrically related 2-tori states on which all symmetries of the system have been broken.</P>
Measurement of Unbound Excited States of 24O
Tshoo, K.,Satou, Y.,Nakamura, T.,Aoi, N.,Bhang, H. C.,Choi, S.,Deguchi, S.,Delaunay, F.,Gibelin, J.,Honda, T.,Ishihara, M.,Kawada, Y.,Kondo, Y.,Kobayashi, T.,Kobayashi, N.,Marques, F. M.,Matsushita, M Korean Physical Society 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.2
Márcio de Oliveira Marques,Fábio Morotti,Camila Bizarro da Silva,Mario Ribeiro Júnior,Rubens César Pinto da Silva,Pietro Sampaio Baruselli,Marcelo Marcondes Seneda 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.3
This study was conducted to evaluate the influence of category (heifers, primiparous or multiparous cows) on pregnancy rates in a large scaleresynchronization ovulation program. Nelore heifers (n = 903), primiparous lactating cows (n = 338) and multiparous lactating cows (n =1,223) were synchronized using a conventional protocol of estradiol/P4-based fixed-time artificial insemination (FTAI). Thirty days afterultrasonography, females who failed the first FTAI were resynchronized with the same hormonal protocol prior to a second FTAI. Thepregnancy status of each cohort was evaluated by ultrasonography 30 days after each FTAI. The average conception rate after the first FTAIand resynchronization was 80.5%. Heifers had a higher conception rate (85%) than primiparous (76%) or multiparous cows (78%; p = 0.0001). The conception rate after the first FTAI was similar among heifers (57%), primiparous cows (51%) and multiparous cows (56%; p = 0.193). After the second FTAI, heifers exhibited a higher conception rate (66%) than primiparous or multiparous cows (51%; p = 0.0001). These resultsdemonstrate the feasibility of resynchronization in large beef herds for providing consistent pregnancy rates in a short period of time. We alsodemonstrated that ovulation resynchronization 30 days after FTAI is particularly effective for heifers, providing a conception rate of up to66%.
Wise, T,Radua, J,Via, E,Cardoner, N,Abe, O,Adams, T M,Amico, F,Cheng, Y,Cole, J H,de Azevedo Marques Pé,rico, C,Dickstein, D P,Farrow, T F D,Frodl, T,Wagner, G,Gotlib, I H,Gruber, O,Ham, B J,Job Macmillan Publishers Limited, part of Springer Nat 2017 Molecular psychiatry Vol.22 No.10
<P>Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.</P>