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( Nam Kyung Im ),( Sung Gyu Lee ),( Dong Sung Lee ),( Pil Hoon Park ),( In Seon Lee ),( Gil Saeng Jeong ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
THis study was carried out to investigate the effect of Spathololbus suberectus Dunn(SS)on the protection of chondral defect and inhibition of osteiclastogenesis. To examine these effecte,we measured the matrix metalloproteinase(MMP)levels in SW1353 chon-drosarcoma cells and performed tartrate-resistant acid phossohatase (TRAP) staining in bone marrow macrophage(BMM)-derived osteoclasts.To investigate the anti-osteoarthritis(OA)effects,we assessed TNF-α-induced MMP-1,-3,-9 and tissue inhibitors of matrix metal- loproteinase(TIMP)expression levels in SW 1353 cells.Also,SS extract inhibiteb the receptpr activator of unclear factor-kB ligand(RANKL)-induced osteoclast differentia- tion. These results suggest that SS extract may have a potential in the treatment of bone loss and chondral defectby suppressing osteoclast differentiation and decreasing the expression of OA factors. Therefore, clarification of the mechanism of the action of SS extract and its active components is needed.
The Improvement Effect of Input Current Waveform of Two New Main Switching Boost Rectifiers
Sung-Hyun Ha,Chang-Il Kim,Soo-Wook Kim,Jing-Rak Nam,Sang-Pil Mun 한국조명·전기설비학회 2008 조명·전기설비학회논문지 Vol.22 No.3
This paper proposes a new sinusoidal rectifier which improves input factor and input current waveform without complicated switching modulation such as pulse width or a complicated feed back control. The proposed rectifier consists of a pair of capacitors connected in series, a full bridge diode rectifier, a pair of inductors, and a pair of switching devices connected in series. While the configuration of the sinusoidal rectifier is simple in itself, it effectively reduces the reactive power and harmonics involved (IEC555-2 SC77A90 Class C) in input line current. The excellent properties of the new sinusoidal rectifier are verified by theoretical analysis and experimental results.
( Pil Soo Sung ),( Dong Jin Yoon ),( Do Seon Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Jeong Won Jang ),( Jong Young Choi ),( Seung Kew Yoon ),( Seok Whan Moon ),( Hong Seok Jang ),( Si Hyun Bae ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: We performed a retrospective study to identify prognostic factors and determine outcomes for patients with brain metastases from hepatocellular carcinoma (HCC). Methods: A total of 72 patients with brain metastases from HCC were identified from two institutions; 26 of 72 patients received tumor-removing surgery or stereotactic radiosurgery with or without whole-brain radiotherapy (WBRT), 23 of 72 received WBRT only, and 23 of 72 received conservative treatment. Estimates for overall survival (OS) after brain metastases were determined and clinical prognostic factors were identified by Cox proportional hazards modeling. Results: Median OS after development of brain metastases was 48 days (one day to 536 days). The median age at the time patients were diagnosed with brain metastasis was 54 years. Fifty-one patients (71%) were male, and 62 patients (86%) were infected with hepatitis B virus. Median time from diagnosis of HCC to brain metastasis was 17.2 months, and 4 patients had brain metastases at the time diagnosis. Intracranial hemorrhage was frequently associated (42%) with brain metastasis. The most common presenting symptoms were motor weakness, mental change, and headache. Sixty-three patients (88%) had lung metastases, 25 patients (35%) had bone metastases, 18 patients (25%) had metastatic lymphadenopathy, and 7 (10%) patients had peritoneal seeding when diagnosed with brain involvement, and there was only one patient without metastasis to other organs. Univariate analyses showed that treatment with curative intent (surgery or SRS) and serum AFP levels were associated with improved survival (P<0.001, and 0.045, respectively), whereas a single brain metastasis, size of metastatic tumor, or intracranial hemorrhage were not. We further divided patients with three groups by the treatment modality; surgery or radiosurgery (group1), WBRT (group 2), or conservative treatment (group 3). Group 1 showed best survival, followed by group 2 and group 3, sequentially (P<0.001). Subgroup analysis with patients with single brain metastasis showed similar results. Multivariate analysis showed that treatment modality was the only factor that is associated with improved OS (P=0.001) Conclusions: When patients with lung metastases from HCC present neurologic symptoms, brain imaging is required to confirm intracranial metastases. Although the overall prognosis of patients with brain metastases from HCC is extremely poor, patients actively treated with surgery or radiosurgery have prolonged survival, suggesting that interventions to control intracranial disease are important treatment modalities.
Impact of hs-CRP on outcomes in acute myocardial infarction according to LDL cholesterol level (초)
( Sang Woong Choi ),( Yun Kyeong Cho ),( Jae Pil Lee ),( Ji Hyun Sohn ),( Hyun Ok Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Seung Ho Hur ),( Yoon Nyun Kim ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
( Sang Duk Ji ),( Gyoo Byung Sung ),( Pil Don Kang ),( Kee Young Kim ),( Yong Soo Choi ),( Nam Suk Kim ),( Soon Ok Woo ),( Sang Mi Han ),( In Pyo Hong ),( Nam Gyu Ha ) 한국균학회 2011 韓國菌學會誌 Vol.39 No.3
This study was conducted to confirm the possible use of female Yangwonjam as a host for synnemata production of Isaria tenuipes in eight local areas in Korea. Silkworm pupation rate, infection rate and synnemata characteristics of I. tenuipes were examined. Normal silkworms had a higher pupation rate than silkworms inoculated with I. tenuipes. The pupae survival percentage of normal silkworm in cocoons was 92.5~97.6%, whereas it ranged from 91.1~95.6% in silkworms sprayed with I. tenuipes. Female Yangwonjam showed the highest survival percentage at 97.6% among the silkworm varieties tested. I. tenuipes infection rate of larvae of 5th instar newly-exuviated silkworms was 89.2~90.7% in the spring rearing season and 98.2~99.3% in the autumn rearing season. Synnemata production of I. tenuipes was excellent in female Yangwonjam with an incidence rate of 98.0% followed by male Yangwonjam (94.1%) and Baegokjam (93.3%) in the spring rearing season. Synnemata living weight ranged from 1.44~0.94 g in the spring rearing season. The female Yangwonjam had the heaviest synnemata weight (1.44 g) in the spring rearing season. The synnemata of I. tenuipes produced on pupae were white or milky-white in color, and were similar in shape and color to wild synnemata collected in Korea.
Mirror Syndrome Resulting from Metastatic Congenital Neuroblastoma to Placenta
( Sung Hyeon Park ),( Jung-man Namgoong ),( Kyeong Nam Ko ),( Chong Jai Kim ),( Pil-ryang Lee ),( Euiseok Jung ),( Byong Sop Lee ),( Ki-soo Kim ),( Ellen Ai-rhan Kim ) 대한주산의학회 2018 Perinatology Vol.29 No.4
Congenital neuroblastoma is a rare disease. Placental metastasis is extremely rare and poor prognosis has been reported in neonates. Mirror syndrome could occur in mother with placental metastasis with possibilities of hypertension and edema. We report a case of detection of left suprarenal mass in fetus at 31<sup>+5</sup> weeks’ gestation. Mother presented with palpitation, edema, headache, and hypertension. Maternal 24 hours urine vanillylmandelic acid (VMA) and normetanephrine (NME) level at 34 weeks’ gestation were elevated. Consequently, emergent cesarean section was done. Based on abdominal ultrasonography and whole body magnetic resonance imaging, left adrenal tumor with liver metastasis was suspected. Neuroblastoma was confirmed by liver and placenta biopsy. Chemotherapy was started with Pediatric Oncology Group 9243 at day 7 and changed into Children's Oncology Group 3961 due to cholestasis and poor response during 2nd cycle. Plasma exchange was done for aggravated direct hyperbilirubinemia. The baby expired at 73 days due to multi-organ failure. Maternal symptoms were completely resolved in 2 weeks after delivery along with normalization of the elevated level of VMA and NME. We report a first case of mirror syndrome in Korean mother and fetus resulting from metastatic congenital neuroblastoma to placenta.