Cytomegalovirus Infection among Pregnant Women in Beijing: Seroepidemiological Survey and Intrauterine Transmissions

( Qing`e Jin ),( Jianrong Su ),( Shanna Wu ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.5

Primary cytomegalovirus (CMV) infection during pregnancy can cause congenital defects. Available data for CMV infection during pregnancy in north China are inadequate. The aim of this study was to evaluate the epidemiology of maternal CMV infection and explore the incidence of congenital infection. In this prospective study, serum CMV IgG and IgM antibodies were measured in 2,887 pregnant women using ELISA, and the IgG avidity test was performed on all IgM-positive subjects. The seroprevalence of anti-CMV IgG was 94.70%, and of anti-CMV IgM was 1.28%. CMV IgG prevalence increased significantly with age (p < 0.01). Women living in downtown areas showed higher IgG prevalence than those residing in urban areas (p = 0.023). CMV-IgM seroprevalence was highest in autumn (p = 0.021). There was no difference in IgM seroprevalence by age, socioeconomic status, geographical area, or gravida. The rate of primary CMV infection was 0.45% (13/2,887) at the first trimester. The seroconversion rate during pregnancy was 0.76% (22/2,887). One woman underwent seroconversion during pregnancy and gave birth to an infant with asymptomatic CMV infection. Congenital CMV infection was diagnosed in five of the 14 infants from 14 mothers with active infection, for a vertical transmission rate of 35.71% (5/14). Three infants were asymptomatic, whereas two infants presented symptomatic infection with hearing deficits. Although CMV IgG prevalence is relatively high in north China, significant attention to primary CMV infection during pregnancy is still needed.

Experimental Investigation on Inelastic Behavior of Composite Box Girder under Negative Moment

Qing-Tian Su,Guo-Tao Yang,Chong Wu 한국강구조학회 2012 International Journal of Steel Structures Vol.12 No.1

The mechanical behavior of negative bending moment zone in composite girder is very complex. The nonlinear characteristics due to the cracking of concrete slab need careful studies. In this experimental research, two specimens of steelconcrete composite box girder with inclined webs under hogging moment were cautiously conducted and tested. The relative slips between the steel and concrete, load-displacement relationship, the strain distribution of the steel girder, the reinforcements and the concrete slab, and the cracking behavior of the concrete slab were measured during the tests. The relatively small slips on the surfaces between the concrete slab and the top flange of the steel girder showed the full shear connection composite behavior of the girders. The initial cracking load was compared with the calculation results from linear analysis and nonlinear analysis based maximum strain. The strain of the steel web measured at different positions along the vertical direction showed the establishment of plane section assumption and the variation of neutral axis in the loading process. Moreover, shear lag effect was found in the strain distribution of the bottom flanges. The strain of concrete slab and the crack spacing showed the effect of the longitudinal reinforcement ratio on the cracking behavior of the concrete. The maximum crack width was observed in the loading process and compared with the calculation results according the design codes. The influence of reinforcement ratio on the strain of reinforcement and on the load capacity in serviceability limit state was studied in the context and it was found that the reinforcement ratio play an important role on the crack control of composite girder under hogging moment.

Structural Behaviour of Perforated Shear Connectors with Flange Heads in Composite Girders: An Experimental Approach

Qing-Tian Su,Guo-Tao Yang,Chen-Xiang Li 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.1

Perforated shear connector with flange head (PSCFH) as a new type of connector behaves high bearing capacity and excellentductility in steel-concrete composite girders. In this paper 15 groups, totally 45 push-out test specimens, were conducted toinvestigate the effects of plate thickness, connector height, flange length, flange number, hole diameter on the web, diameterof reinforcing bars and concrete strength on structural behaviour of PSCFH. In the push-out tests, failure mode, load versusslip curve and bearing capacity of all the specimens were obtained. Based on the results of push-out tests, bearing mechanismwas analyzed and a calculation model of the shear bearing capacity was proposed with respect to the failure modes. Calculationresults based on the proposed model agree well with the experimental values.

Static behaviour of multi-row stud shear connectors in high- strength concrete

Qing-Tian Su,Guotao Yang,Mark A. Bradford 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.17 No.6

In regions of high shear forces in composite bridges, headed stud shear connectors need to be arranged with a small spacing in order to satisfy the design requirement of resisting the high interface shear force present at this location. Despite this, studies related to groups of headed studs are somewhat rare. This paper presents an investigation of the static behaviour of grouped stud shear connectors in high-strength concrete. Descriptions are given of five push-out test specimens with different arrangements of the studs that were fabricated and tested, and the failure modes, load-slip response, ultimate load capacities and related slip values that were obtained are reported. It is found that the load-slip equation given by some researchers based on a single stud shear connector in normal strength concrete do not apply to grouped stud shear connectors in high-strength concrete, and an algebraic load-slip expression is proposed based on the test results. Comparisons between the test results and the formulae provided by some national codes show that the equations for the ultimate capacity provided in these codes are conservative when used for connectors in high-strength concrete. A reduction coefficient is proposed to take into account the effect of the studs being in a group.

Overview of aristolochic acid nephropathy: an update

Zhou Qing-Qing,Jiang Lei,Tao Su,Gang Liu,Yang Liu 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.5

Aristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA). Since the outbreak of AAN in Belgium was reported nearly 30 years ago, the safety of herbal remedies has drawn considerable attention, and AAN has become a global public health problem. Breakthroughs have been made to better understand the disease, including the toxicity of AAs, the possible mechanisms of AAN, the disease patterns, and the pathological features; however, some critical problems remain unresolved. Because of the insidious onset of the disease, the incidence of AAN and the prevalence of exposure to AAs are unknown and might be largely underestimated. During the past decades, AA-containing herbs have been strictly administrated in many regions and the occurrence of AAN has declined sharply, yet cases of AAN are still sporadically reported. Despite the progress in the understanding of the disease’s pathogenesis, there is no effective treatment for delaying or reversing the renal deterioration caused by AAN. Therefore, the risk of exposure to AAs should be taken seriously by public health workers and clinicians. In this review, we updated the latest data on AAN, summarized the advances throughout these years, and put forward some challenges for future research.

MAGED4 Expression in Glioma and Upregulation in Glioma Cell Lines with 5-Aza-2'-Deoxycytidine Treatment

Zhang, Qing-Mei,Shen, Ning,Xie, Sha,Bi, Shui-Qing,Luo, Bin,Lin, Yong-Da,Fu, Jun,Zhou, Su-Fang,Luo, Guo-Rong,Xie, Xiao-Xun,Xiao, Shao-Wen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Melanoma-associated antigen (MAGE) family genes have been considered as potentially promising targets for anticancer immunotherapy. MAGED4 was originally identified as a glioma-specific antigen. Current knowledge about MAGED4 expression in glioma is only based on mRNA analysis and MAGED4 protein expression has not been elucidated. In the present study, we investigated this point and found that MAGED4 mRNA and protein were absent or very lowly expressed in various normal tissues and glioma cell line SHG44, but overexpressed in glioma cell lines A172,U251,U87-MG as well as glioma tissues, with significant heterogeneity. Furthermore, MAGED4 protein expression was positively correlated with the glioma type and grade. We also found that the expression of MAGED4 inversely correlated with the overall methylation status of the MAGED4 promoter CpG island. Furthermore, when SHG44 and A172 with higher methylation were treated with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-AZA-CdR) reactivation of MAGED4 mRNA was mediated by significant demethylation in SHG44 instead of A172. However, 5-AZA-CdR treatment had no effect on MAGED4 protein in both SHG44 and A172 cells. In conclusion, MAGED4 is frequently and highly expressed in glioma and is partly regulated by DNA methylation. The results suggest that MAGED4 might be a promising target for glioma immunotherapy combined with 5-AZA-CdR to enhance its expression and eliminate intratumor heterogeneity.

중국 농촌관광마을 융복합 산업 발전에 관한 연구 : 지도자 역할을 중심으로

한소경(Su-Qing Han),황태규(Tae-Kyu Hwang),강순화(Soon-Hwa Kang) 한국비교정부학회 2021 한국비교정부학보 Vol.25 No.1

(Purpose) The purpose of this study is to identify the role of leaders in the convergence development process of China s rural tourism industry. In order to achieve this research purpose, the characteristics, achievements, and development factors of convergence development of the Chinese rural tourism industry were first analyzed. Second, based on the analysis results, we analyzed the four-factor model of the role of leaders in the convergence development process of the rural tourism industry and the change in importance of each element when the model was applied to different types of rural villages and villages with different industrial convergence models. Third, based on the theory of innovative ecosystem systems, we analyzed the role of leaders, support for innovative ecosystem systems, and the mechanism that creates innovative performance, and conducted empirical verification and analysis through surveys and multidisciplinary regression models. (Design/methodology/approach) Based on prior research, this study divided the role of leaders during the development of convergence industries into 12 manipulation indicators. The survey was conducted from April 2020 to August 2020 by MPA students from Hebei Economic and Trade University, who are the main agents of the development of the rural convergence industry. A total of 350 people were surveyed and 304 were collected. The recovery rate was 86.9 percent. (Findings) As a result of this study, the promotion of the government s policies, the promotion of the system, education and training, and fostering village leaders through cultural influences improve the ability of village leaders. It shows that if the role of leaders is fully exercised, the convergence development performance of the rural industry will be improved. (Research implications or Originality) This study will clarify the direction of rural development and the role of village leaders in the new environment, and will be a theoretical basis for cultivating and nurturing the qualities of village leaders.

Structure and property of a vertical cutting Ca0.4Sr0.6Bi4Ti4O15 ferroelectric ceramic

Su-Hua Fan,Ran Yu,Feng-Qing Zhang,Quan-De Che,Wei Hu 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.3

Ca0.4Sr0.6Bi4Ti4O15 ceramics with a-axis preferred orientation were prepared by a solid-state reaction method. The cylindrical Ca0.4Sr0.6Bi4Ti4O15 ceramics were cut into two types of plates: one was along the cylinder axis (A), and the other was perpendicular to the direction of the cylinder axis. The effects of sintering temperature on the structure and electrical properties of the Ca0.4Sr0.6Bi4Ti4O15 ceramics were investigated. When the sintering temperature was 1180 oC, sample A gave the highest a-axis (200) orientation with a value of about 27.1%. At this sintering temperature, sample A showed better dielectric properties and ferroelectric properties, the relative dielectric constant (εr), dielectric loss (tan δ), remnant polarization (Pr), and coercive field (Ec) were 217.6, 0.0027, 14.2 μC/cm2 and 49.6 kV/cm, respectively.

Anticancer Effects of the Hsp90 Inhibitor 17-Demethoxy-Reblastatin in Human Breast Cancer MDA-MB-231 Cells

( Qing Zhao ),( Cheng Zhu Wu ),( Jae Kyoung Lee ),( Su Rong Zhao ),( Hong Mei Li ),( Qiang Huo ),( Tao Ma ),( Jin Zhang ),( Young Soo Hong ),( Hao Liu ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.7

Triple-negative breast cancer (TNBC) possesses a higher rate of distant recurrence and a poorer prognosis than other breast cancer subtypes. Interestingly, most of the heat shock protein 90 (Hsp90) client proteins are oncoproteins, and some are closely related to unfavorable factors of TNBC patients. 17-Demethoxy-reblastatin (17-DR), a novel nonbenzoquinone- type geldanamycin analog, exhibited potent Hsp90 ATPase inhibition activity. In this study, the anticancer effects of 17-DR on TNBC MDA-MB-231 cells were investigated. These results showed that 17-DR inhibited cell proliferation, induced apoptosis, and suppressed cell invasion and migration in the MDA-MB-231 cells. Down-regulation of the key Hsp90-dependent tumor-driving molecules, such as RIP1 and MMP-9, by 17-DR may be related to these effects. Taken together, our results suggest that 17-DR has potential as a therapeutic agent for the treatment of TNBC.

Genome-scale Metabolic Modeling and In Silico Analysis of Human Skin Pathogen, Cutibacterium acnes

Su-Kyung KIM,Minouk LEE,Yi Qing LEE,Seo-Young PARK,Dong-Yup LEE 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9