이황화탄소 폭로 근로자의 요중 N-Acetyl-β-Glucosaminidase Activity 및 Total protein에 관한 연구

趙浚吉,李恩一,車喆煥,張聖薰 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.1

The results of renal function studies among 45 workers exposed to carbon disulfide as measured bv total protein in a 24-hour urine and N-Acetyl-β-Glucosaminidase (NAG) activity in both 24-hour and spot urine, were further analyzed by fundoscopic examination for evidence of retinopathy. By Measuring spot urine NAG activity in 69 healthy workers, a comparative analysis of spot urine NAG activity was made between healthy workers and those exposed to carbon disulfide and the results were as follows: 1. Of the workers exposed to carbon disulfide, 53.3% had retinopathy, 53.3% showed increased NAG activity above reference value, and 20.0% had proteinuria. These rates tended to increase as the age of the workers and their duration of exposure increased. 2. For workers exposed to carbon disulfide and having retinopathy, the mean value of NAG activity and total protein amount in 24-hour urine were significantly higher (p<0.05), as compared to those having normal retina. 3. Mean values of spot urine NAG activity in healthy workers, those exposed to carbon disulfide with normal retina, and those having retinopathy were 199.1μM of 4-MU/mgCr., 499.1μM of 4-MU/mgCr., and 902.7μM of 4-MU/mgCr., respectively, showing a statistically significant difference.

Akt is involved in the inhibition of cell proliferation by EGF

Soung Hoo Jeon,정우정,Jae-Young Cho,이기호,최강열 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.4

Axin is a negative regulator of the Wnt/β-catenin path-way and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways is poorly understood. In growth regulation by Axin in L929 fibroblasts stimu-lated by EGF. Akt activity was increased by EGF treat-ment and Ras activation, respectively. Both the EGF- and Ras-induced Akt activations were abolished by Axin induction, as revealed by both Western blot and imunocytochemical analyses. The proliferation and Akt activation induced by EGF were decreased by Axin induction, and the efects of EGF were abolished by treatment of an Akt-specific inhibitor. Therefore, Axin by blocking Akt activation.

Comparison of Knee Muscle Strength and Endurance of Affected Legs of Korean Women Diagnosed with Kellgren-Lawrence grade (K-L II) by Age

( Soung-kyun Hong ),( Dong-geon Lee ),( Sun-hae Song ),( Seung-hoo Lee ),( Doo-chul Shin ) 대한물리의학회 2019 대한물리의학회지 Vol.14 No.4

PURPOSE: The purpose of this study was to compare the maximum knee strength and endurance of elderly Korean women with Kellgren-Lawrence grade (K-L II) by age. METHODS: In this study, the total number of participants was 50, divided into five groups of 10 by age. Maximum knee muscle strength was measured at a low speed of 60°/sec using Biodex, an isokinetic device for comparison of maximum knee muscle strength, whereas muscle endurance was measured by muscle contraction at a high speed of 180°/sec. The peak torque values of the extensor and flexor muscles in the muscle strength and muscle endurance tests were collected according to each classification. RESULTS: The results of the experiment show that maximum muscle strength and muscle endurance decreased significantly at 60°/sec and 180°/sec during flexion and extension according to age (p<.05). In particular, the age group of 71 to 75 years showed the most significant correlation with other age groups (p<.05). CONCLUSION: The results of this study can be used as basic data for increasing physical activity and muscle strength in women with knee osteoarthritis.

Comparison of spatio-temporal gait parameters according to shoe types in chronic stroke survivors: a preliminary study

Hong, Soung Kyun,Park, Su Ho,Shin, Sung Ri,Lee, Dong Geon,Lee, Seung Hoo,Jung, Sun Hye,Pyo, Seung Hyeon,Lee, Kyeong-Bong,Lee, Gyu Chang korean Academy of Physical Therapy Rehabilitation 2018 Physical therapy rehabilitation science Vol.7 No.1

Objective: The purpose of this study was to investigate the impact of wearing various types of shoes on gait ability in stroke survivors and in order to gain information in regards to shoes that could possibly replace ankle orthosis. Design: Cross-sectional study. Methods: Eight hemiplegic survivors diagnosed with stroke participated in the study. Gait was analyzed using the GAITRite Electronic Walkway (CIR System Inc., USA) when subjects walked with no showed, walked with non-ankle-covered shoes, and walked with ankle-covered shoes. This study collected gait variables, including velocity, cadence, step length, stride length, single support time, and double support time, respectively. Results: In the comparison of walking with no shoes, non-ankle-covered shoes, and ankle-covered shoes, there were significant differences in gait velocity, step length, stride length, and the less affected side single support time (p<0.05). However, there were no significant differences in cadence, affected side single support time, and double support time. Conclusions: Ankle-covered shoes had a positive impact on the gait of stroke survivors. However, it is necessary to conduct more studies comparing various types of shoes with ankle orthoses.

원저 : 헌혈자에서 enzyme-linked immunosorbent assay (ELISA)검사방법에 의한 검사 양성율과 결과치에 대한 고찰

양혜성 ( Hae Soung Yang ),김현숙 ( Hyun Sook Kim ),김호진 ( Hoo Jin Kim ),최병찬 ( Byung Chan Choi ) 대한임상병리사협회 2003 임상수혈검사학회 발표자료집 Vol.8 No.1

1. 배경 국내 혈액사업에 사용되는 HBsAg EIA의 특이도는 95-100%정도이다. 따라서 1998년부터 2002년까지 최근 5년간 중앙혈액원에서 검사한 검사결과 자료분석을 시행하여, B형간염 양성율의 변화를 관찰하고, 효소면역검사방법의 특성상 나타나는 위양성 검사결과를 판정하는데 있어 검사자의 이혜를 돕고자 이 연구를 계획하였다 2. 방법 검사시약 종류가 연도에 따라 다르기는 하나 모두 효소면역측정법으로 검사하여 총 헌혈 혈액 1,795,992건 중 l차 검사에서 cut-off의 90% 이상인 검체 24,825건을 대상으로 하였다. 1차와 2차검사한 결과값을 Sample-OD값/cut-off(이하 S/C ratio) 계산하여 ratio를 산출하여 결과값으로 하였다. 1차검사 S/C ratio를 기준으로 5개 그룹으로 구분하였으며, 1차와 2차검사한 결과값의 변화를 관찰하였다 3. 결과 1) 1차검사 S/C ratio 0.9-10인 그룹의 2차 검사결과 비교는 전체 6,658건 중 양성 4.26%(285건), 음성 91.56%(6121건), 보류 3.78% (252건)이며, S/C ratio 40.1 이상인 그룹 전체 14,666 중 양성 99.0%(14,529), 음성 0.90%(133), 보류 0.03%(4건) 그룹간 현저한 차이가 있었다(p<0.0l) 2) S/C ratio의 평균값의 변화는 S/C ratio 20.1-30을 제외한 4개 그룹에서 l차와 2차검사간에 차이가 있는 것으로 나타났다(p<0.01)(Table 5). 3) 5개의 모든 그룹에서 최소 R=.030에서 최대 R=.340으로 2차검사 시 결과값이 높아지는 약한 양적 선형관계를 보였다. 4) 연도별 2차검사결과 변화는 1998년과 2002년을 비교하면 S/C ratio 0.9-10의 같은 그룹내에서도 1998년도는 음성전환이 97.0%, 2002년도에는 91.5%으로 검사년도에 따라 차이가 있었다(p<0.0l). 5) HbsAg 양성은 1998년 전체 헌혈자에 1.74%였으나 2002년에는 전체헌혈자에 0,99%로 감소하고, B형간염 양성자 중 C형간염 중복감염 양성자는 1998년 0.004%에서 2002년 0.0007%로 감소하는 경향을 보였다. 4. 결론 효소면역검사방법의 특성상 나타나는 위양성 검사결과를 판정하는데 있어 보다 세심한 정도관리와 비특이적 양성반응을 확인하기 위한 중화검사나 확인검사의 도입도 고려해 볼일이라 사료되며, 헌혈자의 B형간염 표지자 양성율은 해마다 낮아지고 있어 바람직한 일이라 생각된다. Background We evaluated HBsAg screening test results for the donors of Central blood center from 1998 to 2002. The purpose of this study is to observe the change in the positive rate and to give an information for the interpretation as a false positivity. Methods We tested a total of 1,795,992 donor samples ELISA method and re-tested 24,823 donors had more than 90% of cut-off value among Them. Than we calculated S/C ratio(sample-OD/cut-off) and classified S/C ratio in 5 groups. Results 1) 91.56% of the group whose S/C ratio is in the 0.9-1.0 turned out to be negative in the second test. 0.90% of the group whose S/C ratio is more than 40.1 turned out to be negative, which shows a considerable difference between two groups.(p<0.0l) 2) The change in the average of S/C ratio was observed before and after the test, except the group with S/C value of 20-30.(p<0.01) 3) All 5 groups represented the quantative linear relations in which test result values went higher from minimum R=.030 to maximum R=.340 in the second test. 4) The ratio of HBsAg positive was 1.74% of total donor in 1998, but the ratio declined to 0.99% in 2002. 5) The percentage(portion) of positive Anti-HCV results was infected person among the hepatitis B infected was declined to 0.0007% in 2002 from 0.004% in 1998. Conclusion The confirmatory neutralization test needs to aid in interpretation as a false positive in HBsAg test using ELISA. and the percentage of positive HBsAg test is getting lower every year since 1998.

Effect of platelet-rich plasma on dental stem cells derived from human impacted third molars.

Lee, Ui-Lyong,Jeon, Soung Hoo,Park, Joo-Young,Choung, Pill-Hoon Future Medicine 2011 Regenerative medicine Vol.6 No.1

<P>Platelet-rich plasma (PRP) is fabricated from autologous blood and extensively used to promote soft and hard tissue healing. In the dental field, autologous PRP is widely used combined with dental implant installation and bone graft. This study will evaluate the biologic effect of PRP on the proliferation and the differentiation of human dental stem cells, and find the key cytokines inducing these effects to estimate the clinical feasibility of PRP for dental tissue engineering.</P>

Fauna and georaphical distribution of house dust mites in Korea

Han-Il REE(이한일),Soung-Hoo JEON(전성후),In-Yong LEE(이인용),Chein-Soo HONG(홍천수),Dong-Kyu LEE(이동규) 대한기생충학열대의학회 1997 The Korean Journal of Parasitology Vol.35 No.1

Structure of the Female Genitalia of Korean Cetoniidae(Coleoptera , Scarabaeoidea)

Kim, Jin Ill,Jeon, Soung Hoo 고려대학교 한국곤충연구소 1991 昆蟲硏究誌 Vol.17 No.1

The external and internal female genitalia were described on 5 species of Korea, which were Gnorimus subopacus, Glycyphana fulvistemma, Trichius succinctus, Charitovalgus fumosus and Nipponovalgus angusticollis belonging to Cetoniidae. The internal female genitalia of the other species had the tubular type, with separate bursa copulatrix. but G. subopacus had the saccular type, without separate bursa copulatrix. The external female genitalia of the other species had differentiated several sclerotized plates (coxites, paraprocts, proctigers). but G. subopacus had a pair sclerotized plates in the body wall of the vagina and well-developed sclerotized structure lying inner cavity of the vagina characteristically.

Dental Stem Cell Therapy with Calcium Hydroxide in Dental Pulp Capping

Ji, Young-Min,Jeon, Soung Hoo,Park, Joo-Young,Chung, Jong-Hoon,Choung, Yun-Hoon,Choung, Pill-Hoon Mary Ann Liebert 2010 Tissue engineering. Part A Vol.16 No.6

Egg Mortality of German Cockroaches Exposed to Fenitrothion MC Bait and Hydramethylnon Bait

Ree, Han-Il,Jeon, Soung-Hoo 한국곤충학회 1998 Entomological Research Vol.28 No.3

바퀴(Blattella germanica)는 난 발육이 완성될 때까지 난협을 복부말단에 달고 다닌다 최근 널리 사용되고 있는 fenitrothion MC bait와 hydramethylnon bait섭취 후 죽은 암컷의 난협내 알의 부화율을 75% RH의 높은 습도하에서 관찰하여 다음과 같은 결과를 얻었다. Fenitrothion MC bait을 처리한 군에서는 68%의 난협부화율(17/25)과 64.4%의 알부화율(520/807)을 얻었고, hydramethylnon bait 처리군에서는 60% (15/25) 난협부화율과 59.3% (499/842)의 난부화율을 보였는데 이들간의 통계적 유의성은 없었다. 두부를 제거한 대조군의 경우는 84% (21/25)의 난협부화율과 87.2% (728/835)의 난부화율을 보여 상기 살충제 처리군과는 유의성이 있었다(P< 0.05). 45% 습도하의 대조군(두부절단)에서는 28%와 36.7%의 난협 및 난부화율을 각각 나타냈고 20% 습도하의 대조군에서는 전혀 부화하지 않았다. 난협의 발육 정도 또는 난협의 어미로부터의 탈락 여부와 난협 부화율간에는 어떤 연관성도 보이지 않았다. The viability of the oothecae (eggs) of Blattella germanica females which were killed by ingesting fenitrothion MC bait and hydramethylnon bait was studied under the high humidity condition (75 % RH). In case of the females treated with fenitrothion MC bait, 17 oothecae out of 25 (68%) and 520 eggs out of 807 (64.4%) were hatched during the period of 4-24 days after treatment. In case of the females treated with hydramethylnon bait, 15 oothecae out of 25 (60%) and 499 eggs out of 842 (59.3%) were hatched during the period of 1-28 days after treatment. In the control group (decapitated females), 21 oothecae out of 25 (84%) and 728 eggs out of 835 (87.2%) were hatched during the period of 1-24 days after decapitation, which was significantly different from those of the eggs of the females treated with both fenitrothion MC bait and hydramethylnon bait (P<0.05). Neither the degree of maturity of oothecae, nor detachment/attachment of oothecae from/to female abdomens were correlated to the hatching (viability) of the oothecae.