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Woo, Mi-Hee,Chung, Soon-Ok,Kim, Dal-Hwan The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.5
cis-Annonacin (1) and the mixture of (2,4)-cis-and trans-isoannonacins (2 and 3), three known mono-tetrahydrofuran annonaceous acetogenins, have been isolated form the seeds of Annona cherimolia by the use of the brine shrimp lethality test (BST) for bioactivity directed fractionation. Their structures were elucidated based on spectroscopic and chemical methods. 1 showed potent cytotoxicities in the brine shrimp lethality test (BST) and among six human solid tumor cell lines with notable selectivity for the pancreatic cell line (PaCa-2) at about 1,000 times the potency of adriamycin. The mixture of 2 and 3 is over 10,000 times cytotoxic as adriamycin in the pancreatic cell line (PaCa-2). All of the compounds are about 10 to 100 times as cytotoxic as adriamycin in the prostate cell line (PC-3).
General Characteristics of Korean Propolis
Woo, Soon Ok,Han, Sang Mi,Hong, Inpyo,Choi, Yong Soo,Lee, Kwang Gill,Yeo, Joo Hong,Kweon, Hae Yong,Lee, Myoung Ryeol,Lee, Man Young Korean Society of Sericultural Science 2012 International Journal of Industrial Entomology Vol.25 No.2
The propolis was collected from the whole part of Korea Peninsula, such as central, southern, and Jeju island, to analyze the general composition including total flavonoid and phenolic contents, heavy metals, colors, amino acids, and crude lipid. The total flavonoid and phenolic contents of middle region in Korea Peninsula (4.26% and 13.06 g/100 g gallic acid) were higher than southern region (2.53%, 10.9 g/100 g gallic acid) and Jeju island (0.03%, 7.22g/100 g gallic acid), respectively. The heavy metals contents showed that Zn contents were found in $0.44{\pm}0.2ppm$ and a harmful heavy metal such as Cr, Cd, Pb, Ni, Cu, As, and Hg were not detected at all in our experiment. The colors of extracted propolis showed a various spectrum from yellow to red purple. Various amino acids were also detected as proline, valine, methionine and the average crude lipid contents of propolis were 42.4%. All data collected in South Korea were very first executed in our institution for the purposes of utilizing and developing the industrial insects, honeybees as well as silkworm.
Relationship of Hemodynamic Indices and Prognosis in Patients with Liver Cirrhosis
( Soon Koo Baik ),( Myeong Gwan Jee ),( Phil Ho Jeong ),( Jae Woo Kim ),( Sang Won Ji ),( Hyun Soo Kim ),( Dong Ki Lee ),( Sang Ok Kwon ),( Young Ju Kim ),( Joong Wha Park ),( Sei Jin Chang ) 대한내과학회 2004 The Korean Journal of Internal Medicine Vol.19 No.3
( Soon Sun Kim ),( Jung Woo Eun ),( Ji-hye Choi ),( Hyun Goo Woo ),( Hyo Jung Cho ),( Hye Ri Ahn ),( Chul Won Suh ),( Geum Ok Baek ),( Sung Won Cho ),( Jae Youn Cheong ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: We aimed to identify novel single nucleotide variant (SNV) in circulating tumor DNA (ctDNA) in patients with hepatocellular carcinoma (HCC). Methods: Deep sequencing of plasma-derived ctDNA was performed using a panel of 2,924 SNVs in 69 genes from 59 patients with HCC. Validation of frequent SNVs (MLH1, STK11, PTEN, and CTNNB1) identified in ctDNA was conducted using droplet digital PCR (ddPCR) in 62 patients. Additionally, the presence of MLH1 and STK11 SNVs was determined in HCC tissues from 37 patients. Association between the presence of SNVs or the amount of ctDNA and clinical parameters and prognosis was determined in 107 patients. Results: In 33/59 (55.9%) patients, at least one somatic mutation was detected using targeted deep sequencing of ctDNA. Among 25 SNVs in 12 genes, SNVs in KIT (17%), MLH1 (13%), STK11 (13%), PTEN (9%), and CTNNB1 (4%) were the most frequently observed. Using ddPCR, SNVs were detected in 22/62 (35.5%) patients with a frequency of 19% for MLH1 (chr3:37025749_T>A), 11% for STK11 (chr19:1223126_C>G), 8% for PTEN (chr10:87864461_C>G), and 0% for CTNNB1 (chr3: 41224610_C>T). MLH1 and STK11 SNVs in ctDNA were also detected in DNA derived from tumor tissues from all patients. The combination of the presence of MLH1 SNVs and increased ctDNA predicted overall survival in 107 patients. Conclusions: MLH1 SNV (chr3:37025749_T>A) detection in ctDNA is feasible and can be used to detect somatic mutations in HCC. Furthermore, the MLH1 SNV in ctDNA predicts prognosis with or without determining the amount of ctDNA in patients with HCC.
General Characteristics of Korean Propolis
( Soon Ok Woo ),( Sang Mi Han ),( Inpyo Hong ),( Yong Soo Choi ),( Kwang Gill Lee ),( Joo Hong Yeo ),( Hae Yongkweon ),( Myoung Ryeol Lee ),( Man Young Lee ) 한국잠사학회 2012 International Journal of Industrial Entomology Vol.25 No.2
The propolis was collected from the whole part of Korea Peninsula, such as central, southern, and Jeju island, to analyze the general composition includingtotal flavonoid and phenolic contents, heavy metals, colors, amino acids, and crude lipid. The total flavonoid and phenolic contents of middle region in Korea Peninsula (4.26% and 13.06 g/100 g gallic acid) were higher than southern region (2.53%, 10.9 g/100 g gallic acid) and Jeju island (0.03%, 7.22g/100 g gallic acid), respectively. The heavy metals contents showed that Zn contents were found in 0.44±0.2 ppm and a harmful heavy metal such as Cr, Cd, Pb, Ni, Cu, As, and Hg were not detected at all in our experiment. The colors of extracted propolis showed a various spectrum from yellow to red purple. Various amino acids were also detected as proline, valine, methionine and the average crude lipid contents of propolis were 42.4%. All data collected in South Korea were very first executed in our institution for the purposes of utilizing and developing the industrial insects, honeybees as well as silkworm.
Performance Evaluation of a Driving Power Transmission System for 50 kW Narrow Tractors
( Soon-jung Hong ),( Jong-kyou Ha ),( Yong-joo Kim ),( Shaha Nur Kabir ),( Young Woo Seo ),( Sun-ok Chung ) 한국농업기계학회 2018 바이오시스템공학 Vol.43 No.1
Purpose: The development of compact tractors that can be used in dry fields, greenhouses, and orchards for pest control, weeding, transportation, and harvesting is necessary. The development and performance evaluation of power transmission units are very important when it comes to tractor development. This study evaluates the performance of a driving power transmission unit of a 50 kW multi-purpose narrow tractor. Methods: The performance of the transmission and forward-reverse clutch, which are the main components of the driving power transmission unit of multi-purpose narrow tractors, was evaluated herein. The transmission performance was evaluated in terms of power transmission efficiency, noise, and axle load, while the forward-reverse clutch performance was evaluated in terms of durability. The transmission’s power transmission efficiency accounts for the measurement of transmission losses, which occur in the transmission’s gear, bearing, and oil seal. The motor’s power was input in the transmission’s input shaft. The rotational speed and torque were measured in the final output shaft. The noise was measured at each speed level after installing a microphone on the left, right, and upper sides. The axle load test was performed through a continuous equilibrium load test, in which a constant load was continuously applied. The forward-reverse clutch performance was calculated using the engine torque to axle torque ratio with the assembled engine and transmission. Results: The loss of power in the transmission efficiency test of the driving power unit was 6.0-9.7 kW based on all gear steps. This loss of horsepower was equal to 11-18% of the input power (52 kW). The transmission efficiency of the driving power unit was 81.5-89.0%. The noise of the driving power unit was 50-57 dB at 800 rpm, 70-77 dB at 1600 rpm, and 76-83 dB at 2400 rpm. The axle load test verified that the input torque and axle revolutions were constant. The results of the forward-reverse clutch performance test revealed that hydraulic pressure and torque changes were stably maintained when moving forward or backward, and its operation met the hydraulic design standards. Conclusions: When comprehensively examined, these research results were similar to the main driving power transmission systems from USA and Japan in terms of performance. Based on these results, tractor prototypes are expected to be created and supplied to farmhouses after going through sufficient in-situ adaptability tests.