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이시훈,박주식,임영준,김형택 한국화학공학회 1996 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.34 No.1
본 연구에서는 DTF를 이용하여 준역청탄인 Alaska탄의 회분과 deposit을 제조하고 조성을 분석하여 각각의 조성이 용융성에 미치는 영향을 고찰하였으며 ASTM 회분의 결과와 비교하였다. ASTM 회분은 alumina, silica, mullite, Ca-com-pound 등이 결정성으로 존재하는 반면 DTF 회분은 표면에 K, Fe, Ca 등이 농축된 구형의 drop이 만들어지는 것을 알 수 있었다. 또한 DTF 회분에는 mullite만이 결정성으로 존재하였다. Deposit은 용융후 고형화된 glass phase로 만들어 졌는데 Fe는 Fe^(3+) silicate로 전이되고 deposit하부에 Si가 농축되는 것으로부터 석탄 내의 무기물 조성 중에 용융을 지배하는 것은 Si인 것을 알 수 있었다. Alaska탄은 ASTM 회분분석결과로부터는 용융성이 강하게 예측되었으나 DTF에서 형성된 deposit 분석결과 표면에 부착강도를 낮게 하는 Ca가 농축되어 열전달면에서의 제거는 용이한 것으로 판단되었다. Ash and deposits were made using Alaska sub-bituminous coal in a drop tube furnace(DTF) and the effects of their compositions on fusion were compared with those of the ashes prepared from the ASTM aching procedure. It has been found that the ASTM ash includes alumina, silica, mullite, and Ca compounds as crystalline phases, whereas the DTF ash includes spherical drops with K, Fe, and Ca condensed on the surface. In a DTF ash, only mullite existed as crystalline phase. 'Che deposits existed as glass phases which were formed by solidification from melts, and Fe was transformed to Fe^(3+) silicate and Si was concentrated on the lower part of the deposit. This fact indicates that, among various inorganic elements in coal, Si controls the fusion. Although it was initially predicted that Alaska coal ash have strong slagging propensity based on the results of ASTM ash characterization, the results of analysis of the DTF deposits shows that the deposits can be easily removed from the heat transfer area because it is enriched with Ca which reduces the strength of its adhesion to the solid surface.
瀉白散의 肥滿細胞 嫫介性 炎症性 細胞活性物質 分泌 抑制 效果
이병주,신조영,이시형,홍재의,박병민,이승언 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1
Ocjective : Sabaeksan has been used for the purpose of prevention and treatment of bronchial asthma and allergic asthma in korea. Methods : To investigate the biological effect of Sabaeksan, the author examined cytotoxicity and inflammatory cytokines secretion with human leukemic mast cell line, HMC-1. HMC-1 was stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. Sabaeksan by itself had no effect on viability of HMC-1. Result : The effects of Sabaeksan on the secretion of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay. Sabaeksan (1 mg/㎖) inhibited PMA plus A23187-stimulated TNF-α and IL-6 secretion, by 43.86 ± 5.26%, 56.39 ± 3.65%, respectively. Sabaeksan also inhibited the NF-κB (p50/p65) expression. Conclusion : Taken together, these results suggest that Sabaeksan inhibit the production of inflammatory cytokines in HMC-1 cells through blockade of NF-κB activation.
Glycol Oleates의 합성과 절삭유제로서의 물성
최형기,이호식,이치우,강신춘,노시태 한양대학교 공학기술연구소 1993 공학기술논문집 Vol.2 No.1
Glycololeates for the application of cutting fluid were synthesized from oleic acid and glycols such as ethylene glycol, diethylene glycol and triethylene glycol. The ratio of glycol-monooleate and dioleate in product according to the reaction condition was analyzed by TLC, CC and HPLC. Properties of glycololeates as cutting fluid were examined by various testing methods such as profile test, pH test, anti-foaming test friction coefficient test and emulsion stability test to compare those of base oil and cutting fluid trading in the market. Non-catalytic reaction of glycololeates synthesis was showed too low conversion rate, but too fast conversion rate and deep color deterioration of products was obtained with acid-catalyses reaction. Using the SnCl2 catalyst, conversion rate was medium range and products which suitable for the application of cutting fluid with mild colored and with desirable mono- and di-oleate composition was obtained. Cutting fluidal properties of glycololeates with SnCl2 catalyst were better than those of base oil, and were similar level to those of cutting fluid containing various additives.
석진한,심철웅,최현배,이시형,Seok, Jin-Han,Sim, Cheol-Ung,Choi, Hyun-Bae,Lee, Si-Hyeong 대한한의정보학회 2012 大韓韓醫情報學會誌 Vol.18 No.1
Pulse diagnosis has been highly valued in many East Asian medical books, since "Huangdaineijing(黃帝內經)" published. Gigoo-inyoung pulse method(氣口人迎脈法) is one of the four pulse diagnostic methods originally written in"Huangdaineijing(黃帝內經)". At the late 3rd century, "Maijing(脈經)" redefined the positions of Gigoo-inyoung pulse(氣口人迎脈). According to "Maijing(脈經)", both spots were 1fen(分) in front of guan(關) but Gigoo on the right hand and Inyoung on the left hand. At the middle of 13th century, "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" had detailed view points about the manner of reading Gigoo-inyoung pulse. "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" explained clearly the position of 1fen(分) in front of guan(關) by sketch of wrist. The location indicated the border of cun(寸) and guan(關). It also explained clearly corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse by sketch. "Euihackipmoon(醫學入門)" is a comprehensive book on medicine written by Lee-Cheon(李?) in Ming(明) dynasty. In this book, pulse diagnosis is the most emphasized method among the four techniques of diagnosis(四診). Furthermore, it introduces detailed information about Gigoo-inyoung pulse method(氣口人迎脈法) in "Gigoo-inyoungmaekgyole(氣口人迎脈訣)". Lee-Cheon concured in the theory of "Yeongruegumbang(永類鈐方)" and "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and put a short essay about Gigoo-inyoung pulse named "Gigoo-inyoungmaekgyole(氣口人迎脈訣)" quoted from the two books. Therefore, throughout many chapters of "Euihackipmoon(醫學入門)", Gigoo-inyoung pulse is used in order to distinguish internal damage(內傷) and external contraction(外感). "Maekgyolejijangbyungsikdoseol(脈訣指掌病式圖說)" and "Euihackipmoon(醫學入門)" understood Gigoo-inyoung pulse commonly by corresponding certain cun-guan-chi(寸關尺) with Gigoo-inyoung pulse. Therefrom, Gigoo-inyoung pulse can distinguish seven emotions(七情) of internal damage(內傷) or six excesses(六淫) of external contraction(外感).
Si Hyeong Lee,Soo Hyung Ryu,Dong Hoon Lee,Won Eui Yoon,박태영,Hye Kyung Lee,Jeong Seop Moon 대한간암학회 2020 대한간암학회지 Vol.20 No.2
Cholangiocarcinoma is a biliary carcinoma with a wide spectrum of imaging, histological, and clinical features. In immunocompromised patients, pyogenic abscesses are relatively common and an echinococcal hepatic cysts are very rare. The authors experienced a very rare case of cholangiocarcinoma showing multiple hypodense masses with wall enhancement mimicking pyogenic liver abscess, echinococcal hepatic cyst, and cystic metastases. An 83-year-old man, complaining of fatigue and poor oral intake, presented to our outpatient clinic. Abdominal computed tomography (CT) revealed multiple, variable-sized hypodense masses with peripheral rim enhancement throughout the liver. Dynamic liver magnetic resonance images also showed findings similar to those of a CT scan. We performed ultrasound-guided biopsy of the mass which revealed cholangiocarcinoma.
Role of S100A9 in the development of neutrophilic inflammation in asthmatics and in a murine model
Lee, Tae-Hyeong,Chang, Hun Soo,Bae, Da-Jeong,Song, Hyun Ji,Kim, Myung-Sin,Park, Jong Sook,Jun, Ji Ae,Lee, Si Young,Uh, Soo Taek,Kim, Soo Hyun,Park, Choon-Sik Elsevier 2017 Clinical immunology Vol.183 No.-
<P><B>Abstract</B></P> <P>S100A9 is an endogenous danger signal that promotes and exacerbates the neutrophilic inflammatory response. To investigate the role of S100A9 in neutrophilic asthma, S100A9 levels were measured in sputum from 101 steroid-naïve asthmatics using an ELISA kit and the levels were significantly correlated with percentages of neutrophils in sputum. Intranasal administration of recombinant S100A9 markedly increased neutrophil numbers at 8h and 24h later with concomitant elevation of IL-1β, IL-17, and IFN-γ levels. Treatment with an anti-S100A9 antibody restored the increased numbers of neutrophils and the increased airway resistance in OVA/CFA mice toward the levels of sham-treated mice. Concomitantly, the S100A9 and neutrophil elastase double positive cells were markedly reduced with attenuation of IL-1β, IL-17, and IFN-γ levels by the treatment with the anti-S100A9 antibody. Our data support a role of S100A9 to initiate and amplify the neutrophilic inflammation in asthma, possibly via inducing IL-1β, IL-17 and IFN-γ.</P> <P><B>Highlight</B></P> <P> <UL> <LI> S100A9 is an endogenous danger signal that promotes and exacerbates the neutrophilic inflammatory response. </LI> <LI> Our data support a role of S100A9 to initiate and amplify the neutrophilic inflammation via inducing IL-1β, IL-17 and IFN-γ. </LI> <LI> Modulation of S100A9 in the airway may be a therapeutic strategy to control neutrophilic inflammation in asthma. </LI> </UL> </P>
Detection of single nucleotide polymorphisms using a biosensor-containing titanium-well array.
Lee, Joo-Kyung,Cho, Si-Hyeong,Lee, Jinyoung,Lee, Jung-Hwan,Kim, Ah Young,Park, Bae Ho,Park, Jin-Goo,Busnaina, Ahmed,Lee, Hea Yeon American Scientific Publishers 2013 Journal of nanoscience and nanotechnology Vol.13 No.1
<P>The rapid identification and verification of single nucleotide polymorphisms (SNPs) were demonstrated using a well array sensor containing anti-biofouling titanium (Ti). Probe single-stranded DNA (ssDNA) was immobilized inside a titanium-well array on amine-modified glass surfaces with anti-biofouling behavior via a streptavidin-biotin interaction. Fluorescence intensity changes originating from the hybridization of nucleic acids to protein-bound nucleic acids linked to Alexa Fluor (FL) 647 were observed. The protocol was highly sensitive and reproducible for the detection of DNA hybridization. Significant changes in fluorescence signals were observed when using target DNA with a single base mismatch, indicating that this method is applicable to SNP detection. The microarray technology for the detection of SNPs using anti-biofouling Ti and other methods can be used as a highly sensitive in vitro medical sensor, as highlighted by an increase in genotyping accuracy.</P>
α-glucosidase inhibition of Cudrania tricuspidata according to each parts and period. (초)
( Hyeong U Son ),( Chul Hong Park ),( Jin Chul Heo ),( Dong Yoon Nam ),( Si Rim Lee ),( Hyun Jin Lee ),( Tae Yang Cha ),( Jin Hong Baek ),( Sang Han Lee ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2010 한국식품저장유통학회 학술대회 Vol.2010 No.-