Improved DTCWT-LMS and FastICA Based sEMG Signals Filtering

Li Lin,Wang Jianhui,Fang Xiaoke,Gu Shusheng 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.5

A novel design of dual-tree complex wavelet transform (DTCWT) and fastICA was proposed, aiming at the noise interference and aliasing between multi-channels sEMG signals. Firstly, DTCWT was utilized to decompose signals to different frequency band. Secondly, an improved LMS adaptive filter was designed for filtering sub band noise layer by layer. Finally, fastICA algorithm was introduced to separate crosstalk between channels. Some experiments were carried out to compare the proposed method with other algorithms, and the results showed that the algorithm proposed could filter noise effectively, keep better convergence especially in low signal-to-noise ratio and eliminate crosstalk more thoroughly by fastICA.

Vertically constructed monolithic electrodes for sodium ion batteries: toward low tortuosity and high energy density

Li, Ping,Wang, Yanan,Jeong, Jong Yeob,Gao, Xiaoming,Zhang, Kan,Neville, Anne,Xu, Shusheng,Park, Jong Hyeok The Royal Society of Chemistry 2019 Journal of Materials Chemistry A Vol.7 No.45

<P>Nanomaterials for battery applications are strongly appealing to the industrial community, yet conventional electrode fabrication by employing a slurry paste restricts the potential performances of nanoengineered materials, particularly with commercial-level thickness and high mass loading. Here, physical vapor deposition (PVD) prepared monolithic electrodes composed of 40 μm-thick anisotropic WS2 vertical arrays on Al foil with a mass loading of 17.5 mg cm<SUP>−2</SUP>, and several sparsely inserted nanometre-thick carbon layers are reported. The monolithic anode shows an ultra-fast Na-ion diffusivity of 2.05 × 10<SUP>−10</SUP> cm<SUP>2</SUP> s<SUP>−1</SUP>, which is two orders of magnitude faster than that of the anode prepared from a slurry paste. As a sodium-ion battery (SIB) anode, the monolithic electrode achieves prominent areal and volumetric capacities of 5.57 mA h cm<SUP>−2</SUP> and 1.39 A h cm<SUP>−3</SUP>, respectively, at a current density of 100 mA g<SUP>−1</SUP> with less than 20% decay during 300 cycles. Furthermore, a SIB full cell composed of the monolithic anode and a Na2V3(PO4)3/C cathode can provide a reversible capacity around 125 mA h g<SUP>−1</SUP> at 2C with an output voltage of 1.77 V, which demonstrates its potential for further development.</P>

The effect of Lfcin-B on non-small cell lung cancer H460 cells is mediated by inhibiting VEGF expression and inducing apoptosis

Shusheng Wang,Jiancheng Tu,Cuijie Zhou,Jianwei Li,Long Huang,Lei Tao,Lei Zhao 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.2

Lfcin-B, an antimicrobial peptide found invarious exocrine secretions of mammals, showed antitumoreffects. However, the effect and relative mechanism ofLfcin-B on non-small cell lung cancer is unclear. In thisstudy, assay of cell viability, quantitative real-time PCR,Western blot, annexin V/propidium iodide assay, flowcytometry and tumor-xenograft model were applied toelucidate the mechanism of Lfcin-B on non-small cell lungcancer NCI-H460 (H460) cells. Lfcin-B significantly suppressedthe proliferation of H460 cells in vitro. Additionally,the transcription and translation of the VEGF gene inH460 cells were restrained after exposure to Lfcin-B. Moreover, the apoptosis of H460 cells was induced byLfcin-B through stimulating caspase-3, caspase-9 andpreventing survivin expression on both the transcriptionand translation level. Meanwhile, Lfcin-B increased theproduction of reactive oxygen species and suppressed theRNA of antioxidant enzymes (GPX1, GPX2, SOD3 andcatalase) in H460 cells. Finally, Lfcin-B significantly preventedthe tumor growth in the H460-bearing mice model. These results indicated that Lfcin-B could be a potentialcandidate for the treatment of lung cancer.

Interaction of Bilobalide and Ginkgolides B with Bovine Serum Albumin: A Fluorescence Quenching Study

Yan Chen,Guiqing Kai,Shaofei Li,Yi Yang,Shusheng Wang,Ruijun Wang 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.9

The interaction of bilobalide (BB) and ginkgolides B (GB) with bovine serum albumin (BSA) was investigated by fluorescent technique and UV/vis absorption spectroscopy. The results showed that BB and GB could intensively quench the fluorescence of BSA through a static quenching procedure. The binding constants (Ka)and the average binding distance between the donor (BSA) and the acceptor (ginkgolides) were obtained (r_(BB)= 5.33 nm and rGB = 4.20 nm) by the theory of non-radiation energy transfer, and then the thermodynamic parameters such as ΔS^0 (0.17-0.32 kJ/mol), ΔG^0 (-20.76 ~ -17.79 kJ/mol) and ΔH^0 (32.47-76.52 kJ/mol) could be calculated, respectively. All these results revealed that the interaction of BB and GB with BSA were driven mainly by hydrophobie force. The synchronous fluorescence spectroscopy was applied to examine the effect of two ginkgolides on the configuration of BSA. The configuration alteration of BSA could be induced by the hydrophobicitv environment of tyrosine with the increase of the drug concentration.

Interaction of Bilobalide and Ginkgolides B with Bovine Serum Albumin: A Fluorescence Quenching Study

Chen, Yan,Wang, Ruijun,Wang, Shusheng,Yang, Yi,Li, Shaofei,Kai, Guiqing Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.9

The interaction of bilobalide (BB) and ginkgolides B (GB) with bovine serum albumin (BSA) was investigated by fluorescent technique and UV/vis absorption spectroscopy. The results showed that BB and GB could intensively quench the fluorescence of BSA through a static quenching procedure. The binding constants (Ka) and the average binding distance between the donor (BSA) and the acceptor (ginkgolides) were obtained ($r_{BB}$ = 5.33 nm and $r_{GB}$ = 4.20 nm) by the theory of non-radiation energy transfer, and then the thermodynamic parameters such as ${\Delta}S^0$ (0.17-0.32 kJ/mol), ${\Delta}G^0$ (-20.76 ~ -17.79 kJ/mol) and ${\Delta}H^0$ (32.47-76.52 kJ/mol) could be calculated, respectively. All these results revealed that the interaction of BB and GB with BSA were driven mainly by hydrophobie force. The synchronous fluorescence spectroscopy was applied to examine the effect of two ginkgolides on the configuration of BSA. The configuration alteration of BSA could be induced by the hydrophobicitv environment of tyrosine with the increase of the drug concentration.

Sodium tanshinone IIA sulfonate depresses angiotensin IIinducedcardiomyocyte hypertrophy through MEK/ERKpathway

Le Yang,Xiaojing Zou,Qiansheng Liang,Hao Chen,Jun Feng,Li Yan,Zhaohua Wang,Daixing Zhou,Shusheng Li,Shanglong Yao,Zhi Zheng 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.1

Cardiomyocyte hypertrophy is a major cause of morbidity and mortality worldwide. The aim of this study is to determine the effects of sodium tans - hinone IIA sulfonate (STS) on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) in vivo and in vitro. In long-term treatment, adult Wistar rats were infused with Ang II for three weeks via osmotic mini-pumps and some of them were given intragas - trically of STS. Left ventricle was isolated; the ratio of left ventricular weight to body weight and systolic blood pressure (SBP) were determined and heart morphometry was assessed after hematoxylin and eosin staining. Results indicated STS inhibited Ang II-induced increases in myocyte diameter and decreased the LVW/BW ratio independent of decreasing systolic blood pressure. In vitro, treatment of cultured cardiomyocytes with STS inhibited Ang II-induced increase in cell size, protein synthesis, ANP expression, activation of extracellular signalregulated kinase (ERK) and ERK kinase (MEK). Then we reexamined the mechanism of STS-induced antihypertrophic effects. Results revealed MEK inhibitor U0126 (20 µM) markedly enhanced STS-induced depressions in [3H]leucine incorporation and ANP expression. In conclusion, MEK/ERK pathway plays a significant role in the anti-hypertrophic effects of STS.

Low serum total testosterone level as a predictor of upgrading in low-risk prostate cancer patients after radical prostatectomy: A systematic review and meta-analysis

Shu Gan,Jian Liu,Zhiqiang Chen,Songtao Xiang,Chiming Gu,Siyi Li,Shusheng Wang 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.4

Purpose: To investigated the association between serum total testosterone and Gleason score upgrading of low-risk prostate cancer after radical prostatectomy (RP). Materials and Methods: Medline, Web of Science, Embase, and Cochrane Library databases were searched to identify eligible studies published before October 2021. Multivariate adjusted odds ratios (ORs) and associated 95% confidence intervals (CIs) were calculated using random or fixed effects models. Results: Five studies comprising 1,203 low-risk prostate cancer patients were included. The results showed that low serum total testosterone (<300 ng/dL) is associated with a high rate of Gleason score upgrading after RP (OR, 2.3; 95% CI, 1.38–3.83; p<0.001; I2, 92.2%). Notably, sensitivity and meta-regression analyses further strengthen the reliability of our results. Conclusions: Our results support the idea that low serum total testosterone is associated with a high rate of Gleason score upgrading in prostate cancer patients after RP. It is beneficial for urologist to ensure close monitoring of prostate-specific antigen levels and imaging examination when choosing non-RP treatment for low-risk prostate cancer patients.

Host Langerin (CD207) is a receptor for <i>Yersinia pestis</i> phagocytosis and promotes dissemination

Yang, Kun,Park, Chae G,Cheong, Cheolho,Bulgheresi, Silvia,Zhang, Shusheng,Zhang, Pei,He, Yingxia,Jiang, Lingyu,Huang, Hongping,Ding, Honghui,Wu, Yiping,Wang, Shaogang,Zhang, Lin,Li, Anyi,Xia, Lianxu,B Nature Publishing Group 2015 Immunology and Cell Biology Vol. No.

<P><I>Yersinia pestis</I> is a Gram‐negative bacterium that causes plague. After <I>Y. pestis</I> overcomes the skin barrier, it encounters antigen‐presenting cells (APCs), such as Langerhans and dendritic cells. They transport the bacteria from the skin to the lymph nodes. However, the molecular mechanisms involved in bacterial transmission are unclear. Langerhans cells (LCs) express Langerin (CD207), a calcium‐dependent (C‐type) lectin. Furthermore, <I>Y. pestis</I> possesses exposed core oligosaccharides. In this study, we show that <I>Y. pestis</I> invades LCs and Langerin‐expressing transfectants. However, when the bacterial core oligosaccharides are shielded or truncated, <I>Y. pestis</I> propensity to invade Langerhans and Langerin‐expressing cells decreases. Moreover, the interaction of <I>Y. pestis</I> with Langerin‐expressing transfectants is inhibited by purified Langerin, a DC‐SIGN (DC‐specific intercellular adhesion molecule 3 grabbing nonintegrin)‐like molecule, an anti‐CD207 antibody, purified core oligosaccharides and several oligosaccharides. Furthermore, covering core oligosaccharides reduces the mortality associated with murine infection by adversely affecting the transmission of <I>Y. pestis</I> to lymph nodes. These results demonstrate that direct interaction of core oligosaccharides with Langerin facilitates the invasion of LCs by <I>Y. pestis</I>. Therefore, Langerin‐mediated binding of <I>Y. pestis</I> to APCs may promote its dissemination and infection.</P>