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3-deoxyglucosone에 의한 단백질의 modification
신동범,오상환,양융 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.1
pH 7.4, 37℃의 생리적 반응조건에서 HSA, ovalbumine, BSA, lysozyme, RNase A 및 IgG와 3-deoxyglucosone을 반응시키고 단백질의 중합현상과 아미노산 잔기의 손상상태를 연구하였다. 3-deoxyglucosone은 모든 단백질을 중합시킬 수 있으나 특히 lysozyme, RNase A 및 IgG를 현저하게 중합시켰다. 또한 Arginine잔기를 크게 손상시켰다. glucose에 의한 단백질의 중합과정은 glucose가 단백질의 아미노 그룹과의 반응으로 3-deoxyglucosone을 형성시키고, 이것이 단백질의 lysine 잔기와 arginine 잔기를 공격하여 cross link를 형성시키는 것으로 추정되었다. Human serum albumin, bovine serum albumin, ovalbumin, IgG, lysozyme and ribonuclease A were reacted with 3-deoxyglucosone under physiological conditions of 37℃ and pH 7.4, and polimerization of proteins and impairments of amino acid residues were investigated. Proteins tested, especially lysozyme, IgG and ribonuclease A, were polymerized significantly, and lysine residue and arginine residue, espectially arginine residue of proteins were impaired remarkably. Experimental results strongly suggested 3-deoxyglucosone, formed from proteins-glucose reaction system, was the cross-linker responsible for the polymerization of proteins.
申東秀,金在煥 경북대학교 의학연구소 1969 慶北醫大誌 Vol.10 No.2
Author performed microbiological studies on salmonella typhimurium isolated from food poisoning among the employee of university Hospital on Spring, 1968. The results were as follows; 1. Among 78 cases of food poisoning 31 strains of salmonella typhimirium were isolated. 2. The strains were identified by means of serological and biochemical reactions as typical salmonella typhimurium. 3. The sensityvity patterns of the isolated salmonella typhimurium were highly sensitive to chlorampenicol, terramycin, albamycin, kanamycin, streptomycin, sigmamycin and nitrofurantion, and resistant to penicilline, bacitracin, achromycim, erythronycin and oleandomycin. 4. Under the suspicion of pork contamination author tried to isolate the causatie organism of pork from seller, also examined to detect the carriers from employee handled the pork, however, both results were not contributive.
하악골 전돌증 수술 후 하악골 이동량에 따른 발음 양상에 관한 비교 연구
신기영,이동근,오승환,성헌모,이숙향 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1
After performing mandibular setback surgery, we found some changes in patterns and organs of speech. This investigation was undertaken to investigate the aspect and degree of speech patterns according to the amount of surgical setback in mandibular prognathic patients. Thirteen patients with skeletal Class Ⅲ malocclusion were studied preoperative and postoperative over 6 months. They had undergone the mandible setback operation via bilateral sagittal split ramus osteotomy(BSSRO). We split the patients into two groups. Group 1 included patients whose degree of mandibular setback was 6mm or less, and Group 2 above 6mm. Control group was two adults wish normal speech patterns. A phonetician performed narrow phonetic transcriptions of tape-recorded words and sen- tences produced by each of the patients and the acoustic characteristics of the plosives, fricatives, and flaps were analyzed with a phonetic computer program (Computerized Speech Lab(CSL) Model 4300B(USA) ). The results are as fallows : 1. Genera1ly, Patients showed longer closure duration of plosives, shorter VOT(voice onset time) and higher ratio of closure duration against VOT 2. Patients showed more frequent diffuse distribution than the control group in frication noise energy of fricatives. 3. In fricatives, frequency of compact from were higher in group 1 than in group 2. 4. Generally, a short duraction of closure for /ㄹ/ was not realized in the patient's flaps. Instead, it was realized as fricatives, sonorant with a vowel-like formant structure, or trill type consonant. 5. Abnormality of the patient's articulation was reduced, but adaptation of their articulation after surgery was not perfect and the degree of adaptation was different according to the degree of surgical setback.
지로용지 영상의 실시간 압축 및 인식처리를 위한 하드웨어 설계 및 구현
신동욱,오승환 한국기술교육대학교 2001 論文集 Vol.8 No.1
ABSTRACT In this paper, we proposed the algorithms for real time compression and recognition of giro paper image data which is serially inputted by 1 bit unit. Those algorithms are designed and implemented with PLD, and their propriety is confirmed.
신동환,최이송,박재영,오종민 경희대학교 2003 環境硏究 論文集 Vol.12 No.-
In this study, the variation of water quality in Aswan stream was investigated through continuous monitoring and matt balance and metabolism occurred into water body environment was estimated to set up effective management plan of small urban stream. Sated on the results, the rate of output to input (O/I rate. in the flux balance was 1.16 and about 16% sae increased between the section of OS1 ∼ OS3. Also, the SS and BOD loadings between the tame section were increased by 29% and 31%, respectively. Although increase of flux influenced on the increase of SS and BOD loading, it was judged that the larger part of o/I rate of pollutants comparing to O/I rate of flux was due to up-take from sediment on the riverbed. The contribution percentage of BS1 and BS2 for flux between the section of OS1 ∼ OS2 was 17.3%, total section was 31.3% (including BS3). However, the contribution of tributaries for SS, BOD and T-N loading wore 50.3%, 33.0% and 57.6%, respectively. Eventually tributaries contributed the pollution of water quality. To reduce pollution of water quality in the section of OS1 ∼ OS3, firstly, it need that effective management plan for tributaries mutt be set up to improve the water quality in main stream. Secondly, the counter plan for ro-eruptyon of pollutants from sediment in main-stream it required to prevent inner pollution. On this study, we showed that small urban stream can be managed effectively by simple investigation to prevent deterioration of water quality. also, it is more important that matter cycle and matt balance happening in the stream environment must be correctly estimated to make up healthy stream environment and to improve water quality.