Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis

Seunghee Jun(Seunghee Jun),Hyunjin Park(Hyunjin Park),Ui-Jeong Kim(Ui-Jeong Kim),Eun Jeong Choi(Eun Jeong Choi),Hye Ah Lee(Hye Ah Lee),Bomi Park(Bomi Park),Soon Young Lee(Soon Young Lee),Sun Ha Jee(Su 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.

Titelbild: A Facile Strategy for Selective Incorporation of Phosphoserine into Histones (Angew. Chem. 22/2013)

Lee, Sangsik,Oh, Seunghee,Yang, Aerin,Kim, Jihyo,Sö,ll, Dieter,Lee, Daeyoup,Park, Hee‐,Sung WILEY‐VCH Verlag 2013 Angewandte Chemie Vol.125 No.22

<P><I><B>Einen selektiven Phosphoserin‐Einbau</B></I> beschreiben H.‐S. Park et al. in ihrer Zuschrift S. 5883 ff. Eine allgemeine Strategie für den Aufbau rekombinanter Histone mit ortsspezifischer Serinphosphorylierung wurde entwickelt, die auf der Modifizierung einer Phosphoseryl‐tRNA‐Synthetase (SepRS) und des Elongationsfaktors Tu (EF‐Tu) beruht. Die Methode dürfte die Erforschung der Histonphosphorylierung und kreuzregulatorischer Mechanismen vereinfachen.</P>

Post-closure safety assessment of near surface disposal facilities for disused sealed radioactive sources

Lee, Seunghee,Kim, Juyoul Elsevier 2017 Nuclear engineering and design Vol.313 No.-

<P><B>Abstract</B></P> <P>Great attention has been recently paid to the post-closure safety assessment of low- and intermediate-level radioactive waste (LILW) disposal facility for disused sealed radioactive sources (DSRSs) around the world. Although the amount of volume of DSRSs generated from industry, medicine and research and education organization was relatively small compared with radioactive wastes from commercial nuclear power plants, some DSRSs can pose a significant hazard to human health due to their high activities and long half-lives, if not appropriately managed and disposed. In this study, post-closure safety assessment was carried out for DSRSs generated from 1991 to 2014 in Korea in order to ensure long-term safety of near surface disposal facilities. Two kinds of disposal options were considered, i.e., engineered vault type disposal facility and rock-cavern type disposal facility. Rock-cavern type disposal facility has been under operation in Gyeongju city, republic of Korea since August 2015 and engineered vault type disposal facility will be constructed until December 2020 in the vicinity of rock-cavern disposal facility. Assessment endpoint was individual dose to the member of critical group, which was modeled by GoldSim, which has been widely used as probabilistic risk analysis software based on Monte Carlo simulation in the area of safety assessment of radioactive waste facilities. In normal groundwater scenario, the maximum exposure dose was extremely low, approximately 1×10<SUP>−7</SUP> mSv/yr, for both disposal options and satisfied the regulatory limit of 0.1mSv/yr. However, in the drinking well scenario, the maximum exposure dose for engineered vault type disposal facility was assessed as 2.022mSv/yr where the value exceeded the regulatory limit of 1mSv/yr. The maximum exposure dose for rock-cavern type disposal facility was calculated to be 0.634mSv/yr, whose results was relatively very close to the regulatory limit considering high uncertainty of long-term environmental conditions. It was demonstrated that DSRSs including the radionuclides of <SUP>14</SUP>C, <SUP>226</SUP>Ra and <SUP>241</SUP>Am significantly contributed to the large portion of exposure dose to the public based on the long-term safety assessment. Therefore, it was recommended that the near surface disposal of DSRSs containing <SUP>14</SUP>C, <SUP>226</SUP>Ra and <SUP>241</SUP>Am should be restricted and managed by long-term interim storage option in order to minimize their potential radiological health effects.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Post-closure safety assessment of near surface disposal facility for DSRS was performed. </LI> <LI> Engineered vault and rock-cavern type were considered for normal and well scenario. </LI> <LI> <SUP>14</SUP>C, <SUP>226</SUP>Ra, <SUP>241</SUP>Am were primary nuclides contributing large portion of exposure dose. </LI> <LI> Near surface disposal of DSRSs containing <SUP>14</SUP>C, <SUP>226</SUP>Ra and <SUP>241</SUP>Am should be restricted. </LI> </UL> </P>

Improving air quality forecasts in Korea using the 3D-Var aerosol data assimilation

Seunghee Lee,Myong-In Lee,Chang-Keun Song,Ganghan Kim 한국기상학회 2019 한국기상학회 학술대회 논문집 Vol.2019 No.10

STAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex

Lee, Seunghee,Shen, Rongkun,Cho, Hyong-Ho,Kwon, Ryuk-Jun,Seo, So Yeon,Lee, Jae W.,Lee, Soo-Kyung National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.28

<P>The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing analysis and found that the MN–hexamer directly regulates a wide array of motor neuron genes by binding to the HxRE (hexamer response element) shared among the target genes. Interestingly, STAT3-binding motif is highly enriched in the MN–hexamer–bound peaks in addition to the HxRE. We also found that a transcriptionally active form of STAT3 is expressed in embryonic motor neurons and that STAT3 associates with the MN–hexamer, enhancing the transcriptional activity of the MN–hexamer in an upstream signal-dependent manner. Correspondingly, STAT3 was needed for motor neuron differentiation in the developing spinal cord. Together, our studies uncover crucial gene regulatory mechanisms that couple MN–hexamer and STAT-activating extracellular signals to promote motor neuron differentiation in vertebrate spinal cord.</P>

The Effect of Folding Wing on Aerodynamics and Power Consumption of a Flapping Wing

Lee, Seunghee,Han, Cheolheui The Society for Aerospace System Engineering 2016 International Journal of Aerospace System Engineer Vol.3 No.2

Experimental study on the unsteady aerodynamics analysis and power consumption of a folding wing is accomplished using a wind tunnel testing. A folding wing model is fabricated and actuated using servo motors. The flapping wing consists of an inboard main wing and an outboard folding wing. The aerodynamic forces and consumed powers of the flapping wing are measured by changing the flapping and folding wings inside a low-speed wind tunnel. In order to calculate the aerodynamic forces, the measured forces are modified using static test data. It was found that the effect of the folding wing on the flapping wing's total lift is small but the effect of the folding wing on the total thrust is larger than the main wing. The folding motion requires the extra use of the servo motor. Thus, the amount of the energy consumption increases when both the wings are actuated together. As the flight speed increases, the power consumption of the folding wing decreases which results in energy saving.

miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18.

Lee, Seunghee,Yu, Kyung-Rok,Ryu, Young-Sil,Oh, Young Sun,Hong, In-Sun,Kim, Hyung-Sik,Lee, Jin Young,Kim, Sunghoon,Seo, Kwang-Won,Kang, Kyung-Sun Springer 2014 Age Vol.36 No.6

<P>Previously, AIMP3 (aminoacyl-tRNAsynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular tRNA synthetase complex or to act as a tumor suppressor. In this study, we report a novel role of AIMP3/p18 in the cellular aging of human mesenchymal stem cells (hMSCs). We found that AIMP3/p18 expression significantly increased in senescent hMSCs and in aged mouse bone marrow-derived MSCs (mBM-MSCs). AIMP3/p18 overexpression is sufficient to induce the cellular senescence phenotypes with compromised clonogenicity and adipogenic differentiation potential. To identify the upstream regulators of AIMP3/p18 during senescence, we screened for potential epigenetic regulators and for miRNAs. We found that the levels of miR-543 and miR-590-3p significantly decreased under senescence-inducing conditions, whereas the AIMP3/p18 protein levels increased. We demonstrate for the first time that miR-543 and miR-590-3p are able to decrease AIMP3/p18 expression levels through direct binding to the AIMP/p18 transcripts, which further compromised the induction of the senescence phenotype. Taken together, our data demonstrate that AIMP3/p18 regulates cellular aging in hMSCs possibly through miR-543 and miR-590-3p.</P>

POLYMER SURFACE MODIFICATION USING ATMOSPHERIC PRESSURE PLASMA SOURCE ION IMPLANTATION

SEUNGHEE HAN,YEONHEE LEE,JUNGHYE LEE,HAIDONG KIM,GON-HO KIM,YEONGWOO KIM,JUNGHEE CHO 한국진공학회 1999 한국진공학회 학술발표회초록집 Vol.- No.-

Comparison of dental radiography and computed tomography: measurement of dentoalveolar structures in healthy, small-sized dogs and cats

Seunghee Lee,Kichang Lee,Hyeona Kim,Jeongsu An,Junho Han,Taekwon Lee,Hogyun Jeong,Youngkwon Cho 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.5

Background: Dental diseases are common in dogs and cats, and accurate measurements of dentoalveolar structure are important for planning of treatment. The information that the comparison computed tomography (CT) with dental radiography (DTR) is not yet reported in veterinary medicine. Objectives: The purpose of this study was to compare the DTR with CT of dentoalveolar structures in healthy dogs and cats, and to evaluate the CT images of 2 different slice thicknesses (0.5 and 1.0 mm). Methods: We included 6 dogs (2 Maltese and 1 Spitz, Beagle, Pomeranian, mixed, 1 to 8 years, 4 castrated males, and 2 spayed female) and 6 cats (6 domestic short hair, 8 months to 3 years, 4 castrated male, and 2 spayed female) in this study. We measured the pulp cavity to tooth width ratio (P/T ratio) and periodontal space of maxillary and mandibular canine teeth, maxillary fourth premolar, mandibular first molar, maxillary third premolar and mandibular fourth premolar. Results: P/T ratio and periodontal space in the overall dentition of both dogs and cats were smaller in DTR compared to CT. In addition, CT images at 1.0 mm slice thickness was generally measured to be greater than the images at 0.5 mm slice thickness. Conclusions: The results indicate that CT with thin slice thickness provides more accurate information on the dentoalveolar structures. Additional DTR, therefore, may not be required for evaluating dental structure in small-sized dogs and cats.

The inflammatory signature in monocytes of Sjögren’s syndrome and systemic lupus erythematosus, revealed by the integrated Reactome and drug target analysis

Lee Kyung Eun,Mun Seyoung,Kim Song-mi,Shin Wonseok,Jung Won,Paek Joon,Lee Jungnam,Hudson Erin,Reeves Wesley H.,Han Kyudong,Cha Seunghee 한국유전학회 2022 Genes & Genomics Vol.44 No.10

Background: The innate immune regulation, especially by the type I IFN signature in the CD14+ monocytes, is known to be critical in the pathogenesis of autoimmune Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE). Objective: Since patients with one condition can be overlapped with another, this study is to identify shared differentially expressed genes (DEGs) in SjS and SLE compared to healthy controls (HCs) and refine transcriptomic profiles with the integrated Reactome and gene-drug network analysis for an anti-inflammation therapy. Methods: CD14+ monocytes were purified from whole blood of SjS and SLE patients (females, ages from 32 to 62) and subject to bulk RNA-sequencing, followed by data analyses for comparison with HC monocytes (females, ages 30 and 33). Functional categorizations, using Gene Ontology (GO) and the Reactome pathway analysis, were performed and DEGs associated with therapeutic drugs were identified from the Drug Repurposing Hub (DHUB) database. Results: The GO analysis revealed that DEGs in the inflammatory response and the cellular response to cytokine were highly enriched in both conditions. A propensity toward M1 macrophage differentiation appears to be prominent in SjS while the Response to Virus was significant in SLE monocytes. Through the Reactome pathway analysis, DEGs in the IFN signaling and the cytokine signaling in immune system were most significantly enriched in both. Upregulation of NGF-induced transcription activity in SjS and the complement cascade activity in SLE were also noted. Multiple anti-inflammatory drugs, such as prostaglandin-endoperoxide synthase and angiotensin-I-converting- enzyme were associated with the DEGs in these conditions. Conclusions: Taken together, our analysis indicates distinct inflammatory transcriptomic profiles shared in SjS and SLE monocytes. Comprehensive characterizations of the data from these conditions will ultimately allow differential diagnosis of each condition and identification of therapeutic targets.