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Lee, Hye Shin,Choi, Jinhyeok,Son, Taekwon,Lee, Eun Ji,Kim, Jeong-Gyun,Ryu, Soo Hyung,Lee, Danbi,Jang, Myoung Kuk,Yu, Eunsil,Chung, Young-Hwa,Gelman, Irwin H.,Kim, Kyu-Won D.A. Spandidos 2018 Oncology letters Vol.16 No.5
<P>AKAP12 belongs to A-kinase anchoring protein (AKAP) family of scaffold proteins and is known as a tumor suppressor in several human cancer types. Its role as a tumor suppressor in hepatocellular carcinoma (HCC) was proposed due to its downregulation and epigenetic modification in human HCC; however, the effect of its deficiency on liver injuries, such as liver fibrosis and cancer has been poorly studied. By analyzing tumor and non-tumor tissues of 15 patients with HCC, it was confirmed that AKAP12 expression was downregulated in human HCC as compared with adjacent non-tumor tissues. Immunohistochemical staining of mouse liver tissue for AKAP12 revealed that its sinusoidal expression was diminished in capillarized endothelium after 8 weeks of thioacetamide (TAA) administration. AKAP12 deficiency resulted in the promotion of ductular response of biliary epithelial cells, whereas overall fibrosis and myofibroblast activation were comparable between genotypes after short-term TAA treatment. The mRNA expressions of some fibrosis-related genes such as those encoding epithelial cell adhesion molecule, collagen type 1 α1 and elastin were upregulated in liver tissues of AKAP12-knockout mice. Long-term administration of TAA for 26 weeks led to the development of liver tumors; the incidence of tumor development was higher in AKAP12-deficient mice than in wild-type littermates. Together, these results suggest that AKAP12 functions as a tumor suppressor in liver cancer and is associated with the regulation of hepatic non-parenchymal cells.</P>
이기원(Lee Kiwon),권삼영(Kwon Samyoung),조용현(Cho Yong Hyeon),이태권(Lee Taekwon),이경훈(Lee Kyunghoon) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
A detail design of overhead catenary system can be divided into a pegging plan and a design of MD(mounting diagram). In the pegging plan, the mast location, staggering and tension length are determined in the longitudinal point of view according to track condition, location of substation and etc. In the MD, a transversal diagram including masts, all of wires, cantilever, foundation and etc. and materials used are shown. This study presents a development of a software to design the MD for a conventional catenary system automatically. In the program, thin walled steel pole, foundation, cantilever, all of wires and etc. are automatically drawn according to the input and catenary conditions. And materials used in the MD and the section can be also managed respectively in the program. This application of the program is developed using C# for input/calculating and using C++(ObjectARX) for drafting the MD, respectively.
Seunghee Lee,Kichang Lee,Hyeona Kim,Jeongsu An,Junho Han,Taekwon Lee,Hogyun Jeong,Youngkwon Cho 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.5
Background: Dental diseases are common in dogs and cats, and accurate measurements of dentoalveolar structure are important for planning of treatment. The information that the comparison computed tomography (CT) with dental radiography (DTR) is not yet reported in veterinary medicine. Objectives: The purpose of this study was to compare the DTR with CT of dentoalveolar structures in healthy dogs and cats, and to evaluate the CT images of 2 different slice thicknesses (0.5 and 1.0 mm). Methods: We included 6 dogs (2 Maltese and 1 Spitz, Beagle, Pomeranian, mixed, 1 to 8 years, 4 castrated males, and 2 spayed female) and 6 cats (6 domestic short hair, 8 months to 3 years, 4 castrated male, and 2 spayed female) in this study. We measured the pulp cavity to tooth width ratio (P/T ratio) and periodontal space of maxillary and mandibular canine teeth, maxillary fourth premolar, mandibular first molar, maxillary third premolar and mandibular fourth premolar. Results: P/T ratio and periodontal space in the overall dentition of both dogs and cats were smaller in DTR compared to CT. In addition, CT images at 1.0 mm slice thickness was generally measured to be greater than the images at 0.5 mm slice thickness. Conclusions: The results indicate that CT with thin slice thickness provides more accurate information on the dentoalveolar structures. Additional DTR, therefore, may not be required for evaluating dental structure in small-sized dogs and cats.
Ivermectin, praziquantel, tamiflu, triclosan의 환경위해성평가
류태권(Taekwon Ryu),김정곤(Jungkon Kim),김경태(Kyungtae Kim),이재우(Jaewoo Lee),김지은(Jieun Kim),조재구(Jaegu Cho),윤준헌(Junheon Yoon),이재안(Jaean Lee),김필제(Pilje Kim),류지성(Jisung Ryu) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.2
Objectives: The purpose of this study was to assess environmental risk on the emerging contaminants of concern, such as ivermetin, parziquantel, tamiflu and triclosan. Furthermore, we tried to provide a more efficient management practice and a basis for future studies of risk assessment on those substances. Methods: Predicted no effect concentration (PNEC) and predicted environmental concentration (PEC) were determined through modeling and literature reviews. Environmental risk assessment was evaluated by calculating HQ (hazard quotient) by a comparison of PEC (or measured environmental concentration (MEC)) and PNEC. Results: HQ value of tamiflu calculated from MEC was 1.9E-03. For ivermectin and triclosan, the HQ values were not available because these were not detected in the aquatic environment. The toxicity of ivermectin and triclosan showed a very low value, indicating a high level of HQ. However, praziquantel can be categorized into the material that do not require management since they have less than HQ 1. Conclusion: Based on the results of the initial risk assessment, it is assumed that the ivermectin and triclosan have potential to cause direct adverse effects on the aquatic environment. To conduct an accurate environmental risk assessment, the further study on PEC estimation of such contaminants should be actively carried out.
전주 위치 설계 지원 프로그램 개발 (I) : 유기적 3차원 설계 기법을 중심으로
이기원(Kiwon Lee),조용현(Yong Hyeon Cho),권삼영(Sam-Young Kwon),이태권(Taekwon Lee) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.10
The detail design of overhead line can be dievided into a pegging plan and MD(Mounting Diagram) process. A program can perform a MD process was already developed and used in Honam High-Speed project. In this study a pegging plan program which can perform mast distribution automatically is developed. The system is developed based on dot net framework 4.0 and Civil3D 2012 and used spread 4.0 component for grid UI. It can not be directly used a rail horizontal alignment and long-section profile together on drawing. Therefore using Civil3D mathematical alignment and profile of rail can be accomplished. And this program has an advantage of user friendly operation because of close relationship between the two.
Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice
Le, Hoang,Ahn, Bum Ju,Lee, Hye Shin,Shin, Anna,Chae, Sujin,Lee, Sung Yi,Shin, Min Wook,Lee, Eun-Ji,Cha, Jong-Ho,Son, Taekwon,Seo, Ji Hae,Wee, Hee-Jun,Lee, Hyo-Jong,Jang, Yongwoo,Lo, Eng H.,Jeon, Sejin Humana Press 2017 Molecular Neurobiology Vol. No.
<P>Over the last few decades, molecular neurobiology has uncovered many genes whose deficiency in mice results in behavioral traits associated with human neuropsychiatric disorders such as autism, obsessive-compulsive disorder (OCD), and schizophrenia. However, the etiology of these common diseases remains enigmatic with the potential involvement of a battery of genes. Here, we report abnormal behavioral phenotypes of mice deficient in a cell adhesion molecule Ninjurin 1 (Ninj1), which are relevant to repetitive and anxiety behaviors of neuropsychiatric disorders. Ninj1 knockout (KO) mice exhibit compulsive grooming-induced hair loss and self-made lesions as well as increased anxiety-like behaviors. Histological analysis reveals that Ninj1 is predominantly expressed in cortico-thalamic circuits, and neuron-specific Ninj1 conditional KO mice manifest aberrant phenotypes similar to the global Ninj1 KO mice. Notably, the brains of Ninj1 KO mice display altered synaptic transmission in thalamic neurons as well as a reduced number of functional synapses. Moreover, the disruption of Ninj1 leads to glutamatergic abnormalities, including increased ionotropic glutamate receptors but reduced glutamate levels. Furthermore, chronic treatment with fluoxetine, a drug reportedly ameliorates compulsive behaviors in mice, prevents progression of hair loss and alleviates the compulsive grooming and anxiety-like behavior of Ninj1 KO mice. Collectively, our results suggest that Ninj1 could be involved in neuropsychiatric disorders associated with impairments of repetitive and anxiety behaviors.</P>
Lee, Hye Shin,Shin, Hyun-Sang,Choi, Jinhyeok,Bae, Sung-Jin,Wee, Hee-Jun,Son, Taekwon,Seo, Ji Hae,Park, Ji-Hyeon,Kim, Sung-Wuk,Kim, Kyu-Won Spandidos Publications 2016 International journal of oncology Vol.49 No.4
<P>Cirrhosis, the end-stage of hepatic fibrosis, is not only life-threatening by itself, but also a causative factor of liver cancer. Despite efforts to develop treatment for liver fibrosis, there are no approved agents as anti-fibrotic drugs to date. In the present study, we aimed to investigate the anti-fibrotic effect of the AMP-activated protein kinase (AMPK) activator, HL156A. A mouse model of thioacetamide (TAA)-induced liver fibrosis was used to examine the effect of HL156A in vivo. Mice received either TAA alone or a combination of TAA and HL156A intraperitoneally for a total duration of 6 weeks. Including HL156A during exposure to TAA significantly reduced extracellular matrix (ECM) deposition and production of the hepatic transforming growth factor-beta 1 (TGF-(beta 1). Immunohistochemical analysis revealed that the activation of hepatic stellate cells and the capillarization of liver sinusoids were also diminished significantly by HL156A co-treatment. The anti-fibrotic effect of HL156A was further studied in vitro by using a rat hepatic stellate cell line, HSC-T6 cells. The induction of alpha-smooth muscle actin (alpha-SMA) by TGF-beta 1 treatment was reversed by HL156A, which was likely via the activation of AMPK. Moreover, HL156A showed anti-inflammatory effects on macrophages. Treatment with HL156A diminished LPS-induced activation of both Raw264.7 macrophage cells and primary cultured mouse macrophages. Taken together, these results imply that the AMPK activator HL156A inhibits hepatic fibrosis via multiple mechanisms and could be a potentially effective agent for fibrosis treatment.</P>