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Sheen, Seung Hun,Hong, Je Beom,Kim, Hakyung,Kim, Jimin,Han, In-bo,Sohn, Seil The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.4
Objective : The goal of the following statewide age and gender-coordinated cohort study in Korea is to find out if there is a link between acute myocardial infarction (AMI) and Parkinson's disease (PD). Methods : Utilizing the National Health Insurance Sharing Service cohort, patient data were collected. Six thousand four hundred seventy-five individuals with PD were distinguished by utilizing the International Classification of Diseases 10 code G20 and have enrolled in the PD group. The number of participants decreased to 5259 after excluding 1039 patients who were hospitalized less than one time or who visited an outpatient clinic less than twice. Then, 26295 individuals were selected as part of the control group after case control matching was conducted through 1 : 5 age- and gender-coordinated matching. The Cox proportional hazard regression analysis and Kaplan-Meier method were utilized to analyze the likelihood of AMI in PD. Results : After controlling for age and gender, the hazard ratio of AMI in the PD group was 3.603 (95% confidence interval [CI], 2.837-4.577). After that, the following hazard ratio of AMI in the PD group was modified against for co-morbid medical disorders, resulting in 3.551 (95% CI, 2.795-4.511). According to a subgroup analysis, in males and females aged <65 and aged ≥65 and in the non-diabetes and diabetes, hypertension and non-hypertension, dyslipidemia and non-dyslipidemia subgroups, the AMI incidence rates were dramatically higher in the PD group compared to that of the control. Conclusion : Individuals with PD have a greater chance of AMI, according to this cross-national study.
( Joo Hun Park ),( Eunyoung Lee ),( Bumhee Park ),( Yun-jung Jung ),( Woo Young Chung ),( Ji Eun Park ),( Keu Sung Lee ),( Seung Soo Sheen ),( Sung Chul Hwang ),( Kwang Joo Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: The association between blood lead levels and increased mortality was reported on a worldwide level. However, no study has been undertaken concerning the blood lead levels based on COPD and risk factors of COPD. Therefore, this study was conducted to examine the blood lead levels according to COPD and clinical variables associated with COPD. Methods: Data (total number = 36,813) were obtained from Korean National Health and Nutrition Examination Survey from 2008 to 2013. Multivariate linear regression analyses were performed to determine variables associated with elevated blood lead levels. Results: Blood lead levels were higher among older subjects, men, smokers, COPD, lower education group, and lower income groups (p<0.05). The blood lead levels in COPD group were higher than in the non-COPD group regardless of smoking status (p<0.05). Multivariate analysis demonstrated that older age, male sex, smoking, and education level were independently associated with higher blood lead levels, whereas COPD was not (p<0.05). Conclusion : This study demonstrated that smoking status and education level along with old age and male sex were independently associated with higher blood lead levels, however COPD was not, suggesting that the management of co-existing factors for COPD, such as smoking and socioeconomic factors is important.
( Joo Hun Park ),( Tae Rim Shin ),( Seung Soo Sheen ),( Joon Beom Seo ),( Kwang Ha Yoo ),( Ji Hyun Lee ),( Tae Hyung Kim ),( Seong Yong Lim ),( Ho Il Yoon ),( Jae Seung Lee ),( Yeon Mok Oh ),( Sang Do 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The progression of emphysema and airfi ow limitation in chronic obstructive pulmonary disease (COPD) leads to static hyperinfi ation. However, few studies have been conducted so far regarding the prognostic value of static hyperinfi ation marked by residual volume (RV)/ total lung capacity (TLC). Therefore we attempted to fi nd the independent factors related to static hyperinfi ation and to test the hypothesis that static hyperinfi ation is associated with the prognosis of COPD. Methods: We analyzed 380 COPD patients of our Korean Obstructive Lung Disease (KOLD) cohort who were recruited from 16 hospitals in Korea from June 2005 to April 2012. Hyperinfi ated COPD was defi ned as 40% or more of RV/ TLC. Results: Patients with hyperinfi ated COPD was older and male dominant, and had worse pulmonary function (represented by lower FEV1, FEV1/FVC, and FVC), higheremphysema index, and severer air-trapping, compared to non-hyperinfiated COPD group (p<0.05). Multiple logistic regression analysis demonstrated that age (OR = 1.071), FEV1 (OR = 0.923), FEV1/FVC (OR = 0.948), and emphysema index (OR = 1.036) were independently associated with severe static hyperinfiation ( RV/TLC =40%) (p<0.05). According to the severity of static hyperinfi ation, mean survival period was shorter (RV/TLC = 60% : 77.7 ± 4.6 months, 40 = RV/TLC <60 : 94.3 ± 1.9 months, RV/TLC < 40 % : 95.1 ± 1.8 months, p<0.05) and acute exacerbation was more frequent (p<0.05). Conclusions: Old age, emphysema index, FEV1, and FEV1/FVC were independent factors associated with hyperinfi ated COPD. The survival period was shorter according to the severity of static hyperinfi ation. This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for health and welfare (A102065).
( Joo Hun Park ),( Tae Rim Shin ),( Seung Soo Sheen ),( Joon Beom Seo ),( Kwang Ha Yoo ),( Ji Hyun Lee ),( Tae Hyung Kim ),( Seong Yong Lim ),( Ho Il Yoon ),( Jae Seung Lee ),( Yeon Mok Oh ),( Sang Do 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: The progression of emphysema and airflow limitation in chronic obstructive pulmonary disease (COPD) leads to static hyperinflation. However, few studies have been conducted so far regarding the prognostic value of static hyperinflation marked by residual volume (RV)/ total lung capacity (TLC). Therefore we attempted to find the independent factors related to static hyperinflation and to test the hypothesis that static hyperinflation is associated with the prognosis of COPD. Methods: We analyzed 380 COPD patients of our Korean Obstructive Lung Disease (KOLD) cohort who were recruited from 16 hospitals in Korea from June 2005 to April 2012. Hyperinflated COPD was defined as 40% or more of RV/ TLC. Results: Patients with hyperinflated COPD was older and male dominant, and had worse pulmonary function (represented by lower FEV1, FEV1/FVC, and FVC), higher emphysema index, and severer air-trapping, compared to non-hyperinflated COPD group (p<0.05). Multiple logistic regression analysis demonstrated that age (OR = 1.071), FEV1 (OR = 0.923), FEV1/FVC (OR = 0.948), and emphysema index (OR = 1.036) were independently associated with severe static hyperinflation ( RV/TLC =40%) (p<0.05). According to the severity of static hyperinflation, mean survival period was shorter (RV/TLC = 60% : 77.7 ± 4.6 months, 40 = RV/TLC <60 : 94.3 ± 1.9 months, RV/TLC < 40 % : 95.1 ± 1.8 months, p<0.05) and acute exacerbation was more frequent (p<0.05). Conclusions: Old age, emphysema index, FEV1, and FEV1/FVC were independent factors associated with hyperinflated COPD. The survival period was shorter according to the severity of static hyperinflation. This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for health and welfare (A102065).
( Han Seok Ryu ),( Joo Hun Park ),( Seung Soo Sheen ),( Tae Hwan Kim ),( Sung Dam Han ),( Ju-yang Jung ),( Chang-hee Suh ),( Sung Chul Hwang ) 대한류마티스학회 2017 대한류마티스학회지 Vol.24 No.4
Diffuse alveolar hemorrhage (DAH) is a life-threatening condition associated with many disorders. Here, we report a case of 59-year-old female who had diffuse alveolar hemorrhage associated with methimazole. She had been treated with methimazole for two weeks due to the recurrence of Grave`s disease, before visiting the emergency room. She had to be intubated on the 3rd day of hospitalization because of unabated massive hemoptysis and rapid progression of diffuse alveolar infiltration on chest radiographs. Since her clinical condition improved substantially after cessation of methimazole and steroid pulse therapy, she was extubated on the 9th day of hospitalization and then discharged. After discharge, DAH did not recur with cessation of steroid and she had radioactive iodine therapy for her Grave`s disease. This was a rare and interesting case of life-threatening DAH associated with cytoplasmic-antineutrophil cytoplasmic antibody and methimazole. (J Rheum Dis 2017;24:236-240)
Aneurysm of the Posterior Inferior Cerebellar Artery: Clinical Features and Surgical Results
Rhim, Jong-Kook,Sheen, Seung-Hun,Oh, Sung-Han,Noh, Jae-Sub,Chung, Bong-Sub The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.37 No.6
Objective: Aneurysms arising from the posterior inferior cerebellar artery(PICA) are uncommon. We review literature on that and surgical results on aneurysmal treatment by choice of surgical approach. Methods: On the basis of radiologic findings & charts, we review retrospectively the surgical results of 12 cases from Mar 1999 to Dec 2003. Results: The mean age of the 12 patients was 55.8(ranged from 36 to 71) and female was predominant (female:male = 8:4). Locations of PICA aneurysms revealed variously(vertebral artery - PICA junction: 8, lateral medullary segment: 2, PICA - anterior inferior cerebellar artery common trunk: 1, telovelomedullary : 1). Surgical approaches & treatments were attempted in 11 cases and embolization was done in 1 case(Far lateral transcondylar or supracondylar approach & clipping: 9, Far lateral transcondylar or supracondylar approach and trapping: 2, suboccipital approach & clipping: 1). The surgical result were 8 of 12 patients were good outcome, 1 of 12 was severely disabled and 3 of 12 were died. Conclusion: First, we choose surgical approach by the laterality of aneurysms and surgical or interventional treatment is attempted as soon as possible. The PICA aneurysm is regarded as having a relatively good surgical outcome without drilling of the posterior arch of the atlas.
( Keu Sung Lee ),( Seung Soo Sheen ),( Ji Ye Jung ),( Sang Haak Lee ),( Yu Il Kim ),( Jae Yeol Kim ),( Eun Mi Chun ),( Kwang Ha Yoo ),( Chul Min Ahn ),( Tae Hoon Jung ),( Joo Hun Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The objective of this study was to investigate smoking effect on gender and the prevalence of chronic obstructive pulmonary disease (COPD). Method: Data for this study were obtained from Korean National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2012 containing demographics, smoking histories and spirometry data. We recruited 6,159 ever-smokers (male 5,543 and female 616) aged over 40 who adequately performed spirometry according to American Thoracic Society (ATS) guidelines. Subjects with FEV1/FVC<0.7 were defi ned as COPD. To evaluate the loss of lung function per pack-year smoked, we used susceptibility index (SI), calculated using the formula: (% predicted FEV1 - 100)/pack-years. Results: Mean age was lower in male than female (56.7 vs. 58.0, p<0.001) and total amount of smoking expressed as a pack-year was greater in male than female (25.7 vs. 11.0, p<0.001). Total 1,453 (23.6%) subjects were diagnosed with COPD. Even though the prevalence of COPD was higher in male (24.5%) than female (5.4%)(p<0.001), female showed more loss of lung function per pack-year smoked than male (SI in female = -1.43% vs. SI in male= -0.79, p<0.001). To evaluate smoking effect precisely, 3,440 subjects (male 3,337 and female 103) who smoked more than 20 pack-years through life were selected. Mean age was also lower in male than women (57.7 vs. 63.7, p<0.001) and total amount of smoking (pack-year) was greater in male than female (36.3 vs. 31.8, p=0.0029). However the prevalence of COPD was not different between in male (29.0%) and in females (24.3%) (p=0.567). Female stillshowed more loss of lung function per pack-year smoked than male (SI in female = -0.56% vs. SI in male = -0.39, p=0.0003). Conclusion: Korean female ever-smokers have a susceptibility to smoking effect on lung function decline.