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이경호,김영훈,Seokyung Hahn,Kyung Won Lee,이학종,Tae Jung Kim,강성범,Joong Ho Shin,Byung Joo Park 대한영상의학회 2006 Korean Journal of Radiology Vol.7 No.2
Objective: To assess the added value of coronal reformation for radiologists and for referring physicians or surgeons in the CT diagnosis of acute appendicitis. Materials and Methods: Contrast-enhanced CT was performed using 16- detector-row scanners in 110 patients, 46 of whom had appendicitis. Transverse (5-mm thickness, 4-mm increment), coronal (5-mm thickness, 4-mm increment), and combined transverse and coronal sections were interpreted by four radiologists, two surgeons and two emergency physicians. The area under the receiver operating characteristic curve (Az value), sensitivity, specificity (McNemar test), diagnostic confidence and appendiceal visualization (Wilcoxon signed rank test) were compared. Results: For radiologists, the additional coronal sections tended to increase the Az value (0.972 vs. 0.986, p = 0.076) and pooled sensitivity (92% [95% CI: 88, 96] vs. 96% [93, 99]), and enhanced appendiceal visualization in true-positive cases (p = 0.031). For non-radiologists, no such enhancement was observed, and the confidence for excluding acute appendicitis declined (p = 0.013). Coronal sections alone were inferior to transverse sections for diagnostic confidence as well as appendiceal visualization for each reader group studied (p < 0.05). Conclusion: The added value of coronal reformation is more apparent for radiologists compared to referring physicians or surgeons in the CT diagnosis of acute appendicitis.
Lee, Kyoung Ho,Kim, Young Hoon,Hahn, Seokyung,Lee, Kyung Won,Kim, Tae Jung,Kang, Sung-Bum,Shin, Joong Ho Lippincott Williams Wilkins, Inc. 2006 Investigative radiology Vol.41 No.7
OBJECTIVES:: We sought to compare sliding slab mode and standard stack mode in the computed tomography (CT) diagnosis of acute appendicitis. MATERIALS AND METHODS:: Contrast-enhanced CT was performed in 85 patients, 35 of whom had appendicitis. Four readers retrospectively reviewed 5-mm thick transverse sections (4-mm increment) using the stack mode and 2-mm thick sections (1-mm increment) with the sliding slab, average intensity projection. The sliding slab mode started with a 5-mm thick transverse slab, but the readers were encouraged to change the viewing angle and the slab thickness. RESULTS:: In sliding slab mode, the readers changed the viewing angle in 89 of 340 observations (24%) and decreased the slab thickness in 26 observations (8%). Although the receiver operating characteristic analysis did not show a significant difference (P = 0.18), the sliding slab mode enhanced the pooled sensitivity (93.6% vs. 98.6%, P = 0.02), specificity (92.0% vs. 97.5%, P = 0.01), and mean confidence for the diagnosis (P < 0.001) or exclusion (P = 0.002) of acute appendicitis; reduced inconclusive interpretations (5.6% vs. 1.8%, P = 0.01); and visualized the appendix more clearly (P < 0.001). CONCLUSIONS:: Compared with the stack mode, the sliding slab mode enhances diagnostic confidence and more clearly visualizes the appendix.
Ryu, Seungmi,Kim, Hyunbum,Kang, Seokyung,Shin, Kwangsoo,Jung, Seon-Yeop,Heo, Jiwoong,Han, Jin,Yoon, Jeong-Kee,Lee, Ju-Ro,Hong, Jinkee,Ahn, Kyung Hyun,Hyeon, Taeghwan,Hwang, Nathaniel Suk-Yeon,Kim, Byu American Chemical Society 2017 Chemistry of materials Vol.29 No.12
<P>Current heterogeneous cell assembly techniques in coculture systems rely on irreversible cell layering or a cell separation membrane. However, the techniques possess major drawbacks of inefficiency in direct interactions of the assembled cell layers and cell separation following coculture, which hamper characterization and therapeutic applications of the cells following coculture. Here, we develop a reversible cell layering platform for assembly of heterogeneous cells that allows both active direct cell cell interactions and facile cell separation. Anionic maleimide-chondroitin-sulfate is grafted onto the surface membrane of myogenic C2C12 cells and human mesenchymal stem cells (hMSCs) to modify the surface charge of the cells without cytotoxicity. A highly porous chitosan thin film is formed in situ interspacing between the heterogeneous cell layers via ionic cross-linking of cationic chitosan and anionic functionalized cells, forming compactly assembled double-layered cell constructs. The chitosan film enables layering of the cells, which allows active direct interactions between the cell layers, and facile delayering of the cells through simple treatment with mild shear stress. The developed platform promotes the myogenic commitment of hMSCs via direct contact with C2C12 cells, mimicking the interactions that trigger stem cell differentiation in vivo. Delivery of the myogenic committed cells to muscle injured animal models shows evident muscle regeneration.</P>
Enhanced Bone Repair by Guided Osteoblast Recruitment Using Topographically Defined Implant
Yoon, Jeong-Kee,Kim, Hong Nam,Bhang, Suk Ho,Shin, Jung-Youn,Han, Jin,La, Wan-Geun,Jeong, Gun-Jae,Kang, Seokyung,Lee, Ju-Ro,Oh, Jaesur,Kim, Min Sung,Jeon, Noo Li,Kim, Byung-Soo Mary Ann Liebert 2016 Tissue engineering. Part A Vol.22 No.7
<P>The rapid recruitment of osteoblasts in bone defects is an essential prerequisite for efficient bone repair. Conventionally, osteoblast recruitment to bone defects and subsequent bone repair has been achieved using growth factors. Here, we present a methodology that can guide the recruitment of osteoblasts to bone defects with topographically defined implants (TIs) for efficient in vivo bone repair. We compared circular TIs that had microgrooves in parallel or radial arrangements with nonpatterned implants for osteoblast migration and in vivo bone formation. In vitro, the microgrooves in the TIs enhanced both the migration and proliferation of osteoblasts. Especially, the microgrooves with radial arrangement demonstrated a much higher efficiency of osteoblast recruitment to the implants than did the other types of implants, which may be due to the efficient guidance of cell migration toward the cell-free area of the implants. The expression of the intracellular signaling molecules responsible for the cell migration was also upregulated in osteoblasts on the microgrooved TIs. In vivo, the TI with radially defined topography demonstrated much greater bone repair in mouse calvarial defect models than in the other types of implants. Taken together, these results indicate that implants with physical guidance can enhance tissue repair by rapid cell recruitment.</P>