백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

성악 전공 학생의 가칭 시 음성의 SPR(Singing Power Ratio)에 관한 연구

조성미,정옥란,이상욱 한국음성과학회 2004 음성과학 Vol.11 No.4

This study attempted to provide a spectrum analysis for quantitative evaluation of singing voice quality of singing students rather than the presence or absence of the singer's formant. The regression analysis was used to analyse the relationship between ringing quality, SPR, and SPP of singing voice of college student subjects majoring in music. This study measured singing power ratio (SPR) in 41 singing students. Digital audio recordings were made in sung vowels for acoustic analyses. Each sample was judged by 1 experienced singing teacher and 4 voice pathologists on one semantic bipolar 7-point scales (ringing-dull). The results showed that the SPR and SPP had significant correlations with ringing Quality. The SPR had a significant relationship with ringing quality on singing voice in singing students. The SPR can be an important quantitative measurement for evaluating singing voice quality.

실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

한국 대학생의 영어 듣기 이해의 문제점 분석

성창섭,한미향 동아대학교 1999 동아영어영문학 Vol.15 No.-

The purpose of this study is two-fold: to examine the characteristics and problems of Korean university students' English listening comprehension ability and to make some suggestions on the methods of teaching and evaluating English listening. One of the standardized tests, TOEIC, was used as the test material, and the test result was analyzed to reveal the correlation between the content and type of question items and their correct answer ratio. The results of the analysis are as follows. First, students seem to fail to answer the questions correctly in Part Ⅲ, where they are hardly able to understand and catch the gist of the long conversations between the speakers. Second, the lack of the students' linguistic knowledge in phonological, lexical, and grammatical aspects of English constitutes a barrier in inferring the topic, the subject, and the situation of the discourse, all of which have to do with a top-down processing, and eventually leads them to reach the wrong conclusions. To remedy the problems pointed out by the analysis and to boost up students' listening comprehension ability, especially in Part Ⅲ of the TOEIC, it appears to be necessary that teachers of English should train students with the question items and listening materials that require top-down processing and are good for mutual purposes in such a way to sharpen the students' ears.

대두와 강낭콩이 호르몬 의존형 및 비의존형 유방암세포의 성장과 PKC 활성에 미치는 영향

성미경,오영주,박미영 숙명여자대학교 건강·사회과학연구소 2003 生活科學硏究誌 Vol.- No.18

A number of experimental and epidemiological studies have implicated that the consumption of plant foods reduces the risk of breast cancer development. Although antiestrogenic effect of estrogen-like compounds in plant foods is the most plausible mechanism involved in lowering the risk of breast cancer development, precise biochemical mechanisms and responsible components for the anticancer actions of plant foods have not been fully addressed. This study was performed to determine the effects of yellow soybeans, black soybeans and kidneybean extracts on hormone-dependent and hormone-independent human breast canter cells. Cell viability and whole cell protein kinase C (PKC) activity were determined. Methanol- or acetone-soluble fractions of soybeans and kidneybeans were incubated with hormone-dependent (MCF-7) or hormone-independent (MDA-MB-231) cells. Cell cytotoxicity was measured by MTT assay at 24, 48 and 72 hrs of incubation. Effects of these extracts on PKC activity of breast cancer cells were also measured at 72 hrs of incubation. Results indicated that both acetone- and methanol-soluble fractions of all samples with exception of kidneybean acetone fraction exerted a signif;cant cytotoxicity towards MCF-7 and MDA-MB-231 cells at all incubation time points(p<0.05). However acetone fraction(500ppm) of kidneybean stimulated cell viability of both cancer cells. At 72 hrs of incubation, acetone fractions of all three samples signircantly suppressed the 12-0-tetradecanoylphorbol 13-acetate stimulated PKC activity(p<0.05). These results indicate yellow soybeans, black soybeans and kidneybeans may contain a few compounds wirh different polarity which induce cytotoxirity in breast cancer cells. Anticarcinogenic effects of bean extracts are not necessarily depend on the presence estrogen receptors in breast cancer cells, and a pau of their activity may be mediated through che suppression of PKC activity.

백혈병 치료 중 발생된 간비장 칸디다증에 대한 Caspofungin 치험 1예

박상인,정미희,허방,박재선 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

Hepatosplenic candidiasis (HSC) or chronic disseminated candidiasis (CDC) is an invasive fungal infection that affects neutropenic patients. Standard empirical therapy consists of the administration of amphotericin B or fluconazole. In many cases, candidiasis is not easily eradicated, despite the adminstration of these drugs. Caspofungin, a member of the new echinocandin class of compounds, may be an effective alternative that has fungicidal against most candida species and fungistatic against aspergillus species. We report a case of hepatosplenic candidiasis developed during chemotherapy for acute myelocytic leukemia and cured with 5 weeks of caspofungin treatment.

Myocardial Protection by Recombinant Soluble P-selectin Glycoprotein Ligand-1 Suppression of Neutrophil and Platelet Interaction Following Ischemia and Reperfusion

Sang Soo Ham,Yoon Young Jang,Jin Ho Song,Hyang Mi Lee,Kwang Joon Kim,Jun Sik Hong,Yong Kyoo Shin 대한생리학회-대한약리학회 2000 The Korean Journal of Physiology & Pharmacology Vol.4 No.6

<P> Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts following ischemia and reperfusion. Additional control rat hearts were perfused with 75⁓10<SUP>6</SUP> PMNs, with 75⁓10<SUP>6</SUP> platelets, or with 75⁓10<SUP>6</SUP> PMNs⁢75⁓10<SUP>6</SUP> platelets over a five minute perfusion followed by a 75 min observation period. No significant reduction in coronary flow (CF), left ventricular developed pressure (LVDP), or the first derivative of LVDP (dP/dt max) was observed at the end of the observation period in any non-ischemic group. Similarly, global ischemia (I) for 20 min followed by 45 minutes of reperfusion (R) produced no sustained effects on the final recovery of any of these parameters in any group of hearts perfused in the absence of blood cells. However, I/R hearts perfused with either PMNs or platelets alone exhibited decreases in these variables of 5∼10% (p<0.05 from control). Furthermore, I/R hearts perfused with both PMNs and platelets exhibited decreases of 50 to 60% in all measurements of cardiac function (p<0.01). These dual cell perfused I/R hearts also exhibited marked increases in cardiac myeloperoxidase (MPO) activity indicating a significant PMN infiltration, and enhanced P-selectin expression on the coronary microvascular endothelium. All cardiaodynamic effects as well as PMN accumulation and P-selectin expression were markedly attenuated by a recombinant soluble PSGL-1 which inhibits selectin mediated cell adhesion. These results provide evidence that platelets and PMNs act synergistically in provoking post-reperfusion cardiac dysfunction, and that this may be largely due to cell to cell interactions mediated by P-selectin. These results also demonstrate that a recombinant soluble PSGL-1 reduces myocardial reperfusion injury by platelet and PMNs interaction.

여대생의 섭식장애행동과 우울간의 관계

성미혜 인제대학교 2002 仁濟論叢 Vol.17 No.1

The purpose of this study is to investigate the relationship between eating disorder and depression among college women. Data were analyzed by SPSS/PC using frequency, percentage, mean, standard deviation, t-test, Pearson correlation coefficient. The results of this study are as follows : 1. The mean of body weight and height of the subjects were 51.67kg, 161.76cm. 2. Depending upon BMI, the obese subject was not, underweight subjects were 62.% and normal subjects were 37.9%. 3. More than 40% of the subjects perceived their weight as over weight. While 62.1% of the women were underweight as defined by BMI. 4. The total mean score of anorexia nervosa was higher than bulimia nervosa. 5. The score of eating behavior differed significantly by the BMI : the score was highest in the group of normal body weighted(t=-6.94, p=.000). 6. No significant difference was found on depression according to the BMI. 7. There was high positive correlation between BMI and eating disorder(r=.383, p<.01), between eating disorder and depression(r=.161, p<.01).

親核性 置換反應에서 最大速度現象과 Hammett 相關關係

성대동,이종팔,이미정,엄태섭 東亞大學校 大學院 1996 大學院論文集 Vol.21 No.-

The nucleophilic substitution reactions of p-substituted benyl bromide with p-substituted N,N-dimethyl anilines in methanol and acetonitrile binary solvent mixtures which are known as an isodielectric olvent system kinetically and the results are as follows. 1.The postive dharge is developed on the reaction center of the substrate and it means that the bond cleavage is preceded more than bond formation in the transition on the analogy of Hammett ?? values. 2.The bond formation is not progressed in the case of electron donating substituent of substrate. however, the bond formation is much developed in the case of electron withdrawing substituent of substrate on the anlogy of Hammett ?? values. 3.The nucleophilic attacking ability is shown a highest at 80%(V/V) methanol content and the bond formation is well progressed at the same methanol composition on the result of a cross interacton coefficient, ??.

임플란트의 collar design이 변연골과 연조직에 미치는 영향

유현상,강선녀,정창모,윤미정,허중보,전영찬 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

연구 목적: 임플란트 경부가 잘 설계된 경우 양호한 연조직 반응을 통해 변연골을 보존하는데 도움이 된다. 본 실험에서는 연, 경조직 경계부에 가장 가까이 위치하는 임플란트의 collar design이 변연골 변화와 연조직 반응에 미치는 영향을 동물실험을 통해 알아보고자 하였다. 연구 재료 및 방법: 2마리의 건강한 Beagle dog에 임플란트 collar design만 다른 두 종류의 임플란트(Neobiotech Co. Seoul, Korea)를 식립하였다. Collar에 bevel 을 부여한 군(Bevel 군)과 "S"자 형태를 부여한 군(Bioseal 군)으로 나누어 마리 당 7개, 군당 7개, 총 14개의 임플란트를 무작위로 식립한 후 Healing abutment를 즉시 체결하였다. 디지털 표준구내 방사선사진을 이용해 4주 간격으로 총 12주간 근원심 변연골 변화를 관찰하였고, 12주에 희생하여 조직학적 분석을 통해 협설 변연골 흡수 및 임플란트 주변 연조직 반응을 평가하였다. Mann-Whitney test를 통해 동일한 방사선 사진 촬영 시점에서 근원심 변연골 변화량 및 조직계측치를 군 간 비교하였고, Kruskal-Wallis test를 통해 방사선 사진상 근원심 변연골 변화량이 시간에 따른 차이가 있는지 군 내 분석 한 후 Duncan test를 통해 사후 검증하였다(α=.05). 결과: 방사선학적 분석 결과 각 촬영 시점에서 두 군간 근원심 변연골 변화량의 차이를 보이지 않았다(P>.05). 군 내에서 시간에 따른 근원심 변연골의 흡수량을 분석한 결과 Bevel 군에서는 시간에 따른 차이를 보이지 않았으나 (P>.05), Bioseal 군에서는 시간에 따른 차이를 보였으며, 4주및8주와 비교했을 때 12주에서 변연골의 증가를 보였다(P<.05). 조직학적 분석 결과 협설측 변연골 흡수량에서 두 군간 차이를 보이지 않았으나 (P>.05), Bevel 군에 비해 Bioseal 군에서 더 견고한 결합조직부착을 관찰할 수 있었으며, 생물학적 폭경의 값은 두 집단 간 차이를 보이지 않은 반면에 (P>.05), 접합상피부착은 Bevel 군에서 유의하게 길었고, 결합조직부착은 Bioseal 군에서 더 길게 나타났다(P<.05). 결론: Bevel 군에 비해 Bioseal 군에서 결합조직부착은 길게 형성된 반면에 접합상피부착은 더 짧게 나타났으며, 생물학적 폭경과 초기 변연골 흡수에는 차이가 없음을 알 수 있었다. 연조직 반응의 차이가 실제 기능하중 하에서 변연골 변화에 미치는 영향에 대해서 향후 연구가 필요할 것으로 생각된다. PURPOSE. The purpose of this study was to investigate the effects of implant collar design on marginal bone change and soft tissue response by an animal test. MATERIALS AND METHODS. Two types of Implant (Neobiotech Co. Seoul, Korea) that only differs in collar design were planted on two healthy Beagle dogs. The implants were divided into two groups, the first group with a beveled collar (Bevel Group) and the second group with "S" shaped collar (Bioseal group). Standardized intraoral radiographs were used to investigate the mesio-distal change of the marginal bone. Histological analysis was done to evaluate the bucco-lingual marginal bone resorption and the soft tissue response adjacent to the implant. Mann-Whitney test was done to compare the mesio-distal marginal bone change at equivalent time for taking the radiographs and the tissue measurements between the groups. RESULTS. Radiographic and histological analysis showed that there was no difference in marginal bone change between the two groups (P>.05). Histological analysis showed Bioseal group had more rigid connective tissue attachment than the Bevel group. There was no difference in biological width (P>.05). Bevel group showed significantly longer junctional epithelium attachment and Bioseal group showed longer connective tissue attachment (P<.05). CONCLUSION. For three months there were no differences in marginal bone change between the Bevel group and the Bioseal group. As for the soft tissue adjacent to the implant, Bioseal group showed longer connective tissue attachment while showing shorter junctional epithelium attachment. There were no differences in biologic width.