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( Sang Hyun Park ),( Yun Hyeong Lee ),( Kyeong Min Son ),( Dae Yong Kim ),( Yong Sub Lee ),( Chang Seok Bang ),( Gwang Ho Baik ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background/Aims: From the past, the hypothesis has been present that cancer, by virtue of it being a thrombotic diathesis, may enhance ischemic heart disease (IHD). In this study, we evaluated the portion of the IHD patient with cancer and extracted the patient whose IHD caused by their cancer. Methods: From January 2007 to December 2012, near all Hallym University Chuncheon Sacred Heart Hospital patients with ischemic heart disease (IHD) were collected by medical record review. Among them, the patients diagnosed malignancy within 2 years at the time of IHD diagnosis, were selected. We calculated the Framingham risk score and evaluated the risk score difference between the high risk group and moderate to low risk score group. Results: 1636 patients who diagnosed as IHD were collected. Sixty two patients had malignancy, and 15 patients diagnosed cancer within 2 years before or after the time point of IHD diagnosis. Six patients whose score lower than 17 (low to moderate 10 year risk) were extracted. Their Framingham risk score showed lower values with statistical signifi cance by Mann-Whitney test (P<0. 01) than the scores of the other 9 patients with high scores. All of the 6 patients diagnosed cancer within 2year from the point of IHD diagnosis. And types of cancers were, 3 stomach cancer, 2 colon cancer, and one bladder cancer. Except 1 patients, all the 5 patients received coronary angiography, and have atheromatous plaque lesions. Conclusions: Cancer itself could become one of the independent risk factor for ischemic heart disease even under the low risk conditions considering other known risk factors. Therefore, when IHD is diagnosed without well known other risk factors for IHD, screening for cancer could be considered at the time of diagnosis or until one or two years later.