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종 분포 모형을 이용한 구상나무림의 지속 및 쇠퇴에 관한 연구 - 전라남도 광양시 백운산을 중심으로 -
조선희 ( Seon Hee Cho ),박종영 ( Jong Young Park ),박정호 ( Jeong Ho Park ),이양근 ( Yang Geun Lee ),문이만 ( Lee Man Mun ),강상호 ( Sang Ho Kang ),김광현 ( Gwang Hyun Kim ),윤종국 ( Jong Guk Yun ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3
The present study investigated the habitats of Korean fir trees (Abies koreana E. H. Wilson) on Mt. Baekwun (Baekwun-san), determined the current distribution, quantified the contribution of biological and nonbiological environmental factors affecting the distribution, derived actual and potential habitats, presented a plan for the establishment of protected areas, applied RCP 8.5 climate change scenario to analyze the effects of climate change on the future distribution of Korean fir trees, and predicted future potential habitats. According to the results of the study, 3,325 Korean fir trees (DBH >= 2.5 cm) inhabited Mt. Baekwun, and their distribution area was approximately 150 ha. Populations of Korean fir trees were confirmed to exist at an altitude of 900 m above sea level and were distributed up to 1,200 m. Based on potential distribution, areas appropriate for habitation by Korean fir trees were analyzed to be 450 ha, three times the current distribution area, with a focus on Sang Peak (Sang-bong), Eokbul Peak (Eokbul-bong), Ddari Peak (Ddari-bong), and Dosol Peak (Dosol-bong). The forest stands near Sang Peak, the main peak, were evaluated as those with the most appropriate potential for the habitation of Korean fir trees, and populations of the trees tended to prefer the northern slope rather than the southern slope. When climate change scenario RCP 8.5 was applied and future potential distribution was analyzed, the habitats were expected to decrease in area to 20 ha by 2050, with a focus on Sang Peak, and areas appropriate for habitation were predicted not to exist by 2080. Judging from such results, as global warming accelerates, the habitats of Korean fir trees are clearly expected to move from lowlands to highlands.
Effect of p-Phenylenediamine Application to Rat Skin on the Liver Oxygen Free Radical Systems
Park, Hye-Jung,Lee, Sang-Hee,Yoon, Chong-Guk 대한의생명과학회 2003 Journal of biomedical laboratory sciences Vol.9 No.2
To evaluate the influence of hepatic oxygen free radical systems on liver injury by topical p-phenylenediamine (PPD) application on rat skin, PPD (25 mg/16.5 $\textrm{cm}^2$) was topically applied to the abdominal region 5 times every other day and sacrificed. By PPD treatment, increasing rate of liver weight/body weight (%), serum activities of alanine aminotransferase and aspartate aminotransferase and decreasing rate of microsomal glucose-6-phosphatase activity were higher in the rats fed tungstate supplemented diet than those fed a standard diet. These findings indicate that group fed tungstate supplemented diet have more severe liver injury compared with group fed standard diet on topical PPD application. However, the activities of oxygen free radical generating enzymes such as xanthine oxidase (XO) and cytochrome P450 dependent aniline hydroxylase and those of oxygen free radical scavenging enzymes were not found to be different between these two animal groups. In the present study, a novel monitoring method to detect the generating of oxygen free radicals in liver extract was devised. Throughout this method, the oxidized PPD produced by oxygen free radicals was determined colorimetrically. The increasing rate of PPD oxidation by liver homogenate was higher in tungstate fed animals than in standard diet fed ones. Among the fractionations of liver extract, the mitochondrial and postmitochondrial fractions in the liver extract of tungstate fed animals led to a higher availability of PPD oxidation by PPD treatment compared with standard diet fed ones. In conclusion, these results suggest that an enhanced liver injury in tungstate fed animals treated with PPD may be due to oxygen free radicals produced in other systems except oxygen free radicals generating from cytosolic XO system. Especially, oxidative availability by PPD can be used for oxygen free radical detection in some tissue.
Evaluation of Water Quality Using Multivariate Statistic Analysis with Optimal Scaling
Sang Soo Kim,Hyun Guk Jin,Jong Soo Park,Jang Sik Cho 한국데이터정보과학회 2005 한국데이터정보과학회지 Vol.16 No.2
Principal component analysis(PCA) was carried out to evaluate the water quality with the monitoring data collected from 1997 to 2003 along the coastal area of Ulsan, Korea. To enhance evaluation and to complement descriptive power of traditional PCA, optimal scaling was applied to transfoirn the original data into optimally scaled data. Cluster analysis was also applied to classify the monitoring stations according to their characteristics of water quality.
Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways
Park, Ki‐,Ho,Kang, Jong Won,Lee, Eun‐,Man,Kim, Jae Sik,Rhee, Yun Hee,Kim, Minseok,Jeong, Soo Jin,Park, Young Guk,Hoon Kim, Sung Blackwell Publishing Ltd 2011 Journal of pineal research Vol.51 No.2
<P><B>Abstract: </B> Although melatonin has a variety of biological actions such as antitumor, antiangiogenic, and antioxidant activities, the osteogenic mechanism of melatonin still remains unclear. Thus, in the present study, the molecular mechanism of melatonin was elucidated in the differentiation of mouse osteoblastic MC3T3‐E1 cells. Melatonin enhanced osteoblastic differentiation and mineralization compared to untreated controls in preosteoblastic MC3T3‐E1 cells. Also, melatonin increased wound healing and dose‐dependently activated osteogenesis markers such as runt‐related transcription factor 2 (Runx2), osteocalcin (OCN), bone morphogenic protein (BMP)‐2 and ‐4 in MC3T3‐E1 cells. Of note, melatonin activated Wnt 5 α/β, β‐catenin and the phosphorylation of c‐Jun N‐terminal kinase (JNK), and extracellular signal‐regulated kinase (ERK) in a time‐dependent manner while it attenuated phosphorylation of glycogen synthase kinase 3 beta (GSK‐3β) in MC3T3‐E1 cells. Consistently, confocal microscope observation revealed that BMP inhibitor Noggin blocked melatonin‐induced nuclear localization of β‐catenin. Furthermore, Western blotting showed that Noggin reversed activation of β‐catenin and Wnt5 α/β and suppression of GSK‐3β induced by melatonin in MC3T3‐E1 cells, which was similarly induced by ERK inhibitor PD98059. Overall, these findings demonstrate that melatonin promotes osteoblastic differentiation and mineralization in MC3T3‐E1 cells via the BMP/ERK/Wnt pathways.</P>
Genomic Structure of the Immune-related Serpin Gene in the Fall Webworm, Hyphantria cunea
Park, Doo-Sang,Shin, Sang-Woon,Kim, Jong-Guk,Park, Ho-Yong Korean Society of Applied Entomology 2001 Journal of Asia-Pacific Entomology Vol.4 No.1
We previously identified a novel immunerelated serine type protease inhibitor cDNA from Hyphantria cuneas (Drury) (Shin et. al., 1998) that suggested a specific inhibitor directed at the protease (proPO) (Park et al., 200). Herein, we report complete nucleotide sequence and the exon-intron structure of the gene. The Hyphantria serpin gene spans 18kb and is composed of eight oxons and seven introns coding for an 1.8-kb mRNA. In the 5\` flanking sequence, we found several putative regulatory motifs including an enhancer, two NF-IF6 motifs, a TNF-$\alpha$ responsive element, an interferon-${\gamma}$-responsive element, and a GATA motif element that have been found in the promoters of the acute phase protein genes of mammals and insects. In addtiion, a 9-bp inverted repeat sequence located from -270 to -221 region was also found. A reactive site loop sequence was located in exon 8 flanked by 3' untranslation sequence. Phylogenetic analysis showed that this Hyphantria serpin did not cluster with either insect or mammalian serpins that are known, or suspected, to be associated with immune function. Southern blot analysis showed that the Hyphantria serpin gene is present as a single copy in the genome.
Purification and Characterization of a Collagenase from the Mackerel, Scomber japonicus
Park, Pyo-Jam,Lee, Sang-Hoon,Byun, Hee-Guk,Kim, Soo-Hyun,Kim, Se-Kwon 생화학분자생물학회 2002 Journal of biochemistry and molecular biology Vol.35 No.6
Collagenase from the internal organs of a mackerel was purified using acetone precipitation, ion-exchange chromatography on a DEAE-Sephadex A-50, gel filtration chromatography on a Sephadex G-100, ion-exchange chromatography on DEAE-Sephacel, and gel filtration chromatography on a Sephadex G-75 column. The molecular mass of the purified enzyme was estimated to be 14.8 kDa by gel filtration and SDS-PAGE. The purification and yield were 39.5-fold and 0.1% when compared to those in the starting-crude extract. The optimum pH and temperature for the enzyme activity were around pH 7.5 and $55^{\circ}C$, respectively. The $K_m$ and $V_{max}$ of the enzyme for collagen Type I were approximately 1.1 mM and 2,343 U, respectively. The purified enzyme was strongly inhibited by $Hg^{2+}$, $Zn^{2+}$, PMSF, TLCK, and the soybean-trypsin inhibitor.