Mangiferin Induces Apoptosis by Suppressing Bcl-xL and XIAP Expressions and Nuclear Entry of NF-κB in HL-60 Cells

Kaori Shoji,Kaori Shoji,Masanobu Tsubaki,Yuzuru Yamazoe,Takao Satou,Tatsuki Itoh,Yasuhiro Kidera,Yoshihiro Tanimori,Masashi Yanae,Hideaki Matsuda,Atsushi Taga,Haruyuki Nakamura,Shozo Nishida 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3

Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside (C-glucosylxanthone), is a xanthone derivative that is widely distributed in higher plants. Recently, mangiferin was found to exhibit potential antitumor effects. However, the molecular mechanisms of this effect have not been elucidated. In the present study, we attempt to clarify the mechanism of mangiferininduced apoptosis in the human acute myeloid leukemia cell line HL-60; mangiferin was found to induce apoptosis. We also observed a concurrent increase in caspase-3 activity and DNA fragmentation. Furthermore, on examining the survival signals expressed during apoptotic induction, we observed that mangiferin caused a remarkable decrease in the nuclear entry of NF-κB p65. However, there were no changes in the expression of other survival signals,such as extracellular signal-regulated kinase 1/2, protein kinase B, and p38 mitogenactivated protein kinase. In addition, mangiferin suppressed the expressions of Bcl-xL and XIAP; however, we did not note any changes in the levels of Bcl-2, Bax, and Bim. These results indicate that mangiferin induces apoptosis by suppressing NF-κB activation and expressions of Bcl-xL and XAIP. These findings suggest that mangiferin may be useful as an anticancer agent and can be used in combination therapy with other anticancer drugs for the treatment of acute myeloid leukemia.

일본의 연령주의 : 현황과 사회적 대응 (Ageism in Japan)

Okuyama Shoji 한국노년학회 2017 한국노년학회 학술발표논문집 Vol.2017 No.국제학술

Dr. Shoji Okuyama is currently President of Committee for Long-Term Care (LTC) insurance in Higashi-kurume-shi, Tokyo since 2000, and Professor Emeritus at Tokyo Keizai University from April of 2017. He graduated from Chuo University (B.A.), from Seijo University (MA and Ph.D. in Literature) and from Hitotsubashi University in Tokyo, Japan (Ph.D. in Sociology)(Ph.D., social welfare). Since 1972 until 1995, he had been researcher and senior researcher of Tokyo Metropolitan Institute of Gerontology (TMIG, now Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology). This during, he had been as visiting senior researcher at Center for the Study of Aging and Human Development in Duke University(USA). Since 1995 until May 2017, he had been Professor of social gerontology at Tokyo Keizai University and since 1995 until now, president and inspectors of Japan Socio-Erotological Society, Editorial Committee Member in Japanese Society for the Study of Social Welfare and Japan Society of Family Sociology. He also has worked many governmental committees and NGOs in Japan. He also has worked as part-time lecturer at many universities (Ochanomizu Women’s University, Waseda University, Nihon University, Dokkyo University, Toyo University and others). His publications include 30 books (including chapters) and 100 and over papers.

Fluorimetric Determination of Phosphate in Sea Water by Flow Injection Analysis

Shoji Motomizu,Mitsuko Oshima,Naoya Katsumura 한국분석과학회 1995 분석과학 Vol.8 No.4

Making Global Society for Citizens! : a citizens’ perspective on processes and effects of globalization

SHOJI Kokichi 한국사회학회 2007 한국사회학회 기타간행물 Vol.- No.-

Global Society has been emerging through globalization. While wars between nation states have been made actually impossible by the development of atomic bombs, not only ethnic conflicts occur frequently but global terrorism has been spreading against the world rule of the Superpower. Though the mode of economic disparity has been changing due to growth of China, India, Russia, Brazil and so on, internal gaps have been widening even in growing nations besides between advanced and developing nations, which have been yielding the unrest and frustrations of those left behind as hotbeds for terrorism. The crisis of global ecology has been worsening as problems of global environmental disruption such as global warming have not been effectively controlled due to the egoism of the Superpower and others. The population problem is also serious in keeping its balance among advanced nations suffering both aging and low birthrate, nations still suffering population explosion and nations who are prematurely suffering aging due to population policies. To resolve problems of globalization and make global society truly for citizens, we first need activating more and more communication among peoples of the world so that we overcome digital devides and language barriers by making positive use of global informationalization. Based on the activated communication, we secondly need democratize international organizations (IGOs) such as the United Nations, overcome the world rule of the Superpower and its allies, and make global society a global civil society based on the civic voluntarism of the people all over the world. For that we thirdly need to promote religious tolerance anew in order to raise citizens’ consciousness along with democratic science and technology. Many nongovernmental organizations (NGOs) and nonprofit organizations (NPOs) should widen and deepen their networks so as to strengthen the civic or citizens’ initiatives in as many fields and on as global scales as possible.

Present Situation and Problems of Inclusive Education in Japan

Shoji Higo KOREA INSTITUTE FOR SPECIAL EDUCATION 2005 The Asia-Pacific Journal of Inclusive Education Vol.2 No.-

The purpose of this paper was to discuss the inevitability and the difficulties of introducing inclusive education in Japan by analyzing the present special education situation. Attaining the purpose, three directions were discussed. The first was analyzing present tendencies of statistics about special education and outcomes of investigation studies on realities of special or regular school settings. The second was discussing cultural factors against introducing inclusive education to Japan. And the last was reconsidering the meaning of two reports on special education reform. After these discussions, some important points were suggested. Many problems which affected present system arose and preparedness for transition from the present system to inclusive education was proceeding. And solving cultural problems was an important condition if we introduced inclusive education in Japan. In these circumstances, the government has been tried to reform special education system. Achieving this reform, we had to pay attention to cultural factors more intensively and to slough off the remedial education paradigm for reorganize education system effectively.

MRI Update for New Millennium in Neurological Field

Shoji Naruse 가톨릭의과학연구원 2000 가톨릭 의과학연구원 국제학술대회 Vol.4 No.-

Magnetic resonance imaging (MRI) is used widely in neurological field as a powerful diagnostic imaging method which can clearly delineate the anatomical and pathological conditions in the brain. Moreover, the recent development of technology makes it possible to use analytical abilities of various NMR techniques on clinical MRI scanner, Consequently important information required in the neurological fled, such as brain function, metabolism and blood flow, becomes to be measured by using clinical MRI scanners. For last 20 years, we have developed several analytical techniques of NMR on clinical MR scanners, e.g. (a) Chemical shift imaging (CSI) method, which can visualize the distribution of intrinsic metabolites in the brain by obtaining magnetic resonance spectrum (MRS) from multiple, small areas simultaneously; (b) Diffusion weighted imaging (DWI), which can disclose water molecular diffusion in the brain; (c) Perfusion weighted imaging (PWE), which can demonstrate the hemodynamics relating to perfusion in the brain; (d) Functional MH which can visualize the brain function using intrinsic substance. In this seminar, I would like to demonstrate the usefulness of some of those techniques for analyzing the brain function and metabolism in expectation of the further development of those techniques to the New Millennium.

New Water-soluble Cutting Fluids Additives Derived from the Thermal Reaction Products of Unsaturated Fatty Acids with Acrylic Acid and Maleic Anhydride

( Shoji Watanabe ) 한국유화학회 2003 한국응용과학기술학회지 Vol.20 No.4

N/A Water-soluble cutting fluids are used for processing of aluminium materials. This short article describes properties of new additives of water-soluble cutting fluids for aluminium materials. Various Diels-Alder adducts of unsaturated fatty acids with acrylic acid of maleic anhydride were prepared by thermal reactions. Triethanolamine salts of Diels-Alder adducts of dehydrated castor oil fatty acids with acrylic acid or maleic anhydride showed excellent anti-corrosion property of aluminium materals. These thermal adducts showed anti-rust property for cast-iron chips, too.

RECENT DEVELOPMENTS OF MEMBRANE TECHNOLOGY IN JAPAN

Shoji Kimura 한국막학회 1991 멤브레인 Vol.1 No.1

Since the discovery of the Loeb-Sourirajan reverse osmosis membrane, thirty years have passed and many membrane technologies and new membranes for applications have been developed in the world. In the early stage of these developments Japan has not contributed much, but from the middle of 70ties Japan has started its own R&D projects starting from the desalination technology, and now various private industries and government ministries are actively engaging in R & D of membrane technologies in Japan. In Table 1 the chronological developments of important events of developments and projects relating membrane technologies inside and outside of Japan are introduced and their details will be explained. The first membrane technology applied in the Japanese industry was a electrodialysis(ED) process using ion-exchange membranes. These membranes were first developed in early 50ties and the Japanese government decided to use this method for concentration of sea-water to produce salt, which was then produced by solar evaporation. This development program started from 1960 by the Japan Monopoly Corp.(at that time). To apply ED process for sea-water concentration it was necessary to develop ion-exchange membranes having very low electric resistance to avoid energy loss due to Joule heat, and those having selectivity to permeate single valent ions only to avoid scale formation in the ED stacks. Three Japanese companies, Asahi Glass, Asahi Chemical and Tokuyama Soda, have succeeded to develop such membranes, and until 1971 all of the seven salt manufacturing companies had adopted ED for production of food salt.

Factor Structure of the Targeted Inventory on Problems in Schizophrenia

Shoji Tanaka,Takanori Nagase,Takefumi Suzuki,Kensuke Nomura,Hiroyoshi Takeuchi,Shinichiro Nakajima,Hiroyuki Uchida,Gohei Yagi,Koichiro Watanabe,Masaru Mimura 대한정신약물학회 2013 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.11 No.1

Objective: The aim of this study was to explore the factor structure of a novel, 10-item rating scale, the Targeted Inventory on Problems in Schizophrenia (TIP-Sz). Determining the factor structure will be useful in the brief evaluation of medication and non-medication treatment of the disease. Methods: An exploratory factor analysis was performed on TIP-Sz scores obtained from 100 patients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for schizophrenia. Results: The factor analysis extracted four factors that were deemed clinically pertinent, which we labeled: disorganization, social cooperativeness, functional capacity, and emotional state. The items exhibited cross-loadings on the first three factors (i.e.,some items loaded on more than one factor). In particular, the ‘behavioral dyscontrol and disorganization,’ ‘insight and reality testing,’ and ‘overall prognostic impression’ items had comparable cross-loadings on all of the first three factors. The emotional state factor was distinct from the other factors in that the items loading on it did not cross-load on other factors. Conclusion: The TIP-Sz scale comprises factors that are associated with the psychosocial functioning and emotional state of patients, which are important outcome parameters for successful treatment of the disease.

Learning curve of reverse shoulder arthroplasty

Shoji Fukuta,Keisuke Nishidono,Yuichiro Goda,Koichi Seiryo 대한견주관절의학회 2019 대한견주관절학회 학술대회논문집 Vol.2019 No.3