衛氏朝鮮興亡考

李丙燾 서울대학교 1956 서울대학교 論文集 Vol.4 No.-

The Effect of Cyclosporin A on the Growth of human Glioma Cell Lines

Pyen, Jhin-Soo,Kim, Soo-Kie,Choi, Sun-Ju,Park, Yoon-Sun,Cho, Hyun-Chul,Han, Young-Pyo The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.4

Cyclosporin A, an potent immunosuppressant, has been known to be one of the modulators of drug resistance as well as a cytostatic drug. Despite many attempts to basic or clinical application of cyclosporin A, there are few reports on the inhibition of brain tumor cells. In the present experiment, the possibility of cyclosporin A as synergic adjuvant was investigated by MTT assay, $[^{3}H]$ thymidine uptake and through flowcytometric anaysis. Sole treatment of cyclosporin A on the CRT and CH235-MG glioma cell line revealed dose dependent cytotoxicity within a range of tested dose. Combined treatment of cyclosporin A with ACNU, BCNU and hydroxyurea on various glioma cancer cell line led to a significant synergistic cytotoxicity as well as inhibition of DNA synthesis with dose-dependency. In addition, cyclosporin A alone or combined treatment caused discernible changes of cell cycle in the tested cells. These data provide that cyclosporin A could potentiate the effect of nitrosourea compounds in vitro on human glioma cells.

감사태도와 감사표현이 연인관계 만족도에 미치는 영향 : 자기자비와 사회적 지지를 매개로

변상원(Pyen, Sangwon),이동귀(Lee, Donggwi) 한국재활심리학회 2020 재활심리연구 Vol.27 No.1

본 연구는 감사태도와 감사표현이 연인관계 만족도에 영향을 미치는 과정에서 자기자비와 지각된 사회적 지지가 매개하는 연구모형을 경험적으로 검증하였다. 서울 소재 대학생 334명을 대상으로 감사태도, 감사표현, 자기자비, 지각된 사회적 지지 및 연인관계 만족도를 측정하는 온라인 설문을 실시하였고, 이 중 현재 연인관계에 있다고 보고한 173명(남성 69명, 여성 104명)의 자료만 분석에 사용하였다. 주요 결과로 첫째, 감사태도, 감사표현, 자기자비, 지각된 사회적 지지, 연인관계 만족도 간에는 모두 유의한 정적 상관이 나타났다. 둘째, 연구가설대로 감사태도는 자기자비 수준을 높여 연인관계 만족을 증진하였고, 감사표현은 사회적으로 지지받고 있다는 인식을 고양하여 연인관계 만족도를 높이는 것으로 나타났다. 연구 결과를 바탕으로 본 연구의 시사점과 제한점 및 후속 연구에 대한 제안점을 논의하였다. This study empirically examined how gratitude attitude and gratitude expression affect romantic relationship satisfaction as well as the mediating effects of self-compassion and perceived social support in these processes. A sample of 334 undergraduate students from Seoul were recruited to complete an online survey on gratitude attitude, gratitude expression, self-compassion, perceived social support, and romantic relationship satisfaction. The final sample included 173 undergraduates (69 males, 104 females) who were in romantic relationships at the time of the survey. The results revealed significant positive correlations between gratitude attitude, gratitude expression, self-compassion, perceived social support, and romantic relationship satisfaction. Additionally, as hypothesized, gratitude attitude significantly enhanced romantic relationship satisfaction by increasing self-compassion, while gratitude expression significantly increased romantic relationship satisfaction by boosting one s perceived social support. The implications and limitations of this study and recommendations for future research are discussed.

작동 압력과 연료 공급 유량 변화가 고분자 전해질 연료전지 성능에 미치는 영향

편원형(Won-Hyeng Pyen),이상훈(Sang-Hoon Lee),이동호(Dong-Ho Rhee),조형희(Hyung Hee Cho) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11

Operating pressure and mass flow rate of H₂/air are the dominant parameters affecting the performance of PEMFC. To investigate effects of operating pressure and mass flow rate of reactants on the performance of fuel cell, the performance measurements were executed for a unit cell of PEMFC. The active area is 100 ㎠ and each separator made of graphite has a serpentine flow path. The operating pressure ranges from atmospheric pressure to 2 kgf/㎠, while mass flow rate of reactants from 0.3 and 3.5 times ideal value. As a result of this study, the operating pressure of 1 kgf/㎠ has 27% higher performance of PEMFC than atmospheric pressure case. However, the performance for the operating pressure of 2kgf/㎠ is almost similar to that of 1 kgf/㎠. The performance is improved by increasing mass flow rate of air, while increasing mass flow rate of H₂ hardly affects the performance of fuel cell.

濟州道産 소라의 稚貝生産 및 棲息生態에 關한 硏究

변충규(Choong Kyu Pyen),윤정수(Jeong Su Youn) 한국수산과학회 양식분과 1990 韓國養殖學會誌 Vol.3 No.1

자기공명영상 추적관찰에 의한 뇌실출혈의 임상분석

변진수,황금,허철,김헌주,홍순기,한용표,이명섭 연세대학교 원주의과대학 1999 원주의대논문집 Vol.12 No.1

眞珠조개 (Pinctada fucata)의 稚貝生産 및 養殖에 關한 環境學的 硏究-(2) : 天然採苗와 越冬飼育 The Seed Collection in Natural Habitat and the Wintering

卞忠圭,盧暹,全得山 濟州大學校海洋資源硏究所 1986 해양과환경연구소 연구논문집 Vol.10 No.-

1. 慶南 閑山灣內에 있어서의 眞珠조개 (Pinctada fucata) 浮游幼生의 出現時期는 7月 中旬에서 8月 下旬까지 盛期를 나타내었고 D型幼生에서 Umbo 幼生으로 成長하는데 12月 內外가 經過되었다. 2. 1月부터 6月까지의 眞珠조개의 成長은 5月까지는 別差가 없었으며 6月부터는 成長差를 나타내었다. 3. 越冬期間의 斃死率 範圍는 西歸浦쪽 地先이 0.3-2.5%였고 巨文島 地先에서는 0.6-5.5%였다. 4. 濟州道 西歸浦 港口內의 4月의 平均水溫은 15.3℃ 였고 1月에서 3月까지의 平均水溫 範圍는 14.5-15.2℃로서 13℃를 上廻하고 있었다. In Hansan bay, drifting larvae of peal oyster (Pinctada fucata) appeared most abundantly from mid July to late August in 1985. The transition from D shape larvae to Umbo stage larvae required 12 days approximately. Mortality in winter were ranged 0.3-2.5% and 0.6-5.5% at Seogwipo culture bed and Komun Do culture bed respectively. At the harbor area of Seogwipo in Cheju Do, the average water temperature were ranged 14.5-15.2℃, recording 13℃ at the lowest from January to March. It rised to 15.3℃ in April.

소라의 種苗量産에 關한 基礎的 硏究

卞忠圭,盧暹,孫松正 濟州大學校海洋資源硏究所 1986 해양과환경연구소 연구논문집 Vol.10 No.-

濟州道産 소라, Batillus Cornutus (LIGHT FOOT)의 種苗量産을 爲하여 濟州大學校 海洋資源硏究所 및 國立水産振興院 濟州培養場에서 1985年 7月부터 8月 사이에 南濟州 近海에서 採集된 殼高 51.9∼93.1mm의 母貝 387마리를 利用하여 7 回의 産卵誘發刺戟을 實施하였다. 알의發生 및 浮游幼生, 採苗, 附着幼生의 飼育過程에 따른 成長 및 生殘率 等에 關한 結果를 要約하면 다음과 같다. 1. 産卵誘發刺戟으로서 刺戟前夜의 止水處理에 의한 干出, 紫外線照射海水刺戟을 竝行한 方法이 확실히 效果的이었다. 2. 同 方法에 의한 使用母貝의 反應率은 10.42∼36.84%였으며 受精率의 範圍는 71.45∼93.02%였다. 3. 産卵量에 對한 孵化率의 範圍는 63.25∼80.12%였다. 4. 採苗器 設置方法에 따른 浮游幼生의 採苗器當 平均 看生數는 垂直採苗에서 367.38±67.58個體(0.31개個體/㎠)였으나, 水平採苗의 경우는 428.25±318.50個體(0.36個體/㎠)로서 後者가 더 良好하였다. 5. 水槽壁面 着生된 附着稚貝의 垂直分布는 孵化後 70日까지는 附着硅藻의 着生이 많은 水面에서 30cm사이에 出現稚貝의 90.14%가 集中되었다. 6. 秋季採苗에서의 소라稚貝의 孵化後 70日間 飼育에서의 經過日數(D)에 따른 殼徑(S)의 成長關係式은 小型圓形水槽 (φ1.6×0.7m)의 경우 S=0.0090 D+0.4236, 四色水槽 (2.5×1×0.7m)의 경우 S=0.0109D+0.4253의 回歸直線式으로 名名 表示되었다. 7. 附着以後 稚貝의 大量斃死現象은 孵化後 20 日以內에 볼 수 있었고 이때의 生殘率은 圓形水槽에서 49.28%, 四色水槽에서 40.36%였으며 孵化後 70日間의 最終 生殘率은 前者에서 9.11%, 後者의 경우 8.93%였다. For the purpose of mass s production of the seedling of top shell, Batillus cornutus (LIGHT FOOT) in Cheju Do, 387 samples were collected at the southern coast of Cheju Island. Their shell height were ranged 51.9-93.1mm and the experiment to stimulate the spawning induction were excuted 7 times during the period of July, 1985 and August, 1985. The results of egg development, planktonic larvae seed collection, growth and survival rate in relation to the rearing process of settling larvae were as follows: 1. The method of induced spawning stimulation which practiced drying by means of non-circulation on the night before stimulation while irradiating the seawater with ultra-violet ray was most effective. 2. The range of response rate, and fertilization rate of samples by the above method was 10.42%∼36.84% and 71.45%∼93.02% respectively. 3. The range of fertilization rate against spawning was 63.25%∼80.12%. 4. The average of settling numbers per swimming larvae collector in relation to collector set-up method were 367.38±67.58 individual (0.31 individual/㎠) and 428.25±318.50 individual (0.36 individual/㎠) in vertical and horizontal settling respectively. 5. Vertical distribution of attached young top shell on the wall surface in aquarium was 90.14% of total young top shell and this was appeared between the water surface and 30cm depth which was abundant in settling of attatched diatom up 70 days after hatching. 6. The growth relationship equations between shell diameter and growth of 70 days after hatching of young top shell in autumn collection were the linear regression line of S=0.0090D+0.4236 and S=0.0109D+0.4253 in case of small circular aquarium (ψ1.6×0.7m) and rectangular one (2.5×1×0.7m) respectively. 7. Mass motality of young top shell after attatching was detected within 20 days after hatching. Survival rates were 49.28% and 40.36% in circular aquarium and rectangular one respectively. During this period while percentages of survival after 70 days were 9.11%, 8.93% in former and latter respectively.

전복의 증식에 관한 연구

변충규 한국수산학회 1970 한국수산과학회지 Vol.3 No.3

1. 1969년 10월에 전복 Haliotis discus hannai Ino를 제료로 하여 간출 자극에 의한 산란 유발 시험을 실시하여 다량의 수정란을 얻을 수 있었으며 수정율은 1차가 약50.0% 2차가 악30.0%였다. 2. 산란시의 수온은 16.0°∼23.0℃ 내외였으며 사육 수온 14.0∼18.8℃ 범위에서 발생 경과 시간은 Torchophore기(담륜자)까지는 약 22시간, Veliger기(피면자)까지는 악 34시간, 부유 유생기까지는 2.5∼3일이 경과되었으며 7일 경과후부터 부착이 시작되어 9일째는 섬모가 없어지면서 부착이 완료되었다. 이어서 주구각이 생기기 시작하였고, 첫 호수공은 110일만에 생겼다. 3. 10월 10일에 산란 부화한 유생의 성장크기는 15일만에 0.40 ㎜로 크고, 49일만에 1.39 ㎜의 포복기 유생으로 자랐다. 첫 호수공은 110일만에 2.14 ㎜로 큰 후에 생겼으며, 월동이 끝나는 170일만에는 5.20 ㎜로 크고 228일만에 10.00 ㎜로 자랐다. 그 월별 성장은 L=0.9981e^(0.18659M)의 관계식으로 표시된다. 4. 부유 유생의 사육 밀도는 약 10개/100㏄ 내외로 하였으며, 부착기는 30×20 ㎝ 크기의 국곡이 있는 플라스틱판을 사용한 결과 약 10∼600개가 부착하였으나 부착 직전에 넣은 것과 저면에 둔 것이 부착율이 양호하였다. 5. 부착 후의 폐사율은 주구각이 형성되는 10일 경과 후는 약 8%가 폐사하였고, 수온이 10℃로 하강하는 (28일경과)때는 67.9%, 제 1호수공이 생기는 (110일 경과) 때는 79.0%, 월동이 끝나는 170일 경과 후는 약 87.0%가 폐사되어 생존율은 약 13.0%였다. 6. 초기 먹이인 Navicula sp.의 부착 성적은 표면 5 ㎝하에서는 17일이 경과한 후 34.3×10⁴㎠ 개체로 증가하였고 수면 45㎝하에서는 15일만에 27.2×10⁴/㎠ 개체로 증가되었으며 저면인 85 ㎝하에서는 15일만에 26.3×10⁴/㎠ 개체로 증가되었다. 7. 3.0 ㎜ 크기의 새끼 전복의 1개월간의 선체 이동 거리는 11.36m였으며, 18:00∼21:00 사이가 52.2%의 이동율로서 가장 이동이 심하였다. 8. 2.0 ㎜ 내외의 전복은 0℃∼ -1.8℃의 수온범위에서 16:00∼20:00시까지는 1.15㎝의 이동이 있었고 0:00∼08:00시 까지는 0.1㎝의 이동이 있었다. 9. 동해안 쪽인 포항 연안과 남해안 쪽인 여수돌산도와 흑산도에서 채집된 전복에 대하여 각장에 대한 체중과의 관계를 보면 돌산도산 W=0.2479^(2.5721), 흑산도산 W=0.1001L^(3.1021), 포항산 W=0.9632L^(2.0611)의 식으로 표시되었고, 동해안 쪽의 포항산이 남해안산에 비하여 각장에 대한 체중의 증가가 완만한 것으로 보였다. The spawning of the abalone, Haliotis discus hannai, was induced in October 1969 by air exposition for about 30 minutes. At temperatures of from 14.0 to 18.8℃, the youngest trochophore stage was reached within 22 hours after the egg was laid. The trochophore was transformed into the veliger stage within 34 hours after fertilization. For 7∼9 days after oviposition the veliger floated in sea water and then settled to the bottom. The peristomal shell was secreted along the outer lip of the aperture of the larval shell, and the first respiratory pore appears at about 110 days after fertilization. The shell attained a length of 0.40 ㎜ in 15days, 1.39 ㎜ in 49 days, 2.14 ㎜ in 110 days, 5.20 ㎜ in 170 days and 10.00 ㎜ in 228 days respectively. Monthly growth rate of the shell length is expressed by the following equation : L=0.9981 e^(0.18659) where L is shell length and M is time in month. The density of floating larvae in the culture tank was about 10 larvae per 100 cc. The number of larvae attached to a polyethylene collector (30 × 20 ㎝) ranged from 10 to 600. Mortality of the settled larvae on the polyethylene collector was about 87.0% during 170 days following settlement. The culture of Navicula sp. was made with rough polyethylene collectors hung at three different depths, namely 5 ㎝, 45 ㎝ and 85 ㎝. At each depth the highest cell concentration appeared after 15∼17 days, and the numbers of cells are shown as follows: 5 ㎝ 34.3 × 10⁴ cells/㎝² 45 ㎝ 27.2 × 10⁴ cells/㎝² 85 ㎝ 26.3 × 10⁴ cells/㎝² At temperatures of from 13.0 to 14.3℃, the distance travelled by the larvae (3.0 ㎜ in shell length) averaged 11.36 ㎜ for a period of 30 days. Their locomation was relatively active between 6 p.m. and 9 p.m., and 52.2% of them moved during this period. When the larvae (2.0 ㎜ in shell length) were kept in water at 0 to∼1.8℃, they moved 1.15 ㎝ between 4 p.m. and 8 p.m. and 0.10 ㎝ between midnight and 8 a.m. The relationships between shell length and body weight of the abalone sampled from three different localities are shown as follows: Dolsan-do W=0.2479 L^(2.5721) Huksan-do W=0.1001 L^(3.1021) Pohang W=0.9632 L^(2.0611)

Growing Skull Fracture 1례 : A Case Report

변진수,홍순기,김헌주,한용표 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.1

The growing skull fracture represents a particular type of evolution of cranial fracture in young children, and has also been called leptomeningeal cyst. This rare fracture usually occurrs in the parietal region of the skull in infancy, and underlying dura tear is the single most important factor in the process. We are reporting a patient with a posttraumatic growing skull fracture that we have treated surgically.