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RISS 인기검색어
- 검색키워드
- 저자 : Poonam Jain (검색결과 3 건)
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Poonam Sharma,Prachi Kaushik,Swati Jain,Brij Mohan Sharma,Rajendra Awasthi,Giriraj Thirupathirao Kulkarni,Bhupesh Sharma 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3
Objective: Vascular Dementia (VaD), is associated with metabolic conditions. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of ulinastatin (UTI) and sulforaphane (SUL) in streptozotocin (STZ)-diabetes induced vascular endothelium dysfunction and related dementia. Methods: Single dose STZ (50 mg/kg i.p.) was administered to Albino Wistar rats (male, 200−250 g). Morris water maze and attentional set shifting tests were used to assess the spatial learning, memory, reversal learning, and executive functioning in animals. Body weight, serum glucose, serum nitrite/nitrate, vascular endothelial function, aortic superoxide anion, brains’ oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), inflammatory markers (IL-6, IL-10, TNF-, and myeloperoxidase-MPO), acetylcholinesterase activity-AChE, blood brain barrier (BBB) permeability and histopathological changes were also assessed. UTI (10,000 U/kg) and SUL (25 mg/kg) were used alone as well as in combination, as the treatment drugs. Donepezil (0.5 mg/kg) was used as a positive control. Results: STZ-administered rats showed reduction in body weight, learning, memory, reversal learning, executive functioning, impairment in endothelial function, BBB permeability, increase in serum glucose, brains’ oxidative stress, inflammation, AChE-activity, BBB permeability and histopathological changes. Administration of UTI and SUL alone as well as in combination, significantly and dose dependently attenuated the STZ-diabetes-induced impairments in the behavioral, endothelial, and biochemical parameters. Conclusion: STZ administration caused diabetes and VaD which was attenuated by the administration of UTI and SUL. Therefore, these agents may be studied further for the assessment of their full potential in diabetes induced VaD.
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Sejal Chauhan,Raghu Solanki,Ashok Kumar Jangid,Poonam Jain,Pranjali Pranjali,Sunita Patel,Anupam Guleria,Deep Pooja,Hitesh Kulhari 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Enzyme responsive nanocarriers are reactive or sensitive towards a specific enzyme and, therefore, havethe advantages of low systemic toxicity, targeted delivery, and superior therapeutic effect with high efficiency. In this study, we have developed a matrix metalloproteinase 9 (MMP9) enzyme responsive manganesenanocarrier for the site-specific delivery of anticancer drugs. Manganese nanoparticles werecoated with G5 PAMAM dendrimers and loaded with irinotecan hydrochloride (IRI). The drug loadednanoparticles were further coated with collagen-IV (Col-IV) peptide, an MMP9 substrate, to make themMMP9 responsive (Col-IV@IRI-G5MNP). The developed nanoparticles were monodispersed with size ofabout 12 nm and high IRI encapsulation efficiency (80%). A faster but controlled IRI release was observedfrom Col-IV@IRI-G5MNP in HEPES buffer containing MMP9 enzyme. When incubated with human redblood cells, the nanoformulation was hemocompatible and caused <2% hemolysis. The anticancer activityof Col-IV@IRI-G5MNP against HCT116 human colon cancer cells was better than free IRI. The cell viability ofHCT116 cells incubated with 25 lg/mL Col-IV@IRI-G5MNP was significantly lower (p < 0.001) than the cellsincubated with free IRI. Further, Col-IV@IRI-G5MNP showed paramagnetic nature and good T2 relaxivity ata very low concentration, suggesting its potential use for diagnosis through magnetic resonance imaging.
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SARS-CoV-2 IgG Antibody Seroprevalence in Children from the Amritsar District of Punjab
Amandeep Kaur,Narinder Singh,Kanwardeep Singh,Shailpreet Kaur Sidhu,Harleen Kaur,Poonam Jain,Manmeet Kaur,Mohan Jairath 대한임상검사과학회 2022 대한임상검사과학회지(KJCLS) Vol.54 No.3
The majority of the children experience milder coronavirus disease 2019 (COVID-19) symptoms. Children represent a significant source of community transmission. Children under 18 years of age account for an estimated 4.8% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections globally. However, no conclusive statements pertaining to the multi-fold aspects of the virus in children could be drawn due to the lower prevalence of pediatric cases. The present study was conducted to identify the indirect impact of SARS-CoV-2 infections on developing herd immunity among children in the age group 3 to 18 years by investigating their antibody levels. In the study, 240 children aged 3∼18 years were recruited by the Department of Pediatrics, Government Medical College and Hospital, Amritsar, India, and quantification of the antibodies was performed at the Viral Research and Diagnostic Laboratory (VRDL), Government Medical College (GMC), Amritsar, India. Out of the 240 serum samples, 197 (82.08%) showed seropositivity, while 43 (17.92%) were seronegative. When stratified, it was observed that in the age group 3∼6 years, 22.33% of children were found to have anti-SARS-CoV-2 antibodies while in the age groups 7∼10 years, 11∼14 years, and 15∼18 years, respectively, 37.06%, 30.46%, and 10.15% were seropositive. Although there was seroconversion among children which was useful for predicting the next wave, no differences in seropositivity were observed between adults and children.
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