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Ashok Kumar Jangid,Sungjun Kim,김교범 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Immune cell-based therapies are a rapidly emerging class of new medicines that directly treat and prevent targeted cancer. However multiple biological barriers impede the activity of live immune cells, and therefore necessitate the use of surface-modifed immune cells for cancer prevention. Synthetic and/or natural biomaterials represent the leading approach for immune cell surface modulation. Diferent types of biomaterials can be applied to cell surface membranes through hydrophobic insertion, layer-by-layer attachment, and covalent conjugations to acquire surface modifcation in mammalian cells. These biomaterials generate reciprocity to enable cell–cell interactions. In this review, we highlight the diferent biomaterials (lipidic and polymeric)-based advanced applications for cell–surface modulation, a few cell recognition moieties, and how their interplay in cell–cell interaction. We discuss the cancerkilling efcacy of NK cells, followed by their surface engineering for cancer treatment. Ultimately, this review connects biomaterials and biologically active NK cells that play key roles in cancer immunotherapy applications.
Sejal Chauhan,Raghu Solanki,Ashok Kumar Jangid,Poonam Jain,Pranjali Pranjali,Sunita Patel,Anupam Guleria,Deep Pooja,Hitesh Kulhari 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Enzyme responsive nanocarriers are reactive or sensitive towards a specific enzyme and, therefore, havethe advantages of low systemic toxicity, targeted delivery, and superior therapeutic effect with high efficiency. In this study, we have developed a matrix metalloproteinase 9 (MMP9) enzyme responsive manganesenanocarrier for the site-specific delivery of anticancer drugs. Manganese nanoparticles werecoated with G5 PAMAM dendrimers and loaded with irinotecan hydrochloride (IRI). The drug loadednanoparticles were further coated with collagen-IV (Col-IV) peptide, an MMP9 substrate, to make themMMP9 responsive (Col-IV@IRI-G5MNP). The developed nanoparticles were monodispersed with size ofabout 12 nm and high IRI encapsulation efficiency (80%). A faster but controlled IRI release was observedfrom Col-IV@IRI-G5MNP in HEPES buffer containing MMP9 enzyme. When incubated with human redblood cells, the nanoformulation was hemocompatible and caused <2% hemolysis. The anticancer activityof Col-IV@IRI-G5MNP against HCT116 human colon cancer cells was better than free IRI. The cell viability ofHCT116 cells incubated with 25 lg/mL Col-IV@IRI-G5MNP was significantly lower (p < 0.001) than the cellsincubated with free IRI. Further, Col-IV@IRI-G5MNP showed paramagnetic nature and good T2 relaxivity ata very low concentration, suggesting its potential use for diagnosis through magnetic resonance imaging.
Chandrasekaran Karthikeyan,Kokkarachedu Varaprasad,Sungjun Kim,Ashok Kumar Jangid,Wonjeong Lee,Abdulrahman Syedahamed Haja Hameed,Kyobum Kim 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
The new development of inorganic (IO) nanoparticle (NPs)-based nanomedicines in anticancer therapy isan active area of research. The cellular uptake of IO NPs plays a crucial role in their efficacy as anticanceragents. In this case, IO NPs cellular uptake depends on physical and chemical parameters, including size,shape, and surface modification of the nanoparticles. From the cellular uptake, one of the essentialparameters for small size plays a critical role in the NPs’ due to their ability to passively diffuse acrossthe cell membrane or enter cells through endocytosis. In this study, the inorganic SnO2 (tin dioxide)and SA (sodium alginate) were made into SnO2 (SASnO2) using a simple one-pot green method. Biomedical studies have shown that SASnO2 NPs exhibit greater antibacterial, antioxidant, and anticancerproperties than SnO2 NPs. The prepared SnO2 and SASnO2 NPs were tested against breast cancer cells inanticancer studies. In cellular uptake studies, the smaller size of SASnO2 NPs (19 nm) resulted in highercellular uptake compared to SnO2 NPs (38 nm). The larger surface area of these SASnO2 NPs allows formore contact with biological membranes and internalization (cell uptake) by cancer cells, resulting inenhanced anticancer therapy when using SASnO2 NPs.