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RISS 인기검색어
- 검색키워드
- 저자 : Bhupesh Sharma (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Poonam Sharma,Prachi Kaushik,Swati Jain,Brij Mohan Sharma,Rajendra Awasthi,Giriraj Thirupathirao Kulkarni,Bhupesh Sharma 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3
Objective: Vascular Dementia (VaD), is associated with metabolic conditions. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of ulinastatin (UTI) and sulforaphane (SUL) in streptozotocin (STZ)-diabetes induced vascular endothelium dysfunction and related dementia. Methods: Single dose STZ (50 mg/kg i.p.) was administered to Albino Wistar rats (male, 200−250 g). Morris water maze and attentional set shifting tests were used to assess the spatial learning, memory, reversal learning, and executive functioning in animals. Body weight, serum glucose, serum nitrite/nitrate, vascular endothelial function, aortic superoxide anion, brains’ oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), inflammatory markers (IL-6, IL-10, TNF-, and myeloperoxidase-MPO), acetylcholinesterase activity-AChE, blood brain barrier (BBB) permeability and histopathological changes were also assessed. UTI (10,000 U/kg) and SUL (25 mg/kg) were used alone as well as in combination, as the treatment drugs. Donepezil (0.5 mg/kg) was used as a positive control. Results: STZ-administered rats showed reduction in body weight, learning, memory, reversal learning, executive functioning, impairment in endothelial function, BBB permeability, increase in serum glucose, brains’ oxidative stress, inflammation, AChE-activity, BBB permeability and histopathological changes. Administration of UTI and SUL alone as well as in combination, significantly and dose dependently attenuated the STZ-diabetes-induced impairments in the behavioral, endothelial, and biochemical parameters. Conclusion: STZ administration caused diabetes and VaD which was attenuated by the administration of UTI and SUL. Therefore, these agents may be studied further for the assessment of their full potential in diabetes induced VaD.
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Hariom Kumar(Hariom Kumar ),Vishal Diwan(Vishal Diwan ),Bhupesh Sharma(Bhupesh Sharma ) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: Present study was designed to investigate behavioral and biochemical role of nimodipine in prenatal valproic acid (Pre-VPA) induced autism in rats. Methods: Valproic acid was utilized to induce autistic phenotypes in Wistar rats. The rats were assessed for social behavior. Hippocampus and prefrontal cortex (PFC) were utilized for various biochemical assessments, whereas cerebellum was used to assess blood brain barrier (BBB) permeability. Results: Pre-VPA rats showed reduction social interaction. Pre-VPA administration were decreased PFC levels of interleukin- 10 (IL-10), and glutathione along with hippocampus cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF). Also, the animals have shown increase in PFC levels of IL-6, tumor necrosis factor-α, thiobarbituric acid reactive substance, Evans blue leakage and water content. Nimodipine countered Pre-VPA administered reduction in social interaction, CREB, BDNF, inflammation, oxidative stress, BBB permeability. Conclusion: Pre-VPA has induced autistic phenotype, which were attenuated by nimodipine in rats. Nimodipine and other calcium channel blockers should further investigate to check the management of autism.
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Amitoj Singh,Bakshish Singh,Bhupesh Grover,Gautam Bhutani,Aniket Sharma 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.6
General incidents happening ongoing in trains nowadays happen due instant fire in railways because of multiple reasons resulting in health hazards and even deaths. This paper provides a remedy to reduce the losses of life occurring due to fire accidents in trains. In the past few years Indian railways has witnessed various forms of train accidents in which catching of fire is of serious concern. Fire on running bogie is severely dangerous than the stationary ones. The damage is severe because of lack of alertness and lack of communication which leads to the time delay in action. This project provides automation to the trains by applying automatic brakes and along with the ventilation in case of fire and smoke detection. The railway staff and passengers need to take all possible precautions in order to avoid any of the above mistakes so as to minimize the possibility of fire break out. The project consists of thermistor gas sensor, buzzer, fans, pneumatic actuators, solenoid pneumatic valve. Whenever the fire is detected with the help of fire sensors, thermistor and a safety circuit sends signal to solenoid valve and triggers the brakes and allows exhaust fans for proper air flow in and out of a chamber to avoid suffocation and it also starts the alarm to alert the authorities.
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