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배정렬,김은호,황인성,한천구 청주대학교 산업과학연구소 2002 産業科學硏究 Vol.20 No.1
This paper is a fundamental study on the influence on the properties of high peformance concrete by mineral admixture. According to the results, while the fluidity decreases with the increase of replacement ratio of silica fume, it increases with the increase of replacement ratio of the other mineral admixture. Air content shows decreasing tendency with the increase of replacement ratio of fly ash, and the compressive strength of FA-SF2 shows the highest score. And the drying shrinkage increases with the increase of replacement ratio of fly ash, but it does not show much difference with the increase of replacement ratio of blast furnace slag powder. The autogenous shrinkage increases with the increase of replacement ratio of blast furnace slag powder, silica fume, while it decrease with the increase of replacement ratio of fly ash or combination of fly ash and silica fume. Therefore, it is thought that the fluidity, the placeability and the strength will be improved and the crack caused by autogenous shrinkage will be reduced by use of fly ash and silica fume together when making the high performance concrete.
文學龍,裵正烈,황인성,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)
This study is to investigate the influence of W/C and fineness modulus of aggregate on the bleeding of concrete. According to the result, the lower W/C is, the less bleeding occurs. As for the properties of bleeding with the variation of fineness modulus, the amount of bleeding is small with the continuous grading in the middle of the standard grading range in the case of coarse aggregate, and it grows smaller with a decrease of fineness modulus in the case of fine aggregate. Therefore, it proves that using coarse aggregate with the continuous grading in the middle of the standard grading range and fine aggregate with smaller fineness modulus in the standard grading range is the effective method for reducing bleeding at the same W/C.
Yin, Pei-Hao,Liu, Xuan,Qiu, Yan-Yan,Cai, Jian-Feng,Qin, Jian-Min,Zhu, Hui-Rong,Li, Qi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
The induction of apoptosis in target cells is a key mechanism for most anti-tumor therapies. Bufalin is a cardiotonic steroid that has the potential to induce differentiation and apoptosis of tumor cells. Research on bufalin has so far mainly involved leukemia, prostate cancer, gastric cancer and liver cancer, and has been confined to in vitro studies. The bufadienolides bufalin and cinobufagin have been shown to induce apoptosis in a wide spectrum of cancer cell. The present article reviews the anticancer effects of bufalin. It induces apoptosis of lung cancer cells via the PI3K/Akt pathway and also suppressed the proliferation of human non-small cell lung cancer A549 cell line in a time and dose dependent manner. Bufalin, bufotalin and gamabufotalin, key bufadienolides, significantly sensitize human breast cancer cells with differing ER-alpha status to apoptosis induction by the TNF-related apoptosis-inducing ligand (TRAIL). In addition, bufadienolides induce prostate cancer cell apoptosis more significantly than that in breast epithelial cell lines. Similar effects have been observed with hepatocellular carcinoma (HCC) but the detailed molecular mechanisms of inducing apoptosis in this case are still unclear. Bufalin exerts profound effects on leukemia therapy in vitro. Results of multiple studies indicate that bufalin has marked anti-tumor activities through its ability to induce apoptosis. Large-scale randomized, double-blind, placebo or positive drug parallel controlled studies are now required to confirm the efficacy and apoptosis-inducing potential of bufalin in various cancers in the cliniucal setting.
( Pei-pei Han ),( Wen-ji Geng ),( Meng-nan Li ),( Shi-ru Jia ),( Ji-long Yin ),( Run-ze Xue ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.9
Microbially induced calcium carbonate precipitation (MICP) has recently become an intelligent and environmentally friendly method for repairing cracks in concrete. To improve on this ability of microbial materials concrete repair, we applied random mutagenesis and optimization of mineralization conditions to improve the quantity and crystal form of microbially precipitated calcium carbonate. Sporosarcina pasteurii ATCC 11859 was used as the starting strain to obtain the mutant with high urease activity by atmospheric and room temperature plasma (ARTP) mutagenesis. Next, we investigated the optimal biomineralization conditions and precipitation crystal form using Plackett-Burman experimental design and response surface methodology (RSM). Biomineralization with 0.73 mol/l calcium chloride, 45 g/l urea, reaction temperature of 45°C, and reaction time of 22 h, significantly increased the amount of precipitated calcium carbonate, which was deposited in the form of calcite crystals. Finally, the repair of concrete using the optimized biomineralization process was evaluated. A comparison of water absorption and adhesion of concrete specimens before and after repairs showed that concrete cracks and surface defects could be efficiently repaired. This study provides a new method to engineer biocementing material for concrete repair.
Pei-Ying Huang,Xin Yin,Yue-Ting Huang,Qi-Qing Ye,Si-Qing Chen,Xun-Jie Cao,Tian-Ao Xie,Xu-Guang Guo 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.5
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of coronavirus disease 2019. Diagnosticmethods based on the clustered regularly interspaced short palindromic repeats (CRISPR) have been developed to detect SARSCoV-2 rapidly. Therefore, a systematic review and meta-analysis were performed to assess the diagnostic accuracy of CRISPR fordetecting SARS-CoV-2 infection. Materials and Methods: Studies published before August 2021 were retrieved from four databases, using the keywords “SARS-CoV-2”and “CRISPR.” Data were collected from these publications, and the sensitivity, specificity, negative likelihood ratio (NLR), positivelikelihood ratio (PLR), and diagnostic odds ratio (DOR) were calculated. The summary receiver operating characteristic curve wasplotted for analysis with MetaDiSc 1.4. The Stata 15.0 software was used to draw Deeks’ funnel plots to evaluate publication bias. Results: We performed a pooled analysis of 38 independent studies shown in 30 publications. The reference standard was reversetranscription-quantitative PCR. The results indicated that the sensitivity of CRISPR-based methods for diagnosis was 0.94 (95% CI0.93–0.95), the specificity was 0.98 (95% CI 0.97–0.99), the PLR was 34.03 (95% CI 20.81–55.66), the NLR was 0.08 (95% CI 0.06–0.10), and the DOR was 575.74 (95% CI 382.36–866.95). The area under the curve was 0.9894. Conclusion: Studies indicate that a diagnostic method based on CRISPR has high sensitivity and specificity. Therefore, this wouldbe a potential diagnostic tool to improve the accuracy of SARS-CoV-2 detection.
Blind QR Code Steganographic Approach Based upon Error Correction Capability
( Yin-jen Chiang ),( Pei-yu Lin ),( Ran-zan Wang ),( Yi-hui Chen ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.10
A novel steganographic QR code algorithm, which not only coveys the secret into the widely-used QR barcode but also preserves the readability of QR content and the capability of error correction, is presented in this article. Different from the conventional applications for QR barcode, the designed algorithm conceals the secret into the QR modules directly by exploiting the error correction capability. General browsers can read the QR content from the QR code via barcode readers; however, only the authorized receiver can further reveal the secret from the QR code directly. The new mechanism can convey a larger secret payload along with adjustment of the QR version and error correction level. Moreover, the blind property allows the receiver to reveal the secret without the knowledge of the embedded position of modules. Experimental results demonstrate that the new algorithm is secure, efficient and feasible for the low-power QR readers and mobile devices.
Yin Bin Chen,Yu Fang Wang,Wei Hou,Ying-Ping Wang,Sheng-Yuan Xiao,Yang Yang Fu,Jia Wang,Si Wen Zheng,Pei-He Zheng 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.2
Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drugenutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins. Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatographyetandem mass spectrometry. Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with Bcomplex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentrationetime curve from zero to infinity markedly decreasing from 11,830.85 2,366.47 h$ng/mL to 890.55 372.94 h$ng/mL. Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drugenutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally.
Pei Wang,Chenchen He,Lingquan Hu,Shaohua Chen,Xianze Yin,Jing Xu,Luoxin Wang,Hua Wang 한국섬유공학회 2018 Fibers and polymers Vol.19 No.7
Ag3PO4 was loaded on sulfonated polyphenylene sulfide (SPPS) superfine fibre by a facile precipitation method. Both the structure and properties of the as-synthesized Ag3PO4/SPPS composites were characterized via XRD, SEM, EDS, XPS, FTIR, and UV-vis. The photocatalytic performance of Ag3PO4/SPPS composites was investigated via degradation of Methylene blue(MB) solution under visible light irradiation. The degradation results revealed that the photocatalytic activity of Ag3PO4/SPPS composites was greatly enhanced by the incorporation of Ag3PO4 with SPPS superfine fibre. For concentrations of AgNO3 and Na2HPO4 solutions of 0.3 M and 0.06 M in the preparation process, the Ag3PO4/SPPS composite showed higher photocatalytic activity under visible light irradiation.