An Autonomous Driving Approach Based on Trajectory Learning Using Deep Neural Networks

Wang Dan,Wang Canye,Wang Yulong,Wang Hang,Pei Feng 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.6

Autonomous driving approaches today are mainly based on perception-planning-action modular pipelines and the End2End paradigm respectively. The End2End paradigm is a strategy that directly maps raw sensor data to vehicle control actions. This strategy is very promising and appealing because complex module design and cumbersome data labeling are avoided. Since this approach lacks a degree of interpretability, safety and practicability. we propose an autonomous driving approach based on trajectory learning using deep neural networks in this paper. In comparison to End2End algorithm, it is found that the trajectory learning algorithm performs better in autonomous driving. As for trajectory learning algorithm, the CNN_Raw-RNN network structure is established, which is verified to be more effective than the original CNN_LSTM network structure. Besides, we propose an autonomous driving architecture of a pilot and copilot combination. The pilot is responsible for trajectory prediction via imitation learning with labeled driving trajectories, while the copilot is a safety module that is employed to verify the effectiveness of the vehicle trajectory by the results of the semantic segmentation auxiliary task. The proposed autonomous driving architecture is verified with a real car on urban roads without manual intervention within 40 km.

Survival and Performance of Two Cellulose-Degrading Microbial Systems Inoculated into Wheat Straw-Amended Soil

( Pei Pei Li ),( Dong Dong Zhang ),( Xiao Juan Wang ),( Xiao Fen Wang ),( Zong Jun Cui1 ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.1

A cellulose-degrading composite microbial system containing a mixture of microbes was previously shown to demonstrate a high straw-degrading capacity. To estimate its potential utilization as an inoculant to accelerate straw biodegradation after returning straw to the field, two cellulose-degrading composite microbial systems named ADS3 and WSD5 were inoculated into wheat straw-amended soil in the laboratory. The microbial survival of the inoculant was confirmed by a denaturing gradient gel electrophoresis (DGGE) analysis, whereas the enhancement of straw degradation in soil was assessed by measuring the mineralization of the soil organic matter and the soil cellulase activity. The results indicated that most of the DGGE bands from ADS3 were detected after inoculation into straw-amended autoclaved soil, yet only certain bands from ADS3 and WSD5 were detected after inoculation into straw-amended non-autoclaved soil during five weeks of incubation; some bands were detected during the first two weeks after inoculation, and then disappeared in later stages. Organic matter mineralization was significantly higher in the soil inoculants ADS3 and WSD5 than in the uninoculated controls during the first week, yet the enhanced degradation did not persist during the subsequent incubation. Similar to the increase in soil organic matter, the cellulase activity also increased during the first week in the ADS3 and WSD5 treatments, yet decreased during the remainder of the incubation period. Thus, it was concluded that, although the survival and performance of the two inoculants did not persist in the soil, a significant enhancement of degradation was present during the early stage of incubation.

Load of Ag3PO4 Particles on Sulfonated Polyphenylene Sulfide Superfine Fibre with High Visible-light Photocatalytic Activity

Pei Wang,Chenchen He,Lingquan Hu,Shaohua Chen,Xianze Yin,Jing Xu,Luoxin Wang,Hua Wang 한국섬유공학회 2018 Fibers and polymers Vol.19 No.7

Ag3PO4 was loaded on sulfonated polyphenylene sulfide (SPPS) superfine fibre by a facile precipitation method. Both the structure and properties of the as-synthesized Ag3PO4/SPPS composites were characterized via XRD, SEM, EDS, XPS, FTIR, and UV-vis. The photocatalytic performance of Ag3PO4/SPPS composites was investigated via degradation of Methylene blue(MB) solution under visible light irradiation. The degradation results revealed that the photocatalytic activity of Ag3PO4/SPPS composites was greatly enhanced by the incorporation of Ag3PO4 with SPPS superfine fibre. For concentrations of AgNO3 and Na2HPO4 solutions of 0.3 M and 0.06 M in the preparation process, the Ag3PO4/SPPS composite showed higher photocatalytic activity under visible light irradiation.

Chemical Vapor Deposition Growth of Graphene Domains Across the Cu Grain Boundaries

Yang Wang,Yu Cheng,Yunlu Wang,Shuai Zhang,Chen Xu,Xuewei Zhang,Miao Wang,Yang Xia,Qunyang Li,Pei Zhao,Hongtao Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.08

Many aspects in the chemical vapor deposition (CVD) growth of graphene remain unclear such as its behavior near the catalyst grain boundaries. Here we investigate the CVD growth mechanism of graphene across the Cu grain boundaries using unidirectional aligned graphene domains, which simplifies the analysis of both graphene and Cu to a large extent. We found that for a graphene domain grown across the Cu grain boundary, the domain orientation is determined by the Cu grain where the domain nucleation center is located, and the Cu grain boundary will not change the growth behavior for this graphene domain. This growth mechanism is consistent with the Custep-attached nucleation and edge-attachment-limited growth mechanism for H-terminated graphene domains and will provide more guidance for the synthesis of high-quality graphene with less domain boundaries.

The Effect of Agomelatine in Behavioral and Psychological Symptoms of Dementia

Carol Sheei-Meei Wang(Carol Sheei-Meei Wang ),Kuo-Sheng Cheng(Kuo-Sheng Cheng),Chia-Hung Tang(Chia-Hung Tang),Ming-Chyi Pai(Ming-Chyi Pai),Pai-Lien Chen(Pai-Lien Chen),Pei-Fang Chien(Pei-Fang Chien) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4

Objective: Moderate and severe behavioral and psychological symptoms of dementia (BPSD) often need medical treatment to improve symptoms. Agomelatine is a selective melatonergic (MT1/MT2) agonist that has normalizing effects on disturbed circadian rhythms and disrupted sleep−wake cycles. Its activity of 5HT-2C receptor antagonism is associated with lessening depression and anxiety and increasing slow-wave sleep. Based on past clinical records and current findings it suggests that agomelatine can improve BPSD for patients. This retrospective cohort study was designed to compare the BPSD before and after using agomelatine. Methods: Records of dementia cases who had ever received agomelatine treatment for BPSD in a general hospital setting during the past 2.5 years were identified and reviewed. Scores from before and after 3 months of treatment with agomelatine were collected for Neuropsychiatric Inventory (NPI), Brief Psychiatric Rating Scale (BPRS), and Clinical Global Impression (CGI) to compare and analyze the difference of psychological and behavioral symptoms pre- and post-agomelatine used. Results: Records of 144 cases of dementia with BPSD who had ever used agomelatine from January 2015 to June 2017 were collected. All of the 112 cases had BPRS and CGI scores, of which 75 cases had additional NPI scores. Among these 112 cases, the BPRS and CGI scores were significantly improved in all types of dementia. NPI scores indicated that the use of agomelatine alleviated obvious symptoms and decreased overall distress, especially in the depression/poor mood, anxiety, and sleep/night behavior. Conclusion: It is consistent with an effective result of agomelatine in improving BPSD.

Involvement of Yellow-y in the cuticle pigmentation of the larvae, pupae and adults in Henosepilachna vigintioctopunctata

Wang Pei,Ze Long-Ji,Jin Lin,Li Guo-Qing 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.1

Yellow-y (Y-y) contributes to the accumulation of melanins in insect cuticle. However, the underlining mecha nism requires further investigation. Two classical hypotheses have been proposed: Y-y acts as a dopachrome conversion enzyme (DCE) to accelerate biosynthesis of melanins; alternatively, Y-y serves as a cuticular anchor for pigments. Henosepilachna vigintioctopunctata is a serious defoliator attacking Solanaceae and Cucurbitaceae plants. The beetle shows a species-specific pigmentation pattern: stage-dependent dark patches are distributed on pale-yellow background. Here we noted that RNA interference (RNAi)-aided knockdown of Hvyellow-y at the newly-ecdysed second- and third-instar larval, and 1-day-old prepupal stages changed coloration in both dark patches and pale-yellow background. Black pigmentation was lightened in the Hvy-y hypomorphs, including various body portions such as larval heads, antennae, mouthparts, scoli, strumae, legs and exuviae, pupal and adult thoraces and abdomens, and adult elytra and hindwings. Moreover, the coloration background was yel lowed in the RNAi beetles. Specifically, more yellow pigments were observed to deposit around the black dorsal markings in the hypomorphic pupal metathorax. Furthermore, the boundaries between black patches and yellow background were distinct in the resultant ladybirds. Similarly, the margins around bristle follicles and droplet spots were not fuzzy within the RNAi pupal black patches. In summary, even though Y-y facilitates the pigmentation in H. vigintioctopunctata exocuticle, our data did not support the pigment anchor hypothesis.

Recommendation of the types and parameters of radial basis functions for metamodel-based sequential global optimization

Pei Dong Wang(왕베동),최동훈 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.5

For sequential approximate global optimization (SAGO), use of an appropriate metamodel is important for efficiently finding the global minimum. In this study, we adopted a radial basis function (RBF) as a metamodel and constrained optimization by radial basis function interpolation (COBRA) proposed by Regis in 2014 as a SAGO method. Difficulty of selecting an appropriate RBF, i.e. selecting appropriate type and associated parameter (if any) of an RBF, lies in it is different from problem to problem. To cope with this intrinsic difficulty, we chose seven mathematical problems representing various kinds of problems, assessed performances of various RBFs using these example problems, and recommended the types and associated parameters (if any) of radial basis functions whose performances were generally good for most of the example problems. the types of RBFs examined were Gaussian, Multi-quadric, and thin plate spline, and associated parameter values (if any) examined were in a range. Also, the number of initial sample points was varied from NDV+1 to 50*NDV, where NDV denotes the number of design variables, to consider its influence on performance. Analyzing all these test results, we recommended the types and parameters of RBFs that are expected to perform well for the SAGO of many problems.

Efficacy and Safety of Sorafenib for Advanced Non-Small Cell Lung Cancer: a Meta-analysis of Randomized Controlled Trials

Wang, Wei-Lan,Tang, Zhi-Hui,Xie, Ting-Ting,Xiao, Bing-Kun,Zhang, Xin-Yu,Guo, Dai-Hong,Wang, Dong-Xiao,Pei, Fei,Si, Hai-Yan,Zhu, Man Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: Many clinical trials have been conducted to evaluate sorafenib for the treatment of advanced NSCLC, but the results for efficacy have been inconsistent. The aim of this study was to evaluate the efficacy and safety of sorafenib in patients with advanced NSCLC in more detail by meta-analysis. Methods: This meta-analysis of randomized controlled trials (RCTs) was performed after searching PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, and the proceedings of major conferences for relevant clinical trials. Two reviewers independently assessed the quality of the trials. Outcomes analysis were disease control rate (DCR), progression- free survival (PFS), overall survival (OS) with 95% confidence intervals (CI) and major toxicity. Subgroup analysis was conducted according to sorafenib monotherapy, in combination with chemotherapy or EGFR-TKI to investigate the preferred therapy strategy. Results: Results reported from 6 RCTs involving 2, 748 patients were included in the analysis. Compared to sorafenib-free group, SBT was not associated with higher DCR (RR 1.31 (0.96- 1.79), p=0.09), PFS (HR 0.82 (0.66-1.02), p=0.07) and OS (HR 1.01 (0.92-1.12), p=0.77). In terms of subgroup results, sorafenib monotherapy was associated with significant superior DCR and longer PFS, but failed to show advantage with regard to OS. Grade 3 or greater sorafenib-related adverse events included fatigue, hypertension, diarrhea, oral mucositis, rash and HFSR. Conclusions: SBT was revealed to yield no improvement in DCR, PFS and OS. However, sorafenib as monotherapy showed some activity in NSCLC. Further evaluation may be considered in subsets of patients who may benefit from this treatment. Sorafenib combined inhibition therapy should be limited unless the choice of platinum-doublet regimen, administration sequence or identification of predictive biomarkers are considered to receive better anti-tumor activity and prevention of resistance mechanisms.

Basic, HCCbasic : PO-20 ; DUSP1 induces p53 target gene expression through p38MAPK/HSP27 pathway and tumor suppression in hepatocellular carcinoma

( Pei Pei Hao ),( Mi Jin Lee ),( Yun Peng Wang ),( Goung Ran Yu ),( In Hee Kim ),( Dae Ghon Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Constitutive DUSP1 expression has been shown to be involved in cell cycle inhibition, apoptosis, and senescence. This study was aimed to examine whether DUSP1 functions as tumor suppressor in hepatocarcinogenesis and to explore underlying mechanism whereby DUSP1 suppresses hepatocarcinogenesis. Methods: Immunohistochemistry and real-time PCR analysis were performed in HCC tissues. Cellular localization of DUSP1 was detected by immunofluorescence. Cell proliferation was tested by MTT assay. Cell death and cell cycle were measured by FACS analysis. Apoptotic and kinase signaling were explored by western blot analysis. Tumorigenicity and survival analysis were tested by xenotransplant of SH-J1 cells stably expressing DUSP1 or infected with Ad-DUSP1 in mouse model. Phospho-related factors expression profile in DUSP1 stable cell lines as determined by phospho-kinase array. Results: The mRNA and protein expression level of DUSP1 was down-regulated in tumor than that of the corresponding non-tumor in HCC tissues. Cellular localization of DUSP1 showed that the endogenous DUSP1 and ectopic expression of GFP-tagged DUSP1 was mainly located in the nucleus. DUSP1 down-regulation was associated with reciprocal activation of ERK1/2 in HCC cell lines. DUSP1 was up-regulated in a dose dependent manner after parthenolide or doxorubicin treatment. DUSP1 over-expression was correlated with the increased susceptibility to apoptotic cell death through caspase activation. Ectopic DUSP1 over-expression resulted in the inhibitions of cell cycle progression, colony generation, and tumor growth in vitro and in vivo system. Furthermore, survival rate of mice xenoplanted with DUSP1 overexpressed HCC cells is significantly higher than control group. Inhibition of tumorigenic potential by DUSP1 may involve in p38MAPK- HSP27-P53 pathway. Conclusions: DUSP1 functions as a tumor suppressor during hepatocarcinogenesis, which seemed to be mainly associated with the activation of p53 target genes through p38MAPK/ HSP27 pathway.

Color Digital Image Encryption Technology and Software Implementation based on Chaotic Map

Pei Wang 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.3

Digital image information security, is accompanied by the rapid development of computer network and multimedia technology and the emergence of new problems. In recent years, the image information on the Internet more and more popular, but for some image information relating to personal privacy and national security, we must take the secret transmission mode, the image encryption technology more and more attention, research has important image encryption technology practical significance. Based on MFC and Matlab7.0 development tools, the paper design color image based on coupling chaotic encryption algorithm developed into an application software that fully implements all the performance of the proposed design of the cryptographic algorithm, and a beautiful interface, easy operation intuitive algorithm evaluation function and so on. In this paper, a digital color image encryption algorithm based on chaotic mapping. It was proposed based on color image encryption algorithm disaster and chaos mapping combined color image encryption algorithm based on logistic mapping, and two encryption algorithms performance comparison and analysis.