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朴耕模,朴種鉉,安圭錫 대한동의병리학회 1999 동의생리병리학회지 Vol.13 No.1
현재까지 개발된 어혈 동물모형들은 각각 그 특성이 달라 약물의 활혈화어 효과를 검증하는데 일괄적으로 적용시킬 수 없는 난점이 있었고, 실험상 변수의 통제가 어렵고 정확한 기전을 밝히기도 어려울 뿐 아니라 비용이 많이 들어 대규모적인 스크리닝을 하기가 힘들었다. 따라서 이들 모형의 차이점을 비교검토할 필요가 있고 이 문제점들을 보완해줄 in vitro에서의 새로운 병태모형이 필요하여 본 연구를 실행하였다. 동물을 이용한 어혈 모형의 경우, 혈전증모형은 출혈기전과 응고기전과 관련있는 어혈모형으로 생각되며, HA와 dextran으로 유발한 고점도혈증은 응고기전과 직접 관련되는 모형이라기 보다는 혈액의 점성이 증가되어 혈의 흐름이 정체되어 나타나는 혈어모형에 가깝다고 볼 수 있다. 압상어혈모형은 대퇴부의 압박으로 인한 국소 어혈모형이며, 전신의 혈류상태에는 큰 영향을 미치지 않았다. 또한, in vitro에서는 ECV304 cell line과 ECVPAR cell line에서의 세포부착효과, Angiogenic lumen formation, MMP-9, uPA의 발현양상, Integrin αvβ3, LFA-1, ELAM-1의 발현 등을 지표로 삼아 혈관신생을 통한 어혈병태모형을 구축하였으며, 이 모형은 기존 동물에서의 어혈모형의 문제점들을 보완할 수 있을 것으로 생각된다. This experimental study was carried out to characterize in modern medical understanding the concept of Blood Stasis as proposed in the traditional medical system of Korea, Japan, and China. Another objective was to construct a new model of blood stasis via in vitro. We divided the original model of blood stasis into three catergories: thrombosis, high blood viscorsity and trauma. The thrombosis model was induced by endotoxin and is related to the mechanisms of bleeding and coagulation. the high blood viscosity model was induced by hydrocortisone acetate and dextran and is related to the hemodynamic derangement rather than the bleeding and coagulation. the trauma model was induced by compression and is related to the local and hematological change by the compression of the thigh of rats. Finally, we induced an in vitro blood stasis model using ECV304 and ECVPAR cell lines. The focus being inducing angiogenesis and correlating the mitigating factors of cell adhesion, angiogenic lumen formation, mRNA expression of MMP-9 and uPA, and expressions of integrin αvβ3, LFA-1 and ELAM-1. We expect that this model may complement the problems associated with the original models.
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최선미,박경모,신민규,신현규,Choi Sun-Mi,Park Geong-Mo,Shin Min-Kyu,Shin Hyeun-Kyoo 대한예방한의학회 2000 대한예방한의학회지 Vol.4 No.2
Korea follows the Korea standard classification of disease and causes of death according to the ICD(international classification of disease) Oriental medicine began to of officially follow the classification of disease for using the Korean classification of diseases in 1972. The classification of OM(oriental medicine) has changed in shape experiencing two amendments. The largest difficulty was to overcome the different names of diseases between OM and ICD. A one-to-one correspondence of the name of a disease between OM and ICD is impossible So in the primary stage one-to-one and one-to-many correspondence was made. During the first amendment the international disease names were re-classified on the oriental medicine disease name's basis and at the same time the classification of OM was corresponded on a one-to-one basis to the ICD . During the second amendment this changed to many-to-many correspondence . Analyzing the history of classification of OM during the first and second amendments, it was discovered that establishment of the standards of classification, the unification of oriental medical terms, and overcoming the difference of disease names between the OM and ICD is necessary Also th classification and standardazation of OM must not stop as a single round. It must go on for a long time. The hosts of this project Korean oriental medical society and AKOM(association of korean oriental medicine) need to build a independant department which will supervise the classification project and monitor any problems to come up. Also a route through which suggestions can be taken in and new solutions can be brought up needs to be secured and an atmosphere in which studies can take place about the basis of classifications needs to be developed.
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