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Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria
( Byung Soo Kim ),( Yong Kyun Kim ),( Young Shin Shin ),( Young Ok Kim ),( Ho Cheol Song ),( Yong Soo Kim ),( Euy Jin Choi ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.4
Background/Aims: No definite conclusions have been reached about the natural history of patients with isolated microscopic hematuria (IMH). In this study, we observed the natural history of patients with IMH and examined factors related to a pathologic diagnosis and subsequent prognosis. Methods: We retrospectively evaluated 156 subjects with IMH who had a renal biopsy performed. Of the 156 subjects, 33.3% were diagnosed with IgA nephropathy, 23.7% with mesangial proliferative glomerulonephritis, 15.4% with glomerular minor lesion, and 12.8% with thin basement membrane nephropathy; 6.4% had normal biopsies. Results: We followed up with 100 subjects for about 31 months. During this follow-up period, two subjects who had received a pathologic diagnosis of IgA nephropathy developed chronic kidney disease. During the course of the study, one of these subjects presented with proteinuria and hypertension and the other with proteinuria. The overall incidences of proteinuria and hypertension were 6% and 5% respectively. Conclusions: The prognosis for patients with IMH was relatively favorable, but patients developing proteinuria and/or hypertension require careful observation and management during the follow-up period. (Korean J Intern Med 2009;24:356-361)
Choi, Kwon‐,Young,Jung, Eun‐,Ok,Jung, Da‐,Hye,Pandey, Bishnu Prasad,Lee, Nahum,Yun, Hyungdon,Park, Hyung‐,yun,Kim, Byung‐,Gee Wiley Subscription Services, Inc., A Wiley Company 2012 Biotechnology and bioengineering Vol.109 No.3
<P><B>Abstract</B></P><P>CYP51, a sterol 14α‐demethylase, is one of the key enzymes involved in sterol biosynthesis and requires electrons transferred from its redox partners. A unique CYP51 from <I>Nocardia farcinica</I> IFM10152 forms a distinct cluster with iron–sulfur containing NADPH‐P450 reductase (FprD) downstream of CYP51. Previously, sequence alignment of nine reductases from <I>N. farcinica</I> revealed that FprC, FprD, and FprH have an additional sequence at their N‐termini that has very high identity with iron–sulfur clustered ferredoxin G (FdxG). To construct an artificial self‐sufficient cytochrome P450 monooxygenase (CYP) with only FprD, CYP51, and iron–sulfur containing FprD were fused together with designed linker sequences. CYP51–FprD fusion enzymes showed distinct spectral properties of both flavoprotein and CYP. CYP51–FprD F1 and F2 in recombinant <I>Escherichia coli</I> BL21(DE3) catalyzed demethylation of lanosterol more efficiently, with <I>k</I><SUB>cat</SUB>/<I>K</I><SUB>m</SUB> values of 96.91 and 105.79 nmol/min/nmol, respectively, which are about 35‐fold higher compared to those of CYP51 and FprD alone. Biotechnol. Bioeng. 2012; 109:630–636. © 2011 Wiley Periodicals, Inc.</P>
Choi, Ok-Byung,Park, Joo-Hoon,Lee, Ye-Jin,Lee, Chang-Kwon,Won, Kyung-Jong,Kim, Jung-Hwan,Lee, Hwan-Myung,Kim, Bo-Kyung The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.2
Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anticancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated proliferation and migration of rat aortic smooth muscle cells (RASMCs). PDGF-BB induced the migration and proliferation of RASMCs that were inhibited by olibanum extract in a dose-dependent manner. The PDGF-BB-increased phosphorylation of p38 mitogen-activated protein kinase (MAPK); the heat shock protein (Hsp) 27 was significantly inhibited by the olibanum extract. The effects of PDGF-BB-induced extracellular signal-regulated kinase1/2 was not altered by the olibanum extract. Treatment with olibanum extract inhibited PDGF-BB-stimulated sprout out growth of aortic rings. These results suggest that the water extract of olibanum inhibits PDGF-BB-stimulated migration and proliferation in RASMCs as well as sprout out growth, which may be mediated by the inhibition of the p38 MAPK and Hsp27 pathways.
Calcific Amyloidoma of Tibialis Anterior Muscle
Byung-Ki Cho(조병기),Yong-Min Kim(김용민),Dong-Soo Kim(김동수),Eui-Sung Choi(최의성),Hyun-Chul Shon(손현철),Kyung-Jin Park(박경진),Hu-Shan Cui(최호산),Seok-Won Kim(김석원),Ok-Jun Lee(이옥준) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.3
연부조직에 발생하는 단발성 아밀로이드종은 매우 드물다. 저자들은 경골 근위부 골절 후 20여년 뒤에 전경골근에서 발생한 염증을 동반한 석회화성 아밀로이드종 1예를 경험하였으며, 종양 제거술 후 재발없이 만족스런 결과를 얻을 수 있었다. 아밀로이드종은 매우 드물기도 하고 골수염이나 골종양과 구분이 어려웠던 경우이므로 문헌고찰과 함께 증례보고를 하는 바이다. Calcific amyloidoma of the soft tissue is quite rare and it is difficult to make a differential diagnosis from other lesions such as osteomyelitis or bone tumor. We encountered a case of a calcified amyloidoma found in the anterior tibial muscle that occurred more than 20 years after a proximal tibial fracture adjacent to the origin of the muscle. The features of the lesion resembled osteomyelitis. Satisfactory result was obtained by a thorough mass excision. We report this case with review of the relevant literature.
Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
Choi, Bo Gil,Kim, Ok Young,Chung, Byung Ho,Cho, Won Jea,Cheon, Seung Hoon,Choi, Sang Un,Lee, Chong Ock 전남대학교 약품개발연구소 1998 약품개발연구지 Vol.7 No.1
Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.