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Lee, Geun Taek,Ha, Yun-Sok,Jung, Yeon Suk,Moon, Sung-Kwon,Kang, Ho Won,Lee, Ok-Jun,Joung, Jae Young,Choi, Yung Hyun,Yun, Seok-Joong,Kim, Wun-Jae,Kim, Isaac Yi Raven Press 2014 Annals of Surgical Oncology Vol. No.
<P>The DHCR24 gene that encodes 3b-hydroxysterol ??24-reductase, an oxidoreductase involved in cholesterol biosynthesis, has been identified as a progression-related gene based on the quantitative real-time PCR (qPCR) gene signature. Here, the functional role of DHCR24 and its clinical relevance in non-muscle-invasive urothelial carcinoma (NMIUC) were investigated.</P>
Stress Optimization of plastic IC package in reflow soldering process
김근우(Geun Woo Kim),이강용(Kang Yong Lee),이택성(Taek Sung Lee),김옥환(Ok Whan Kim) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.8
In order to reduce stress in the plastic small outline J-lead(SOJ) package and prevent the interface delamination under the infrared(IR) soldering process, parameterization, parametric study and optimization are used. The design variables of dimensions and material properties are determined among all the possible variables from the parametric study. Their optimized values are determined by applying the constraint optimization to the parameterized IC package.
진간식풍탕가감방(鎭肝熄風湯加減方)이 중추신경계(中樞神經系)에 미치는 효능에 관한 연구(硏究)
이상택 ( Sang Taek Lee ),김경옥 ( Kyeong Ok Kim ),이인 ( Ihn Lee ),정윤관 ( Yun Gwan Jung ),김근우 ( Geun Woo Kim ),구병수 ( Byung Soo Koo ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.3
objective : This study was designed to assess Effects of Jingansikpungtanggagam-bang on Central Nerve System. Method : Jingansikpungtanggagam-bang, a Korean traditional prescription, was evaluated for its anticonvulsant effect, hypnotic activity, analgesic action, anxiolytic effect, memory enhancement, and MAO inhibitory activity and determined the content of neurotransmitter in brain by HPLC method. Result : 1. The extract increased potently anticonvulsant effect at 1g/kg by 5.6-fold extention of onset time against control group. 2. The extract increased hypnosis at 500mg/kg by over twofold length of sleeping time compared to control.3. The extract showed a significant analgesic effect with 86.0% inhibition on writhing frequency at 500mg/kg by phenylquinone-induced writhing test.4. The extract inhibited dose-dependently the activity of monoamine oxidase in vitro. 5. This prescription increased the brain levels of serotonin and 5-hydroxyindoleacetic acid by 3.3% and 1.4%, respectively. 6. the extract exhibited the anxiolytic effect with 21.3% decrease of the immobility duration against control group.7. the extract enhanced memory recovery on scopolamine-induced impairment of passive avoidance performance at 1g/kg pretreatment with 20.2% increase of latency time. Conclusion : The result sugguest that Jingansikpungtanggagam-bang can be used effectively as a sedative prescription in Korean traditional medicine.
지속가능발전 도시를 위한 청소년 기후감수성 향상 프로그램 개발
오승근(Oh, Seung Geun),김미옥(Kim, Mi Ok),강선미(Kang, Seon Mi),조안나(Cho, An Na),김선경(Kim, Seon Kyung),이응택(Lee, Eung Taek) 인천발전연구원 2021 도시연구 Vol.- No.19
본 연구의 목적은 청소년 대상의 기후감수성 향상 프로그램을 개발하는 것이다. 프로그램 개발은 분석, 설계, 개발 및 실행, 평가 단계로 진행하였다. 분석단계는 기후위기 관련 인식과 실태를 조사하였다. 설계단계는 요구조사를 토대로 프로그램의 방향과 목적 그리고 목표를 설정하였다. 개발 및 실행단계는 프로그램 내용을 구성하였고, 5명을 대상으로 시범운영을 실시하였다. 평가단계는 프로그램 운영 시 문제를 기반으로 프로그램을 수정하여 최종 프로그램을 도출하였다. 그 결과, 8회기의 프로그램이 개발되었다. 1-2회는 기후위기의 심각성 인식과 기후위기와 청소년과의 관련성을 탐색하는 내용으로 구성하였다. 3-4회기는 기후위기와 먹거리의 내용, 5회기는 기후위기와 교통의 내용으로 구성하였다. 6-7회기는 기후위기에 적극적인 대응을 위한 참여자의 실천계획을 수립하도록 하였고, 8회기는 기후위기 대응에 필요한 지속적인 노력을 위한 방안탐색에 대한 내용이다. 본 프로그램은 청소년들이 기후위기의 문제점을 인식하고 나아가 이를 해결하기 위한 실천행동을 마련하는데 효과적일 것이다. This study develops a climate sensitivity improvement program. The program development was divided into analysis, design, development and execution, and evaluation. The analysis step investigated the perception and condition of the climate crisis. The design step set up the direction, purpose, and objectives of the program. In the development and execution step, content was developed according to program components. In addition, a pilot test was executed with five people to confirm the appropriateness of the program. In the evaluation step, the final program was derived by modifying the program based on the pilot test. The final program is a total of eight sessions. Sessions 1-2 are about understanding the seriousness of the climate crisis and exploring the relationship between the climate crisis and youth. Sessions 3-4 consisted of climate crisis and food, and Session 5 was composed of climate crisis and transportation. Session 6-7 were for participants to establish action plans to actively respond to the climate crisis and Session 8 consisted of exploring ways to make continuous efforts. This program will be effective for youth to recognize the problems of the climate crisis and to prepare practical actions to solve them.
증례 : 감염 ; 다이어트 약물 치료 후 Candida guilliermondii에 의한 칸디다 혈증
임민희 ( Min Hee Lim ),허상택 ( Sang Taek Heo ),배인규 ( In Gyu Bae ),정용근 ( Yong Geun Jeong ),김현옥 ( Hyun Ok Kim ),고관수 ( Kwan Soo Ko ),김선주 ( Sun Joo Kim ) 대한내과학회 2009 대한내과학회지 Vol.77 No.2
최근 우리나라의 경우 다이어트에 대한 관심이 많아짐에 따라 검증되지 않은 다이어트 보조 약물을 복용하는 사례가 많은데 이러한 다이어트 약물을 복용하는 사람들에서 원인이 불분명한 발열 소견을 보일 때는 만약 다른 특별한 원인을 찾을 수 없을 경우 이러한 약물에 의한 면역 기능의 감소로 발생할 수 있는 전신 칸디다 혈증과 같은 기회 감염에 대해서 고려해 보아야 할 필요가 있을 것이다. 저자들은 면역기능에 특별히 이상이 없던 건강한 성인에서 다이어트 약물 치료 후 C. guilliermondii에 의한 전신 칸디다 혈증을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Candida guilliermondii is found in sea water, animal feces, buttermilk, and beer and has been isolated from human infections, mostly of cutaneous origin. It usually causes skin and soft tissue infections and has decreased susceptibility to fluconazole. Systemic infections occur mostly in immunocompromised patients. A 38-year-old female was admitted with a 4-day fever. Her cal and family histories were unremarkable, except for obesity. She had been taking diet pills for 3 months and had undergone injection therapy into her abdomen for lipolysis for 1 month. She did not respond to empirical antibiotics. A Candida species was isolated from blood cultures and identified as C. guilliermondii based on partial LSU rRNA gene sequence analyses. She was treated with amphotericin B, and recovered completely. (Korean J 77:251-254, 2009)
옥택근,조준휘,박찬우,천승환,이승용,김성은,최기훈,배지훈,서정열,안희철,안무업,조병렬,김용훈,Ok Taek Geun,Cho Jun Hwi,Park Chan Woo,Cheon Seung Whan,Lee Seung Yong,Kim Sung Eun,Choi Ki-Hoon,Hae Ji Hoon,Seo Jeong Yeul,Ahn Hee Cheol,Ahn Moo Eo 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.1
The majority of acute toxic poisoning occur via oral route. The most important emergency treatment of acute poisoning are gastric lavage. Gastric lavage should be considered a patient has ingested a potentially life-threatening amount of a poison and the procedure can be undertaken within 60 mins of ingestion. But, gastric lavage does not consist properly in the cases of emergency situation or an inexperienced doctors treat. The purpose of this study was to determine whether gastric lavage is performed properly. Eighty patients were enrolled in the study in 12-month period from January to December 2002. A retrospective chart review was performed on patients identified as drug overdose who admitted to ER. To assess whether there was a subgroup of patients who may have been candidates for the initiation of gastric lavage in the ER, the patients divided in two groups by time interval from toxin ingestion to ER arrival. The group 1 that admit within 60 minutes after drug ingestion was 38 cases ($47.5\%$), and the group 2 patient who admitted after 60 minutes was 42 cases ($52.5\%$). The average age was $44\pm19$ years in group 1, and $48\pm24$ years in group 2. There were no differences in sexual distribution of two groups. The mean time interval was $49\pm20$ minutes in the group $1,258\pm190$ minutes in the group 2. Only thirty ($37.5\%$) of the patients had an overdose for which the treatment of gastric lavage was potentially feasible according to guideline. The correctly performed gastric lavage was 18 ($47.4\%$) in group 1, 12 ($28.6\%$) in group 2. We must enforce education about the gastric lavage, and do so that may treat according to guideline.