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감송향 정유성분의 흡입 및 경구투여시의 중추신켱 억제효과
구병수,김대근,최정현,이동웅,Koo Byung-Soo,Kim Dae-kun,Choi Jung-Hyun,Lee Dong-Ung 한국생명과학회 2006 생명과학회지 Vol.16 No.1
The essential oil of Nardostachys jatamansi (Valerianaceae), which has been used for a long time in aroma therapy, was investigated after inhalation or oral administration for its analgesic effect, anticonvulsant action, hypnotic effect and in vitro inhibitory activity on monoamine oxidase. This fragrance oil showed a significant analgesic effect in the phenylquinone-induced .writhing test, suppressed the convulsion induced by pentylenetetrazole and lengthened the pentobarbital-induced sleeping time in a time-dependent manner after fragrance inhalation or dose-independently by oral administration. Its inhibitory activity on monoamine oxidase was remarkable, showing $49.4\%$ inhibition at a concentration of 5.0 mg/ml. Six new terpenes with seven known compounds were detected by our GC-MS analytical conditions used. As a result, the essential oil fragrance of Nardostachys jatamansi would be clinically useful for a sedative by either inhalation or oral administration.
가미귀비탕(加味歸脾湯)의 우울증 투약지침 개발을 위한 기초연구 -우울증 변증 설문지의 신뢰도 타당도 평가-
구병수 ( Byung Soo Koo ),이상재 ( Sang Jae Lee ),한창호 ( Chang Ho Han ),김호준 ( Ho Jun Kim ),박세환 ( Se Hwan Park ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.4
Objectives: As depression falls into the category of Wuljeung, Gamiguibi-Tang(Jiaweiguipitang) is the standard prescription to cure Wuljeung. This study develops a questionnaire for building the guidelines to administer Gamiguibi-Tang to depression and evaluates reliability and validity of questionnaire. Methods: With extracting the text related to depression and Gamiguibi-Tang through total 9 Korean medicine books and consulting the experts, the study selected 80 items and converted them into a questionnaire. It surveyed the neuropsychiatry professors and the medical specialists three times by Delphi method, and lastly selected 21 final items of a questionnaire. On the basis of the questionnaire, it collected total 216 samples and tested their reliability and validity. Results: 21 items all didn`t reduce total Cronbach alpha coefficient and satisfied test-retest reliability. As a result of factor analysis, totally 5 factors were extracted such as mental state, sleep, accompaniment, fatigue and weakness. Finally, in comparing a depression group with a normal control group, two groups all showed meaningful difference in each 21 items` point, the sum of factor 1 to 5 items` points, and the sum of 21 items` points. Conclusions: The questionnaire on the updated depression prescription guideline of Gamiguibi-Tang satisfied both of reliability and validity. Later it can help objectifying to apply Gamiguibi-Tang to depression cure.
박세환 ( Se Hwan Park ),황정현 ( Joeng Hyun Hwang ),윤여국 ( Yeo Guk Yun ),김근우 ( Geun Woo Kim ),구병수 ( Byung Soo Koo ),김보람 ( Bo Ram Kim ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.3
Objectives: This study was performed to report the effect of Autogen training and Korean traditional treatment for Hwa-Byung. Methods: In this case, a 41 years old female patient has been suffered by Hwa-Byung symptoms for 20 years. We treated the patient with Korean traditional treatments(acupuncture, herb-medication and aroma theraphy), Autogen training and Korean traditional psychotherapy. The effects of treatment were measured by Beck Depression Inventory(BDI), Zung Depression Rating Scale(SDS), State-Trait Anxiety Inventory(STAI-X-1), SCL-90-R. Results: After treatment, the chief complaints and accompanying symptoms were subsided and improved. And BDI, SDS, STAI-X-1 score were decreased. Conclusions: According to this study, the Korean traditional treatment such as acupuncture, herb-medication and Autogen training are effective for the cure of Hwa-Byung.
박세환 ( Se Hwan Park ),김지훈 ( Jee Hoon Kim ),김근우 ( Geun Woo Kim ),구병수 ( Byung Soo Koo ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.4
Objectives: This study was performed to report the effect of Korean traditional treatments for Hwa-Byung with menopausal symptoms. Methods: In this case, a 48 years old female patient has been suffered by Hwa-Byung with menopausal symptoms for 3 years old. We treated the patient with Korean traditional treatments (acupuncture, herb-medication and aroma theraphy), mindfulness and Korean traditional psychotherapy. The effects of treatment were measured by Beck Depression Inventory(BDI), Zung Depression Rating Scale(SDS), Kupperman Index(KI), Menopause Rating Scale(MRS). Results: After treatment, the chief complaints and accompanying symptoms were subsided and improved. And BDI, SDS, KI and MRS score were decreased. Conclusions: According to this study, the Korean traditional treatment such as acupuncture, herb-medication is effective for the cure of Hwa-Byung with menopausal symptoms.
원인불명의 보행장애를 비위허약형(脾胃虛弱型) 위증으로 판증(辦證)한 치험 1례
유종호,구병수,김근우,Yoo, Jong-Ho,Koo, Byung-Soo,Kim, Geun-Woo 대한한방신경정신과학회 2007 동의신경정신과학회지 Vol.18 No.2
Wi syndrome is the syndrome that reveals muscle relaxation without contraction and muscle relaxation occurs in the low or upper limb, in severe case leads to death. We experienced a 80year-old woman who had a Wi syndrome, and treated by the way of reinforcing weakness of the spleen and stomach(脾胃虛弱). After being treated, the patient showed that symptoms (gait disturbance, ptosis, dysphonia) was improved. This result suggests that oriental medical treatment has good effect on Wi syndrome.
정희상,김근우,구병수,Jeung, Hee-Sang,Kim, Geun-Woo,Koo, Byung-Soo The Korean Society of Oriental Neuropsychiatry 2009 동의신경정신과학회지 Vol.20 No.1
목적 : 이 연구는 알쯔하이머 병에 대한 육미지황가미방의 효과를 조사하였다. 육미지황가미방은 산약, 산수유, 복령, 목단피, 구기자, 택사, 숙지황을 포함한 여러 가지 한약재의 전탕액으로 치매의 한약 치료제로 널리 사용되어 왔다. 방법 : 이 약물의 신경보호 작용을 조사하기 위해, 수중미로를 사용하여 학습과 기억에 대한 육미지황가미방의 효과를 평가 했고, 트리메틸틴은 강력한 유독물질로 선택적으로 중추신경계와 면역계의 세포를 파괴시킨다. 트리메틸틴(6.0 mg/kg, i.p.)주입 후, 쥐에게 육미지황가미방(400mg/kg, p.o.)를 2주 동안 날마다 복용시켰으며, 수중미로를 수행시켰다. 결과 : 육미지황가미방을 트리메틸틴에 노출시킨 쥐에 투약했으며, 그들은 수중미로에서 학습과 기억의 향상을 보였고, 이는 육미지황가미방이 어떠한 환경에서는 트리메틸틴으로 유발된 신경퇴화 후 중추신경계의 결손을 감소시킬 수 있음을 보여준다. 결론 : 이러한 결론은 육미지황가미방이 인지능력을 증가시키고, 트리메틸틴으로 유발된 신경퇴화에서 콜린 아세틸전환효소의 정도를 변화시킬 수 있음을 보여준다.