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Anti-inflammatory tirucallane saponins from Paramignya scandens.
Phan, Nguyen Huu Toan,Thuan, Nguyen Thi Dieu,Ngoc, Ninh Thi,Thao, Nguyen Phuong,Kim, Sohyun,Koh, Young Sang,Thanh, Nguyen Van,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Cha Pharmaceutical Society of Japan 2015 Chemical & pharmaceutical bulletin Vol.63 No.7
<P>Five new tirucallane saponins, paramignyosides A-E (1-5), were isolated from the water fraction of the Paramignya scandens stem and leaves. Their structures were elucidated on the basis of spectroscopic evidence including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and one dimensional (1D)- and 2D-NMR. The effects of isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Paramignyoside C (3) exhibited selective and potent inhibitory effect (IC50=5.030.19??M) on the production of IL-12 p40 comparable to that of the positive control, SB203580 (IC50=5.000.16??M). Further studies are required to confirm efficacy in vivo and the mechanism of anti-inflammatory effects.</P>
Nguyen Huu Nghia,Nguyen Thi Nguyen,Phan Trong Binh,Le Thi May,Tong Tran Huy,Pham Thai Giang,Sophie St-Hilaire,Phan Thi Van 한국수산과학회 2022 Fisheries and Aquatic Sciences Vol.25 No.8
This study assessed the effects of oxygen and ozone nanobubbles on gill morphology, weight gain, and mortality of Pacific white shrimp (Penaeus vannamei), as well as the level of Vibrio parahaemolyticus and water quality of shrimp culture tanks under lab conditions. Two experiments were carried out with oxygen macrobubble, ozone macrobubble, oxygen nanobubble, ozone nanobubble, and control treatments (air-stone macrobubble). Experiments were done in triplicate in 100 L tanks with 15‰ saline water, and 20 shrimp per tank. Tanks in Experiment 1 were not inoculated with bacteria; tanks in Experiment 2 were inoculated with V. parahaemolyticus at a concentration of 106 CFU/mL. The results revealed that short treatments with ozone nanobubbles had minimal impact on shrimp gills, mortality, and growth rates, reduced V. parahaemolyticus concentration in water compared to the other groups, and improve water quality. These laboratory results indicate that ozone nanobubble treatment may be useful for controlling V. parahaemolyticus. More work is needed to find the best protocol to apply the technology on a commercial scale.
구리 촉매를 이용한 알킬싸이오피리미딘 화합물의 산화적 탈수소화 반응에 관한 연구
( Nguyen Huu Trong Phan ),손정훈 ( Jeong-hun Sohn ) 충남대학교 기초과학연구원 2020 충남과학연구지 Vol.37 No.1
A copper-catalyzed aerobic oxidative dehydrogenation reaction method for the conversion of 2-(alkylthio)-1,4-dihydropyrimidines to 2-(alkylthio)pyrimidines was developed. The reaction proceeded efficiently with a wide range of 2-(alkylthio)-1,4-dihydropyrimidine substrates in the absence of additives, such as an oxidant, acid, or base.
Nguyen Xuan Nhiem,Pham Hai Yen,Nguyen Thi Thanh Ngan,TRANHONG QUANG,Phan Van Kiem,Chau Van Minh,Bui Huu Tai,Nguyen Xuan Cuong,Seok Bean Song,김영호 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4
Momordica charantia is used to treat various diseases, including inflammatory conditions. Previous reports indicated that the extract of this plant inhibits activation of nuclear transcription factor-jB (NF-jB) but activates peroxisome proliferator-activated receptor (PPAR). Additionally, cucurbitane-type triterpene glycosides are the main bioactive components of the fruit of M. charantia. Therefore, we investigated the anti-inflammatory activity of 17 cucurbitane-type triterpene glycosides (1–17) isolated from this plant. Their inhibition of NF-jB and activation of PPAR activities in HepG2 cells were measured using luciferase reporter and PPAR subtype transactivation assays. Compounds 6 and 8 were found to inhibit NF-jB activation stimulated by tumor necrosis factor-a (TNFa) in a dose-dependent manner. With 50% inhibition concentration (IC50) values of 0.4 lM, compounds 6 and 8 were more potent inhibitors than the positive control, sulfasalazine (IC50 = 0.9lM). Compounds 4, 6, and 8 also inhibited TNFa-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2mRNA. However, only compound 13 significantly increased PPARc transactivation.
Nguyen Huu Tung,Chau Van Minh,Phan Van Kiem,Hoang Thanh Huong,Tran Thu Ha,Nguyen Tien Dat,Nguyen Xuan Nhiem,Nguyen Xuan Cuong,Jae-Hee Hyun,Hee-Kyoung Kang,김영호 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
One new C29 sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8-27.8 μM.
Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme
Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
Nguyen Phuong Thao,Nguyen Hoai Nam,Nguyen Xuan Cuong,Bui Thi Thuy Luyen,Bui Huu Tai,김지은,송석빈,Phan Van Kiem,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
Anti-inflammatory transcriptional effects ofnineteen compounds (1–19) from the soft coral Sinulariamaxima were evaluated using NF-jB luciferase and reversetranscriptase polymerase chain reaction. Compounds 1, 2,4, 8, 15, 17, and 18 significantly inhibited TNFa-inducedNF-jB transcriptional activity in HepG2 cells in a dosedependentmanner, with IC50 values ranging from15.81 ± 2.29 to 29.10 ± 1.54 lM. Furthermore, the transcriptionalinhibitory function of these compounds wasconfirmed by a decrease in intercellular adhesion molecule-1 and inducible nitric oxide synthase gene expressionlevels in HepG2 cells. These results provide a scientificrationale for the use of the soft coral S. maxima warrantfurther studies to develop new agents for the preventionand treatment of inflammatory.
Two New C-Glucosyl Benzoic Acids and Flavonoids from Mallotus nanus and Their Antioxidant Activity
Phan Van Kiem,Nguyen Thi Mai,Chau Van Minh,Nguyen Huu Khoi,Nguyen Hai Dang,Nguyen Phuong Thao,Nguyen Xuan Cuong,Nguyen Hoai Nam,Nguyen Xuan Nhiem,Yvan Vander Heyden,Joëlle Quetin-Leclercq,김교남,장해동,김영호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.2
Two new 2-C-β-D-glucopyranosyl benzoic acid derivatives named mallonanosides A (1) and B (2) were isolated from the methanolic extract of the leaves of Mallotus nanus along with five known flavonoids, kaempferin (3), juglanin (4), quercitrin (5), myricitrin (6), and rhoifolin (7). Their structures were established on the basis of spectral and chemical evidence. Their antioxidant activities were shown to depend on the number of hydroxyl groups, and the location and species of sugar moiety.
Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Ha, Le Minh,Tai, Bui Huu,Quang, Tran Hong,Tung, Nguyen Huu,Kim, Young Ho John Wiley Sons, Ltd. 2010 Magnetic resonance in chemistry Vol.48 No.5
<P>The chemical study of Momordica charantia fruits led to the isolation of three new cucurbitane triterpene glycosides, momordicosides U, V, and W (1–3). The structures of these compounds were determined to be (19R, 23R)-5β, 19-epoxy-19-methoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (1), (23R)-5β, 19-epoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (2), and (19R)-5β, 19-epoxy-19,25-dihydroxycucurbita-6,23(E)-diene-3β-ol 3-O-β-D-glucopyranoside (3), by chemical and spectroscopic methods. Copyright © 2010 John Wiley & Sons, Ltd.</P> <B>Graphic Abstract</B> <P>Three new cucurbitane triterpene glycoside named momordicosides U-W (1–3), respectively, have been isolated from Momordica charantia. Their chemical structures were identified by chemical and spectroscopic methods. <img src='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001.gif' alt='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001'> </P>