ĐÁNH GIÁ KHẢ NĂNG LÀM LÀNH VẾT BỎNG TRÊN CHUỘT CỦA HYDROGEL TỪ AgNP-CHITOSAN-CURCUMIN

Hoang Ngoc Anh Nhan,Nguyen Ba Trung,Giang Thi Kim Lien,Truong Thi My Phuong,Ho Kha Vinh Nhan,Pham Xuan Anh 한국베트남학회 2023 베트남연구 Vol.21 No.1

Skin burn is one of the major causes of morbidity and mortality in burn patients due to its susceptibility to infection. The disruption of the epidermal barrier, combined with the denaturation of proteins and lipids, provides a fertile environment that is rich in bacterial nutrients for microbial growth, making it significantly prone to infection. This study aimed to formulate a thermoresponsive hydrogel containing silver nanoparticles (300 ppm), oligo chitosan 2%, and curcumin (0.1%) in the polymer pluronic F127 matrix with a final concentration of 13% to effectively promote the healing of skin wounds. The prepared thermoresponsive hydrogel was investigated for its physical and chemical stability, gelation temperature, and chemical composition. In addition to in vitro antibacterial activity against Staphylococcus aureus found in burn infections, in vivo burn healing and antibacterial activities were also investigated and compared with those of a commercial product using burn-induced infected wounds in mice. The formulation showed antibacterial activity with effective values for wound healing properties, as shown in vivo and by histopathological studies. This study also demonstrates that the thermoresponsive hydrogel was successful as an antibacterial and burned wound-healing transdermal drug delivery system.

Development of a Novel Methanotrophic Platform for Plant Growth Promotion

Diep Ngoc PHAM,Dung Hoang Anh MAI,Anh Duc NGUYEN,Tin Hoang Trung CHAU,Eun Yeol LEE 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.4

The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome

Ho, Vu Ngoc Anh,Pham, Toan Duong,Nguyen, Nam Thanh,Hoang, Hieu Le Trung,Ho, Tuong Manh,Vuong, Lan Ngoc The Korean Society for Reproductive Medicine 2022 Clinical and Experimental Reproductive Medicine Vol.49 No.2

Objective: This study aimed to investigate the impact of hyperandrogenism (HA) on the outcomes of ovulation induction (OI) using gonadotropin and intrauterine insemination (IUI) in patients with polycystic ovary syndrome (PCOS). Methods: This was a retrospective cohort study including 415 patients undergoing OI using gonadotropin and IUI treatment between January 2018 and December 2020 at a single infertility center. Baseline characteristics, clinical and laboratory parameters, and pregnancy outcomes were investigated. Results: Among the study population, there were 105 hyperandrogenic (25.3%) and 310 non-hyperandrogenic patients (74.7%). The live birth rate was lower in the HA group than in the non-HA group, but this difference did not reach statistical significance due to the limited sample size (14.3% vs. 21.0%, relative risk=0.68; 95% CI, 0.41-1.14, p=0.153). No predictive factors for live birth were identified through logistic regression analysis. Conclusion: HA did not negatively affect the outcomes of OI using gonadotropin and IUI cycles in Vietnamese women with PCOS. The result may not be applicable elsewhere due to the large variation in the characteristics of women with PCOS across races and populations.

Factors Affecting the Internal Control System: A Case Study of Chemical Enterprises in Vietnam

Hoang Thanh NGO,Tung Dao NGUYEN,Nga Thuy Thi NGUYEN,Ha Ngoc DAO,Anh Phuong Tran VU 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.12

The article analyzes the impact of factors affecting the internal control system of chemical enterprises in Vietnam, providing more empirical evidence on factors affecting the system of internal control. Research data is collected in the form of face-to-face interviews and email interviews with managers and employees working in different positions, managers at all levels, chief accountants, and accountants of 52 chemical enterprises in Vietnam. The survey results collected 310 questionnaires. After eliminating the invalid questionnaires due to many blank cells, the authors chose to use 297 questionnaires. Quantitative research was carried out with SPSS 25 software. Research results show that Business Strategy, Organizational Structure, Organization’s perception of the instability of the external environment, and Organizational culture are the factors that positively affect the internal control system of chemical enterprises. This can be explained that, for chemical enterprises, Business strategy, Organizational structure, Organization’s perception of the instability of the external environment, and Good organizational culture will positively impact the internal control system of chemical enterprises. Based on the research results, the authors have proposed recommendations to enhance the effectiveness of the internal control system of chemical enterprises in Vietnam, thereby contributing to improving the performance of enterprises in the chemical Vietnamese.

The other sides of SPACE

Hoang Anh Le Trieu,Quynh Giao Pham Ngoc 한국디자인학회 2018 한국디자인학회 국제초대전도록 Vol.2018 No.6

A novel mathematical modelling for simulating the spread of heavy metals in solid waste landfills

Ngoc Ha Hoang,Anh My Chu,Kim Thai Thi Nguyen,Chi Hieu Le 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.3

Municipal solid waste (MSW) landfills create the environmental pollutions due to problems related to toxins, leachate, and greenhouse gas, which are the growing environmental concerns, especially in developing countries. This paper presents a novel mathematical modelling for simulating the spread of heavy metals in soil layers in the MSW landfills. A new mathematical modelling procedure is studied for deriving the governing equation which describes the time varying concentration of pollutants in the leachate in a 3-dimensional (3D) space of soil layers. A Finite Element Method (FEM) based algorithm is then constructed to solve numerically the governing equation over time in 3D space for effectively analyzing the variation of pollutants concentrations. Finally, the applicability and advantages of the proposed novel method are demonstrated through the case study with soil samples collected from the actual MSW landfill. The successfully developed algorithm can be applied to model and predict the spread of different heavy metals in the MSW landfill sites; and to develop effective solutions and policies for solid waste classification and management, in order to minimise the negative impacts from the potential risk of the toxic heavy metal pollutions, soil contaminations and groundwater pollutions in the areas nearby the MSW landfill.

The extraction of lignocelluloses and silica from rice husk using a single biorefinery process and their characteristics

Ngoc Thuy Nguyen,Nhat Thong Tran,Tan Phat Phan,Anh Thu Nguyen,My Xuyen T. Nguyen,Nguyen Ngan Nguyen,Young Ho Ko,Dai Hai Nguyen,Tran T.T. Van,DongQuy Hoang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

While the efficient usage of biomass waste can significantly help in addressing environmental issues,there are only a few reports that discuss about processing such waste effectively at a low-cost. Such challengearises from the strong association between the components biomass. In this study, an abundantagricultural byproduct, rice husk (RH), was used as the starting resource. A simple biorefining processof alkaline peroxide treatment followed by acid precipitation and ethanol extraction was performed onRH to obtain cellulose, hemicellulose, lignin, and silica. The chemical structures, morphologies, andphysic-chemical properties of the separated components were identified through a wide range of characterizationapproaches. The final products obtained from of this process were (i) bundles of fiber-likecellulose with a fiber width of 6 mm and (ii) small particles of hemicellulose and lignin with nonuniformshapes. The lignocelluloses products had over 90 wt% carbon with 52.28% crystalline ratio. Meanwhile, the other products comprising hemicelluloses, lignin, and silica were amorphous. The outcomeof this study contributes to expanding and developing the simple and efficient conversion processof biomass waste into sustainable value-added materials. It is crucial to reduce the environmental impactby using renewable materials as the new building block resources for synthetic chemicals.

Electrostatically Self-assembled Quinazoline-based Anticancer Drugs on Negatively-charged Nanodiamonds for Overcoming the Chemoresistances in Lung Cancer Cells

Anh Thu Ngoc Lam,윤진하,Nguyen Hoang Ly,주상우 한국바이오칩학회 2018 BioChip Journal Vol.12 No.2

The nanodiamond (ND) conjugates of gefitinib (GF) and erlotinib (EL) were assembled for in vitro lung cancer treatments. The carboxylate infrared bands along with the negative surface charge of -28.3 (±2.1) mV were found efficient to conjugate the nitrogen- containing quinazoline ring drugs, due to the electrostatic interactions, resulting from the surface changes to -12.0 (±1.2) mV and -9.1 (±1.2) mV after adsorption of GF and EL on NDs, respectively. The physicochemical properties of NDs were characterized by transmission electron microcopy, X-ray diffraction, X-ray photoelectron, infrared and Raman spectroscopic tools. The size distributions of NDs after the self-assembly of GF and EL could be checked by dynamic light scattering measurements. The uptake of NDs in cancer cells was estimated by fluorescence microscopy. Cell viability appeared to decrease by 30-50% at 50 and 100 nM of GF and EL, respectively, after the treatment of PEG-assembled NDs compared to the cases using free drugs. Our ND conjugates may be potentially useful for overcoming the chemoresistances in lung cancer cells.

Tobacco Control Policies in Vietnam: Review on MPOWER Implementation Progress and Challenges

Hoang, Van Minh,Tran, Thu Ngan,Vu, Quynh Mai,Nguyen, Thi Tuyet My,Le, Hong Chung,Vu, Duy Kien,Tran, Tuan Anh,Nguyen, Bao Ngoc,Vu, Van Giap,Nguyen, Manh Cuong,Pham, Duc Manh,Kim, Bao Giang Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1

In Vietnam, the WHO Framework Convention on Tobacco Control (WHO FCTC) took effect in March 2005 while MPOWER has been implemented since 2008. This paper describes the progress and challenges of implementation of the MPOWER package in Vietnam. We can report that, in term of monitoring, Vietnam is very active in the Global Tobacco Surveillance System, completing two rounds of the Global Adult Tobacco Survey (GATS) and three rounds of the Global Youth Tobacco Survey (GYTS). To protect people from tobacco smoke, Vietnam has issued and enforced a law requiring comprehensive smoking bans at workplaces and public places since 2013. Tobacco advertising and promotion are also prohibited with the exception of points of sale displays of tobacco products. Violations come in the form of promotion girls, corporate social responsibility activities from tobacco manufacturers and packages displayed by retail vendors. Vietnam is one of the 77 countries that require pictorial health warnings to be printed on cigarette packages to warn about the danger of tobacco and the warnings have been implemented effectively. Cigarette tax is 70% of factory price which is equal to less than 45% of retail price and much lower than the recommendation of WHO. However, Vietnam is one of the very few countries that require manufacturers and importers to make "compulsory contributions" at 1-2% of the factory price of cigarettes sold in Vietnam for the establishment of a Tobacco Control Fund (TCF). The TCF is being operated well. In 2015, 67 units of 63 provinces/cities, 22 ministries and political-social organizations and 6 hospitals received funding from TCF to implement a wide range of tobacco control activities. Cessation services have been starting with a a toll-free quit-line but need to be further strengthened. In conclusion, Vietnam has constantly put efforts into the tobacco control field with high commitment from the government, scientists and activists. Though several remarkable achievements have been gained, many challenges remain. To overcome those challenges, implementation strategies that take into account the contextual factors and social determinants of tobacco use in Vietnam are needed.

The Study of Mach Waves Generated by a Roughness Element

Hoang Quan Dinh,Anh Tuan Nguyen,Ivan Vladimirovich Egorov,Ngoc Hai Duong 한국항공우주학회 2022 International Journal of Aeronautical and Space Sc Vol.23 No.3

In this paper, a simplified inviscid boundary condition is applied to solve the problem of Mach waves generated by a roughness element on the wall surface of a supersonic wind tunnel. The geometry of the roughness element is simplified by a parabolic function, to which mathematical formulas are introduced to model the boundary condition. These techniques help simplify the problem and minimize the required computer resources for the simulation performance. Using the direct numerical simulation (DNS) method while employing the above-mentioned techniques, the authors can simulate the generation and the propagation of Mach waves from a roughness element at a Mach number of 2.5. The result shows that a pair of Mach waves are generated at the leading and trailing edges of the roughness element and oscillate with small amplitudes. We also study the effect of the height of the element, the flow speed, the Reynolds number, and the unsteadiness of the flow on the simulation result. The numerical result is compared with published experimental data for the validation.