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Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis and Their Cytotoxic Activity
Do Thi Ha,Quan Cheng Chen,Tran Manh Hung,Tran Minh Ngoc,Phuong Thien Thuong,김홍진,성연희,민병선,배기환,윤의중 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-ε -viniferin (3), gnetinH (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)- ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC50 values ranging from 15.7 ± 2.1 to 30.9 ± 1.8 μM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC50 values of 30.6 ± 4.1 and 28.7 ± 2.81μM, respectively) and K562 (IC50 values of 38.6 ± 0.82 and 24.6 ± 0.76 μM, respectively). Gnetin H (4)showed only weak cytotoxic activity against L1210 with an IC50 value of 40.1 ± 4.23 μM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-ε -viniferin (3), (+)-ampelopsin F (7), and piceatannol(9) exhibited no activity on three cancer cell lines.
To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
NGOC, Tran Minh,HUNG, Tran Manh,THUONG, Phuong Thien,KIM, Jin-Cheon,CHOI, Jae Sue,BAE, KiHwan,HATTORI, Masao,CHOI, Chung-Sig,LEE, Joon Seok,MIN, Byung-Sun Japan Society for Bioscience, Biotechnology, and A 2008 Bioscience, Biotechnology, and Biochemistry Vol.72 No.8
<P>Two phenolics, 1,2,6-trigalloylglucose (<B>1</B>) and 1,2,3,6-tetragalloylglucose (<B>2</B>), isolated from the stem-bark of <I>Juglans mandshurica</I> were evaluated for their antioxidative activities. The results showed that compounds <B>1</B> and <B>2</B> exhibited strong scavenging activities against 1,1′-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS<SUP>•+</SUP>), and superoxide radicals (O<SUB>2</SUB><SUP>•−</SUP>), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation. The strong superoxide radical scavenging of <B>1</B> and <B>2</B> resulted from the potential competitive inhibition with xanthine at the active site of xanthine oxidase (OX). In addition, compounds <B>1</B> and <B>2</B> displayed significant lipoxygenase inhibitory activity, the mode of inhibition also being identified as competitive. In comparison, the antioxidative activities of compounds <B>1</B> and <B>2</B>, together with gallic acid, indicated that the number of galloyl moieties could play an important role in the antioxidative activity.</P>
Acetylcholinesterase Inhibitory Effect of Lignans Isolated from Schizandra chinensis
Hung, Tran Manh,Na, Min-Kyun,Min, Byung-Sun,Ngoc, Tran Minh,Lee, Ik-Soo,Zhang, XinFeng,Bae, Ki-Hwan 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. The compounds having both aromatic methylenedioxy and hydroxyl groups on their cyclooctadiene ring, such as gomisin C (6), gomisin G (7), gomisin D (8), schisandrol B (11) and gomisin A(13), entirely inhibited AChE in dose dependent manners, with IC$_{50}$ values of 6.71 ${\pm}$ 0.53, 6.55 ${\pm}$ 0.31, 7.84 ${\pm}$ 0.62, 12.57 ${\pm}$ 1.07 and 13.28 ${\pm}$ 1.68 ${\mu}$M, respectively. These results indicate that the lignans could potentially be a potent class of AChE inhibitors.
Ngoc Hung TRAN,Thi Thuy Hanh NGUYEN,Thi Phuong NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.7
This study aims to find out and measure the level of factors affecting the applicability of environmental management accounting (EMA) in Vietnamese automobile industry enterprises. Data was collected using both quantitative and qualitative methods. First, in general research, qualitative methodology was used to find out factors (variables) that can impact the possibility of implementing EMA in Vietnamese automobile enterprises. Second, in detailed research, all variables are measured using a quantitative method by collecting data through sampling and sending questionnaires. 500 questionnaires were sent to automobile enterprise managers and only 352 questionnaires met the criteria for the data analysis. The study used a mixed research design approach- a procedure for collecting, analyzing, and “mixing” both quantitative and qualitative research and methods in a single study to understand the research problem. Results show that 7 factors affect the possibility of implementing EMA in Vietnamese automobile industry enterprises. These factors are coercive pressure, normative pressure, mimetic pressure, business environmental uncertainty, environmental strategy, benefits when applying EMA, and task complexity. Based on the results of the study, promoting EMA in the automotive industry should depend mainly on the role of governmental departments.
Tran, Ngoc Hung,Kim, Byung-Soo The Korean Society of Plant Pathology 2012 Plant Pathology Journal Vol.28 No.4
Eleven hot pepper accessions collected in Vietnam showed stable resistance to bacterial wilt as well-known resistance sources, MC4 and MC5, in repeated inoculation tests with different Ralstonia solanacearum isolates conducted from 2004 to 2010. Seven of these accessions (specifically KC981, KC1006, KC1021, KC1027, KC1045, KC1050, and KC1055) resulted in stable male sterile F1 plants in the crosses with a cytoplasmically male sterile (CMS) Chilseong (CMS-A, Srfrf ), and therefore, they were maintainers (CMS-B) with a genotype of Nrfrf. The rest (KC980, KC995, KC999, and KC1009) produced stable male fertile F1 plants in the crosses, and therefore, were restorers (CMS-C) with a genotype of N(S)RfRf. Therefore, the maintainer and restorer sources of resistance may be used in preference in breeding maternal (CMS and their maintainers) and paternal parents (restorers) for resistance to bacterial wilt, respectively, in the hybrid breeding system utilizing cytoplasmic male sterility.
Factors Impacting on Social and Corporate Governance and Corporate Financial Performance
Ngoc Hung TRAN,Thi Thuy Hanh NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.6
This study aims to investigate the factors, which impact the social and corporate governance performance and corporate financial performance of listed Vietnamese enterprises. A survey was carried out with listed Vietnamese enterprises on HOSE, HNX and UPCOM, gathering 280 usable respondents, with data and theoretical model analyzed by using SPSS, AMOS with SEM method. The results show that the social and corporate governance (ESG) performance and corporate financial performance were driven by elements including the size of enterprise, the institutional ownership, the managerial ownership, the broad structure, the government ownership, and the managerial perception. The study findings suggest that in larger the enterprises, more institutional and state-owned shareholders and modern managerial members can help to enhance the corporate governance performance and therefore help to improve the corporate financial performance. However, this study’s results only account for 60.6% of the impact factors on the social and corporate governance performance and corporate financial performance in listed Vietnamese enterprises, so there are still some other factors that should be identified in future research. This study contributes not only to the existing empirical literature on corporate governance performance and corporate financial performance, but also on practical management in Vietnam and other developing economies.
Tran Ngoc Hung Anh(트란녹훙안),Myungsik Yoo(유명식) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.2
The expansion of 5G technology recently leads to the develop of Multi-Access Edge Network (MEC) as a potential solution to achieve the quality of service (QoS) of applications inside user devices (UDs). This article proposes a method in which MEC servers (MECSs) can communicate together, all receive the decision from MEC controller about how to sharing the resource to achieve the optimal processing delay of all QoS classes. This problem can be solved by proposed Deep Deterministic Policy Gradient (DDPG) framework.
Lipoxygenase Inhibitory Constituents from Rhubarb
Tran Minh Ngoc,Pham Thi Hong Minh,Tran Manh Hung,IkSoo Lee,민병선,Phuong Thien Thuong,배기환 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Phytochemical study on the ethanol extract of rhubarb led to the isolation of fifteen compounds, including five anthraquinones: chrysophanol (1), physcion (2), emodin (7), chrysophanol- 8-O-β-D-glucopyranoside (9) and emodin-8-O-β-D-glucopyranoside (15), and ten stilbenes: desoxyrhaponticin (3), rhaponticin (4), resveratrol (5), desoxyrhapotigenin (6), rhapontigenin (8), piceatannol-3'-O-β-D-glucopyranoside (10), piceid (11), ε -viniferin (12), ampelopsin B (13) and isorhaponticin (14). Their structures were identified by comparing the physicochemical data with those of published papers. Among the isolated compounds, stilbene derivatives (3-6, 8 and 10-14) showed remarkable inhibitory effect on lipoxygenase with IC50 values ranging from 6.7 to 74.1 μM. The inhibition kinetics analyzed by Lineweaver-Burk plots found that they were competitive inhibitors with the linoleic acid at the active site of lipoxygenase. In addition, stilbenes exhibited significantly free radical scavenging activity against ABTS•+ with trolox equivalent activity capacity (TEAC) values ranging from 1.16 to 4.64. Whereas, anthraquinone derivatives (1-2, 7, 9 and 15) neither inhibited lipoxygenase nor scavenged free radical ABTS•+. These results indicated that stilbene derivatives were considerate to be mainly lipoxygenase inhibitor and free radical scavenger constituents of rhubarb.