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김동준,김철민,강충남,왕진만,노권재,윤여헌 대한골절학회 1994 대한골절학회지 Vol.7 No.1
The clavicle plays very important role in the motion of the shoulder girdle and maintenance of power and stability of the arm. The most clavicular shaft fractures can be treated by conservative methods with a high rate of union and low rate of complications. The operative treatment in clavicular fracture is limited in such as wide separation of the fragments with soft tissue interposition, nonunion, or neurovascular involvements. From 1989 to 1991, eighty six consecutive patients with clavicular shaft fractures were treated at Ewha Womans University Hospital. Fifty eight patients were treated conservatively(Group I ) and twenty eight patients operatively(Group II) Authors compared both groups and obtained the following results; 1. The most common cause of injuries was the traffic accident and the most common associated skeletal injury around the shoulder was the rib fracture. 2. The degree of comminution and displacement of the clavicular shaft fracture were more severe in Group lI. 3. The average time to union was 8.7 weeks in Group I and 10.3 weeks in Group II. 4. The average rate of union at 4 months was 93.1% in Group I and 96.4% in Group II. 5. The functional result was good or excellent in over 90% in both Groups according to the Kang's criteria. 6. The rate of complication was 8.6% in Group I (one nonunion, three delayed unions and one malunion) and 3.6% in Group lI(only one case of nonunion) 7. The immobilization period was between 6 to 8 weeks in Group I and within 4 weeks in Group II in most cases.
Yeo, Inhyuk,Lee, Yong-Jik,Song, Kyeongseop,Jin, Hyeon-Su,Lee, Jae-Eun,Kim, Dajeong,Lee, Dong-Woo,Kang, Nam Joo Elsevier 2018 Journal of biotechnology Vol.271 No.-
<P><B>Abstract</B></P> <P>Bioactive peptides contribute to various cellular processes including improved skin physiology. Hence, bioactive keratins have attracted considerable attention as active cosmetic ingredients for skin health. Here, we obtained low molecular weight (LMW) keratins from native chicken feathers by anaerobic digestion with an extremely thermophilic bacterium <I>Fervidobacterium islandicum</I> AW-1, followed by stepwise fractionation through ultrafiltration. To assess the effects of the feather keratins on skin health, we performed in vitro and ex vivo assays to investigate their inhibitory effects on matrix metalloproteinases (MMPs). As results, LMW feather keratins marginally inhibited collagenase, elastase, and radical scavenging activities. On the other hand, LMW feather keratins significantly suppressed the expression of ultraviolet B (UVB)-induced MMP-1 and MMP-13 in human dermal fibroblasts. Furthermore, phospho-kinase antibody array revealed that LMW feather keratins suppressed UVB-induced phosphorylation of Akts, c-Jun N-terminal kinases 1, p38 beta, and RSK2, but not ERKs in human dermal fibroblast. Overall, these results suggest that LMW feather keratins are potential candidates as cosmeceutical peptides for anti-skin aging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Anaerobic digestion of native chicken feathers with <I>Fervidobacterium islandicum</I> AW-1, followed by ultrafiltration, can produce low molecular weight (LMW, < 1 kDa) keratins. </LI> <LI> LMW feather keratins marginally inhibited collagenase, elastase, and radical scavenging activities. </LI> <LI> LMW feather keratins significantly suppressed the expression of UVB-induced MMP-1 and MMP-13 in human dermal fibroblasts. </LI> <LI> LMW feather keratins are potential candidates as cosmeceutical peptides for anti-skin aging. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kang, Sunhee,Kim, Ryang Yeo,Seo, Min Jung,Lee, Saeyeon,Kim, Young Mi,Seo, Mooyoung,Seo, Jeong Jea,Ko, Yoonae,Choi, Inhee,Jang, Jichan,Nam, Jiyoun,Park, Seijin,Kang, Hwankyu,Kim, Hyung Jun,Kim, Jungjun American Chemical Society 2014 Journal of medicinal chemistry Vol.57 No.12
<P>A critical unmet clinical need to combat the global tuberculosis epidemic is the development of potent agents capable of reducing the time of multi-drug-resistant (MDR) and extensively-drug-resistant (XDR) tuberculosis therapy. In this paper, we report on the optimization of imidazo[1,2-<I>a</I>]pyridine amide (IPA) lead compound <B>1</B>, which led to the design and synthesis of Q203 (<B>50</B>). We found that the amide linker with IPA core is very important for activity against <I>Mycobacterium tuberculosis</I> H37Rv. Linearity and lipophilicity of the amine part in the IPA series play a critical role in improving in vitro and in vivo efficacy and pharmacokinetic profile. The optimized IPAs <B>49</B> and <B>50</B> showed not only excellent oral bioavailability (80.2% and 90.7%, respectively) with high exposure of the area under curve (AUC) but also displayed significant colony-forming unit (CFU) reduction (1.52 and 3.13 log<SUB>10</SUB> reduction at 10 mg/kg dosing level, respectively) in mouse lung.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2014/jmcmar.2014.57.issue-12/jm5003606/production/images/medium/jm-2014-003606_0013.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm5003606'>ACS Electronic Supporting Info</A></P>
Kang, Kui-Won,Kim, Hyo-Tae,Hwang, Joon-Cheol,Nam, Joong-Hee,Yeo, Dong-Hun The Korean Ceramic Society 2004 한국세라믹학회지 Vol.41 No.8
The sintering behavior, microstructure and microwave dielectric properties of Ca $Ti_{0.5}$F $e_{0.25}$N $b_{0.25}$ $O_3$ with CuO have been investigated. Among the range of additions, 3 wt% CuO was observed to perform most satisfactory for acting as a sintering aid. The dielectric properties were found to strongly depend on the sintered densities. The dielectric constant increased with sintering temperatures, while the Q${\times}$ $f_{0}$ value affected by second phase. For Ca $Ti_{0.5}$F $e_{0.25}$N $b_{0.25}$ $O_3$ with 3 wt% CuO sintered at 100$0^{\circ}C$ for 2 h, the dielectric properties with an $\varepsilon$$_{r}$ value of 56, a Q${\times}$ $f_{0}$ value of 3,500 GHz and a $\tau$$_{f}$ value of 10 ppm/$^{\circ}C$ were obtained and suggested for practical applications.cations.ons.ons.ons.