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안토시아닌 발현이 좋고, 저온기 다수성 잎상추 ‘미선’ 육성
장석우(Suk-Woo Jang),이종남(Jong-Nam Lee),김점순(Jeom-Sun Kim),전명희(Myeong-Hee Cheon),서명훈(Myeong-Hoon Seo),송명규(Myeong-Gyu Song),엄미정(Mi-Jeong Um),김희대(Hee-Dae Kim),고순보(Sun-Bo Ko) 한국육종학회 2015 한국육종학회지 Vol.47 No.2
A new lettuce cultivar ‘Misun’ (Lactuca sativa L.) with wrinkled traverse narrow elliptic and deep red leaf, which has late bolting and high yield. It was developed from a cross between ‘Yeoreum Jeocgchima’ (deep red leaf color) and ‘Yeoreum dukseomjeokchukmyeon’ (high yield). The cross and selection for advanced lines had been done by the pedigree method from 2001 to 2008. The advanced lines were evaluated for yield and adaptability at several locations in Korea (Gangwon-do, Gyeonggi-do, Chungcheongbuk-do, Jeollabuk-do, Gyeongnam-do, and Jeju-do) from 2009 to 2011 year. The ‘Misun’ has gray seed color and traverse narrow elliptic leaves. The shelf-life of ‘Misun’ was four weeks longer than ‘Dukseomjeokchukmyeon’ at 4℃. The anthocyanin content of ‘Misun’ (88.32 mg/100 g) was higher than that of ‘Dukseomjeokchukmyeon’(74.78 mg/100g). The BSL (latucin+8-deoxylactucin+lactucopicrin) content of ‘Misun’ (5.0 ug/g, DW) is lower than that of ‘Dukseomjeokchukmyeon’(12.0 ug/g, DW). Compared to ‘Dukseomjeokchukmyeon’, marketable yield of ‘Misun’(289 g per plant) was 11% higher than that of it, showed good yield in fall season cultivation and has particularly improved expression of red leaf color at high temperature cultivation in the field. Furthermore, its taste is better, more crispy, and sweeter than those of ‘Dukseomjeokchukmyeon’. Thus, this new cultivar ‘Misun’ can be suitable for cultivation in low temperature during spring and fall season season.
천선희,김준명,김응,홍천수 대한감염학회 1989 감염 Vol.21 No.2
Clinical and bacteriologic data of 50 anaerobic bacteremia patients were evaluated at Yonsei Medical Center during the period of January 1985 to June 1988. 1) The incidence of anaerobic bacteremia by age was 24% in the fifth decade and 20% in the sixth. The incidence by sex was 52% in males and 48% in females. 2) Of the 52 anaerobic microorganisms causing bacteremia, gram-negative bacilli were responsible in 25 cases (48%), gram-positive bacilli in 17 cases(33%) and gram-positive cocci in 10 cases(19%). 3) The most frequently isolated anaerobic bacteria were Bacteroides fragilis (33%) and Clostridium perfringens(15%). 4) Underlying diseases predisposing anaerobic bacteremia were neoplastic disease(34%), infectious disease(14%), liver and biliary disease(12%) and gastrointestinal disease (10%), etc. 5) The gastrointestinal tract (28.8%)was considered the most frequent route of infection in anaerobic bacteremia and the second nost frequent was the liver and biliary tract(17.4%). 6) The overall mortality was 30.2% and the factors associated with poor prognosis were severe underlying disease, polymicrobial infection, predisposing surgery, nosocomial acquisition, presence of shock or DIC and inadequate antibiotics. In conclusion, anaerobic bacteremia has a significant role of morbidity and mortality and severity of underlying disease has the greatest prognostic significance.
Cheon, Myeong-Sook,Kim, Myung-Hee,Lee, Su-Ui,Ryu, Shi-Yong,Kim, Ho-Kyoung,Min, Yong-Ki,Kim, Seong-Hwan Korean Institute of Oriental Medicine 2007 한국한의학연구원논문집 Vol.13 No.2
An imbalance in bone remodeling that is caused by increased bone resorption over bone formation leads to most adult skeletal diseases including osteoporosis. Since the development of anti-resorptive agents from natural substances has recently gained more interest in the treatment of osteoporosis, we evaluated the effects of 222 natural compounds on receptor activator of $NF-{\kappa}B$ ligand (RANKL)-induced of tartrate-resistance acid phosphatase (TRAP) activity in RAW264.7 murine macrophage cell, and found that berberine chloride is one of compounds inhibiting RANKL-induced TRAP activity. Berberine chloride significantly inhibited the RANKL-induced TRAP activity and the formation of multinucleated osteoclasts in a dose-dependent manner. In addition, berberine chloride prevented the RANKL-induced mRNA expression of TRAP, matrix metalloproteinase 9 and c-Src, which have been known to be highly expressed in the process of osteoclastogenesis. Interestingly, berberine chloride prevented the RANKL-induced activation of extracellular signal-regulated kinase (ERK) which is one of mitogen-activated protein (MAP) kinases. In conclusion, berberine chloride could inhibit the osteoclastogenesis via preventing the activation of ERK/MAP kinase signaling pathway.
Myeong Sook Cheon,Myung Hee Kim,Su-Ui Lee,Shi Yong Ryu,Ho Kyoung Kim,Yong Ki Min,Seong Hwan Kim 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.2
An imbalance in bone remodeling that is caused by increased bone resorption over bone formation leads to most adult skeletal diseases including osteoporosis. Since the development of anti-resorptive agents from natural substances has recently gained more interest in the treatment of osteoporosis, we evaluated the effects of 222 natural compounds on receptor activator of NF-κB ligand (RANKL)-induced of tartrate-resistance acid phosphatase (TRAP) activity in RAW264.7 murine macrophage cell. and found that berberine chloride is one of compounds inhibiting RANKL-induced TRAP activity. Berberine chloride significantly inhibited the RANKL-induced TRAP activity and the formation of multinucleated osteoclasts in a dose-dependent manner. In addition, berberine chloride prevented the RANKL-induced mRNA expression of TRAP. matrix metalloproteinase 9 and c-Src, which have been known to be highly expressed in the process of osteoclastogenesis. Interestingly. berberine chloride prevented the RANKL-induced activation of extracellular signal-regulated kinase (ERK) which is one of mitogen-activated protein (MAP) kinases, In conclusion, berberine chloride could inhibit the osteoclastogenesis via preventing the activation of ERK!MAP kinase signaling pathway.
Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin
Choi, Sung-Hee,Park, Hae-Sim,Cheon, Myeong-Sook,Lee, Kyung-Lim 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16
Aspirin is a popular nonsteroidal anti-inflammatory drug, but some patients suffer from hγpol·sensitivity to it. This prompted us to identify the factors or molecules related to these responses. A commercially available DNA microarray was used to study changes in gene expression in human peripheral blood mononuclear cells (PBMCs) after aspirin treatment. The BMCS were tollected from a patient with aspirin-intolerant asthma and one normal healthy control. We identifed 61 and 107 genes respectively induced and repressed by aspirin treatment in the PBMCS derived from the normal control. In the patient showing aspirin-induced asthma responses, 31 genes were up-regulated and 6 were down-regulated after aspirin treatment. Among these, 1 gene was expressed with the same pattern in the control and the patient. In contrast, 19 genes showed different expression patterns, and it turned out that most of them were involved In immune responses, cell growth/proliferation, transcription/translation, and signaling pathways. These results show the molerules involved in hypersensitivity to aspirin and may lead to a better understanding of adverse responses to aspirin. Furthermore, they can provide clues for identifying novel therapeutic and/or preventive molecular targets of the adverse effects of aspirin.
Lim, Soyoung,Cheon, Jae Hee,Son, Myeong Jin,Shin, Eui Sup Elsevier 2018 Materials & Design Vol.149 No.-
<P><B>Abstract</B></P> <P>This paper proposes a systematic procedure for the quantitative analysis of the surface changes caused by ablation of carbon-based ablators using a high-resolution non-contact profilometer. The ablation tests were performed under high enthalpy flow conditions using a 0.4MW arc-heated wind tunnel. The high-resolution profilometer was used to measure the surface data of carbon-based ablators. The key parameters for the analysis of the surface changes, such as surface recession and roughness, were calculated by the proposed procedure. In addition, a finite element model of the sample after the ablation test was constructed from the measured surface data. The proposed procedure can be effectively used to perform various analyses of the ablated surface using the measured data and numerical analysis method.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Carbon-based ablators were tested in an arc-heated wind tunnel at a maximum heat flux level of 9.6MW/m<SUP>2</SUP>. </LI> <LI> A surface data of carbon-based ablators were measured by a high-resolution profilometer. </LI> <LI> A systematic procedure using the measured surface data was proposed. </LI> <LI> The key parameters of the surface changes were calculated by the proposed procedure. </LI> <LI> A finite element model was developed from the measured surface data using proposed procedure. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>