근막 결손의 복원과 자궁천골인대 고정을 통한 전자궁적출술 후 질탈출의 성공적 교정

문화숙(Hwa Sook Moon),최진국(Jin Koo Choi),김경서(Kyung Seo Kim),박근식(Kyun Sik Park),황지영(Ji Young Hwang),문성은(Sung Eun Moon),한지원(Ji Won Han),김상국(Sang Gook Kim),김상갑(Sang Gap Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7

목적 : 본 연구는 전자궁적출술 후 질탈출을 부위-특이적인 결함의 개념에 입각하여 치골경부 근막과 직장질 격막의 연결을 통한 골반내 근막의 복원과 자궁천골인대 고정술을 이용한 질탈출의 성공적인 수술적 교정의 방법과 결과를 보고하고자 한다. 연구 방법 : 1999년부터 2001년 8월까지 자궁적출술 후 질궁탈출 증상으로 문화병원 산부인과를 내원, 탈출된 질의 근막을 재건시킨 다음, 이를 자궁천골인대에 고정시킴으로써 질의 부위-특이적인 교정술을 받은 3명의 환자를 대상으로 하였다. 3명중 1명은 개복술을 하였고 2명은 내시경 수술을 하였다. 결과 : 환자의 연령 분포는 49-67세였으며, 수술시간은 평균 113분 (105-125)이었다. 세 환자 모두 수술 후 질의 상태가 해부학 및 기능적으로 정상이었으며, 9일째 특이사항 없이 퇴원하였다. 수술 후 HRT를 시행한 1명을 포함한 3명 모두 각각 24개월, 12개월, 7개월간의 추적 검사에서도 특이한 합병증이나 재발 없이 좋은 경과를 보였다. 결론 : 골반 근막 결손의 복원과 자궁천골인대 고정술은 전자궁적출술 후 질탈출의 교정에 매우 안전하고 효과적이며, 기능적인 방법으로 사료되며, 자궁천골인대를 질탈출 교정에 이용한 연구는 본 연구가 국내에서 처음이다. Objective : To report the method and efficacy of the site specific-defects repair in the endopelvic fascia and uterosacral ligament suspension for the correction of posthysterectomy vaginal vault prolapse. Methods : This study was performed in 3 patients with posthyterectomy vaginal vault prolapse who underwent the surgery for the reconstruction of endopelvic fascia and the correction of vault prolapsed vagina by using uterosacral ligament suspension at the department of Obstetrics and Gynecology in Moon-Hwa Hospital. Among them, 1 patient was treated by laparotomy, and 2 patients were treated by laparoscope. Results : The age of patients ranged from 49 to 67 years. The mean operation time was 111 minutes (105-120 minutes). The status of postoperative vagina was normal in all 3 patients, who were discharged 9 days after operation without symptoms. No complication or recurrence were found in them despite long-term follow-up for 24 months, 12 months, 7 months, respectively after operation. One patient has been treated with HRT therapy. Conclusion : The reconstruction of the defect of endopelvic fascia and uterosacral ligament fixation may be very safe, effective, and functional in the correction of vaginal vault prolapse. This study reports the treatment of vaginal vault prolapse using uterosacral ligament within Korea for the first time.

균열을 내포하는 기계구조물의 파괴강도 및 피로수명설계 자동화를 위한 3차원 수치 모델링 기법 개발

韓文植 동양대학교 1995 동양대학교 논문집 Vol.1 No.1

본 논문에서는 최근 각종대형사고의 대책기술이 되고 있는 기계구조물의 안전설계 및 파괴 관리 제어 기술의 핵심부분으로서, 기계구조물에 필연적으로 존재하게 되는 임의의 평면 크랙 또는 표면 크랙등 다양한 결함이 되고 있는 파괴강도 평가 및 피로 수명설계 자동화를 위한 3차원 수치 모델링 기법을 유한요소법과 선형파괴역학을 이용하여 개발ㆍ제시하였다.개발된 기법은 공학상의 실제 문제인 기계구조물내 다양한 형태의 결함에 대한 해석에 많은 잇점이 있었으며, 기존의 해석방법보다 정확하고 간편함을 보였다. This paper describes a versatile finite element technique which has been used to investigate the fatigue life and fracture strength of a wide range of structural defects of practical importance.The procedure automatically remeshes the three-dimensional finite element model during the stages of crack growth for the design automation of the fatigue life and fracture strength. Problems analyzed to date include the subsurface cracks in leak-before-break situations, the development of quarter-elliptical corner defects, the interaction and coalescence of five adjacent coplanar semi-elliptical surface defects and the fatigue life and fracture strength according to the fatigue growth of a defect in machine structure.

혈관평활근세포에서 산화에너지대사 억제에 의한 아밀로이드전구단백질 대사의 변화

한문구,최웅,김헌식,안희열,한설희 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: A reduction in the activity of cytochrome c oxidase(COX) has been recently identified in mitochondria from platelets and postmortem brain tissue of AD patients Sodium azide (NaN₃). a COX inhibitor, is an effective chemical agent producing energy shortage and oxidative stress both in vitro and in vivo system Furthermore it has been suggested that vascular compromise could be either directly involved AD pathogenesis or indirectly associated with triggering pathogenetic events leading to AD This study was performed to investigate amyloid precursor protein (APP) metabolism by inhibition of mitochondrial energy metabolism in cultured vascular smooth muslce cells (VSMCs) Materials and Methods: VSMCs isolated from the aorta of seven weeks old Spraque-Dawley rat were treated with NaN₃in a low concentration (100-500μM) or in a high concentration (1-100mM) Cellular proliferation and viability were determined by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenly)-2H-tetrazolium) assay Cellular APP was detected with N-terminal specific antibody 22C11. Celldeath was determined by observation of morphology and terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick end labeling stain (TUNEL) We used ginkgo biloba extract(EGb761) and melatonin as anti-oxidants to investigate the mechanism of latered APP metabolism Results: The viability of VSMCs was increased after treatment with 1 mM and 10mM NaN₃(p<0.05) unitl 3 hr and then dimnished Many TUNEL positive cells were found in 10mM and 100mM treatment group. but were not apoptotic in nature 22C11 immunoreactivity was not changed at 3 hr, 6hr, 12hr Anti-oxidants reduced cellular proliferation (p<0.05). but did not block TUNEL positivities and did not influence the 22C11 immunoreactivity In a low concentration NaN₃ treatment group the viability of VSMCs was increased concentration dependently(p<0.05) Immunoblot with 22C11 showed the concentration dependent decrease at 145 kDa, 125 kDa. and high molecular weight range (>160kDa) TUNEL staining showed DNA fragmentations and condensations of nuclear chromatin suggesting apoptosis After treatment with anti-oxidants, the cellular proliferation was more decreased (p<0.05), and TUNEL positive cell deaths were blocked Immunoreactivities of 125 kDa (immature APP). 145 kDa (mature APP). and higher molecular weight bands were recovered below 400μM of NaN₃ Immunoreactivity of 145 kDa was recovered in 100 μM NaN₃ treated group Conclusions: The presumed mechanism of low concentration COX inhibitor is the overproduction of reactive oxygen species resulting from a depression of the mitochondiral electron transport chain. whereas potential consequence of high concentration COX inhibitor might be related to decreassion of ATP synthesis and bioenergetic impairment Reactive oxygen radicals in response to low concentration COX inhibitor alter the processing of APP in VSMCs This investigation demonstrated analtered APP metabolism as a peripheral marker of AD Therefore VSMCs treated with low concentration COX inhibitor could be concsidered as a novel in vitro model of AD.

아파트 프로젝트의 시공성 실무적용방안 분석에 관한 연구

한경훈,김문규,박찬식 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

Process of construction project is made of plan, design, procurement, construction, and maintenance, which are closely related each other. for the success of project, each step of process should maintain the interface. The concept of constructability appeared in the practical business of an advanced country to maximize efficient integration. However, the concept of constructability in our country is not used in overall process to optimize each phase. To proceed the study, first, impact factors of constructability were identified, and had an interview with professionals. As a result, complexity of design in design phase, and responsibility of the contractors in construction phase are analyzed as the most important thing. Based on this result, I made secondary survey to identify the facts needs to be considered to applicate the analysis on the practical business. As the result of secondary survey, the ranking of considerations for application of practical business was identified. Therefore, this study suggested the basic direction to the applications of constructability.

낙동강 중류부에서의 최적 수질관리 기법의 개발

한건연,박문호,이정식 경북대학교 산업기술연구소 1991 産業技術硏究誌 Vol.19 No.-

Optimum water quality management in the midstream of the Nakdong river was studied. Deterministic water quality model RQ1 and stochastic water quality model RQ2 have been developed. RQ1 contains two codes, RQ1-1 for hydraulic analysis and RQ1-2 for water quality analysis. RQ2 consists of Monte-Carlo simulation for the DO analysis in river. A water quality simulation using RQ1 and RQ2 in the midstream of the Nakdong river has been made. The computed concentration of DO and BOD at several points have good agreements with the observed data. BOD-DO profiles in this basin and the probability distribution for DO concentration at some points have been predicted in 1996 and 2001. This study provides the optimum water quality management planning in the future using the deterministic and stochastic water quality model.

아말감 와동의 파절에 관한 3차원 유한요소법적 연구

김한욱,엄정문,이정식 大韓齒科保存學會 1994 Restorative Dentistry & Endodontics Vol.19 No.2

판재에 있는 구멍 또는 이종재료 사이에서의 크랙 전파 거동

조재웅,한문식 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This study investigates the behavior of fatigue crack propagating between holes or holes filled with another materials. When holes or the holes bonded with another materials exist near center crack symmetrically, crack propagation rate is influenced by the bonding force of brazing part and the elastic modulus ratio of another material to matrix. It is experimentally and analytically confirmed that the center crack stops when its tip reaches near the center line of the holes and a small crack is initiated from the boundaries of holes or the holes filled with another materials and it propagates to final fracture. The mechanical behaviors of center crack near another materials are also investigated.

원판 브레이크에서의 피로 파괴 해석

조재웅,한문식 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This study investigates the fatigue life and the damage possibility of disk brake by the fatigue tool of Ansys workbench. Among nonconstant fatigue loads, the case of 'SAE Bracket History' which is severest at the variation of load tends to be most unstable. The case of 'Sample History' which becomes a little slow at the variation of load tends to be most stable. The maximum relative damage in case of 'SAE Bracket History' is occurred near the average stress '0' and this case can be shown to have the possibility to take more damage than another case.

동적 파괴 가속장치의 보정 및 시험장치 설계

조재웅,한문식 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

The force transducer in the acceleration plant due to dynamic fracture is calibrated by dynamically using the stress pulses from a longitudinal bar. The bar is supported by two strings attached to the ceiling. The bar velocities before and after impact are measured and a full bridge at bar and transducer is formed by the four strain gauges. A transient recorder is used to store the stress pulse signals of force transducer and bar. For the first test series, three point bend test specimens can be chosen by means of test rig design and the inspection as sample experiment in this presented paper is sufficient for proving with the numerical simulation of the specimen model.

방사선 조사에 의한 흰주 난포의 퇴축과 난포세포의 방사선 감수성

김수일,한승로,조근자,허대영,이영호,조문준,김무강,김원식 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

The aim of this study were to investigate radiation-induced atresia and radiation susceptibility in the rat ovary morphologically. Female rats (Sprague Dawley strain) of 4 weeks old were irradiated with dose of 4 Gy and 8 Gy, and sacrificed at hour 6, 12, and 24 after radiation. The H & E stain, the TUNEL method (ApopTag kit) and transmission electron microscopy (TEM) were used. In light microscopic observation, the number of atresia of ovarian follicles were increased significantly at 6h after irradiation (p<0.01). There was no significant difference between 4 Gy and 8 Gy irradiated groups. In TEM observation, granulosa cells in radio-sensitive follicles were characterized by several structural features including condensation of nuclear chromatin granules, nuclear fragmentation and apoptotic body formation. An apoptotic cell is observed to have been phagocytosed by a normal granulosa cell. Granulosa cells in radio-resistant follicles were characterized by several structural features including nuclear indentation, partial condensation of chromatin granules, mitochondrial swelling, dilatation of RER cisterns, accumulation of dense irregular masses, accumulation of lipid droplets, and increased lysosomal bodies. Number of gap junctions between granulosa cells were decreased, and intercellular space were widen than that of control animals. These findings were prominent at 6h after irradiation and were diminished at 12h and 24h after irradiation. With these results, it was concluded that radiation-induced follicular cell apoptosis and ovarian follicular atresia in rat ovary increased considerably at 6h after irradiation. Further studies are needed to reveal the more extensive differences between radiosensitive and radioresistant follicular granulosa cells.