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朴在贊,金武剛,金弘善,申台均 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1
This paper dealt with the histological feature of the Pekin duck olfactory mucosa and the specificity of the types of mucopolysaccharides present in the secretory cells of the duck olfactory mucosa. The nasal parts of ducks (1-week-old and 10-week-old) were fixed with 10% neutral formalin, decalcified, embedded in paraffin. Serial sections were cut 5 um thick and stained with alcian blue(pH 2.5) to demonstrate acidic mucopolysaccharides and the periodic acid-Schiff reaction to identify neutral mucopolysaccharides. The results were summarized as follows. 1. The duck olfactory mucosa consisted of the olfactory epithelia which compose of the receptor neurons, supporting cells, basal cells and goblet cells, and the lamina propria which contained Bowman's glands, olfactory nerve bunbles and connective tissue cells. 2. The thickness of the olfactory mucosa was 121.5±25.67um in the 1-week-old ducks, and 202±45.82km in the 10-week-old ducks. Increased thickness of olfactory mucosa was due to the increased thickness of lamina propria. 3. Histochemical techniques of the olfactory mucosa in 10-week-old ducks demonstrated that Goblet cells, sppporting cells and Bowman's gland contained both neutral and acidic mucopolysacc harides, the neutral mucopolysaccharides staining became enhanced first in the Goblet cells and Bowman's gland, and then in supporting cells. In 1-week-old ducks, both acidic and neutral mucopolysaccharides of Goblet cells reacted strongly, but those of supporting cells and Bowman's gland reacted presumably.
폴리에스테르 섬유 감량시스템용 프로세서 타이트레이터 개발
조진호,이흥락,이종현,김명남,구성모,김무영,진경찬,유병희,강민수,김국진 경북대학교 센서기술연구소 1993 연차보고서 Vol.1993 No.-
폴리에스테르 섬유 감량시스템의 제어를 위해서는 처리조 내에서 감량되는 섬유가 목표 감량치에 도달했는지를 판단해 주는 장치가 필요하다. 본 연구에서는 가성소다용액의 초농도 및 섬유 감량 정도의 정확한 측정과 감량 종료시간의 산출 및 이에 따른 종료신호를 발생할 수 있는 폴리에스테르 섬유 감량기 전용의 자동적정장치를 개발하였다. To control caustic soda treatment system for the polyester fabric reduction, we need the device to determine that the fabric has been arrived target reduction value. In this study, we develope an automatic process titrator for the caustic soda treatment system. Major functions of the target titrating system are accurate measurements of the caustic soda concentration and then producing the end point signal for caustic soda treatment system.
Kang, Chan Woo,Jang, Kang Won,Sohn, Jinyoung,Kim, Sung-Moo,Pyo, Kyoung-Ho,Kim, Hwan,Yun, Mi Ran,Kang, Han Na,Kim, Hye Ryun,Lim, Sun Min,Moon, Yong Wha,Paik, Soonmyung,Kim, Dae Joon,Kim, Joo Hang,Cho, American Association for Cancer Research 2015 Molecular Cancer Therapeutics Vol.14 No.10
<P><I>RET</I> rearrangement is a newly identified oncogenic mutation in lung adenocarcinoma (LADC). Activity of dovitinib (TKI258), a potent inhibitor of FGFR, VEGFR, and PDGFR, in <I>RET</I>-rearranged LADC has not been reported. The aims of the study are to explore antitumor effects and mechanisms of acquired resistance of dovitinib in <I>RET</I>-rearranged LADC. Using structural modeling and <I>in vitro</I> analysis, we demonstrated that dovitinib induced cell-cycle arrest at G<SUB>0</SUB>–G<SUB>1</SUB> phase and apoptosis by selective inhibition of RET kinase activity and ERK1/2 signaling in <I>RET</I>-rearranged LC-2/ad cells. Strong antitumor effect of dovitinib was observed in an LC-2/ad tumor xenograft model. To identify the acquired resistance mechanisms to dovitinib, LC-2/ad cells were exposed to increasing concentrations of dovitinib to generate LC-2/ad DR cells. Gene-set enrichment analysis of gene expression and phosphor-kinase revealed that Src, a central gene in focal adhesion, was activated in LC-2/ad DR cells. Saracatinib, an src kinase inhibitor, suppressed ERK1/2 phosphorylation and growth of LC-2/ad DR cells. Taken together, these findings suggest that dovitinib can be a potential therapeutic option for <I>RET</I>-rearranged LADC, in which acquired resistance to dovitinib can be overcome by targeting Src. <I>Mol Cancer Ther; 14(10); 2238–48. ©2015 AACR</I>.</P>
Kim, Sung-Moo,Kim, Hwan,Jang, Kang Won,Kim, Min Hwan,Sohn, Jinyoung,Yun, Mi Ran,Kang, Han Na,Kang, Chan Woo,Kim, Hye Ryun,Lim, Sun Min,Moon, Yong Wha,Kim, Joo Hang,Paik, Soonmyung,Cho, Byoung Chul American Association for Cancer Research 2016 Molecular Cancer Therapeutics Vol.15 No.7
<P>Although treatment of BRAF V600E-mutant non-small cell lung cancer (NSCLCV600E) with GSK2118436 has shown an encouraging efficacy, most patients develop resistance. To investigate the mechanisms of acquired resistance to GSK2118436 in NSCLCV600E, we established GSK2118436-resistant (GSR) cells by exposing MV522 NSCLCV600E to increasing GSK2118436 concentrations. GSR cells displayed activated EGFR-RAS-CRAF signaling with upregulated EGFR ligands and sustained activation of ERK1/2, but not MEK1/2, in the presence of GSK2118436. Treatment of GSR cells with GSK2118436 enhanced EGFR-mediated RAS activity, leading to the formation of BRAF-CRAF dimers and transactivation of CRAF. Interestingly, sustained activation of ERK1/2 was partly dependent on receptor-interacting protein kinase-2 (RIP2) activity, but not on MEK1/2 activity. Combined BRAF and EGFR inhibition blocked reactivation of ERK signaling and improved efficacy in vitro and in vivo. Our findings support the evaluation of combined BRAF and EGFR inhibition in NSCLCV600E with acquired resistance to BRAF inhibitors. (C) 2016 AACR.</P>
Thermal Performance of a Finned-tube Heat Exchanger used in Condensing Gas Boiler
Kang, Hie-Chan,Lim, Bok-Bin,Lee, Jung-Man,Kim, Moo-Han The Society of Air-Conditioning and Refrigerating 2009 International Journal of Air-Conditioning and Refr Vol.17 No.2
In the present study, an experiment was conducted to investigate the heat and mass transfer performance of heat exchangers used in the condensing gas boiler. Two types of spiral circular fin-tube heat exchangers and a plain tube were tested in the flue gas of propane and dry air. Heat and mass transfer coefficients were measured and compared with the previous correlations. The experimental data for the sensible heat transfer of the plain tube reasonably agreed with the previous correlations for dry air and flue gas. However, the mass transfer coefficient of the plain tube was greater than the previous correlations. The pH, $NO_x$, and $SO_x$ data of condensate were provided.
강진무,권태찬,이상락,엄정심 啓明大學校 醫科大學 1992 계명의대학술지 Vol.11 No.3
The clinical study was done on 19 cases of near-drowning which were admitted to the Department of Pediatrics, Dong-San Hospital, Keimyung University during the period from January, 1983 to June, 1990. The results were as follows: Out of 19 cases, 15 were male and 4 were female. The sites of the accident included river in 6 cases, ponds in 4 cases, bathtub in 3 cases, toilet in 3 cases and pool in 2 cases. Out of 19 cases, 14 were recovered without detectable neurologic sequelae, 3 had anoxic encephalopathy and 2 had delayed death. 5 cases who were dead or associated with anoxic encephalopathy had duration of immersion over 5 minutes and needed cardiopulmonary resuscitation at emergency room. The parent's estimation of the duration that the child was missing and/or immersed correlated with the child's neurologic prognosis. Severe metabolic acidosis and mild hypokalemia occured in patients who had anoxic encephalopathy and delayed death. The most common respiratory complications were aspiration pneumonia and pulmonary edema. The neurologic sequelae were hemiparesis & language disability.