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Ming-Zhe Hou,Ai-Guo Wu,Guang-Ren Duan 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.2
This paper presents a novel stochastic finite-time stability theorem and gives its application in the finitetimeL2 L¥ filter design for nonlinear stochastic systems. Different form the frequently-used stochastic finitetimestability result, the proposed one does not require that all the states have the same fractional order exponent. Based on this result, a sufficient condition is given for nonlinear stochastic systems to possess the finite-time L2 L¥ performance with a prescribed gain. Further, an existence condition of the finite-time L2 L¥ filter with aprescribed disturbance attenuation level is given for nonlinear stochastic systems with external disturbance inputs. The effectiveness of the obtained results is illustrated by an example.
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Hou Ming-dong,Zhou Xiang-wen,Liu Bing 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.2
Beryllium oxide (BeO) is being re-emphasized and utilized in Micro Modular Reactors (MMR) because of its prominent nuclear and high temperature properties in recent years. The implications of the research about effects of neutron irradiation on the microstructure and properties of BeO are significant. This article comprehensively reviews the effects of neutron irradiation on BeO and proposes the maximum permissible neutron doses at different temperatures for BeO without cracks in appearance according to the data in the previous literature. This maximum permissible neutron dose value has important reference significance for the experimental study of BeO. The effects of neutron irradiation on the thermal conductivity and flexural strength of BeO are also discussed. In addition, microstructure evolution of irradiated BeO during post-irradiation annealing is summarized. This review article has important implications for the application of BeO in MMR
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Robust Adaptive Dynamic Surface Control of Uncertain Nonlinear Systems
Ming-Zhe Hou,Guang-Ren Duan 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.1
This paper studies the robust adaptive dynamic surface control of a class of nonlinear systems with unmatched uncertainties. The unmatched uncertainties consist of not only the linearly parameterized terms but also the nonlinearly parameterized terms. The bound of each nonlinearly parameterized uncertainty term is supposed to be expressed by a known nonnegative function multiplied by a constant called bound parameter. According to whether the bound parameters are known or not, two different kinds of robust adaptive dynamic surface control algorithms are proposed. It is proved that in each case all the states of the closed-loop system are kept uniformly ultimately bounded, and the output is driven to track a feasible desired output trajectory with an arbitrarily small error. An example is also employed to indicate the effect of the proposed methods.
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Hou Ming-dong,Zhou Xiang-wen,Liu Bing 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.12
In recent years, beryllium oxide has been widely utilized in multiple compact nuclear reactors as the neutron moderator, the neutron reflector or the matrix material with dispersed nuclear fuels due to its prominent properties. In the past 70 years, beryllium oxide has been studied extensively, but rarely been systematically organized. This article provides a systematic review of the application history, thermal properties, mechanical properties, corrosion behavior and fabrication methods of beryllium oxide. Data from previous literature are extracted and sorted out, and all of these original data are attached as the supplementary material, so that subsequent researchers can utilize this paper as a database for beryllium oxide research in reactor design or simulation analysis, etc. In addition, this review article also attempts to point out the insufficiency of research on beryllium oxide, and the possible key research areas about beryllium oxide in the future.
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Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
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Fang-Ming Chen,Hsueh-Wei Chang,Sheau-Fang Yang,Ya-Fang Huang,Pei-Yung Nien,Yao-Tsung Yeh,Ming-Feng Hou 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.5
The mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) belongs to the MAPK cascades which are central to cell proliferation and apoptosis. The carcinogenic role of MKP-1 has been reported in many types of cancer but it has rarely been investigated in breast cancer. The present study was designed to evaluate the MKP-1 mRNA expression and its possible regulation by methylation of MKP-1 promoter in the model of several breast cancer cell lines and tissues as well as controls. Our data demonstrate MKP-1mRNA expression significantly decreased in five breast cancer cell lines compared to breast controls (P <0.01). Using the methylation-specific PCR (MSP) analysis,the unmethylated reaction (U) is dominant in both normal cell lines and benign breast tumors (100% vs. 86.2%), whereas the methylated reaction (M) is dominant in both breast cancer cell lines and invasive breast tumors (100% vs. 57.2%). In terms of methylation ratio (M/M+U), methylation level in MKP-1 promoter is significantly higher in the invasive breast tumor tissues (n = 152) than in benign breast tumor tissues (n = 29)(P < 0.0001). Assessing the methylation ratio of the promoter of MKP-1 gene to diagnose the breast malignancy (invasive vs. benign), the area under the receiver-operating characteristic (ROC) curve was 0.809(95% CI: 0.711-0.906, P < 0.001). The best performance for this prediction has a sensitivity of 76.32% and a specificity of 82.76% at the cutoff value of 0.38. Taken together, we firstly demonstrated that the promoter methylation of MKP-1 gene is a potential breast cancer biomarker for breast malignancy.
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Yan-Ming Mu,Xiang-ying Hou,Si-wei Yang,Xue-Ming He 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.5
For upgrading the transmission performance of spiral bevel gear and extending the time between overhauls of the helicopter reducer, an innovative multi-objective collaborative optimization strategy of shape and performance is put up for the super-high-contact-ratio spiral bevel gear transmission with the contact path along tooth width based on ease-off. Firstly, according to the preset contact path curve along tooth width and the symmetrical transmission error curve, the pinion optimal surface satisfying the preset functions is obtained based on ease-off. Secondly, based on the basic principles of simulated annealing and gravitational search, the simulated annealing-gravity search cooperative intelligent optimization algorithm is set up for the calculation of the multi-objective collaborative optimization model of the spiral bevel gear transmission, and the modified surface of pinion satisfying the function requirements is obtained based on the collaborative optimization of shape and performance. Finally, combined with the tooth contact analysis method, meshing impact analysis method and dynamic analysis method, the loaded transmission error, meshing impact and dynamic performance of the super-high-contact-ratio spiral bevel gear transmissions are discussed. The simulation result shows the contact path of the collaborative designed spiral bevel gear transmission is along the tooth width, and the contact ratio reaches the maximum. The loaded transmission error, meshing impact, dynamic load factor and root mean square of vibration acceleration of the collaborative design spiral bevel gear transmission are all smaller than the original design and optimized design spiral bevel gear transmissions. The feasibility of the innovative multi-objective collaborative optimization strategy of shape and performance for the spiral bevel gear is verified, and the super-high-contact-ratio design can greatly cut down the contact vibration of the spiral bevel gear transmissions and better the helicopter’s performance.
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Nai-ming Hou,Xiang-zhe Cui 한국인터넷방송통신학회 2022 International journal of advanced smart convergenc Vol.11 No.4
For a long time, traditional culture has been regarded as one of the sources of the inspiration, method and language of Chinese writing. In this article, we studied the medium- and long-term impact of a traditional Chinese culture seminar attended by college students on the output of creative writing. The seminar included traditional Chinese philosophy, history, literature, art, etc. It spanned three years (22 months) and held lectures lasting for approximately two hours once a week. The subjects of the prospective cohort study included 130 first-year college students who participated in the seminar and 130 controls. From September 2016 to June 2018, 72 lectures were held. We measured the creative writing output from the first lecture (September 2016) to December 2021 (64 months in total), including novels, essays, poems, and plays. Two indicators, the total number of words (TNW) and the quality of yield (QY), were evaluated by a 15-member panel. Although the TNW and QY of the participants and their controls were similar before the seminar, we found that the participants have higher TNW and QY than the controls after participating in the seminar. The difference in TNW became significant after month 51 (p<0.05), and the difference in QY became significant after month 46 (p<0.05). After these dates, the differences stabilized. In addition, text analysis indicates that by month 64, traditional cultural elements in the works of the participating group had a higher frequency (p<0.001). The research shows that the traditional culture seminar not only enhanced the yield of college students' creative writing but also improved the quality of their work. The traditional cultural elements enriched the works of the seminar participants.
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