용도지역의 공간적 특성과 범죄발생 특성 분석 연구

서민진(Min-jin Seo),서연아(Yeon-a Seo),강석진(Seok-jin Kang) 한국셉테드학회 2019 한국셉테드학회지 Vol.10 No.3

Developed at the center of the Old Downtown, J-City became a multi-centralization structure as the functions of the city center were dispersed after the creation of the innovative city, and the Old Downtown is declining due to the reduction of the floating population and the differentiation of functions. Crime data analysis shows that theft-crime hot spot are forming in the newly formed urban areas, but hot spots in the Old Downtown are also steadily maintained. In this study, the relationship between crime and spatial characteristics and physical factors was analyzed among residential Areas and commercial Areas located in the Old Downtown of J-City, based on the most frequent cases of theft in the A-Dong (Residential Areas) and B-Dong (Commercial Areas). The targeted crime was set at the center of theft (street, invasion) considered controllable by the CPTED(Crime Prevention Through Environmental Design). Physical factors to be used for analysis through prior research were classified as street characteristics, building characteristics, facilities and space characteristics, crime safety characteristics, and space characteristics. The study found that first, in the residential Areas of A-dong theft is related to emergency bell Presence or Absence and fifth major crimes are related to street-wide appropriateness, emergency bell Presence or Absence and integration, and violent crime is related to entertainment place. In particular, crime tended to increase as the degree of integration by segmented axial angle analysis was reduced. This is consistent with existing studies, which show that the centrality of space and the amount of walking (or floating population) are closely related to crime. Second, in the commercial Areas of B-dong, there was no significant relationship between theft and five major crimes with physical factors. But Violent crimes were found to be related to the state of management of the street environment, whether or not to enter a separate space, whether empty houses or public notices are available, and Presence or Absence there is a safe place (convenience store). Third, the analysis of the relationship between spatial characteristics and theft without distinction of use area showed that appropriateness of street width, cleaning and management of street, hideable obstacle, management of entrance door on the first floor, installation of barrier windows, CCTV monitoring range, lighting facility, visibility of crime facilities, entertainment center, and safe space are related to crime. The area under study is narrow and the crime sample is small, so the generalization of the results is limited. But, The significance of the research is that the differences in the physical environment of each Land Use Areas were identified and the occurrence of theft changed depending on the spatial characteristics and physical factors. In subsequent studies, it is necessary to consider the relationship of criminal occurrence by combining the characteristics of the social population along with the spatial characteristics for a wider range of use areas. 원도심을 중심으로 발달한 J시는 혁신도시조성 후 도심 기능이 분산되면서 다핵화 구조가 되었고, 유동인구 감소 및 기능의 분화로 원도심은 쇠퇴하고 있다. 범죄자료 분석결과 새로 형성된 도심지역으로 절도범죄 핫스팟이 형성되고 있지만 원도심에서의 핫스팟도 꾸준히 유지되는 것으로 나타났다. 이에 본 연구에서는 J시 원도심에 위치한 주거밀집지역과 상가밀집지역 중 절도범죄가 가장 많이 일어난 A동(주거밀집지역)과 B동(상업밀집지역)을 대상으로 범죄와 공간특성 및 물리적 요인의 관계를 분석하였다. 대상 범죄는 범죄예방디자인(Crime Prevention Through Environmental Design, CPTED)으로 통제 가능하다고 여겨지는 절도범죄(노상, 침입) 중심으로 설정하고, 선행연구고찰을 통해 분석에 사용할 물리적 요인은 가로특성, 건물특성, 시설특성, 범죄안전 특성, 공간구조 특성으로 분류하였다. 연구결과 첫째, 주거밀집지역인 A동에서 절도범죄는 비상벨 유무, 5대 범죄는 가로 폭의 적절성, 비상벨 유무, 통합도와 관계가 있으며, 폭력범죄는 유흥업소와 관계가 있는 것으로 나타났다. 특히 분절축선 각도분석에 의한 통합도가 낮아질수록 범죄가 증가하는 경향이 있었는데, 이는 기존 연구와 일치하는 것으로 공간의 중심성과 보행량(또는 유동인구)이 범죄와 밀접한 관련이 있음을 알 수 있다. 둘째, 상업밀집지역인 B동에서는 절도범죄와 5대 범죄는 물리적 요인과 유의미한 관계는 확인되지 않았지만, 폭력범죄는 가로환경 관리상태, 이격공간 출입통제 여부, 빈집 또는 공지여부, 안심공간(편의점) 유무가 관계가 있는 것으로 나타났다. 셋째, 용도지역을 구분하지 않고 공간적 특성과 절도범죄의 관계를 분석한 결과 가로 폭의 적절성, 가로의 청소 및 관리상태, 은신가능 장애물, 1층 출입문 관리상태, 방범창 설치여부, CCTV 감시범위, 조명시설, 방범시설 시인성, 유흥업소, 안심공간 유무 등이 범죄와 유의미한 관계가 있는 것으로 나타났다. 연구대상 지역의 범위가 협소하고 범죄표본이 적어 결과의 일반화에 한계가 있지만 용도지역별 물리적 환경의 차이를 규명하였고, 공간적 특성 및 물리적 요인에 따라서 절도범죄 발생이 변함을 확인했다는 측면에서의 연구의 의의를 가진다. 후속 연구에서는 보다 다양한 용도지역을 대상으로 공간적 특성과 함께 사회인구적 특성을 종합하여 범죄발생의 관계를 고찰할 필요가 있다.

Effect of Jaeumkanghwatang (JEKHT), a Polyherbal Formula on the Pharmacokinetics Profiles of Tamoxifen in Male SD Rats (1)

Min A Kwak,Soo Jin Park,Sung Hwan Park,Young Joon Lee,Sae Kwang Ku 대한한의학회 2016 대한한의학회지 Vol.37 No.2

대전 지역에서 급성 A형 간염의 유전자형에 따른 임상 특성 고찰

이영우 ( Young Woo Lee ),양현웅 ( Hyeon Woong Yang ),이진아 ( Jin A Lee ),윤기호 ( Ki Ho Yun ),양성은 ( Seong Eun Yang ),이민지 ( Min Ji Lee ),박세영 ( Se Young Park ),김새희 ( Sae Hee Kim ),이향이 ( Hyang Ie Lee ),이윤정 ( Yun Ju 대한내과학회 2011 대한내과학회지 Vol.80 No.5

Background/Aims: Acute viral hepatitis A is a major health problem in Korea and the influx of genotype IIIA is thought to be one reason. We examined the differences in the clinical characteristics and laboratory findings of genotypes IA and IIIA in Daejeon. Methods: From November 2009 to June 2010, 81 patients positive for IgM anti-HAV were enrolled prospectively. The hepatitis A was genotyped using real-time polymerase chain reaction. The clinical characteristics and laboratory results were compared on the Results: The mean patient age was 32.6±7.4 years. The mean hospitalization was 7.7±2.4 days. The patient occupation varied. Clinically, vomiting and diarrhea were relatively more prevalent in genotype IIIA than in IA. Abdominal pain and skin spots were relatively more prevalent in genotype IA than in IIIA. The hemoglobin, peak aspartate aminotransferase (AST) level, and C-reactive protein were statistically higher in genotype IIIA than in IA. The distributions of the peak AST, alanine aminotransferase (ALT) and total bilirubin values tended to be perched in genotype IIIA than in IA. The international normalized ratio (INR) tended to be slightly prolonged in genotype IIIA than in IA. Conclusions: Recently, genotype IIIA of acute viral hepatitis A has become prevalent in Daejeon. Hepatitis A genotype IIIA probably causes worse laboratory abnormalities than genotype IA.

Poly(vinylbenzyl chloride-glycidyl methacrylate)/Polyethylene Composite Anion Exchange Membranes for Vanadium Redox Battery Application

Park, Min-A,Shim, Joonmok,Park, Se-Kook,Jeon, Jae-Deok,Jin, Chang-Soo,Lee, Ki Bong,Shin, Kyoung-Hee Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.6

Anion exchange membranes for a vanadium redox flow battery (VRB) were prepared by pore-filling on a PE substrate with the copolymerization of vinylbenzyl chloride (VBC) and glycidyl methacrylate (GMA). The ion exchange capacity, water uptake and weight gain ratio were increased with a similar tendency up to 65% of GMA content, indicating that the monomer improved the pore-filling degree and membrane properties. The vanadium ion permeability and open-circuit voltage were also investigated. The permeability of the VG65 membrane was only $1.23{\times}10^{-7}\;cm^2\;min^{-1}$ compared to $17.9{\times}10^{-7}\;cm^2\;min^{-1}$ for Nafion 117 and $1.8{\times}10^{-7}\;cm^2\;min^{-1}$ for AMV. Consequently, a VRB single cell using the prepared membrane showed higher energy efficiency (over 80%) of up to 100 cycles compared to the commercial membranes, Nafion 117 (ca. 58%) and AMV (ca. 70%).

Genetic diversity analysis of Agaricus bisporus strains by Inter simple sequence repeat (ISSR) and SSR–PCR

Kyong-Jin Min,Sang-Su Kim,A-Min Kwak,Youn-Lee Oh,Won-Sik Kong,Hee-Wan Kang 한국버섯학회 2014 버섯 Vol.18 No.2

Twenty Inter simple sequence repeat (ISSR) and 30 SSR primers were used to assess genetic diversity of 64 Agaricus strains including 45 A. bisporus strains and other 19 Agaricus spp. Of them, four ISSR primers, (GA)₈T, (AG)₈YC, (GA)₈C and (CTC)₆and seven SSR markers produced PCR polymorphic bands between the Agaricus species or within A. bisporus strains. PCR polymorphic bands were inputted for UPGMA cluster analysis. Forty five strains of A. bisporus are genetically clustered into 6 groups, showing coefficient similarity from 0.75 to 0.9 among them. The varieties, Saea, saedo, Saejeong and Saeyeon that have recently been developed in Korea were involved in the same group with closely genetic relationship of coefficient similarity over 0.96, whereas, other strains were genetically related to A. bisporus strains that were introduced from USA, Eroupe and Chinese.

Effect of Jaeumkanghwatang (JEKHT), a Polyherbal Formula on the Pharmacokinetics Profiles of Tamoxifen in Male SD Rats (1) - Single Oral Combination Treatment of Tamoxifen 50 mg/kg with JEKHT 100 mg/kg within 5 min -

Kwak, Min A,Park, Soo Jin,Park, Sung Hwan,Lee, Young Joon,Ku, Sae Kwang The Society of Korean Medicine 2016 대한한의학회지 Vol.37 No.2

Objectives: The objective of this study was to elucidate the effect of Jaeumkanghwatang (JEKHT) on the plasma concentration and pharmacokinetics of tamoxifen in combination therapy as a process of the comprehensive and integrative medicine against breast cancer. Methods: After 50 mg/kg of tamoxifen treatment, JEKHT 100 mg/kg was orally administered within 5 min. The plasma were collected at 30 min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of JEKHT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen ($T_{max}$, $C_{max}$, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats. Results: JEKHT did not influenced on the plasma concentrations and pharmacokinetics of tamoxifen after single oral co-administration, within 5min except for some negligible effects on plasma concentration. The $T_{max}$, $C_{max}$, AUC, $t_{1/2}$ and $MRT_{inf}$ of tamoxifen in co-administered rats were quite similar to those of tamoxifen single treated rats. Conclusions: Based on the results of the present study, JEKHT did not influenced on the oral bioavailability of tamoxifen, when they were single co-administered within 5min. However, more detail pharmacokinetic studies should be tested to conclude the possibilities that can be used as comprehensive and integrative therapy with JEKHT and tamoxifen for breast cancers, when they were co-administered, like the effects on the pretreatment of JEKHT and after repeat co-administrations.

지역불균형 시각에서 인천경제자유구역과 원도심과의 상호작용 분석: 인천시 중구, 연수구 및 서구를 중심으로

정진원(Jung, Jin-Won),최민아(Choi, Min-A) 인천발전연구원 2021 도시연구 Vol.- No.19

본 연구는 지역불균형 시각에서 인천경제자유구역과 각 자치구 원도심과의 상호작용 분석을 실시하였다. 지역의 경제성장과정에서 불균형 발전을 논한 A. Hirschman과 G. Myrdal은 경제발전 초기에는 성장 잠재력이 높은 거점지역이 주변지역의 많은 경제활동들을 흡수하는 분극화(역류) 효과 이후 누적(파급)효과가 나타는데 A. Hirschman은 불균형 발전의 완화를 가져온다고 주장하는 반면, G. Myrdal은 불균형 발전의 누적적 가속화가 진행된다고 주장한다. 2003년 인천경제자유구역 지정이후 18년 가량 지난 시점에서 각 자치구와의 경제요소간 상호작용 분석 결과, 인천경제자유구역 각 지구와 자치구 원도심간의 불균형 발전이 심화되는 것으로 나타났다. 이러한 불균형 발전을 완화하기 위해, 중구 원도심 활성화, 서구 및 연수구 원도심의 정주성 제고, 보행친화적 연계를 위한 공간계획 수립 및 IFEZ에서 원도심으로 파급효과를 야기할 수 있는 산업경제정책 마련 등이 필요함을 제시하였다. This study analyzed the interaction between the Incheon Free Economic Zone (IFEZ) and the old downtown of each autonomous district from a perspective of regional imbalance. In discussing uneven development in the economic growth process of a region, Hirschman and Myrdal argue that in the early stages of economic development, a regional base with high growth potential has a trickle-down (spread) effect after the polarized (back-wash) effect in that it absorbs a lot of economic activities from surrounding areas. However, while Hirschman argues that this mitigates uneven development, Myrdal argues that cumulative acceleration of uneven development continues. About 18 years after the designation of the IFEZ in 2003, this analysis of the interaction between economic factors of each autonomous district revealed that uneven development between each district of the IFEZ and the old downtowns of autonomous districts has been deepening. To alleviate this uneven development, this study suggested the necessity to revitalize the old downtown of Jung-gu, enhance the settlement of the old downtowns of Seo-gu and Yeonsu-gu, establish a space plan for pedestrian-friendly connections, and prepare industrial economic policies that can bring trickle-down effects from IFEZ to old downtowns, and so on.

환경생물독성시험에서 사용되는 Reference Chemical의 대체가능성 연구

배철한(Chul-Han Bae),민석기(Seok-Ki Min),유성민(Sung-Min Ryu),임성혁(Sung-Hyuk Im),김세일(Sa-Il Kim),조인선(In-Sun Cho),조재구(Jae-Gu Cho),오진아(Jin-A Oh),박연기(Yeon-Ki Park) 한국농약과학회 2018 농약과학회지 Vol.22 No.2

The ring test was conducted in seven laboratories in order to find a substitute for PCP-Na and dimethoate, which are used a reference chemical in the fish acute toxicity test and honeybee acute toxicity test. Copper(II) sulfate and 3,5-dichlorophenol were selected as substitutes for the acute toxicity test of fish, and carbaryl and phenthoate were selected for the honeybee acute toxicity test. Acute toxicity testing of these chemicals were conducted on carp, ricefish, muddy loach and honeybee. The results showed that 48-h LC<SUB>50</SUB> values for carp were 0.992~3.024 ㎎/L of 3,5-dichlorophenol and 0.10~0.312 ㎎/L of copper(II) sulfate, 48-h LC<SUB>50</SUB> values for muddy loach were 0.992~3.024 ㎎/L of 3,5-dichlorophenol and 0.28~1.094 ㎎/L of copper(II) sulfate, 48-h LC<SUB>50</SUB> values for ricefish were 2.04~2.834 ㎎/L of 3,5-dichlorophenol and 0.77~1.987 ㎎/L of copper(II) sulfate, 48-h LD<SUB>50</SUB> values for honeybee oral test were 0.185~0.916 μg a.i./bee of carbaryl and 0.168~0.915 ㎍ a.i./bee of phenthoate, 48-h LD<SUB>50</SUB> values for honeybee contact test were 0.141~0.507 ㎍ a.i./bee of carbaryl and 0.038~0.113 ㎍ a.i./bee of phenthoate. As a result of examine the toxicity level and the reliability using the test results of each laboratory, 3,5-dichlorophenol and copper(II) sulfate were found to be suitable as a reference chemical for the fish acute toxicity test, and phenthoate was suitable for honeybee acute toxicity test.

Optimization of Agrobacterium tumefaciens-Mediated Transformation of Xylaria grammica EL000614, an Endolichenic Fungus Producing Grammicin

( Min-hye Jeong ),( Jung A. Kim ),( Seogchan Kang ),( Eu Ddeum Choi ),( Youngmin Kim ),( Yerim Lee ),( Mi Jin Jeon ),( Nan Hee Yu ),( Ae Ran Park ),( Jin-cheol Kim ),( Soonok Kim ),( Sook-young Park ) 한국균학회 2021 Mycobiology Vol.49 No.5

An endolichenic fungus Xylaria grammica EL000614 produces grammicin, a potent nematicidal pyrone derivative that can serve as a new control option for root-knot nematodes. We optimized an Agrobacterium tumefaciens-mediated transformation (ATMT) protocol for X. grammica to support genetic studies. Transformants were successfully generated after co-cultivation of homogenized young mycelia of X. grammica with A. tumefaciens strain AGL-1 carrying a binary vector that contains the bacterial hygromycin B phosphotransferase (hph) gene and the eGFP gene in T-DNA. The resulting transformants were mitotically stable, and PCR analysis showed the integratin of both genes in the genome of transformants. Expression of eGFP was confirmed via fluorescence microscopy. Southern analysis showed that 131 (78.9%) out of 166 transformants contained a single T-DNA insertion. Crucial factors for producing predominantly single T-DNA transformants include 48 h of co-cultivation, pretreatment of A. tumefaciens cells with acetosyringone before co-cultivation, and using freshly prepared mycelia. The established ATMT protocol offers an efficient tool for random insertional mutagenesis and gene transfer in studying the biology and ecology of X. grammica.

A case of subdural hematoma in patient with chronic myeloid leukemia treated with high-dose imatinib mesylate

Min Sik Kim,Dong Hyun Lee,Yu Rim Lee,Dong Kyun Kim,Suk Hyang Bae,Jin Yeon Hwang,Kyung A Kwon,이수이,한진영,김기욱,김성현 대한혈액학회 2010 Blood Research Vol.45 No.1

Imatinib mesylate (IM) is used to treat a wide range of diseases, including Philadelphia chromosome-positive chronic myeloid leukemia (CML), on account of its high tolerability and low incidence of minor adverse events. Hemorrhage is thought to be a rare complication of IM. Recently, IM has been associated with reduced a2-plasmin inhibitor and platelet dysfunction. We report here the case of a 33-year-old female patient with CML who experienced subdural hematoma after an incremental increase in IM dosage due to a loss of complete molecular response. This case indicates that physicians should be alert to this atypical cause of headache in patients taking high-dose IM.