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지능형 내시경용 초소형 형상기억합금 엑츄에이터의 제작 및 특성에 관한 연구
김민성,박두환,박현철,이준탁 동아대학교 정보기술연구소 2001 情報通信硏究所論文誌 Vol.9 No.1
A SMA actuator fabricated in this paper generates the large force and it's structure is very simple. The SMA actuator was fabricated by small size with diameter of 9mm and length of 27mm and also it's actuations toward all the directions can be acquired because of three springs which was fabricated with diameter of 2.4mm and 28 turns. We showed into applicability to smart catheter by analysing accurately the dynamic characteristics such as heading angle, force, displacement.
이철,박민수 韓國國際經營學會 1995 國際經營硏究 Vol.6 No.1
본 논문은 우리나라 제조기업들이 수출활동을 수행할때 사용하는 유통경로에 대해 살펴보고 기업의 수출유통경로 결정에 영향을 미치는 요인을 찾아보기 위한 것이다. 이를 위해 먼저 유통경로의 전방통합에 관한 전반적인 문헌적 고찰을 하였고 이 중 윌리암슨의 거래비용분석모델을 중심으로 유통경로의 통합수준에 관한 논의를 전개하였다. 덧붙여 거래비용분석모델에서 간과하고 있는 전략적 측면을 고려하여 연구모형을 설정하고 가설을 도출하였다. 이러한 연구모형에 따라 실증적 검증을 함으로써 모형의 적용가능성과 이에 따르는 전략적 시사점을 도출해내는 것으로 본 논문을 구성하였다. 분석 결과 외부환경의 가변성과 내부 불확실성이 통합수준에 영향을 미치는 것으로 나타났고 자산의 특유성, 외부환경의 다양성 및 해외시장 지향적 태도는 영향을 미치지 못하는 것으로 나타났다.
미세가공기술을 이용한 Interdigitated Array 전극의 제작 및 응용
이강신,김태한,김승렬,신민철,이원용,박제균 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
Interdigitated array (IDA) electrodes were fabricated using silicon technology for highly sensitive biosensing. Thin-film platinum and gold IDA electrodes were fabricated with 10 μm band width and 7 μm gap between the bands using photolithographic techniques. The IDA electrode has 100 fingers consisting of 50 finger anodes and 50 finger cathodes. By applying both the oxidation and the reduction potentials of a reversible redox couple, ferrocyanide, to the pairs of the IDA electrode, an increased current generation can be observed. In our experiment, the collection efficiency of IDA electrode was 46% and amplification factor was 12.6. This preliminary experiment implies that the IDA electrode could be applied to biosensor fabrications as the sensitive electrochemical transducer when a lower detection limit is needed such as phenol sensor for drinking water analysis.
Park, Bo-Young,Yang, Jae-Jeong,Yang, Ji-Hyun,Kim, Ji-Min,Cho, Lisa-Y.,Kang, Dae-Hee,Shin, Chol,Hong, Young-Seoub,Choi, Bo-Youl,Kim, Sung-Soo,Park, Man-Suck,Park, Sue-K. The Korean Society for Preventive Medicine 2010 Journal of Preventive Medicine and Public Health Vol.43 No.6
Objectives: The Korean Genome and Epidemiology Study (KoGES), a multicenter-based multi-cohort study, has collected information on body composition using two different bioelectrical impedence analysis (BIA) machines. The aim of the study was to evaluate the possibility of whether the test values measured from different BIA machines can be integrated through statistical adjustment algorithm under excellent inter-rater reliability. Methods: We selected two centers to measure inter-rater reliability of the two BIA machines. We set up the two machines side by side and measured subjects' body compositions between October and December 2007. Duplicated test values of 848 subjects were collected. Pearson and intra-class correlation coefficients for inter-rater reliability were estimated using results from the two machines. To detect the feasibility for data integration, we constructed statistical compensation models using linear regression models with residual analysis and R-square values. Results: All correlation coefficients indicated excellent reliability except mineral mass. However, models using only duplicated body composition values for data integration were not feasible due to relatively low $R^2$ values of 0.8 for mineral mass and target weight. To integrate body composition data, models adjusted for four empirical variables that were age, sex, weight and height were most ideal (all $R^2$ > 0.9). Conclusions: The test values measured with the two BIA machines in the KoGES have excellent reliability for the nine body composition values. Based on reliability, values can be integrated through algorithmic statistical adjustment using regression equations that includes age, sex, weight, and height.
Hyeong Min Park,Young Hoe Hur,Chol Kyoon Cho,Yang Seok Koh,Hee Joon Kim,Eun Kyu Park 한국간담췌외과학회 2016 Annals of hepato-biliary-pancreatic surgery Vol.20 No.4
Backgrounds/Aims: Despite hepatolithiasis being a risk factor for biliary neoplasm including cholangiocarcinoma, the incidence of underlying biliary neoplasm is unknown in patients with preoperative benign hepatolithiasis. The aim of this study was to evaluate the incidence of underlying biliary neoplasm in patients who underwent major hepatectomy for preoperative benign hepatolithiasis. Methods: Between March 2005 and December 2015, 73 patients who underwent major hepatectomy for preoperative benign hepatolithiasis were enrolled in this study. The incidence and pathological differentiation of concomitant biliary neoplasm were retrospectively determined by review of medical records. Postoperative complications after major hepatectomy were evaluated. Results: Concomitant biliary neoplasm was pathologically confirmed in 20 patients (27.4%). Biliary intraepithelial neoplasia (BIN) was detected in 12 patients (16.4%), and 1 patient (1.4%) had intraductal papillary mucinous neoplasm (IPMN), as the premalignant lesion. Cholangiocarcinoma was pathologically confirmed in 7 patients (9.6%). Preoperative imaging of the 73 patients revealed biliary stricture at the first branch of bile duct in 31 patients (42.5%), and at the second branch of bile duct in 39 patients (53.4%). Postoperative complications developed in 14 patients (19.1%). Almost all patients recovered from complications, including intra-abdominal abscess (9.6%), bile leakage (4.1%), pleural effusion (2.7%), and wound infection (1.4%). Only 1 patient (1.4%) died from aspiration pneumonia. Conclusions: The incidence of underlying biliary neoplasm was not negligible in the patients with hepatolithiasis, despite meticulous preoperative evaluations.
Synthesis and electroluminescent properties of new conjugated bithiazole-containing polymers.
Shin, Chol-Min,Kim, Myeong-Jong,Park, Jong-Wook,Kim, Sung-Ryong,Min, Byung-Gak,Chung, Min-Chul,Lee, Ji-Hoon American Scientific Publishers 2008 Journal of nanoscience and nanotechnology Vol.8 No.10
<P>Three new bithiazole-based conjugated copolymers were synthesized and characterized. The EL device using PNBTV as the emitting layer showed red electroluminescence at 641 nm with a peak luminance of ca. 160 cd/m2 (0.008 cd/A). The red electroluminescence was attributed to the formation of excimers between the polymer chains. An EL device using PNBTV6 as the emitting material, which had two n-hexyl groups introduced to the phenylene in the main chain of PNBTV, showed a reddish orange emission that was blue shifted by approximately 52 nm compared with that observed with PNBTV. This observation was attributed to the significant decrease in interactions between the chains of the polymers due to the two bulky n-hexyl groups. On the other hand, PNBTV6 was found to have superior hole transporting ability compared with its electron transporting ability.</P>
Choi, Jae Yong,Park, Ji-Ae,Kim, Jung Young,Lee, Ji Woong,Lee, Minkyung,Shin, Un Chol,Kang, Joo Hyun,An, Gwang Il,Lee, Kyo Chul,Ryu, Young Hoon,Kim, Kyeong Min 대한방사성의약품학회 2016 Journal of radiopharmaceuticals and molecular prob Vol.2 No.2
Molecular imaging with the radiolabeled RGD peptides for ${\alpha}_v{\beta}_3$ integrin has been an increasing interest for tumor diagnosis and the treatment monitoring. Recently, $^{64}Cu$-NODAGA-gluco-E[c(RGDfK)]$_2$ was developed for quantification of ${\alpha}_v{\beta}_3$ integrin and its biological properties was elucidated. To better understand the molecular process in vivo, we performed the kinetic analysis for the $^{64}Cu$-NODAGA-gluco-E[c(RGDfK)]$_2$. After preparation of a radiotracer, dynamic PET images were obtained in the U87MG xenograft mice for 60 min (n = 6). Binding potential values were estimated from the 3-tissue compartment model, reference Logan and simplified reference tissue model. In the early time frame (0-20 min), the liver, kidney, intestine, urinary bladder and tumor were visualized but these uptakes were diminished as time went by. The tumors showed a good contrast at 40 min after administration. $^{64}Cu$-NODAGA-gluco-E[c(RGDfK)]$_2$ showed the 2-fold uptake in the tumor compared with that in the muscle. The parametric maps for binding values also provide the higher tumor-to-background contrast than the static images. A binding value obtained from the 3-tissue compartment model was comparable to other modeling methods. From these results, we conclude that $^{64}Cu$-NODAGA-gluco-E[c(RGDfK)]$_2$ may be a promising PET radiotracer for the evaluation of angiogenesis.
Park, Ji-Ae,Lee, Yong Jin,Lee, Ji Woong,Yoo, Ran Ji,Shin, Un Chol,Lee, Kyo Chul,Kim, Byung il,Kim, Kyeong Min,Kim, Jung Young American Chemical Society 2016 MOLECULAR PHARMACEUTICS Vol.13 No.7
<P>To obtain an additional pharmacological agent for the diagnosis of inflammation, we investigated the medical use of Zr-89-oxalate as a positron emission tomography (PET) probe for the in vivo imaging of inflammation and compared its efficacy to that of 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) and sodium [F-18]fluoride. Zr-89-oxalate exhibited observable higher uptake in a macrophage cell line than in tumor cells. The inflammatory lesions and tumors were clearly visualized by PET imaging and autoradiography using Zr-89-oxalate. Compared to [F-18]FDG and sodium [F-18]fluoride, Zr-89-oxalate demonstrated a high selectivity index to the tumor at an early time point after injection and to inflammation at a delayed time point after injection (24 h). Through histological examination, large numbers of macrophages and neutrophils were observed in the tumor lesions with the highest Zr-89-oxalate uptake. In a rheumatoid arthritis (RA) mouse model, Zr-89-oxalate demonstrated a high level of accumulation in inflammatory lesions. Zr-89-oxalate is a new strategic tool for tumor imaging and inflammatory processes.</P>