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Effectiveness of Intravitreal Ranibizumab for Diabetic Macular Edema with Serous Retinal Detachment
Mahmut Kaya,Eyyup Karahan,Taylan Ozturk,Nilufer Kocak,Suleyman Kaynak 대한안과학회 2018 Korean Journal of Ophthalmology Vol.32 No.4
Purpose: To evaluate the effectiveness of intravitreal injection of ranibizumab (IVR) in treating diabetic macular edema (DME) with serous retinal detachment (SRD) based on spectral domain optical coherence tomography (SD-OCT) patterns. Methods: One hundred thirty-four eyes of 134 patients with DME who underwent SD-OCT evaluation were included in this study. We retrospectively analyzed the medical records of patients who received IVR for the treatment of DME. Their eyes were classified into three groups according to the following SD-OCT features: SRD, diffuse retinal thickness and cystoid macular edema. The three groups were compared regarding changes in best-corrected visual acuity and central foveal thickness (CFT) after IVR. Results: The mean age was 61.4 ± 9.2 years (range, 44 to 81 years). The average length of the follow-up period was 9.4 ± 3.4 months (range, 6 to 24 months). The mean CFT value was significantly reduced in all groups (p < 0.001) after treatment. Increases in best-corrected visual acuity were statistically significant for the diffuse retinal thickness and cystoid macular edema groups (p < 0.001 and p < 0.001, respectively). However, there was no significant improvement after IVR injection in the SRD group (p = 0.252). In the SRD group, patients with ellipsoid zone disruption and external limiting membrane disruption demonstrated poorer visual gains at the last follow-up visit (p < 0.005 and p = 0.002, respectively). Conclusions: A significant reduction in CFT with required IVR injections in DME with SRD was achieved but was accompanied by a worse functional outcome in the SRD group. The presence of subretinal fluid on SD-OCT in study eyes may be a poor prognostic factor for visual acuity.
Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice
Mahmut Sozmen,Alparslan Kadir Devrim,Recai Tunca,Murat Bayezit,Serpil Dag,Dinc Essiz 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1
The present study was conducted to investigate the effect ofsilymarin on experimental liver toxication induced byFumonisin B1 (FB1) in BALB/c mice. The mice were dividedinto six groups (n = 15). Group 1 served as the control. Group2 was the silymarin control (100 mg/kg by gavage). Groups 3and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1,intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), andGroup 6 was given a higher dose of FB1 (4.5 mg/kg FB1) withsilymarin (100 mg/kg). Silymarin treatment significantlydecreased (p < 0.0001) the apoptotic rate. FB1 administrationsignificantly increased (p < 0.0001) proliferating cell nuclearantigen and Ki-67 expression. Furthermore, FB1 elevated thelevels of caspase-8 and tumor necrosis factor-alpha mediatorswhile silymarin significantly reduced (p < 0.0001) theexpression of these factors. Vascular endothelial growthfactor (VEGF) and fibroblast growth factor-2 (FGF-2)expressions were significantly elevated in Group 4 (p <0.0001). Silymarin administration alleviated increased VEGFand FGF-2 expression levels (p < 0.0001). In conclusion,silymarin ameliorated toxic liver damage caused by FB1 inBALB/c mice.
Mahmut Yıldız 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.76 No.-
The oxidative coupling of methane (OCM) is one of the most important direct method to convert naturalgas into value added products. For thefirst time in literature mesoporous TiO2-rutile supported MnxOy-Na2WO4 catalyst was prepared, characterized and tested in the OCM. The activity parameters (X-CH4, SC2,Y-C2) did not change substantially during the reaction and they were mostly stable. The MnxOy-Na2WO4/mes-TiO2-rutile catalyst seems to have promising potential for the OCM. Moreover, when it iscompared with commercial TiO2-rutile and TiO2-anatase supported catalysts in literature, it can beconcluded that it is a candidate showing even better performance in the OCM.
Mahmut Kalman,Özgür Şimşek 한국교육개발원 2023 KEDI Journal of Educational Policy Vol.20 No.2
This study aimed to explore the relationship between school principals’ learning-centered leadership (LCL) and teacher professional learning (TPL) and the mediating effect of school climate (SC) on this relationship. The sample consisted of 500 middle and secondary school teachers working at urban schools in a large province in the Mediterranean region of Türkiye. A causal relation model was employed. The results indicated that school principals’ LCL affected TPL both directly and indirectly. LCL had a statistically significant and positive effect on SC. SC was detected to have a positive and significant effect on TPL. Furthermore, LCL had a positive and significant effect on TPL, and SC had a partial mediating effect on the relationship between LCL and TPL. The study recommends further research on a multilevel analysis of teacher individual variables and organizational variables to explore the linkage between LCL, TPL, and SC.
Evaluation of Oxidative Status in Patients Treated with Electroconvulsive Therapy
Mahmut Şenyurt,Hulya Aybek,Hasan Herken,Bunyamin Kaptanoglu,Ali Korkmaz 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.1
Objective: Electroconvulsive therapy (ECT) is used in the treatment of many psychiatric diseases and this therapy may be effective on antioxidant defence system. In this study, we aimed to evaluate the effects of ECT on oxidative stress. Methods: Fourteen major depression, 11 schizophrenia and 8 bipolar affective disorder patients diagnosed and received ECT treatment, and 37 healthy volunteers enrolled in the study. ECT was applied to all patients. Before ECT, after the first and last ECTs, serum samples were obtained. Serum total antioxidant status (TAS), total oxidant status (TOS), and calculated oxidative stress index (OSI) were measured in patients before and after ECTs. Results: TOS values before ECT were higher in major depression (p=0.005) and schizophrenia (p=0.001) groups compared to the control group. TAS values were lower in major depression (p=0.0001), schizophrenia (p=0.004), bipolar affective disorder (p=0.004) groups compared to the controls. Also OSI values were higher in major depression (p=0.0001), schizophrenia (p=0.001), bipolar affective disorder (p=0.009) groups compared to healthy group. After the last ECT, TOS values were significantly lower compared to TOS values before ECT in major depression (p=0.004) and schizophrenia patients (p=0.004). TAS values after the first ECT were higher compared to values before ECT in major depression patients (p=0.004). After last ECT, OSI values were significantly lower compared to before ECT in schizophrenia patients (p=0.006). Conclusion: As a result, it can be said that ECT did not increase oxidative stress. However, further studies with more patients are needed.
ISOTROPIC SMARANDACHE CURVES IN THE COMPLEX 4-SPACE
( Mahmut Ergut ),( Suha Yilmaz ),( Yasin Unluturk ) 호남수학회 2018 호남수학학술지 Vol.40 No.1
We define the e1<sup>a</sup> e3<sup>a</sup> -isotropic Smarandache curves of type-1 and type-2, the e1<sup>a</sup> e2<sup>a</sup> e3<sup>a</sup> -isotropic Smarandache curve, and e1<sup>a</sup> e2<sup>a</sup> e4<sup>a</sup>-isotropic Smarandache curves of type-1 and type-2. Then we examine these kinds of isotropic Smarandache curve according to Cartan frame in the complex 4-space C<sup>4</sup> and give some differential geometric properties of these Samarandache curves.
VLC4WoT : Visible Light Communication for Web of Things
( Mahmut Durgun ),( Levent Gökrem ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.4
Recently, new devices have been developed for the Internet of Things concept. The devices commonly use RF (Radio Frequency) based wireless communication. With the increase in the number of devices, the space allocated for the radio frequency band in wireless communication fills rapidly. Visible Light Communication (VLC) is an alternative, secure and economical communication technology that uses light instead of radio frequencies. While Web of Things (WoT) is the adaptation of the experience and knowledge acquired from the web into the internet of things ecosystems. By combining these two technologies, the development of the Visible Light Communication for Web of Things (VLC4WoT) system, which can use VLC and WoT technologies, has been our motivation. In our study, microcontroller control circuit was created for VLC4WoT system. Control of the circuits over the internet was performed. VLC based receiver and transmitter units have been developed for wireless communication. Web based interface was created for control. The test apparatus consisting of four objects with four outputs and a transfer unit was carried out. In this test, communication was achieved successfully. It was presented in the study that VLC can be used in the web of things architecture. In the future, it is envisaged to use this system as a safe and economical system in indoor environments.