Comparison of three different risk-stratification models for predicting lymph node involvement in endometrioid endometrial cancer clinically confined to the uterus

Vakkas Korkmaz,Mehmet Mutlu Meydanli,Ibrahim Yalçın,Mustafa Erkan Sarı,Hanifi Sahin,Eda Kocaman,Ali Haberal,Polat Dursun,Tayfun Güngör,Ali Ayhan 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.6

Objective: To compare the clinical validity of the Gynecologic Oncology Group-99 (GOG-99), the Mayo-modified and the European Society for Medical Oncology (ESMO)-modified criteria for predicting lymph node (LN) involvement in women with endometrioid endometrial cancer (EC) clinically confined to the uterus. Methods: A total of 625 consecutive women who underwent comprehensive surgical staging for endometrioid EC clinically confined to the uterus were divided into low- and high-risk groups according to the GOG-99, the Mayo-modified, and the ESMO-modified criteria. Lymphovascular space invasion is the cornerstone of risk stratification according to the ESMO-modified criteria. These 3 risk stratification models were compared in terms of predicting LN positivity. Results: Systematic LN dissection was achieved in all patients included in the study. LN involvement was detected in 70 (11.2%) patients. LN involvement was correctly estimated in 51 of 70 LN-positive patients according to the GOG-99 criteria (positive likelihood ratio [LR+], 3.3; negative likelihood ratio [LR−], 0.4), 64 of 70 LN-positive patients according to the ESMO-modified criteria (LR+, 2.5; LR−, 0.13) and 69 of the 70 LN-positive patients according to the Mayo-modified criteria (LR+, 2.2; LR−, 0.03). The area under curve of the Mayo-modified, the GOG-99 and the ESMO-modified criteria was 0.763, 0.753, and 0.780, respectively. Conclusion: The ESMO-modified classification seems to be the risk-stratification model that most accurately predicts LN involvement in endometrioid EC clinically confined to the uterus. However, the Mayo-modified classification may be an alternative model to achieve a precise balance between the desire to prevent over-treatment and the ability to diagnose LN involvement.

An analytical approach for offshore structures considering soil-structure interaction

Ali Sari,Kasim Korkmaz Techno-Press 2024 Advances in computational design Vol.9 No.1

This paper presents an advanced analytical approach for the design and analysis of fixed offshore structures with soil structure interaction considered. The proposed methodology involves conducting case studies to illustrate and assess the structural response of a structure considering seven different earthquakes, with the primary goal of ensuring there is no global collapse in the structures. The case studies focus on developing a model for structural analysis and its topside, incorporating nonlinear axial and lateral springs to capture soil-pile interaction. Additionally, mass and damping ratios are considered through the use of dashpots in the analyses. Finite Element Software was employed for structural analyses with detailed modeling, with soil spring nodes applied in the entire structure across various depths. After the finite element analysis was carried out, a sensitivity analysis was conducted to quantify and report the effects of different parameters.

The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study

Korkmaz Muhammet Furkan,Türe Esra,Dorum Bayram Ali,Kılıç Zeliha Banu 대한의학회 2020 Journal of Korean medical science Vol.35 No.25

Background: Coronavirus disease-2019 (COVID-19) pandemic has affected millions of people throughout the world since December 2019. However, there is a limited amount of data about pediatric patients infected with the disease agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: The epidemiological, laboratory, radiological, and treatment features of the pediatric patients who were positive for SARS-CoV-2 based on the reverse-transcription polymerase chain reaction (RT-PCR) test, were investigated retrospectively. Results: The median age of 81 children included in the study was 9.50 years (0–17.75 years). The most frequent symptoms at the time of admission were fever (58%), cough (52%), and fatigue or myalgia (19%). The abnormal laboratory findings in these cases were decreased lymphocytes (2.5%, n = 2), leucopenia (5%, n = 4), and increased lactate dehydrogenase (17.2%, n = 14), C-reactive protein (16%, n = 13), procalcitonin (3.7%, n = 3), and D-dimer (12.3%, n = 10). Three (4%) patients had consolidation in chest computed tomography, and three (4%) had ground-glass opacities. None of the patients needed intensive care except for the newborns. The median time to turn SARS-CoV-2 negative in the RT-PCR test was 5 (3–10) days. The median length of hospital stay was 5 (4–10) days. The time to turn SARS-CoV-2 negative in the RT-PCR test and the length of hospital stay were significantly longer for those aged five years or younger than others (P = 0.037, P = 0.01). Conclusion: Compared to adults, COVID-19 is milder and more distinctive in children. As a result, more conservative approaches might be preferred in children for the diagnostic, clinical, and even therapeutic applications.

Cationic Dye (Methylene Blue) Removal from Aqueous Solution by Montmorillonite

Baybars Ali Fil,Cengiz Özmetin,Mustafa Korkmaz 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.10

Color impurity in industrial effluents pose a significant risk to human health and the environment, so much effort has been expended to degrade them using various methods, including the use of clay minerals as adsorbent. The purpose of this study was to advance understanding of the mechanisms for the removal of methylene blue (MB) from aqueous solutions onto montmorillonite as an adsorbent. Preliminary experiments showed that montmorillonite was effective for this purpose and adsorption equilibrium could be reached in about 24 h. Adsorption capacity of the clay decreased with increase in temperature and ionic strength, and increased with in pH. The fitness of equilibrium data to common isotherm equations such as the Langmuir,Freundlich, Elovich, Temkin and Dubinin-Radushkevich were tested. The Langmuir equation fitted to equilibrium data better than all tested isotherm models. Thermodynamic activation parameters such as ΔG0,ΔS0 and ΔH0 were also calculated and results were evaluated. As result montmorillonite clay was found as effective low cost adsorbent for removal of cationic dyes from waste waters.

Seismic assessment of R/C residential buildings with infill walls in Turkey

Kasim Armagan Korkmaz,Ali Haydar Kayhan,Taner Ucar 사단법인 한국계산역학회 2013 Computers and Concrete, An International Journal Vol.12 No.5

In 1999 Marmara and 2011 Van earthquakes in Turkey, majority of the existing buildings either sustained severe damage or collapsed. These buildings include masonry infill walls in both the interior and exterior R/C frames. The material of the masonry infill is the main variant, ranging from natural stones to bricks and blocks. It is demanding to design these buildings for satisfactory structural behavior. In general, masonry infill walls are considered by its weights not by interaction between walls and frames. In this study, R/C buildings with infill walls are considered in terms of structural behavior. Therefore, 5 and 8-story R/C buildings are regarded as the representative models in the analyses. The R/C representative buildings, both with and without infill walls were analyzed to determine the effects of structural behavior change. The differences in earthquake behavior of these representative buildings were investigated to determine the effects of infill walls leading structural capacity. First, pushover curves of the representative buildings were sketched. Aftermath, time history analyses were carried out to define the displacement demands. Finally, fragility analyses were performed. Throughout the fragility analyses, probabilistic seismic assessment for R/C building structures both with and without infill walls were provided. In this study, besides the deterministic assessment methodology, a probabilistic approach was followed to define structural effect of infill walls under seismic loads.

Cationic Dye (Methylene Blue) Removal from Aqueous Solution by Montmorillonite

Fil, Baybars Ali,Ozmetin, Cengiz,Korkmaz, Mustafa Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.10

Color impurity in industrial effluents pose a significant risk to human health and the environment, so much effort has been expended to degrade them using various methods, including the use of clay minerals as adsorbent. The purpose of this study was to advance understanding of the mechanisms for the removal of methylene blue (MB) from aqueous solutions onto montmorillonite as an adsorbent. Preliminary experiments showed that montmorillonite was effective for this purpose and adsorption equilibrium could be reached in about 24 h. Adsorption capacity of the clay decreased with increase in temperature and ionic strength, and increased with in pH. The fitness of equilibrium data to common isotherm equations such as the Langmuir, Freundlich, Elovich, Temkin and Dubinin-Radushkevich were tested. The Langmuir equation fitted to equilibrium data better than all tested isotherm models. Thermodynamic activation parameters such as ${\Delta}G^0$, ${\Delta}S^0$ and ${\Delta}H^0$ were also calculated and results were evaluated. As result montmorillonite clay was found as effective low cost adsorbent for removal of cationic dyes from waste waters.

A new stability and sensitivity design and diagnosis approach

Kasim A. Korkmaz,Ali Sari 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.6

In the stability and sensitivity design and diagnosis approaches, there are various methodologies available. Bond graph modeling by lumping technique is one of the universal methodologies in methodical analysis used by many researchers in all over the world. The accuracy of the method is validated in different arenas. Bond graphs are a concise, pictorial representation of the energy storage, dissipation and exchange mechanisms of interacting dynamic systems, subsystems and components. This paper proposes a bond graph modeling for distributed parameter systems using lumping techniques. Therefore, a steel frame structure was modeled to analyze employing bond graph modeling of distributed system using lumping technique. In the analytical part, the effectiveness of bond graphs to model this system is demonstrated. The dynamic responses of the system were computed and compared with those computed from the finite element analysis. The calculated maximum deflection time histories were found to be comparable. The sensitivity and the stability of the steel frame structure was also studied in different aspects. Thus, the proposed methodology, with its simplicity, can be used for stability and sensitivity analyses as alternative to finite element method for steel structures. The major value brought in the practical design is the simplicity of the proposed method for steel structures.

Identification of royal jelly as a potential new drug to protect the ovarian reserve and uterus against cyclophosphamide in rats

Mehmet Bulbul,Ali Tekce,Ebru Annac,Omer Korkmaz,Muhittin Onderci,Deniz Korkmaz,Akin Mustafa Demirci The Korean Society for Reproductive Medicine 2023 Clinical and Experimental Reproductive Medicine Vol.50 No.1

Objective: The aim of this study was to investigate the effect of royal jelly (RJ), a powerful natural antioxidant, on cyclophosphamide-induced ovarian damage. Methods: Thirty-two Wistar albino rats were divided into four groups. Oral treatment was administered to all rats for 16 days after a single intraperitoneal injection. The control group received intraperitoneal and oral saline; the RJ group received intraperitoneal saline and 100 mg/kg/day oral RJ; the cyclophosphamide group received intraperitoneal 100 mg/kg cyclophosphamide and oral saline; and the treatment group received intraperitoneal 100 mg/kg cyclophosphamide and 100 mg/kg/day oral RJ. The groups were compared in terms of ovarian reserve tests and histopathological changes in the ovary and uterus. Results: All follicle counts were higher in the treatment group than in the cyclophosphamide group. The increase in the number of preantral follicles (p=0.001) and the decrease in the number of atretic follicles (p=0.004) were statistically significant. RJ treatment significantly improved follicular degeneration and cortical fibrosis in the ovary and epithelial and gland degeneration in the uterus due to cyclophosphamide toxicity. Conclusion: According to these results, RJ reduces cyclophosphamide-related ovarian and endometrial damage in rats. For this reason, it should be further investigated to determine its effects on reproductive function.

Effects of Rhinophototherapy on Quality of Life in Persistant Allergic Rhinitis

Emel Çadalli Tatar,Hakan Korkmaz,Ünzile Akpinar Sürenoğlu,Güleser Saylam,Ali Özdek 대한이비인후과학회 2013 Clinical and Experimental Otorhinolaryngology Vol.6 No.2

Objectives. To investigate the effect of rhinophototherapy with medical therapy on quality of life in persistent allergic rhinitis. Methods. A prospective, randomized study was being performed between December 2009 and March 2010. The study included65 patients with persistent allergic rhinitis. The diagnosis was confirmed with positive skin tests. All of the patientshad house dust mite allergies. We divided the patients into two groups. First group (n=33) was given topicalmometasone furoate 200 mcg/day and levocetirizine 5 mg/day for a month. Rhinophototherapy was applied withthe same medical therapy to the second group (n=32), twice a week for three weeks continuously. Rhinophototherapyincluded visible light, ultraviolet A and ultraviolet B. We evaluated patients before the treatment, at the first monthand at the third month after treatment with rhinoconjunctivitis quality of life questionnaire, nasal symptom scoresand visual analogue scale (VAS) scores. Results. Improvements of all variables of the quality of life questionnaire, nasal symptom scores and VAS were statisticallysignificant in the second group both on the first and the third months when compared with the first group. Conclusion. Allergic rhinitis is a social problem and impairs quality of life. Rhinophototherapy with medical therapy improvesthe quality of life in allergic rhinitis.

Cyclin D1 Gene G870A Variants and Primary Brain Tumors

Zeybek, Umit,Yaylim, Ilhan,Ozkan, Nazli Ezgi,Korkmaz, Gurbet,Turan, Saime,Kafadar, Didem,Cacina, Canan,Kafadar, Ali Metin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Alterations of cyclin D1, one of the main regulators of the cell cycle, are known to be involved in various cancers. The CCDN1 G870A polymorphism causes production of a truncated variant with a shorter half-life and thus thought to impact the regulatory effect of CCDN1. The aim of the present study was to contribute to existing results to help to determine the prognostic value of this specific gene variant and evaluate the role of CCDN1 G870A polymorphism in brain cancer susceptibility. A Turkish study group including 99 patients with primary brain tumors and 155 healthy controls were examined. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. The CCDN1 genotype frequencies in meningioma, glioma and control cases were not significantly different (p>0.05). No significant association was detected according to clinical parameters or tumor characteristics; however, a higher frequency of AG genotype was recorded within patients with astrocytic or oligoastrocytic tumors. A significant association between AG genotype and gliobilastoma multiforme (GBM) was recorded within the patients with glial tumors (p value=0.048 OR: 1.87 CI% 1.010-3.463). According to tumor characteristics, no statistically significant difference was detected within astrocytic, oligoasltrocytic tumors and oligodentrioglias. However, patients with astrocytic astrocytic or oligoastrocytic tumors showed a higher frequency of AG genotype (50%) when compared to those with oligodendrioglial tumors (27.3%). Our results indicate a possible relation between GBM formation and CCDN1 genotype.