Epstein-Barr Virus and p16INK4A Methylation in Squamous Cell Carcinoma and Precancerous Lesions of the Cervix Uteri

Lin Zhenhua,Kim Insun,Kim Na Rae,Kim Kyong Rae,조현이 대한의학회 2005 Journal of Korean medical science Vol.20 No.4

The design of a scintillation system based on SiPMs integrated with gain correction functionality

Lin, Zhenhua,Hautefeuille, Benoit,Jung, Sung-Hee,Moon, Jinho,Park, Jang-Guen Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.1

Use of SiPM has been considered as an alternative to PMT, because of its compact size, low-operating voltage, non-sensitive to electromagnetic, low costs and so on. The main limitation for the use of SiPM is due to its small sensitive area compared to PMT that limits the light collection, and therefore the sensor energy resolution. In this article we studied the effect of increasing the number of SiPM by connecting them in parallel to increase the active detection area. This allowed us to compare the different energy resolution measurements. ¹³⁷Cs has been selected as reference to study the energy resolution for 662 keV gamma-rays. Another investigation was to compare the minimum detectable gamma energy under various SiPM configurations. It has been found that the use of 4 SiPM arrays can greatly improve the energy resolution up to 4% than only one SiPM array, meanwhile use of more than 2 SiPM arrays does not increase the energy resolution significantly. Thus we can conclude that for a large area of cylindrical scintillator (3 × 3 inches), the use of SiPMs are limited to a certain number or certai active area depending on the commercial SiPMs, and its cost should be less than traditional PMT for the cost-effective and compact size considerations. It is well known that the gain of SiPM varies with temperature. In this article, we also calibrated gain to guarantee the same position of photoelectric peak in response of different temperatures.

Wake effects of an upstream bridge on aerodynamic characteristics of a downstream bridge

Zhenhua Chen,Zhenyun Lin,Haojun Tang,Yongle Li,Bin Wang 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.6

To study the wake influence of an upstream bridge on the wind-resistance performance of a downstream bridge, two adjacent long-span cable-stayed bridges are taken as examples. Based on wind tunnel tests, the static aerodynamic coefficients and the dynamic response of the downstream bridge are measured in the wake of the upstream one. Considering different horizontal and vertical distances, the flutter derivatives of the downstream bridge at different angles of attack are extracted by Computational Fluid Dynamics (CFD) simulations and discussed, and the change in critical flutter state is further studied. The results show that a train passing through the downstream bridge could significantly increase the lift coefficient of the bridge which has the same direction with the gravity of the train, leading to possible vertical deformation and vibration. In the wake of the upstream bridge, the change in lift coefficient of the downstream bridge is reduced, but the dynamic response seems to be strong. The effect of aerodynamic interference on flutter stability is related to the horizontal and vertical distances between the two adjacent bridges as well as the attack angle of incoming flow. At large angles of attack, the aerodynamic condition around the downstream girder which may drive the bridge to torsional flutter instability is weakened by the wake of the upstream bridge, and the critical flutter wind speed increases at this situation.

Effect of Occupational Health and Safety Management System on Work-Related Accident Rate and Differences of Occupational Health and Safety Management System Awareness between Managers in South Korea's Construction Industry

Yoon, Seok J.,Lin, Hsing K.,Chen, Gang,Yi, Shinjea,Choi, Jeawook,Rui, Zhenhua Occupational Safety and Health Research Institute 2013 Safety and health at work Vol.4 No.4

Background: The study was conducted to investigate the current status of the occupational health and safety management system (OHSMS) in the construction industry and the effect of OHSMS on accident rates. Differences of awareness levels on safety issues among site general managers and occupational health and safety (OHS) managers are identified through surveys. Methods: The accident rates for the OHSMS-certified construction companies from 2006 to 2011, when the construction OHSMS became widely available, were analyzed to understand the effect of OHSMS on the work-related injury rates in the construction industry. The Korea Occupational Safety and Health Agency 18001 is the certification to these companies performing OHSMS in South Korea. The questionnaire was created to analyze the differences of OHSMS awareness between site general managers and OHS managers of construction companies. Results: The implementation of OHSMS among the top 100 construction companies in South Korea shows that the accident rate decreased by 67% and the fatal accident rate decreased by 10.3% during the period from 2006 to 2011. The survey in this study shows different OHSMS awareness levels between site general managers and OHS managers. The differences were motivation for developing OHSMS, external support needed for implementing OHSMS, problems and effectiveness of implementing OHSMS. Conclusion: Both work-related accident and fatal accident rates were found to be significantly reduced by implementing OHSMS in this study. The differences of OHSMS awareness between site general managers and OHS managers were identified through a survey. The effect of these differences on safety and other benefits warrants further research with proper data collection.

Influence of Water on the Methanation Performance of Mo-Based Sulfur-Resistant Catalysts with and without Cobalt Additive

Haiyang Wang,Can Lin,Zhenhua Li,Baowei Wang,Xinbin Ma 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.1

The activities of Mo-based and Co-containing Mo-based catalysts for sulfur-resistant methanation in the presence and the absence of water are compared. When water was added to the Mo-based catalyst, its methanation activity decreased and the activity could not be recovered even after the water was removed from the system. However, for the Co-containing Mo-based catalysts, the formation of Co9S8 improved not only the methanation activity of the catalyst as active sites but also the stability of the catalyst especially in water-containing hydrogenation. The deactivation of the Mo-based catalyst in the presence of water is mainly due to reduction of the external acid sites and fewer molybdenum sulfide (MoS2) stacks. The addition of Co protects the active MoS2 phase, thereby preventing the deactivation of the catalyst in the presence of water.

Effect of Occupational Health and Safety Management System on Work-Related Accident Rate and Differences of Occupational Health and Safety Management System Awareness between Managers in South Korea's Construction Industry

Seok J. Yoon,Hsing K. Lin,Gang Chen,Shinjea Yi,최재욱,Zhenhua Rui 한국산업안전보건공단 산업안전보건연구원 2013 Safety and health at work Vol.4 No.4

BackgroundThe study was conducted to investigate the current status of the occupational health and safety management system (OHSMS) in the construction industry and the effect of OHSMS on accident rates. Differences of awareness levels on safety issues among site general managers and occupational health and safety (OHS) managers are identified through surveys. MethodsThe accident rates for the OHSMS-certified construction companies from 2006 to 2011, when the construction OHSMS became widely available, were analyzed to understand the effect of OHSMS on the work-related injury rates in the construction industry. The Korea Occupational Safety and Health Agency 18001 is the certification to these companies performing OHSMS in South Korea. The questionnaire was created to analyze the differences of OHSMS awareness between site general managers and OHS managers of construction companies. ResultsThe implementation of OHSMS among the top 100 construction companies in South Korea shows that the accident rate decreased by 67% and the fatal accident rate decreased by 10.3% during the period from 2006 to 2011. The survey in this study shows different OHSMS awareness levels between site general managers and OHS managers. The differences were motivation for developing OHSMS, external support needed for implementing OHSMS, problems and effectiveness of implementing OHSMS. ConclusionBoth work-related accident and fatal accident rates were found to be significantly reduced by implementing OHSMS in this study. The differences of OHSMS awareness between site general managers and OHS managers were identified through a survey. The effect of these differences on safety and other benefits warrants further research with proper data collection.

Fabrication of Unique and Green Tin(IV) Sulfide/Moss Photocatalyst for Highly Effective Photocatalytic Reduction of Cr(VI)

Xia Zhang,Yumin Wang,Chao Hou,Xiaohui Lin,Hongli Jiang,Zhenhua Wei 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.3

We report a simple and green method for fabricating SnS2 modified moss composites for removal of heavy metal (Cr(VI)) considering the fact that the issue of wastewater caused by the discharge of heavy metal is becoming increasingly serious. More importantly, this kind of functional materials that are capable of removing effectively Cr(VI) from wastewater for water purification is quite few on the market. Hence, in the paper, such SnS2 decorated moss photocatalysts for removal of heavy metal (Cr(VI)) were designed and prepared via a simple and green method: chemical bath reaction. The as-designed materials (C@SnS2) integrate the independent properties of moss (with excellent performance in absorption of heavy metal) and SnS2 (with good photocatalytic reduction of Cr(VI) under visible light irradiation), showing a faster photocatalytic rate than those independent components. The experiment results indicate that more than 98.5% of Cr(VI) was reduced under visible light irradiation for 70 min, while only 18.2% and 84.4% of Cr(VI) were removed in the presence of C-moss and pure SnS2 at the same condition, respectively. Furthermore, the as-designed C@SnS2 has good recyclability in the removal of Cr(VI). We believe such simple and green method to prepare photocatalyst for wastewater treatment with excellent performance will provide a good platform to design new photocatalytic materials for water purification.

Thickness-dependent reversible hydrogenation of graphene layers.

Luo, Zhiqiang,Yu, Ting,Kim, Ki-Jeong,Ni, Zhenhua,You, Yumeng,Lim, Sanhua,Shen, Zexiang,Wang, Shanzhong,Lin, Jianyi American Chemical Society 2009 ACS NANO Vol.3 No.7

<P>In this work, graphene layers on SiO(2)/Si substrate have been chemically decorated by radio frequency hydrogen plasma. Hydrogen coverage investigation by Raman spectroscopy and micro-X-ray photoelectron spectroscopy characterization demonstrates that the hydrogenation of single layer graphene on SiO(2)/Si substrate is much less feasible than that of bilayer and multilayer graphene. Both the hydrogenation and dehydrogenation process of the graphene layers are controlled by the corresponding energy barriers, which show significant dependence on the number of layers. The extent of decorated carbon atoms in graphene layers can be manipulated reversibly up to the saturation coverage, which facilitates engineering of chemically decorated graphene with various functional groups via plasma techniques.</P>

Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis

Nan Li,Junjie Piao,Xinyue Wang,김기열,배정윤,Xiangshan Ren,Zhenhua Lin 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4

Purpose This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. Materials and Methods The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Results Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. Conclusion Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.

Identification of a nuclear-recessive gene locus for male sterility on A2 chromosome using the Brassica 60 K SNP array in nonheading Chinese cabbage

Guolin Zhou,Xia Li,Aihua Wang,Feng Zu,Zhenhua Hu,Jiazao Lin,Jinxing Tu 한국유전학회 2016 Genes & Genomics Vol.38 No.12

WS24-3 is a newly bred recessive genic male sterility line of the non-heading Chinese cabbage (Brassica rapa ssp. chinensis). Here, an F2 population was produced from the cross between WS24-3 and a male-fertile breeding line (WS135). The Illumina Brassica 60 K single nucleotide polymorphism (SNP) array was used for SNPs detecting between sterile and fertile bulks from the F2 population, and 62 SNPs were identified. BLAST analysis of the 62 SNPs revealed that the A2 chromosome of Brassica rapa genome contained 22 SNPs, whereas the other chromosomes did not contain more than 6 SNPs each. These data indicated that the potential target gene locus, named Bra2Ms, might be located on A2. Based on 10 of the 22 SNPs, allele-specific-polymerase chain reaction (AS-PCR) primers and single sequence repeat (SSR) primers were designed, 5 AS-PCR primers and 9 SSR primers showed difference between the bulks in electrophoretic determination. Analysis of these markers in F2 population revealed that Bra2Ms was genetically delimited to a region of 1.2 cM. We also detected two co-segregated markers SSRa2-951 and SSRa2-960 in this region. The markers identified in our study might facilitate the transfer of recessive genic male sterility alleles to other favorable genetic backgrounds. Furthermore, these markers will support a map-based clone of Bra2Ms.