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Shaomei Liu,Jiaxin Li,Yuan Wu,Yanna Ren,Qi Liu,Qiyao Wang,Xiangshan Zhou,Menghao Cai,Yuanxing Zhang 한국유전학회 2017 Genes & Genomics Vol.39 No.3
Aspergillus glaucus HB1-19 is a typical marinederived fungus preferring the dependence on sea water for its growth, asexual development and polyketides biosynthesis. Therein, salt stress greatly functions even in superior to light illumination, which is also a critical regulation signal for fungi. Here, comparative RNA-seq analysis of this strain was performed under conditions of saltstress ? dark (group A), non salt-stress ? dark (group B), salt-stress ? light (group C). The RNA-seq generated a total of 19,024 unigenes with an average length of 1415 bp. Differentially expressed genes were very similar between group A and group C but greatly differed between group A and group B, proving that salt stress functioned superior to light illumination globally. Salt stress highly enhanced primary metabolism and activated Ras and MAPK signaling pathways. There seems no direct interaction between asexual development and polyketides biosynthesis. Salt stress inhibited terpenoids biosynthesis but showed little influences on polyketide pathway as well as other secondary metabolism pathways. These findings provide a better understanding of marine fungi adapting to marine environment. Also, it indicates that the so-called ‘salt stress-induced’ may truly be a ‘metal ions-induced’ for biosynthesis of secondary metabolites in marine fungi.
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Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis
Nan Li,Junjie Piao,Xinyue Wang,김기열,배정윤,Xiangshan Ren,Zhenhua Lin 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. Materials and Methods The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Results Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. Conclusion Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
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