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간외담관 폐쇄에서의 초음파소견 : 담관벽 경계소실의 중요성 Significance of Decreased Echotexture of Bile Duct Wall-Interface
신현준,손은주,이창희,최영칠,전혜정,박정희,이태의 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-
Ultrasound is very useful in evaluation of obstructive jaundice. We retrospectively evaluated the useful findings of ultrasonography in differentiating benign extrahepatic duct obstruction from malignant diseases. Among the 36 patients, 25 patients were benign extrahepatic obstruction and 11 patients were malignant obstruction. The shapes of extrahepatic dilatation were classified into fustiform, meniscus, and abrupt cut off by bowel gas. The diameter, length, and bile duct wall-interface were compared between benign and malignant groups and serum bilirubin and alkaline phosphatase were also compared between two groups retrospectively. The results were as follows. The most common form of extrahepatic dilatation was meniscus(10 of 26 patients, 38%) in benign obstruction, and fusiform(8 of 11 patients, 73%) in malignant obstruction. No significant difference was noted in diameter, length, serum bilirubin, and alkaline phosphatase between benign and malignant groups. Only one case showed decreased bile duct wall-interface in benign obstruction, but loss or decrease of bile duct wall-interface were 8 patients in malignant obstruction. The combined findings of fusiform dilatation and loss of bile duct wall-interface in ultrasonography will be helpful in differential diagnosis of malignant extrahepatic bile obstruction from benign conditions.
Lee, Ui Yun,Jung, Jinmu,Kwak, Hyo Sung,Lee, Dong Hwan,Chung, Gyung Ho,Park, Jung Soo,Koh, Eun Jeong The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.6
Objective : The goal of this study was to compare several parameters, including wall shear stress (WSS) and flow pattern, between unruptured and ruptured anterior communicating artery (ACoA) aneurysms using patient-specific aneurysm geometry. Methods : In total, 18 unruptured and 24 ruptured aneurysms were analyzed using computational fluid dynamics (CFD) models. Minimal, average, and maximal wall shear stress were calculated based on CFD simulations. Aneurysm height, ostium diameter, aspect ratio, and area of aneurysm were measured. Aneurysms were classified according to flow complexity (simple or complex) and inflow jet (concentrated or diffused). Statistical analyses were performed to ascertain differences between the aneurysm groups. Results : Average wall shear stress of the ruptured group was greater than that of the unruptured group (9.42% for aneurysm and 10.38% for ostium). The average area of ruptured aneurysms was 31.22% larger than unruptured aneurysms. Simple flow was observed in 14 of 18 (78%) unruptured aneurysms, while all ruptured aneurysms had complex flow (p<0.001). Ruptured aneurysms were more likely to have a concentrated inflow jet (63%), while unruptured aneurysms predominantly had a diffused inflow jet (83%, p=0.004). Conclusion : Ruptured aneurysms tended to have a larger geometric size and greater WSS compared to unruptured aneurysms, but the difference was not statistically significant. Flow complexity and inflow jet were significantly different between unruptured and ruptured ACoA aneurysms.
Lee, Ui Yun,Jung, Jinmu,Kwak, Hyo Sung,Lee, Dong Hwan,Chung, Gyung Ho,Park, Jung Soo,Koh, Eun Jeong The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.2
Objective : The objective of this study was to analyze patient-specific blood flow in ruptured aneurysms using obtained non-Newtonian viscosity and to observe associated hemodynamic features and morphological effects. Methods : Five patients with acute subarachnoid hemorrhage caused by ruptured posterior communicating artery aneurysms were included in the study. Patients' blood samples were measured immediately after enrollment. Computational fluid dynamics (CFD) was conducted to evaluate viscosity distributions and wall shear stress (WSS) distributions using a patient-specific geometric model and shear-thinning viscosity properties. Results : Substantial viscosity change was found at the dome of the aneurysms studied when applying non-Newtonian blood viscosity measured at peak-systole and end-diastole. The maximal WSS of the non-Newtonian model on an aneurysm at peak-systole was approximately 16% lower compared to Newtonian fluid, and most of the hemodynamic features of Newtonian flow at the aneurysms were higher, except for minimal WSS value. However, the differences between the Newtonian and non-Newtonian flow were not statistically significant. Rupture point of an aneurysm showed low WSS regardless of Newtonian or non-Newtonian CFD analyses. Conclusion : By using measured non-Newtonian viscosity and geometry on patient-specific CFD analysis, morphologic differences in hemodynamic features, such as changes in whole blood viscosity and WSS, were observed. Therefore, measured non-Newtonian viscosity might be possibly useful to obtain patient-specific hemodynamic and morphologic result.
Lee, Su Ui,Kim, Mun-Ock,Kang, Myung-Ji,Oh, Eun Sol,Ro, Hyunju,Lee, Ro Woon,Song, Yu Na,Jung, Sunin,Lee, Jae-Won,Lee, Soo Yun,Bae, Taeyeol,Hong, Sung-Tae,Kim, Tae-Don Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.1
Airway mucus secretion is an essential innate immune response for host protection. However, overproduction and hypersecretion of mucus, mainly composed of the gel-forming MUC5AC protein, are significant risk factors for patients with asthma and chronic obstructive pulmonary disease (COPD). The transforming growth factor β (TGFβ) signaling pathway negatively regulates MUC5AC expression; however, the underlying molecular mechanism is not fully understood. Here, we showed that TGFβ significantly reduces the expression of MUC5AC mRNA and its protein in NCI-H292 cells, a human mucoepidermoid carcinoma cell line. This reduced MUC5AC expression was restored by a TGFβ receptor inhibitor (SB431542), but not by the inhibition of NF-κB (BAY11-7082 or Triptolide) or PI3K (LY294002) activities. TGFβ-activated Smad3 dose-dependently bound to MUC5AC promoter. Notably, TGFβ-activated Smad3 recruited HDAC2 and facilitated nuclear translocation of HDAC2, thereby inducing the deacetylation of NF-κB at K310, which is essential for a reduction in NF-κB transcriptional activity. Both TGFβ-induced nuclear translocation of Smad3/HDAC2 and deacetylation of NF-κB at K310 were suppressed by a Smad3 inhibitor (SIS3). These results suggest that the TGFβ-activated Smad3/HDAC2 complex is an essential negative regulator for MUC5AC expression and an epigenetic regulator for NF-κB acetylation. Therefore, these results collectively suggest that modulation of the TGFβ1/Smad3/HDAC2/NF-κB pathway axis can be a promising way to improve lung function as a treatment strategy for asthma and COPD.
Lee, Jin-Wook,Lim, Hyun-Chang,Lee, Eun-Ung,Park, Jin-Young,Lee, Jung-Seok,Lee, Dong-Woon,Jung, Ui-Won,Choi, Seong-Ho Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.4
Purpose: The aim of this study was to assess the possible paracrine effect of bone morphogeneticprotein-2 (BMP-2) at the experimental site on the adjacent control site for validating a rabbit calvarial defect model as a means of verifying the effect of BMP-2. Methods: Sixteen rabbits were divided into two groups (n=8 in each) according to whether or not BMP-2 would be used. Two circular defects (8 mm in diameter) were created side by side, 2 mm apart, in the calvarium of all of the rabbits. In each animal, one of the defects was grafted with either BMP-2-loaded carrier or carrier material alone. The control defects adjacent to these grafted defects, designated CB (the nongrafted defect adjacent BMP-2-loaded carrier-grafted defect) and CC (the nongrafted defect adjacent to carrier only-grafted defect), respectively, were the focus of this study, and were filled only with a blood clot in all of the animals. Histologic observation and histomorphometric analysis were performed at 2 and 8 weeks (n=4 animals per point in time) after surgery. Results: There was no noteworthy difference in the healing pattern, and no statistically significant differences in histomorphometric parameters such as the defect closure, new bone area, or total augmented area between the CC and CB groups. Conclusions: The results of this study suggest that rabbit calvarial defects separated by a distance of 2 mm are suitable for evaluating the effects of BMP-2 and the control defect can be regarded not to be affected by BMP-2 applied defect.
Microstructure and Pattern Size Dependence of Copper Corrosion in Submicron-Scale Features
Lee, Ui-hyoung,Jeon, Hyoung Jin,Kang, Tak,Sohn, Hun-Joon,Oh, Kyu Hwan,Her, Eun Kyu,Han, Heung Nam,Lee, H. W.,Kim, Insoo,Kim, Donggyu,Lee, Sung-Keun,Lee, Hyo-Jong The Electrochemical Society 2011 Journal of the Electrochemical Society Vol.158 No.5
Delayed intentional replantation of periodontally hopeless teeth: a retrospective study
Lee, Eun-Ung,Lim, Hyun-Chang,Lee, Jung-Seok,Jung, Ui-Won,Kim, Ui-Sung,Lee, Seung-Jong,Choi, Seong-Ho Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.1
Purpose: The purpose of this study was to retrospectively evaluate the survival of periodontally hopeless teeth that were intentionally extracted and replanted after a delay and to compare the radiographic characteristics of the survival group with those of the failure group. Methods: The clinical and radiographic data from patients who underwent delayed intentional replantation between March 2000 and July 2010 were reviewed. Twenty-seven periodontally hopeless teeth were extracted and preserved in medium supplemented with antibiotics for 10-14 days. The teeth were then repositioned in the partially healed extraction socket and followed for 3 to 21 months. The radiographic parameters were analyzed using a paired t test and the cumulative survival rate was analyzed using Kaplan-Meier analysis. Results: Seven replanted teeth failed and the overall cumulative survival rate was 66.4%. In the survival group, the amount of bone loss was reduced from 68.45% to 34.66% three months after replantation. There was radiologic and clinical evidence of ankylosis with 5 teeth. However, no root resorption was found throughout the follow-up period. In the failure group, bone formation occurred from the bottom of the socket. However, a remarkable radiolucent line along the root of a replanted tooth existed. The line lengthened and thickened as time passed. Finally, in each case of failure, the tooth was extracted due to signs of inflammation and increased mobility. Conclusions: Delayed intentional replantation has many advantages compared to immediate intentional replantation and could serve as an alternative treatment for periodontally involved hopeless teeth. However, techniques for maintaining the vitality of periodontal structures on the tooth surface should be developed for improved and predictable results.
Measurement of proton beam range by using scintillating fiber optic dosimeter
Ui-Jung Hwang,Hojin Jeong,Jeong-Eun Rah,Seung Hoon Yoo,Byung Jun Min,Sang-Yeob Lee,Myonggeun Yoon,Dong Ho Shin,Se Byeong Lee,Sung Yong Park,Kyong Won Jang,DongHyun Cho,Bongsoo Lee 대한방사선방어학회 2010 대한방사선방어학회 학술발표회 논문요약집 Vol.2010 No.11
Lee Seung Jae,Lee Ji-Eun,Lee Chang-Jin,Jeong Ui-Hyun,이우국,Kwon Hyo-Jun,Kim Min-Won,Shim Tae-Hun,Park Jea-Gun 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.10
I–III–VI-based quantum dots (QDs) are promising eco-friendly light-emitting materials for next-generation displays. Thus far, I–III–VI-based QDs (i.e., AgIn1-xGaxS2) are still insufcient as light-emitting materials for display felds because of their deteriorated optical properties caused by lattice mismatch between the core/shell materials. We designed a novel passivation process using a shell material (i.e., ZnGa2S4) with crystalline structure identical to that of AgGaS2-xSex core QDs (tetragonal). Green and red light-emitting AgGaS2/ZnGa2S4 core/shell QDs demonstrated superior optical properties owing to the minimum lattice mismatch between the AgGaS2-xSe2 core and ZnGa2S4 shell materials. In particular, a higher quantum yield (QY) and narrow full-width at half-maximum (FWHM) for the green and red light-emitting QDs were achieved, i.e., QYs of 69% and 64% and FWHMs of 26 and 28 nm, respectively. In addition, this remarkable enhancement of optical properties resulted in an increase of~94.4% in the color-space agreement with ITU-R recommendation BT.2020. This means that AgGaS2-xSex-based core/shell QDs have the potential to be used as eco-friendly QDs for light-emitting materials in next-generation displays.
Comprehensive and synthetic inventory of Dokdo Island, Republic of Korea
Ui Wook Hwang,Hyun Soo Rho,Bia Park,Eun Hwa Choi,Cho Rong Shin,Sa Heung Kim,Jongrak Lee,Hack Cheul Kim,Mann Kyoon Shin,Taeseo Park,Jumin Jun,Heegab Lee,Jong Eun Lee,Yoon Sik Oh,Jung-Goo Myoung,Chang G The National Institute of Biological Resources 2023 Journal of species research Vol.12 No.no.spc
This study aims to establish a comprehensive, synthetic inventory system for the fauna and flora of Dokdo Island, Republic of Korea, which has been conducted by a specialized research group consisting of more than 50 experts. The research was conducted over five years(2015-2019) and supported by the National Institute of Biological Resources, Ministry of Environment, Republic of Korea. All possible publications on the fauna and flora of Dokdo Island over the last 68 years from 1952 to 2020 were reviewed. As a result, 1,302 species were found on Dokdo Island during the study period. An updated list of 1,963 species was created. This is expected to be of great help for the conservation and national publicity of important indigenous biological resources of Dokdo Island.