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宋亨燮,郭炅鎬 忠南大學校 地域開發硏究所 1993 地域開發論叢 Vol.5 No.-
Since 1988, Forestry Administration of Korea has established Recreation forests to meet the increasing needs for forest recreation. The purpose of this study is to obtain information on the users’ behaviors and socio-economic characteristics in recreation forest. Respondents were selected 568 adults more than 18 years old randamly from 3 recreation forest of manin, yumyung, and youngchu. Analysis of users’ behaviors and socio-economic characteristics was carried out through frequency and factor analysis methods. The most of noticeable characteristic of users for recreation forest were rather youth groups, high education level, city residents. The major preference activities were walking and climbing in recreation forest. With difference age groups, professional groups, recreation forest site, people tend to have their preference activities differently. According to factor analysis for visit motives three most explanatory factors of visit motives for recreation forest were contact with natural land, life with family, and cultivate mutual friendship.
Acupuncture treatment of drug addiction
Oh, Jin-Kyung,Chae, Youn-Byoung,Shim, In-Sop,Park, Hi-Joon,Lee, Hye-Jung Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.2
Acupuncture as a therapeutic intervention has been widely used for treatment for many functional disorders, such as substances abuse and mental dysfunction. In general, acupuncture is known to be simple, economic; painless, non-traumatic, and without untoward reaction, being able to inhibit the abstinence syndrome. Although a number of studies on acupuncture have been reported, a few studies described acupuncture effect on drug addiction. Evidences suggest that substances abuses including nicotine, cocaine and alcohol are in part related to its effects on dopamine neurons in the reward pathways of the brain. The effects of acupuncture on drug addiction may be mediated through the neuronal cells within the limbic structures, which are known to be involved in rewarding properties of drug abuse. This essay reviews clinical and experimental evidences for its effectiveness on the drug addiction, and discusses a plausible explanation for the mechanism of acupuncture on substances abuse.
( Jin Kyung Oh ),( Sin Soo Jeun ),( Seok Gu Kang ),( Kyung Soo Kim ),( In Sop Shim ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.12
Trimethyltin (TMT) is a potent toxicant which selectively kills cells in the central nervous system (CNS) and immune system. Within the CNS, TMT selectively destroyed neurons in the neocortex, amygdala, and olfactory tubercle, however its most striking effects were observed in the hippocampal formation. In the present study, we examined the effects of human umbilical cord blood (hUCB)-derived mesenchymal stem cells (MSCs) on TMTinduced hippocampal cell death and the impairments of learning and memory in Morris water maze in rats. The hUCB-MSCs were grafted into the hippocampus 1 week after TMT (6.0 mg/kg, i.p.)-induced neurodegeneration. We identified that hUCB-MSCs survived and were differentiated in TMT-induced rat brain by the hoechst dye analysis, bromodeoxyuridine and neuronal marker NeuN immunofluorescence. In rats exposed to TMT, the hUCBMSCs grafts improved spatial learning and memory in the water maze, suggesting that grafts can in some circumstances reduce spatial deficits on the CNS after TMT-induced neurodegeneration. The present results suggest that hUCB-MSCs grafted into the TMT-induced rat brain are capable of differentiation into neurons as well as improving spatial recognition.
Pharmacokinetics and Biodistribution of a pGT2-VEGF Plasmid DNA After Administration in Rats
Son, Mi-Kyung,Choi, Jae-Hoon,Lee, Dong-Sop,Kim, Chae-Young,Choi, Seul-Min,Kang, Kyung-Koo,Byun, Jonghoe,Kim, Duk-Kyung,Kim, Byong-Moon Lippincott Williams Wilkins, Inc. 2005 Journal of cardiovascular pharmacology Vol.46 No.5
Intramyocardial administration of gene therapy vectors expressing angiogenic factors have been attempted as an alternative to conventional surgical methods for the management of myocardial ischemia. In this study, we have developed the pGT2-VEGF, a plasmid DNA vector expressing human VEGF165, for the management of ischemic cardiovascular disease and investigated in vivo pharmacokinetics and tissue distribution of pGT2-VEGF after intramyocardial and intravenous administration in rats. A high concentration of pGT2-VEGF was observed in the heart after intramyocardial injection of 300 μg, which is in line with the assumption that direct intramyocardial delivery enables extended localization at the administration site. Leakage of the pGT2-VEGF to the blood circulation was observed after intramyocardial injection, with an area under the curve (AUC) of 3.8 μg min/mL, as compared with 37.3 μg min/mL after intravenous injection of the same dose. The pGT2-VEGF concentration in blood peaked at 5 minutes after intramyocardial administration and declined rapidly to undetectable levels by 2 hours post-administration. In tissue distribution studies, pGT2-VEGF peaked at 5 minutes post-administration in various organs but was undetectable at 2 hours in all organs except heart, lung, and liver. Taken together, the results suggest that intramyocardial-delivered pGT2-VEGF was degraded rapidly in vivo and mainly persisted in target tissues, the heart. In addition, intramyocardial-administered pGT2-VEGF was expressed for longer periods than the persistence of the pGT2-VEGF plasmid DNA in a target tissue. Therefore, a direct myocardial injection of pGT2-VEGF might be useful for local therapeutic angiogenesis.
자연휴양림과 도시형 산림이 주는 심리적 이완효과의 차이
김경목(Kyung-Mok Kim),임효진(Hyo Jin Lim),김상희(Sang Hee Kim),최윤호(Yoon Ho Choi),신원섭(Won-Sop Shin),박범진(Bum-Jin Park) 한국산림휴양학회 2012 한국산림휴양학회지 Vol.16 No.1
본 연구의 목적은 자연휴양림과 도시형 산림이 주는 심리적 이완효과의 차이를 밝히는 것이다. 50명의 건강한 대학생이 피험자로 참여하였다. 피험자는 15분간 의자에 앉아서 자연휴양림, 도시형 산림 그리고 도시의 경관을 감상하였다. 기분의 변화를 측정하기 위한 지표로 기분상태검사(POMS)와 의미분별법(SD법)을 활용하였다. SD법의 측정결과 도시형 산림은 도시환경보다 쾌적감과 자연감이 유의하게 높았으며, 자연휴양림은 도시형 산림보다 쾌적감과 자연감이 유의하게 높았다. 기분상태 검사의 측정결과 자연휴양림과 도시형 산림 모두 도시환경과 비교하여 긴장-불안, 분노, 혼란, 그리고 종합감정장해가 유의하게 낮게 조사되었고 자연휴양림과 도시형 산림 간에는 유의한 차이를 볼 수 없었다. 이에 반하여 우울은 휴양림에서만이 유의하게 낮아지는 것으로 조사되었다. 이상의 결과는 심리적 이완효과의 관점에서 본다면 자연휴양림과 도시형 산림의 체류효과는 서로 다르며 이에 따라 방문목적도 서로 다르게 설정할 필요가 있을 것으로 판단된다. The purpose of this study was to clarify to the difference of psychological relaxation effects between natural recreation forest and urban forest. Fifty university students participated in the study as subjects. The subjects seated on a chair and viewing a natural recreation forest landscape, urban forest landscape and urban landscape for 15minutes. The profile of mood states (POMS) method and the semantic differential (SD) method were employed in which a questionnaire after subjects sat and viewed the natural recreation forest landscape, urban forest landscape and urban landscape. Responses to the SD questionnaire indicated that compared to urban settings, urban forest settings are perceived as being significantly pleasant and natural. Also, comparing to urban forest settings, natural recreation forest setting are significantly pleasant and natural. The POMS measures of tension and anxiety (T-A), anger and hostility (A--H), confusion (C), and total mood disturbance (TMD) showed significant differences between the forests (national recreation forest and urban forest) and urban areas without significant differences between national recreation forest and urban forest. The POMS measures of depression and dejection (D) showed significant differences between national recreation forest and urban area without significant differences between urban forest and urban place. These results support the suggestion that natural recreation forest and urban forest has another aims to visit for gain psychological relaxation effects.