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On the mater plan of the green in Kamakura City
Koshimizu, hajime,Ishikawa, Mikik,Koshizawa, Akira,Tsuchiya, Shiro Korean Institute of Landscape Architecture 2001 Journal of the Korean institute of landscape archi Vol.1 No.-
Decision progress, plan content and planning division title of the master plan of the green in Kamakura City Japan were described. Conservation of the green and various effectiveness of the measure for realizing the green creation plan and the future development were discussed. It was indicated that the cooperation between citizens land owners and administration of the country, prefecture and city was important.
Nagasawa, Hiroshi,Koshimizu, U.,Yamamoto, K. Asian Australasian Association of Animal Productio 1988 Animal Bioscience Vol.1 No.1
Based on our previous results that among 4 strains of mice SHN and GR/A showed the highest mammary growth potentials in females and males, respectively. Effects of crossbreeding on normal and neoplastic mammary growth were studied in $(SHN\;{\times}\;GR/A)F_1$ virgin female mice. $F_1$ mice were higher than the parental strains in the end-bud formation and the ductal growth of mammary glands at 60 days of age and at tumorous age, respectively. While there was little difference between $F_1$ and both parental strains in the onset age of the first mammary tumors, mammary tumorigenic potential was apparently higher in the former than in the latters. This would be the first report that demonstrated directly the contribution of mammary growth potential of males to that of female offspring.
Miyake, N.,Tsukaguchi, H.,Koshimizu, E.,Shono, A.,Matsunaga, S.,Shiina, M.,Mimura, Y.,Imamura, S.,Hirose, T.,Okudela, K.,Nozu, K.,Akioka, Y.,Hattori, M.,Yoshikawa, N.,Kitamura, A.,Cheong, H.,Kagami, S University of Chicago Press [etc.] 2015 American journal of human genetics Vol.97 No.4
The nuclear pore complex (NPC) is a huge protein complex embedded in the nuclear envelope. It has central functions in nucleocytoplasmic transport, nuclear framework, and gene regulation. Nucleoporin 107 kDa (NUP107) is a component of the NPC central scaffold and is an essential protein in all eukaryotic cells. Here, we report on biallelic NUP107 mutations in nine affected individuals who are from five unrelated families and show early-onset steroid-resistant nephrotic syndrome (SRNS). These individuals have pathologically focal segmental glomerulosclerosis, a condition that leads to end-stage renal disease with high frequency. NUP107 is ubiquitously expressed, including in glomerular podocytes. Three of four NUP107 mutations detected in the affected individuals hamper NUP107 binding to NUP133 (nucleoporin 133 kDa) and NUP107 incorporation into NPCs in vitro. Zebrafish with nup107 knockdown generated by morpholino oligonucleotides displayed hypoplastic glomerulus structures and abnormal podocyte foot processes, thereby mimicking the pathological changes seen in the kidneys of the SRNS individuals with NUP107 mutations. Considering the unique properties of the podocyte (highly differentiated foot-process architecture and slit membrane and the inability to regenerate), we propose a ''podocyte-injury model'' as the pathomechanism for SRNS due to biallelic NUP107 mutations.
Photo- and radio- luminescence characterizations in rare-earth-doped SrAl2O4 crystals
Daisuke Nakauchi,Masanori Koshimizu,Noriaki Kawaguchi,Takayuki Yanagida 한양대학교 세라믹연구소 2019 Journal of Ceramic Processing Research Vol.20 No.4
SrAl2O4 bulk crystals doped with all rare-earth (RE) ions except for Sc, Y, La, Pm and Lu were synthesized by the optical floating zone method to systematically investigate the photoluminescence (PL) and radioluminescence (RL) properties for radiation detector applications. The crystal samples show PL and RL signals due to the 5d-4f or 4f-4f transitions of doped RE ions, and each decay curve consists of a sum of exponential functions with the typical decay time constants. Under VUV photon excitation, the Ce-, Pr-, Eu-, Tb-, Dy- and Ho-doped samples exhibit PL predominantly with two broad emission bands around 320 and 600 nm, which are possibly due to self-trapped excitons (STEs) perturbed by RE ions.
Effect to optical properties by changing the Al2O3 ratio in K2O-Al2O3-P2O5 glasses
D. Shiratori,Y. Isokawa,H. Samizo,M. Koshimizu,N. Kawaguchi,T. Yanagida 한양대학교 세라믹연구소 2019 Journal of Ceramic Processing Research Vol.20 No.4
In this study, we prepared glasses with the composition of 0.1% Ce-doped (100−x) KPO3-xAl2O3 and investigated luminescent characteristics. The glass samples with different Al2O3 ratio (x = 5, 10, 15, 20, 25, 30 and 40) were synthesized by the melt quenching method. The All samples had high transmittance (80−90%) at wavelengths longer than 350 nm except for x = 40, and by increasing the Al2O3 ratio, the transmittance of the samples was improved. From the measurements of photoluminescence (PL) decay curve, the luminescence decay time was confirmed to be typical for the 5d−4f transition of Ce3+ (~30 ns). The samples showed thermally-stimulated luminescence (TSL), and the sensitivity of dose response was confirmed to be linear in the dose range from 0.01 mGy to 1 Gy for the x = 25 and 30 samples which showed the highest sensitivity among the present samples. The scintillation spectra show the broad luminescence around 300−500 nm, and these emission intensities were increased by increasing the Al2O3 ratio.
Sarcopenia in elderly patients with chronic low back pain
Yoshihito Sakai,Hiroki Matsui,Sadayuki Ito,Tetsuro Hida,Kenyu Ito,Hiroyuki Koshimizu,Atsushi Harada 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.4
Objectives: The prevalence of chronic low back pain (CLBP) increases with age and several mechanisms are involved in the development of CLBP, including osteoporosis; however, no associations with sarcopenia have yet been identified. Methods: In total, 100 patients with CLBP and 560 patients without CLBP (nCLBP) aged over 65 years were studied. Skeletal muscle mass index (SMI) and percentage of body fat were evaluated using wholebody dual-energy X-ray absorptiometry. Sarcopenia was diagnosed when the relative SMI was more than 2 standard deviations below the mean in young adults. Thus, the cutoff value for sarcopenia was defined according to Sanada's Japanese population data. Paraspinal muscle cross-sectional areas of the lumbar multifidus and the erector spinae muscles were calculated using magnetic resonance imaging. Results: Forty patients (40.0%) from the CLBP group and 149 (26.6%) from the nCLBP group met the criteria of sarcopenia. SMI was significantly lower and the body fat ratio was significantly higher in the CLBP group compared with the nCLBP group. Sarcopenic obesity was significantly observed in the CLBP group. Lumbar multifidus and the erector spinae muscle cross sectional area were significantly lower in the CLBP group. Conclusions: Elderly patients with CLBP have significantly lower skeletal muscle mass, and age-related mechanisms in sarcopenia are considered to be associated with chronic pain. Therapeutic procedures that are used to treat elderly aging muscle, including muscle strengthening and performance training, can possibly be a treatment for or used to prevent elderly CLBP. © 2017 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Anti-tumor Promoting Activity of Some Malaysian Traditional Vegetables (Ulam)
L. Yang Mooi,A. M. Ali,A. B. Norhanom,K. Mat Salleh,A. Murakami,K. Koshimizu 한국생약학회 1999 Natural Product Sciences Vol.5 No.1
Ethanolic extracts of different parts of 10 loyal traditional vegetables (ulam) (Amarunthus gangeticus, Jussiaea linifolia, Eugenic polyantha, Trapa incisca, Trichosanthes anquina, Mangifera indica, Pachyrrhirus erosus, Barringtonia mcarostachya, Carica papaya, and Coleus tuberosus) were screened for in vitro anti-tumor promoting activity using the inhibition test of Epstein-Barr virus (EBV) activation in Raji cells induced by phorbol 12-myristate 13-acetate and sodium-n-butyrate. All the extracts were found to have strong inhibition activity toward EBV-activation, except for leaf extract of T. anquina. The extracts were non-cytotoxic to the Raji cells except for the extracts of A. gangeticus (leaves), B. mucrostachya (leaves), E. polyuntha (young leaves), and J. linifolia (leaves) where the viability of the cells were decreased significantly.
Ito Sadayuki,Sakai Yoshihito,Ando Kei,Nakashima Hiroaki,Machino Masaaki,Segi Naoki,Tomita Hiroyuki,Koshimizu Hiroyuki,Hida Tetsuro,Ito Kenyu,Harada Atsushi,Imagama Shiro 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.2
Study Design: Retrospective study.Purpose: Cervical laminoplasty is safe and effective for treating cervical myelopathy but has a higher frequency of postoperative axial pain compared to other methods. Several studies have reported on the causes of postoperative axial pain, but none have fully elucidated them. This study aimed to investigate the association between postoperative neck pain and intraoperative transcranial motor-evoked potential (MEP) waveforms of the trapezius muscles using transcranial MEPs.Overview of Literature: Few studies have investigated the association between postoperative neck pain and intraoperative transcranial MEP waveforms of the trapezius muscles in patients with cervical laminoplasty.Methods: A total of 79 patients with cervical myelopathy who underwent cervical laminoplasty at our facility between June 2010 and March 2013 were included in this study. Intraoperative control and final waveform were evaluated based on the trapezius muscle MEPs by measuring the latency and amplitude. A neck pain group comprised patients with higher neck pain Visual Analog Scale scores from preoperative value to 1 year postoperatively. The cross-sectional areas of the trapezius muscles and the MEP latencies and amplitudes were compared between patients with and without neck pain.Results: The latency and amplitude of the control waveforms were not significantly different between groups. The neck pain group had a significantly shorter final waveform latency (neck pain: 23.6±2.5, no neck pain: 25.8±4.5; p =0.019) and significantly larger amplitude (neck pain: 2,125±1,077, no neck pain: 1,630±966; p =0.041) than the no neck pain group.Conclusions: Postoperative neck pain was associated with the final waveform latency and amplitude of the trapezius muscle MEPs during cervical laminoplasty. Intraoperative electrophysiological trapezius muscle abnormalities could cause postoperative neck pain.