Protectionism and the Future of the World Economy

Shiina, Motoo 仁荷大學校 國際關係硏究所 1986 The Pacific Century Vol.1986 No.-

The Protection of the Cultural Heritage in Japen

shiina, Shintaro 忠北大學校 法科大學 法學硏究所 1990 法學硏究 Vol.2 No.-

Radiofrequency Ablation(RFA) for Hepatocellular Carcinoma(HCC)

( Shuichiro Shiina ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)

An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia

Akihiro Shiina,Nobuhisa Kanahara,Tsuyoshi Sasaki,Yasunori Oda,Tasuku Hashimoto,Tadashi Hasegawa,Taisuke Yoshida,Masaomi Iyo,갠지하시모토 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.1

Objective: Schizophrenia is a mental disorder characterized by severe cognitive impairment. Accumulating evidence suggests a role for oxidative stress in the pathophysiology of schizophrenia. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. In this study, we attempted to evaluate the effect of SFN on cognitive impairment in medicated patients with schizophrenia. Methods: We recruited a total of 10 outpatients with schizophrenia, all of whom gave informed consent. Participants took 3 tablets of SFN, consisting of 30 mg of SFN-glucosinolate per day, for 8 weeks. Clinical symptoms using the Positive and Negative Syndrome Scale (PANSS) and cognitive function using the Japanese version of CogState battery were evaluated at the beginning of the study and at week 8. Results: A total of 7 patients completed the trial. The mean score in the Accuracy component of the One Card Learning Task increased significantly after the trial. However, we detected no other significant changes in participants. Conclusion: This result suggests that SFN has the potential to improve cognitive function in patients with schizophrenia.

Current Approaches to the Treatment of Early HCC in Japan

( Shuichiro Shiina ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Hepatocellular carcinoma (HCC) is the 4th most common cause of cancer-related deaths in Japan. In Japan, the most common etiology of HCC is HCV, which is different from that in most Asian countries, where HBV is the most prevalent. About a half of HCC is HCV-related, although the ratio has been gradually decreasing. Since the ethanol injection period, we have had strong argument regarding which treatment is superior for HCC, surgical resection or percutaneous ablation. The Japanese clinical practice guidelines for HCC (4th JSH-HCC guidelines) recommends both surgery and ablation for patients with HCC who have three or fewer lesions, each 3 cm or less in diameter, and whose liver functions are in Child-Pugh grade A or B. Comparison of surgical resection with ablation is considerably difficult; the indications are somewhat different between the two treatments. Patients with a large lesion tend to undergo surgical resection while those with multiple lesions, advanced age, or more deteriorated liver function tend to receive ablation. Furthermore, both treatments are highly operator-dependent and their indications may be different from institution to institution. Thus, a patient who is decided by medical professionals to undergo ablation or surgical resection at an institution may not be given the same treatment at others. There were four randomized controlled trials (RCTs) to compare surgery with RFA; one showed superiority of surgery in survival while the remaining three did not show the difference in survival between the two therapies. To compare surgery with radiofrequency ablation, we conducted a multicenter RCT (SURF trial) in Japan. We recruited patients with primary HCC at 49 hospitals who had three or fewer lesions, each 3 cm or less in diameter ≤ 3 cm, and whose liver functions were in Child-Pugh score of 7 or lower, age between 20 and 79 years. Before randomization, technical and liver functional feasibility for both treatment arms were confirmed by joint chart review by surgeons and hepatologists. Patients were then randomly assigned in a 1:1 ratio to surgery and RFA, stratified by age, infection of HCV, number of tumors, tumor size and institution. The primary endpoints were recurrence free survival (RFS) and overall survival (OS). Between April 2009 and August 2015, a total of 308 patients were enrolled to this trial. Seven patients were excluded because of ineligibility, therefore 150 patients were assigned to surgery and 151 patients to RFA. There was no perioperative mortality. Under the median follow-up of 5 years, the 3-year RFSs of patients who were assigned to surgery and RFA were 49.8% and 47.7%, respectively (hazard ratio [HR] 0.96, 95% CI 0.72-1.28; p = 0.793). The RCT trial did not show difference in RFS between surgery and RFA. In parallel with the RCT, we also conducted SURF Cohort trial. In this cohort trial, HCC patients who fulfilled the enrollment criteria but did not give consent to participate in the RCT were enrolled. Baseline characteristics, such as sex, HCV positivity, size, Child-Pugh score, and platelet count were significantly different between the two treatment groups. Patient’s age was not significantly different between the two treatment. However, it might be due to the age limitation of 79 years in the eligibility criteria. The imbalance in background characteristics may reflect a real-world clinical practice of choosing a treatment. In the cohort study, RFS was not significantly different, either between surgery group and RFA group after adjustment of inversed probability of treatment weighting. SURF trial is ongoing for the final analysis of 5-year overall survival. OS will be assessed after August 2020 as scheduled in the protocol. New-generation MWA systems incorporating water or gas antenna cooling and high-power generation have recently attracted attention. New-generation MWA may create a more predictable ablation zone, a larger ablation volume in a shorter time period. Many high volume centers of ablation have introduced new-generation MWA for liver tumor ablation in Japan. However, its clinical data have been insufficient compared with that of RFA. There have been four RCTs to compare new-generation MWA with RFA. None of them have proved superiority of MWA over RFA from the viewpoint of overall survival. Further studies are mandatory especially in terms of long-term survival. Both surgery and ablation are highly operator-dependent. The skills and outcomes are very different from operator to operator. In surgery, the Japanese Society of Hepato-Biliary-Pancreatic Surgery has a board-certification system for expert surgeons. On the other hand, in ablation, there is no established training system yet. Because the procedure appears to be relatively simple, we are afraid that ablation is sometimes done without sufficient training. It is mandatory to have the system which enhances acquisition of knowledge and skills for successful ablation. In Japan, more than 80% of liver tumor ablation is performed by gastroenterologists or hepatologists. The remaining are done by surgeons or radiologists. The result of final analysis in SURF trial is not coming yet. However, we expect ablation would be proved to be the first-line treatment even for solitary HCC. Ablation would play a more important role in the aging society. In ablation, it is mandatory to establish the system to exchange knowledge and experience and standardize the procedure.

Poster Session : PS 0617 ; Others ; Four-Year Trend of Inpatients in the Second-Line Hospital Before and After the Great East Japan Earthquake

( Kuni Shiina ),( Shinpei Yamashita ),( Yuta Tezuka ),( Hiroko Sakurai ),( Hisanori Gamada ),( Toru Yoshida ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Iwate Prefectural Senmaya Hospital (Senmaya Hospital) adjoins the coastal area where seriously damaged by the Tsunami on 2011.3.11. From the disaster, we are working as the second-line hospital. We perform this study to verify the role of the second-line hospital of tsumami disaster, for taking better steps to deal with the future disasters. Methods: The data was obtained from patient record of Senmaya Hospital and assessed. Results: The patient surge started on the day of the tsunami. Overall 136 patients from tsunami swept area (60% from Iwate Prefecture and 40% from Miyagi Prefecture, next to Iwate) was admitted to Senmaya Hospital within 1 month after the disaster. Temporally, the number of inpatients decreased on 16th, the next day of the restoration of electricity, but increased again. The average inpatient per month was 1.0-1.8 fold (average 1.3) compared with that of the previous year (before tsunami). The highest number of the inpatients was found in February 2012, the coldest month in the fi rst winter. Then cost-free pneumococcus vaccination was introduced to the population more than 65 years old. The rate of pneumonia on admission and discharge by death were signifi cantly decreased from 2012-2013 winter. Conclusions: The second-line hospital must receive many patients immediately after the disaster and continuously accept the excess of the inpatients at least 1 year. The pneumococcus vaccination was effective to decrease admission and hospital death by pneumonia. The second-line hospital should store additional space, equipments and goods for the immediate and continuous excess of the patients.

Radiofrequency Ablation ( RFA ) for Hepatocellular Carcinoma ( HCC )

(Shuichiro Shiina) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.3(S)

日本と韓國における子守歌詞章の比較硏究 -愛情の表現を對象に

시이나쇼코 ( Shiina Shoko ) 韓國日語日文學會 2009 日語日文學硏究 Vol.70 No.1

Development and clinical translation of photoacoustic mammography

Tsuyoshi Shiina,Masakazu Toi,Takayuki Yagi 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.2

To practically apply photoacoustic (PA) imaging technology in medicine, we have developed prototypes of a photoacousticmammography (PAM) device to acquire images for diagnosing breast cancer in the Kyoto University/Canon joint researchproject (CK project supported by MEXT, Japan). First, the basic ability of the PAM system to visualize the network ofblood vessels and the Hb saturation index was evaluated using a prototype of PAM that has a flat scanning detector and iscapable of simultaneously acquiring photoacoustic (PA) and ultrasound images. Next, another prototype of a PAM devicewith hemispherical sensors was developed to improve the visibility of the 3D structure of vessels by reducing the limitedview effect. In clinical examination of breast cancer cases, the PAM system allowed 3D visualization of fine vesselnetworks with a spatial resolution of a half-millimeter and enabled us to determine the features of tumor-related vascularstructures in human breast cancer. In addition, the oxygen saturation status of Hb was visualized using two differentwavelengths, enabling more precise characterization of the tumor microenvironment. Results of clinical evaluation usingour developed prototype of a PAM device confirmed that PA imaging technology has the potential to promote earlydetection of breast cancer, and realization of its practical use is expected in the near future.

Heavy Fermion in Ferromagnetic Kondo Model with Integer Spin

Shingo Kuniyoshi,Ryousuke Shiina 한국물리학회 2023 새물리 Vol.73 No.12

A weakly anisotropic ferromagnetic Kondo model with an integer impurity spin is investigated as an effective Hamiltonian for the underscreened Kondo physics. It is shown by using the numerical renormalization group (NRG) method that the thermodynamic properties exhibit an unexpected heavy fermion behavior at low temperatures. The mechanism of the heavy fermion formation and an approximated analytic formula for the γ value of the specific heat have been discussed in conjunction with the fixed point analysis in the NRG method.