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Kippeum Lee,Young-Jin Se,Ji-Hyoen Song,최성우,이부용 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: Panax ginseng Meyer is known as a conventional herbal medicine, and ginsenoside Rg1, asteroid glycoside, is one of its components. Although Rg1 has been proved to have an antiobesity effect,the mechanism of this effect and whether it involves adipose browning have not been elucidated. Methods: 3T3-L1 and subcutaneous white adipocytes from mice were used to access the thermogeniceffect of Rg1. Adipose mitochondria and uncoupling protein 1 (UCP1) expression were analyzed byimmunofluorescence. Protein level and mRNA of UCP1 were also evaluated byWestern blotting and realtimepolymerase chain reaction, respectively. Results: Rg1 dramatically enhanced expression of brown adipocyteespecific markers, such as UCP1 andfatty acid oxidation genes, including carnitine palmitoyltransferase 1. In addition, it modulated lipidmetabolism, activated 50 adenosine monophosphate (AMP)-activated protein kinase, and promoted lipiddroplet dispersion. Conclusions: Rg1 increases UCP1 expression and mitochondrial biogenesis in 3T3-L1 and subcutaneouswhite adipose cells isolated from C57BL/6 mice. We suggest that Rg1 exerts its antiobesity effects bypromoting adipocyte browning through activation of the AMP-activated protein kinase pathway.
Lee, Kippeum,Seo, Young-Jin,Song, Ji-Hyoen,Chei, Sungwoo,Lee, Boo-Yong The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.4
Background: Panax ginseng Meyer is known as a conventional herbal medicine, and ginsenoside Rg1, a steroid glycoside, is one of its components. Although Rg1 has been proved to have an antiobesity effect, the mechanism of this effect and whether it involves adipose browning have not been elucidated. Methods: 3T3-L1 and subcutaneous white adipocytes from mice were used to access the thermogenic effect of Rg1. Adipose mitochondria and uncoupling protein 1 (UCP1) expression were analyzed by immunofluorescence. Protein level and mRNA of UCP1 were also evaluated by Western blotting and realtime polymerase chain reaction, respectively. Results: Rg1 dramatically enhanced expression of brown adipocyte-especific markers, such as UCP1 and fatty acid oxidation genes, including carnitine palmitoyltransferase 1. In addition, it modulated lipid metabolism, activated 5' adenosine monophosphate (AMP)-activated protein kinase, and promoted lipid droplet dispersion. Conclusions: Rg1 increases UCP1 expression and mitochondrial biogenesis in 3T3-L1 and subcutaneous white adipose cells isolated from C57BL/6 mice. We suggest that Rg1 exerts its antiobesity effects by promoting adipocyte browning through activation of the AMP-activated protein kinase pathway.
전자기록의 증거적 가치 수립을 위한 기능요건에 관한 연구: 미국 eDiscovery 적용을 중심으로
최기쁨,이젬마,오효정,Choi, Kippeum,Lee, Gemma,Oh, Hyo-Jung 한국정보관리학회 2021 정보관리학회지 Vol.38 No.2
근래까지 증거개시의 대상은 본래 종이 문서로 제한되어 왔으나, 디지털 시대로의 전환에 발맞추어 증거개시의 대상도 확대됨에 따라 현 시점에서는 전자적으로 생성된 정보에 관한 쟁점을 해결하는 것이 소송에서 중요해졌다. 따라서 본 연구에서는 전자기록이 증거로서 인정받기 위한 각 영역의 요건을 분석하고 기록관리 관점에서 고려해야 하는 요소를 설명하였다. 특히, 증거로서 전자기록을 활용되기 위한 선진 사례로, 미국의 전자증거개시제도인 eDiscovery를 선정하여 전자적 정보가 어떻게 수집, 보존되어 최종적으로 법원에 제출되는지를 살펴보았다. 특히 증거 보존 조치 지침을 조사하여 기록이 증거로서 보존되기 위해 고려되어야 하는 요건이 무엇인지 파악하였으며, 증거력이 있는 전자기록을 제출할 수 있도록 도와주는 도구인 eDiscovery 솔루션의 기능을 분석하였다. 본 연구결과를 통해 전자증거개시를 지원하는 시스템 구현 시 실질적인 도움이 될 수 있는 필수 기능요건을 도출하였다. Discovery's collection was originally paper documents, but with the advent of the digital age, its collection expanded. Resolving the issue of ESI has now become important in litigation. Therefore, this study analyzes the requirements of each domain for electronic records to be recognized as evidence. It also explained the factors that should be considered in record management. In addition, eDiscovery in the United States was selected as an advanced case to utilize records as evidence. This study investigated the Commentary on Legal Holdings: The Trigger & The Process and analyzed which functions must be considered in order for electronic records to be preserved as evidence. To this end, we analyze the functional requirements of the eDiscovery solution. Through this, necessary functional requirements are derived to help implement the system in preparation for eDiscovery.