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송지현,김귀진,Sungwoo Chei,Young-Jin Seo,Kippeum Lee,Boo Yong Lee 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2
Background: Continuous exposure to high temperatures can lead to heat stress. This stress responsealters the expression of multiple genes and can contribute to the onset of various diseases. In particular,heat stress induces oxidative stress by increasing the production of reactive oxygen species. The liver isan essential organ that plays a variety of roles, such as detoxification and protein synthesis. Therefore, itis important to protect the liver from oxidative stress caused by heat stress. Korean ginseng has a varietyof beneficial biological properties, and our previous studies showed that it provides an effective defenseagainst heat stress. Methods: We investigated the ability of Korean Red Ginseng and Korean black ginseng extracts (JP5 andBG1) to protect against heat stress using a rat model. We then confirmed the active ingredients andmechanism of action using a cell-based model. Results: Heat stress significantly increased gene and protein expression of oxidative stresserelatedfactors such as catalase and SOD2, but treatment with JP5 (Korean Red Ginseng extract) and BG1(Korean black ginseng extract) abolished this response in both liver tissue and HepG2 cells. In addition,JP5 and BG1 inhibited the expression of inflammatory proteins such as p-NF-kB and tumor necrosisfactor alpha-a. In particular, JP5 and BG1 decreased the expression of components of the NLRP3inflammasome, a key inflammatory signaling factor. Thus, JP5 and BG1 inhibited both oxidative stressand inflammation. Conclusions: JP5 and BG1 protect against oxidative stress and inflammation induced by heat stress andhelp maintain liver function by preventing liver damage.